• 융합신호처리학회논문지
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• 제16권4호
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• pp.162-167
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• 2015

본 논문에서는 한일상관센터에서 운영하고 있는 대전상관기의 복층패턴에 대한 원인과 문제 해결에 대해 기술한다. 대전상관기의 상관결과에서 입력신호의 전력파워가 잡음에 묻힐 정도로 작은 경우에는 잘 보이지 않지만, 전력파워가 큰 경우 입력신호에 특정한 패턴을 가진 신호가 출현하는 문제가 보고되었다. 이는 관측데이터의 상관결과와 소프트웨어 상관기와 비교하여 AIPS 소프트웨어에서 분석할 때 관측결과의 천체신호 진폭이득에는 3% 정도의 영향을 미치고 있음이 확인되었다. 따라서 복층패턴의 문제를 해결하기 위해 주기적으로 발견되는 복층패턴의 원인으로 상관기의 데이터 입력과 직렬화를 담당하는 모듈에서 메모리 관리 영역에 문제가 있음을 발견하였다. 즉, 직렬화 모듈에서 데이터를 직렬화할 때 할당된 각 메모리 영역의 데이터가 반복적으로 읽혀져 직렬화되면서 중복된 데이터가 마지막으로 할당된 메모리의 데이터와 중첩이 되면서 발생하는 것이다. 따라서 직렬화 모듈의 메모리 관련 영역의 FPGA 프로그램을 수정하여 문제를 해결하여, 정상적인 상관결과가 출력되는 것을 확인하였다.

• 융합신호처리학회논문지
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• 제16권4호
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• pp.175-181
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• 2015

본 논문은 전파천문 관측데이터 분석을 위해 소프트웨어를 이용한 디지털필터 설계방법에 대해 제안한다. 전파천문 관측시스템은 컴퓨팅 시스템의 발전과 함께 하드웨어에서 소프트웨어를 이용한 분석방법으로 넘어가는 단계이다. 기존 하드웨어로는 특정규격에 맞도록 설계 제작되었기 때문에 규격을 변경하는 것이 어렵고 제작에 많은 비용이 소요되지만, 소프트웨어는 규격 변경이 유연하고 공개 소프트웨어를 이용할 경우 저렴하게 설계할 수 있는 장점이 있다. 그러나 소프트웨어로 전파천문과 같이 많은 자료를 분석하기 위해서는 컴퓨터 시스템의 성능이 우수해야 하는 점도 있다. 본 연구에서는 한국우주전파관측망에서 운영하고 있는 관측시스템 중에서 하드웨어로 구성된 디지털필터와 같은 성능을 갖는 소프트웨어 디지털 필터 설계에 대해 제안한다. 제안 방법은 표준 C언어를 이용하여 디지털 필터를 설계하였으며, 설계한 디지털필터에 대해 GNU Octave로 시뮬레이션을 수행하여 유효성을 검토하였다. 또한 설계한 디지털필터의 고속연산을 위해 병렬연산이 가능한 SSE 라이브러리를 도입하였다. KVN 관측모드 중에 광대역 관측데이터를 대상으로 제안한 방법의 디지털 필터를 통하여 협대역 관측모드로 데이터 필터링을 수행하였다. 그 결과, 대역 내의 필터링이 설계대로 수행되었고 리플이 발생하지 않아, 제안방법이 유효함을 확인하였다.

• Nutrition Research and Practice
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• 제15권6호
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• pp.715-731
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• 2021

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

• 생물정신의학
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• 제25권4호
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• pp.118-124
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• 2018

Objectives Although impulsivity has long been thought as an important factor influencing suicidal behaviors, it is unknown whether impulsivity increases the risk of dying from suicidal behaviors and what specific component among constructs of impulsivity contributes to the risk of dying among suicide attempters. Methods To elucidate the association between impulsivity and medical lethality of suicide attempt among suicide attempters, we consecutively recruited 46 suicide attempters who visited an emergency room of a general hospital located in a metropolitan area, Seoul, Republic of Korea, due to suicide attempts and consented to participate in this study. Then we assessed medical lethality with the Beck Lethality Scale (LS) and impulsivity with the Korean version of the Barratt Impulsiveness Scale-11-Revised (BIS). Demographic variables were obtained from medical records and structured social work reports for suicide attempters. Results Although total scores of the BIS did not correlate with LS scores, only the scores of self-control, that is one of the Barrett's six theoretical constructs of impulsivity in which the higher score indicates less self-control and more impulsivity, had a significant positive correlation with scores of LS (p = 0.003). The association remained significant after adjusting for variables known to affect suicide lethality such as job status, recent alcohol consumption, diagnosis of depressive disorders, and having a plan for suicide (${\beta}=0.429$, p = 0.009). Conclusions Not impulsivity in general, but poor self-control, in particular, predicts lethal suicidal behaviors among suicide attempters. The degree of self-control should be evaluated when assessing patients with elevated suicide risk, and proper measures should be installed to prevent possible future lethal suicide attempts.

• 융합신호처리학회논문지
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• 제19권4호
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• pp.153-161
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• 2018

본 논문은 GPU를 이용한 소프트웨어(SW) 디지털 필터의 성능개선에 대해 기술한다. 기존에 개발한 SW 디지털 필터는 CPU 기반에서 동작하여 속도가 느린 문제점이 있었는데, EAVN 관측데이터의 디지털 필터링을 위해 GPU를 도입하여 연산속도를 개선하였고, 필터링을 통하여 다른 관측국과의 데이터 처리가 가능하도록 하였다. SW 디지털 필터의 연산속도를 개선하기 위해 Tensor Core가 내장된 NVIDIA Titan V GPU 보드를 사용하였으며, 2Gbps (512 MHz BW, 1-IF)의 95초 관측데이터를 필터링하는데 관측시간의 약 1.1배, 1Gbps (16MHz BW, 16-IF)로 필터링하는데 약 0.78배 처리속도를 각각 달성하였다. 또한 KVN으로 1, 2Gbps 동시관측한 데이터에 대해 2Gbps 데이터를 디지털 필터링하여 기존 1Gbps와 비교한 결과, 교차전력스펙트럼, 위상, SNR 등이 유사한 값을 얻어 본 연구에서 개발한 SW 디지털 필터를 활용한 데이터 처리와 분석을 수행하는데 유효함을 확인하였다. 향후에는 여러 개의 GPU 보드를 사용하기 위한 소스 코드의 분산처리 최적화를 수행할 경우 실시간으로 관측데이터를 필터링할 수 있을 것으로 기대된다.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.790-798
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• 2021

The objective of this study was evaluation of pig behavior changes related to temperature, relative humidity, volatile organic compounds (VOCs), and illuminance. A total of 24 growing pigs ([Yorkshire × Landrace] × Duroc) were used in the experiment. A sensor was installed at a height of 0.5 m in the center of the pig house. In experiment 1, temperature was changed every four days to 18℃ (T1), 22℃ (T2), 26℃ (T3), and then 30℃ (T4). In experiment 2, relative humidity was adjusted to 45% (low humidity [LH]), 60% (middle humidity [MH]), and then 75% (high humidity [HH]) for four days. In experiment 3, after cleaning the pig house just before experiment, only minimal ventilation was provided. VOCs and pig behaviors were observed for 7 days without cleaning the pig house. In experiment 4, three light bulbs of 40 W (470 lumens / 45 lx; low illuminance [LI]), 75 W (1,055 lumens / 103 lx; middle illuminance [MI]), and 100 W (1,521 lumens / 146 lx; high illuminance [HI]) were used for four days each. Pig behavior analysis was performed for following criteria : Feed intake, Standing, Lying, Sitting, Drink water, Rooting, Posture transition (lying-standing), Posture transition (standing-lying), Wallowing, and Biting. In experiment 1, feed intake time was lower (p < 0.05) for the T3 than other treatment groups. Standing time was highest (p < 0.05) for the T1 and lowest (p < 0.05) for the T3. Lying time was shorter (p < 0.05) in T1 and T2 compared to T3 and T4. Drinking frequency was higher (p < 0.05) for the T4 than other treatment groups. In experiment 2, the frequency of rooting and wallowing increased (p < 0.05) with increasing humidity. LH showed the lowest (p < 0.05) rooting frequency and HH showed the highest (p < 0.05) rooting frequency. In experiment 3, VOCs concentration did not (p > 0.05) change pig behavior. In experiment 4, lying time was the longest (p < 0.05) at LI and shortest (p < 0.05) at HI. Therefore, pig behavior is heavily influenced by the environment, especially temperature and humidity. However, correlation between pig behavior to VOCs and illuminance seems to be needed more research.

• 한국산업보건학회지
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• 제31권2호
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• pp.173-183
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• 2021

Objectives: This study evaluated the skin permeability of lawsone in henna hair dyes to understand the exposure characteristics of henna hair dyes in the human body. It examined the protective effects of protectants by applying protectants A, B, and C to test skin. Methods: Skin absorption tests were conducted using Franz diffusion cells according to OECD test guideline 428. After applying one kind of natural henna hair dye and chemical henna hair dye, respectively, to a standardized pig skin model, samples of receptor fluid were collected at 1h, 3h, 6h, and 24h. The skin permeation of lawsone was determined using HPLC. After the skin absorption experiment, the skin to which hair dye was applied was analyzed to determine the residual amount of lawsone in the skin. Results: The cumulative permeation of both natural and chemical henna hair dyes increased over time, and the natural henna hair dye had a flux value (t=3.194, p<.05) high both in the K_p value (t=3.207, p<.05) and the residual amount (t=22.701, p<.001). For skin treated with a protectant, the cumulative permeation of natural henna hair dye 24h control and the cumulative permeation of protectant A, B, and C increased over time. Flux and K_p values were in the order control > protectant A > protectant C > protectant B. The residual amount (F=4.469, p<.05) was in the order of protectant C > protectant A > protectant B > control. At 3h, the dye application time of natural henna hair dye, the lawsone flux value (F=4.454, p<.05) and K_p value (F=4.455, p<.05) were higher in the control group than in the protectant groups. The 24h cumulative permeation of the chemical henna hair dye increased with time in both the control and the protectant groups, and the flux and K_p values were in the order of protectant A > protectant C > protectant B > control. The residual amount (F=7.901, p<.01) was in the order of protectant B > protectant A> protectant C > control. Conclusions: Within the normal dyeing time for henna hair dye (three hours for natural henna hair dyes and 30 minutes for chemical henna hair dyes) lawsone skin penetration was not observed even when no protective agent was applied. After that time, however, evidence of skin penetration and retention of lawsone and the protective effect of protective agents were observed.

• 정보보호학회논문지
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• 제30권6호
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• pp.1291-1300
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• 2020

최근 딥러닝 기반 비프로파일링 부채널 분석이 제안됐다. 딥러닝 기반 비프로파일링 분석은 신경망 모델을 모든 추측키에 대해 학습시킨 뒤, 학습된 정도의 차이를 통해 올바른 비밀키를 찾아내는 기법이다. 이때, 신경망 학습모델 설계에 따라 비프로파일링 분석성능이 크게 달라지기 때문에 올바른 모델 설계의 기준이 필요하다. 본 논문은 학습모델 설계에 사용 가능한 2가지 loss 함수와 8가지 label 기법을 설명하고, 비프로파일링 분석과 소비전력모델 관점에서 각 label 기법의 분석성능을 예측했다. 해밍웨이트 소비전력모델을 가정했을 때의 비프로파일링 분석 특징을 고려해서 One-hot 인코딩을 적용하지 않은 HW(Hamming Weight) label과 CO(Correlation Optimization) loss를 적용한 학습모델이 가장 좋은 분석성능을 가질 것으로 예측했다. 그리고 AES-128 1라운드 Subbytes 연산 부분 데이터 집합 3가지에 대해 실제 분석을 수행했다. 제시한 각 label 기법과 loss 함수를 적용한 총 16가지 MLP(Multi-Layer Perceptron)기반 학습모델로 두 데이터 집합을 비프로파일링 분석하여 예측에 대해 검증했다.

• 한국산학기술학회논문지
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• 제21권12호
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• pp.354-361
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• 2020

본 연구에서는 반려견의 건강증진을 위해 보라지유를 사료에 혼합하여 급여하였을 경우 사료로써의 안전성을 평가하고 염증완화 효능이 있는지 알아보았다. 총 12마리의 공시견을 대상으로 보라지유 1% 또는 2% 함유된 사료를 12주간 급여 실시한 후 혈액 생화학, 혈액 세포, 사이토카인 등의 안전성 평가 실험을 실시하였다. 또한 경피 수분 손실도를 측정하여 피부 건강에 미치는 보라지유의 효능을 평가하였다. 본 급여 시험의 결과, 보라지유는 반려견의 체중, 혈액세포, 면역관련 사이토카인에 영향을 미치지 않는 것으로 나타났다. 그리고, 경피 수분 손실도 측정 결과 역시 유의적인 차이를 보이지 않았다. 하지만, 혈액 내 젖산탈수소효소의 농도는 보라지유 함유 사료를 먹기 전과 비교하여 유의적으로 감소한 것을 확인하였다. 본 실험을 통해, 보라지유를 섭취하였을 경우 반려견에서 체중감소 및 혈액 지표 이상 등의 문제점을 야기하지 않고, 오히려 체내 세포 손상 정도를 감소시키는 효과의 가능성을 확인하였다. 본 연구 결과를 통해, 보라지유가 반려견 사료원료로써 안전하게 활용될 수 있을 것으로 보인다.

• 한국환경보건학회지
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• 제47권6호
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• pp.530-539
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• 2021

Background: In South Korea, areas around abandoned metal mines are designated as regions with high arsenic (As) contamination. However, studies assessing urinary As exposure, As metabolism, and relevant genetic polymorphisms in residents of these metal mine areas are lacking. Objectives: To identify factors associated with As exposure and evaluate the effects of MTHFR, As3MT, and GSTO1 genetic polymorphisms on As metabolism in residents of abandoned metal mine areas by measuring urinary As species. Methods: Urinary As species (arsenite [As³⁺], arsenate [As⁵⁺], monomethyl arsonic acid, and dimethylarsinic acid) were isolated using high-performance liquid chromatography in combination with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Four genetic polymorphisms (MTHFR A222V, MTHFR E429A, GSTO1 A140D, As3MT M287T) were analyzed in 144 residents of four areas around abandoned metal mines. Results: The study sample was comprised of 34.7% men and 65.3% women, with a mean age of 70.7±10.9 years. The urinary inorganic As concentration was higher among those consuming more than half locally produced rice (0.31 ㎍/L) than those consuming less than half such rice (0.18 ㎍/L). The urinary dimethylarsinic acid concentration was higher in the group that had consumed seafood in the past day (31.68 ㎍/L) than in those who had not (22.37 ㎍/L). Furthermore, individuals heterozygous in the MTHFR A222V and GSTO1 A140D polymorphism had higher urinary arsenic species concentrations than did individuals with a wild type or homozygous for the variant allele. Conclusions: Consumption of locally produced rice was associated with inorganic As exposure, whereas seafood consumption was associated with organic As exposure among residents of abandoned metal mine areas. There was no clear association between MTHFR A222V and GSTO1 A140D polymorphisms and As metabolism.