• Computers and Concrete
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• 제33권6호
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• pp.659-670
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• 2024

The mechanical behaviour of layered concrete samples containing an internal crack was numerically studied by modelling the geo-mechanical specimens in the particle flow code in two dimensions (PFC2D). The numerical modelling software was calibrated with the experimental results of the Brazilian tensile strengths gained from the laboratory disc-type specimens. Then, the samples with the bedding layers and internal notch were numerically simulated with PFC2D under uniaxial compressive loading. In each specimen, the layers' thickness was 10 mm but the layer's inclination angle was changed to 0°, 30°, 60°, 90°, 120° and 150°. Of course, the layers'interfaces are considered to have very low strengths. The internal notch was kept at 3 cm in length however, its inclination angle was changed to 0°, 40°, 60° and 90°. Therefore, a total, of 24 numerical models were made to study the failure mechanism of the layered concrete samples. Considering these results, it has been concluded that the inclination angles of both internal crack and bedding layers affect the failure mechanism and uniaxial compressive strength of the concrete.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3285-3292
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• 2012

The interaction of thiazole drug with (6,0) zigzag single-walled boron nitride nanotube of finite length in gas and solvent phases was studied by means of density functional theory (DFT) calculations. In both phases, the binding energy is negative and presenting characterizes an exothermic process. Also, the binding energy in solvent phase is more than that the gas phase. Binding energy corresponding to adsorption of thiazole on the BNNT model in the gas and solvent phases was calculated to be -0.34 and -0.56 eV, and about 0.04 and 0.06 electrons is transferred from the thiazole to the nanotube in the phases. The significantly changes in binding energies and energy gap values by the thiazole adsorption, shows the high sensitivity of the electronic properties of BNNT towards the adsorption of the thiazole molecule. Frontier molecular orbital theory (FMO) and structural analyses show that the low energy level of LUMO, electron density, and length of the surrounding bonds of adsorbing atoms help to the thiazole adsorption on the nanotube. Decrease in global hardness, energy gap and ionization potential is due to the adsorption of the thiazole, and consequently, in the both phases, stability of the thiazole-attached (6,0) BNNT model is decreased and its reactivity increased. Presence of polar solvent increases the electron donor of the thiazole and the electrophilicity of the complex. This study may provide new insight to the development of functionalized boron nitride nanotubes as drug delivery systems for virtual applications.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8345-8349
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• 2014

Background: Cancer is an increasing cause of mortality and morbidity worldwide. Incidences of common cancers has been growing in different provinces of Iran in recent years but trends in Khuzestan which shares a border with Iraq and is located in south west of Iran have not been investigated. This study aimed to assess secular changes in incidences of common cancers in Khuzestan province from 2004 to 2008. Materials and Methods: Data were collected from Khuzestan cancer registry which is a branch of Iranian Ministry of Health Cancer Registry (http://ircancer.ir) for the period 2004-2008. Data were presented as incidence rates by site, sex, age, using the crude rate and age-standardized rate (ASR) per $10^5$ persons. A direct method of standardization was applied according to the WHO guideline and data analysis was performed using the SPSS package. Results: During the 2004-2008 period, 14,893 new cases of cancer were registered in Khuzestan cancer registry. The age-standardized incidence rate of all cancers was 153.7 per $10^5$ in males and 156.4 per $10^5$ in females. The incidence was increased over the period of five years. The most incident cancers among males were skin cancer ($ASR=18.7/10^5$), stomach cancer ($ASR13.8/10^5$), lung cancer ($ASR12.9/10^5$), leukemia ($ASR=12.6/10^5$) and prostate cancer ($ASR=12.4/10^5$). In females, the most incident cancers were breast cancer ($ASR=41/10^5$), skin cancer ($ASR=16.4/10^5$), colorectal cancer ($ASR=10.0/10^5$), leukemia ($ASR=8.1/10^5$) and lung cancer ($ASR=6.9/10^5$). Conclusions: Incidences of various cancers are rising in Khuzestan. It is necessary to develop and implement comprehensive cancer control programs in this region which could be monitored and evaluated by the future trend data from Khuzestan cancer registry.

• Structural Engineering and Mechanics
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• 제66권5호
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• pp.569-582
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• 2018

Effects of crack separation, bridge area, on the tensile behaviour of concrete are studied experimentally and numerically through the Brazilian tensile test. The physical data obtained from the Brazilian tests are used to calibrate the two-dimensional particle flow code based on discrete element method (DEM). Then some specially designed Brazilian disc specimens containing two parallel cracks are used to perform the physical tests in the laboratory and numerically simulated to make the suitable numerical models to be tested. The experimental and numerical results of the Brazilian disc specimens are compared to conclude the validity and applicability of these models used in this research. Validation of the simulated models can be easily checked with the results of Brazilian tests performed on non-persistent cracked physical models. The Brazilian discs used in this work have a diameter of 54 mm and contain two parallel centred cracks ($90^{\circ}$ to the horizontal) loaded indirectly under the compressive line loading. The lengths of cracks are considered as; 10 mm, 20 mm, 30 mm and 40 mm, respectively. The visually observed failure process gained through numerical Brazilian tests are found to be very similar to those obtained through the experimental tests. The fracture patterns demonstrated by DEM simulations are mostly affected by the crack separation but the tensile strength of bridge area is related to the fracture pattern and failure mechanism of the testing samples. It has also been shown that when the crack lengths are less than 30 mm, the tensile cracks may initiate from the cracks tips and propagate parallel to loading direction till coalesce with the other cracks tips while when the cracks lengths are more than 30 mm, these tensile cracks may propagate through the intact concrete itself rather than that of the bridge area.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2415-2421
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• 2016

E-cadherin (CDH1) genetic variations alter gene transcriptional activity of epithelial cells in vitro and may cause susceptibility to various cancers. Associations of CDH1 -160C>A polymorphism with various cancers have been widely reported. However, the results are controversial and inconsistent. To derive a more accurate estimation of the relationship, a meta-analysis was performed with regard to gastrointestinal (GI) cancer risk. Eligible studies were identified through a search of PubMed database until December 2015. Associations between the CDH1 -160C>A polymorphism and GI cancer risk was considered by odds ratios (ORs) together with their 95% confidence intervals (CIs). A total of 31 studies including 11,606 cases and 12,655 controls were involved in this meta-analysis. Overall, this meta-analysis showed no association between CDH1 -160C>A polymorphism and GI cancer risk (A vs. C: OR = 1.08, 95%CI = 0.98-1.18, P = 0.086;CA vs. CC: OR = 1.09, 95%CI = 0.97-1.22, P = 0.118; AA vs. CC: OR = 1.10, 95%CI = 0.89-1.35, P = 0.356; AA vs. CC + CA: OR = 1.06, 95%CI = 0.96-1.18, P = 0.207; CA+AA vs. CC: OR = 1.01, 95%CI = 0.84-1.22, P = 0.89). In subgroup analysis, similar results were found. In conclusion, this meta-analysis has demonstrated that there is a lack of association of the CDH1-160C>A polymorphism with GI cancer susceptibility.

• Computers and Concrete
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• 제21권2호
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• pp.189-197
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• 2018

A discrete element approach is used to investigate the effects of confining stress on the shear behaviour of joint's bridge area. A punch-through shear test is used to model the concrete cracks under different shear and confining stresses. Assuming a plane strain condition, special rectangular models are prepared with dimension of $75mm{\times}100mm$. Within the specimen model and near its four corners, four equally spaced vertical notches of the same depths are provided so that the central portion of the model remains intact. The lengths of notches are 35 mm. and these models are sequentially subjected to different confining pressures ranging from 2.5 to 15 MPa. The axial load is applied to the punch through the central portion of the model. This testing and models show that the failure process is mostly governed by the confining pressure. The shear strengths of the specimens are related to the fracture pattern and failure mechanism of the discontinuities. The shear behaviour of discontinuities is related to the number of induced shear bands which are increased by increasing the confining pressure while the cracks propagation lengths are decreased. The failure stress and the crack initiation stress both are increased due to confining pressure increase. As a whole, the mechanisms of brittle shear failure changes to that of the progressive failure by increasing the confining pressure.

• Structural Engineering and Mechanics
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• 제67권5호
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• pp.493-504
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• 2018

In this paper, the tensile failure behaviour of transversally bedding layers was numerically simulated by using particle flow code in two dimensions. Firstly, numerical model was calibrated by uniaxial, Brazilian and triaxial experimental results to ensure the conformity of the simulated numerical model's response. Secondly, 21 circular models with diameter of 54 mm were built. Each model contains two transversely bedding layers. The first bedding layer has low mechanical properties, less than mechanical properties of intact material, and second bedding layer has high mechanical properties, more than mechanical properties of intact material. The angle of first bedding layer, with weak mechanical properties, related to loading direction was $0^{\circ}$, $15^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, $75^{\circ}$ and $90^{\circ}$ while the angle of second layer, with high mechanical properties, related to loading direction was $90^{\circ}$, $105^{\circ}$, $120^{\circ}$, $135^{\circ}$, $150^{\circ}$, $160^{\circ}$ and $180^{\circ}$. Is to be note that the angle between bedding layer was $90^{\circ}$ in all bedding configurations. Also, three different pairs of the thickness was chosen in models; i.e., 5 mm/10 mm, 10 mm/10 mm and 20 mm/10 mm. The result shows that In all configurations, shear cracks develop between the weaker bedding layers. Shear cracks angel related to normal load change from $0^{\circ}$ to $90^{\circ}$ with increment of $15^{\circ}$. Numbers of shear cracks are constant by increasing the bedding thickness. It's to be note that in some configuration, tensile cracks develop through the intact area of material model. There is not any failure in direction of bedding plane interface with higher strength.

• Steel and Composite Structures
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• 제15권6호
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• pp.585-603
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• 2013

Generally the required strength and stiffness of an I-shaped beam to the box-shaped column connection is achieved if continuity plates are welded to the column flanges from all sides. However, welding the forth edge of a continuity plate to the column flange may not be easily done and is normally accompanied by remarkable difficulties. This study was aimed to propose an alternative for box columns with continuity plates to diminish such problems. For this purpose a double-web I-shaped column was proposed. In this case the strength and rotational stiffness of the connection was provided by nearing the column webs to each other. Finite element studies on about 120 beam-column connections showed that the optimum proportion of the distance between two column webs and the width of the column flange (parameter ${\beta}$) was a function of the ratio of the beam flange width to the column flange width (parameter ${\alpha}$). Hence, based on the finite element results, an equation was proposed to estimate the optimum value of parameter ${\beta}$ in terms of parameter ${\alpha}$ to achieve the highest connection performance. Results also showed that the strength and ductility of post-Northridge connections of such columns are in average 12.5 % and 54% respectively higher than those of box-shaped columns with ordinary continuity plates. Therefore, a double-web I-shaped column of optimum arrangement might be a proper replacement for a box column with continuity plates when beams are rigidly attached to it.

• Smart Structures and Systems
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• 제25권4호
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• pp.433-446
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• 2020

In this paper the effect of confining pressure and tunnel depth on the ground vertical settlement has been investigated using particle flow code (PFC2D). For this perpuse firstly calibration of PFC2D was performed using both of tensile test and triaxial test. Then a model with dimention of 100 m × 100 m was built. A circular tunnel with diameter of 20 m was drillled in the middle of the model. Also, a rectangular tunnel with wide of 10 m and length of 20 m was drilled in the model. The center of tunnel was situated 15 m, 20 m, 25 m, 30 m, 35 m, 40 m, 45 m, 50 m, 55 m and 60 m below the ground surface. these models are under confining pressure of 0.001 GPa, 0.005 GPa, 0.01 GPa, 0.03 GPa, 0.05 GPa and 0.07 GPa. The results show that the volume of colapce zone is constant by increasing the distance between ground surface and tunnel position. Also, the volume of colapce zone was increased by decreasing of confining pressure. The maximum of settlement occurs at the top of the tunnel roof. The maximum of settlement occurs when center of tunnel was situated 15 m below the ground surface. The settlement decreases by increasing the distance between tunnel center line and measuring circles in the ground surface. The minimum of settlement occurs when center of circular tunnel was situated 60 m below the surface ground. Its to be note that the settlement increase by decreasing the confining pressure.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4861-4864
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• 2014

Background: The Ewing's sarcoma family is a group of small round cell tumors which accounts for 10-15% of all primary bone neoplasms. The aim of this study was to evaluate the survival of Ewing's sarcoma patients in our province and to determine of influencing factors. Materials and Methods: All patients with documented Ewing's sarcoma/primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years. For all of them local and systemic therapy were carried out. Overall and event free survival and prognostic factors were evaluated. Results: Thirty two patients were enrolled in the study. The median age was 17.5 years. Twenty (65.2%) were male and 9 (28.1%) were aged 14 years or less. Mean disease free survival was 26.8 (95%CI; 13.8-39.9) months and five year disease free survival was 26%. Mean overall survival was 38.7 months (95%CI; 25.9-50.6) and median overall survival was 24 months. Five year overall survival was 25%. From the variables evaluated, only presence of metastatic disease at presentation (p value=0. 028) and complete response (p value =0. 006) had significant relations to overall survival. Conclusions: Survival of Ewing's sarcoma in our province is disappointing. It seems to be mostly due to less effective treatment. Administration of adequate chemotherapy dosage, resection of tumor with negative margins and precise assessment of irradiation volume may prove helpful.