• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 춘계학술대회 논문집
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• pp.215-218
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• 2004

This paper is about a study of development on multi crusher system. This system use the principle of the Yeon-Ja-Bang-A. This system consists of the power part and the power transmit part, the Yeon-Ja Stone part, the crusher part, an input part, an output part. The advantage of this system decrease about working hours and installation aera.

• Journal of Microbiology and Biotechnology
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• 제32권10호
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• pp.1299-1306
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• 2022

Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher's method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC₅₀ values ranging from 24.60 ± 3.37 µM to 49.93 ± 4.52 µM.

• 생약학회지
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• 제37권1호통권144호
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• pp.42-47
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• 2006

The contents of quercetin glyciside in Saururus chinensis Baill was higher in the 2nd year, 1st year and 3rd year in leaves, and in the 1st year, 3rd year and 2nd year in stems in that orders. Content of lignans in the rhizome was not significantly different cultivated years. The total phenolics, quercetin glycoside and EDA of plant parts were higher in order of flower, leaf and chopping sample. The total phenolics and EDA of stem were much lower than parts and quercetin glycoside was not detected.

• 임상간호연구
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• 제14권3호
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• pp.15-25
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• 2008

Purpose: This study was aimed to investigate the effects of gum-chewing on the recovery of bowel movement and oral cavity discomfort after abdominal surgery. Method: The nonequivalent control group, non-syncronized repeated treatment design was used. A total of 99 patients were participated in the study. The 44 patients were in the experimental group and the rest in the control group. The experimental group chewed gum three times a day until they passed gas. As the patient reported gas-passing, bowel movement time, subjective symptoms of oral cavity, and oral status were recorded precisely. The frequency, percentage, $x^2$-test and t-test were analyzed by SPSS PC 12.0. Results: There were significant differences in bowel movement, gas passing, oral cavity symptoms, and oral status scores between the experimental and the control group. Conclusion: The findings of the study demonstrated the fact that gum-chewing helps early recovery from post-operative ileus and thirst. It is because gum chewing stimulates bowel mobility and secretion of saliva. Thus gum-chewing seems to be an effective nursing intervention in reducing post-operative side effects for patients with abdominal surgery.

• 한국환경복원기술학회지
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• 제2권4호
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• pp.27-34
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• 1999

The purpose of this study was to suggest the vegetation structure and management plan of forests at Anmyundo. Sixteen plot were established in the forests and surveyed. The plant communities were classified into three community type, which were Pinus densiflora-Quercus serrata community, Pinus densiflora community, Quercus variabilis community. It was hypothesized that Pinus densiflora-Quercus serrata community will be changed to Quercus Spp. community. The vegetation management for successional controls on long-term basis was suggested. Dominant trees were mid-size trees(21~30year-old and DBH 18~28cm), and large trees(over DBH 30cm) appeared only at the Recreation Forest and Kuksabong. Anmyundo forests should be managed with a priority given to Pinus densifolra. Forest trees should be planted in consideration of environmental conditions and Pinus densifolra densities.

• 농촌계획
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• 제15권4호
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• pp.11-17
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• 2009

Rural Amenity Design Competition is opened every year since 2003 having an intention of improving spatial design and planning of rural area through developing values of rural amenity resources and applying in that area. The subject of this competition is broad and there's no limit in locations so that various solutions and original ideas could be proposed. This research examined 165 prizewinning works of the competition and analyzed the locations and areas, aims, main resources, spatial planning contents and experience programs to find out trends of rural spatial design. According to the study, the prizewinning works tends to 1) include spatial plan for an existing village planning, 2) aim rural tourism for citizens and increasement of resident's incomes, 3) develop vegetation and agricultural resources, 4) plan for natural landscape, commercialization of local special productions and agriculture, and 5) propose ecological experience programs. The same theme of the competition repeated every year had led to advanced design skills but also a stagnant of design contents. A subject and a main goal of the Rural Amenity Design Competition should be departmentalized each time hereafter to make for the weak points and propose progressive direction for the rural spatial design.

• 동의신경정신과학회지
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• 제19권3호
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• pp.117-127
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• 2008

Objective: Bee venom (BV) has been used for the treatment of inflammatory diseases such as rheumatoid arthritis and relief of pain in Oriental medicine. The two main components of BV are melittin and phospholipase A2 (PLA2). Of these, melittin, the major active ingredient of BV, has been reported to induce apoptosis and to possess anti tumor effects. Several studies have established that the agents inducing apoptosis in target organs suppress tumorigenesis. As the other component, PLA2 has been reported to induce neurite outgrowth in PC12 cells. However, there was no report about proliferative effect of BV in neuronal cells. In order to examine the effect of BV on glioma cell, human glioma cell line, U87 was used. Methods: Analysis of proliferation was confirmed by MTT assay. BV increased cell number through dose and duration dependent manner and these effects are apparent at a concentration of 10 ug/ml. To observe which signaling molecules will be activated by BV, phosphorylation of Akt, MAPK, PYK2 or CREB were examined by Western blot analysis. To study the long term effect of BV in U87 cells, the image of cells treated with BV for 4 days were obtained. Results: The phosphorylation levels of PYK2 and Akt were increased at 5 min after addition of 10 ug/ml of BV and sustained to 2 hours. On the other hand, phosphorylation of MAPK and CREB were increased at 5 min, maximum at 10 min, and returned to 30 min. These imply that BV may activate two different signaling pathways, PYK2/Akt and MAPK/CREB. BV treated cells showed increased neurite number and length. Conclusion: These results propose that BV may induce differentiation as well as proliferation of U87 cells through the activation of PYK2/ Akt and MAPK/ CREB.

• 한국자원식물학회지
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• 제18권3호
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• pp.505-511
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• 2005

삼백초 수확 후 광 노출정도에 따른 선도유지 및 유효성분 함량 변화를 구명하여 품질향상을 위한 기초자료를 제공하고자 시험을 수행한 결과, 건물율은 잎, 줄기, 꽃 모두 광노출 시간이 길수록 높았으며, 색도중 명도는 광노출시간이 짧을수록 높았으나, 적색도는 상반된 경향이었다. 황색도와 채도는 건조전에는 광노출 2시간시에, 건조후에는 광노출시간이 짧을수록 높았으나, 경엽 탕전시에는 상반된 경향이었고, 광노출 시간이 짧을수록 rutin, quercitri 의 함량과 떫은 맛이 많았고, 품질 선호도와 경엽 탕전 시 기호도도 우수하였다.

• Journal of Gastric Cancer
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• 제18권1호
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• pp.69-81
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• 2018

Purpose: It has been reported that the survival of patients with locally advanced gastric cancer (LAGC) is better in East Asia countries than in developed western countries; however, the prognosis of LAGC remains poor. This study aimed to evaluate the effects of perioperative chemotherapy on the long-term survival of East Asia patients with LAGC. Materials and Methods: From October 2006 through August 2008, 43 patients with LAGC received perioperative S-1 combined with weekly docetaxel in a phase II study (neoadjuvant group). These patients were matched using propensity scores to patients who underwent surgery without neoadjuvant chemotherapy during the same period (surgery group). The surgical outcomes and long-term survivals were compared between the 2 groups. Results: After matching, 43 and 86 patients were included in the neoadjuvant and surgery groups, respectively, and there was no significant difference in their baseline characteristics. Although the operating time was longer in the neoadjuvant group, there was no significant difference in postoperative complications between the 2 groups. The neoadjuvant group had a significantly higher 5-year overall survival (OS) rate (73.3% vs. 51.1%, P=0.005) and a trend towards higher 5-year progression-free survival (PFS) (62.8% vs. 49.9%, P=0.145). In the multivariate analysis, perioperative chemotherapy was an independent factor for OS, with a hazard ratio of 0.4 (P=0.005) and a marginal effect on the PFS (P=0.054). Conclusions: Perioperative chemotherapy was associated with better long-term survival without increasing postoperative complications in the setting of D2 surgery for patients with LAGC, suggesting that perioperative chemotherapy can be a therapeutic option in East Asia countries.

• 한국약용작물학회지
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• 제14권3호
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• pp.143-147
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• 2006

삼백초(三白草) 재배에 있어서 토성에 따른 생육과 유효성분을 분석하여 안정적인 재배법을 확립하고 고품질 삼백초를 생산하고자 시험을 수행한 결과를 요약하면 다음과 같다. 가. 삼백초의 절수와 엽수, 분지수는 토성 간 차이가 없었으며, 주당 줄기와 잎의 무게는 사양토가 가장 많고, 양토, 식양토, 사토의 순으로 무거웠다. 직경 5mm이하 뿌리는 토성 간차이가 없었으나, $5.1{\sim}10.9\;mm$의 굵기는 사양토, 양토 그리고 식양토에서 $437{\sim}465\;g$로 차이가 없었고, 11 mm이상은 식양토가 많았다. 건물율은 $19.1{\sim}20.8%$로 차이가 없었다. 나. 잎의 quercetin-glycoside 함량은 양토와 사양토에서 $219.3{\sim}222.4\;mg/100\;g$로 가장 높았으며, quercitrin>rutin>isoquercitrin>hyperin의 순으로 높았다. 줄기는 사토와 사양토가 각각 14.8 mg/100 g과 12.4 mg/100 g로 가장 많았으며, quercetin-glycoside 중 rutin이 가장 높았다. 다. 뿌리의 lignans 함량은 식양토, 양토, 사앙토, 사토의 순으로 높은 경향이었으며, lignans 관련 물질 중 manassatin B가 가장 많았다.