• Molecules and Cells
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• v.40 no.9
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• pp.685-695
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• 2017

Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood. In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation. Two dimensional difference in-gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was carried out. A total of 28 proteins were identified with a statistically significant difference in abundance and a 1.5-fold change (ANOVA, $p{\leq}0.05$) between the groups. 11 proteins showed increased abundance while 17 proteins were decreased in the metabolically unhealthy obese compared to the healthy obese. The differentially expressed proteins belonged broadly to three functional categories: (i) protein and lipid metabolism (ii) cytoskeleton and (iii) regulation of other metabolic processes. Network analysis by Ingenuity pathway analysis identified the $NF{\kappa}B$, IRK/MAPK and PKC as the nodes with the highest connections within the connectivity map. The top network pathway identified in our protein data set related to cellular movement, hematological system development and function, and immune cell trafficking. The VAT proteome between the two groups differed substantially between the groups which could potentially be the reason for metabolic dysfunction.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.49 no.5
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• pp.419-422
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• 2004

Soybean is a major source of protein meal in the world. Kunitz trypsin inhibitor (KTI) protein is responsible for the inferior nutritional quality of unheated or incompletely heated soybean meal. The objective of this research was to identify RAPD markers linked to KTI protein allele using bulked segregant analysis. Cultivar Jinpumkong2 (TiTi) was crossed with C242 (titi, absence of KTI protein) and F. seeds were planted. The $F_1$. plants were grown in the greenhouse to produce $F_2$ seeds. Each $F_2$ seed from $F_1$. plants was analysed electrophoretically to determine the presence of the KTI protein band. The present and absent bulks contained twenty individuals each, which were selected on the basis of the KTI protein electrophoresis, respectively. Total 94 $F_2$ individuals were constructed and 1,000 Operon random primers were used to identify RAPD primers linked to the Ti locus. The presence of KTI protein is dominant to the lack of a KTI protein and Kunitz trypsin inhibit protein band is controlled by a single locus. Four RAPD primers (OPAC12, OPAR15, OPO12, and OPC08) were linked to the Ti locus. RAPD primer OPO12 was linked to Ti locus, controlling kunitz trypsin inhibitor protein at a distance of 16.0 cM. This results may assist in study of developing fine map including Ti locus in soybean.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5225-5231
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• 2015

Background: One of the most prevalent cancers in whole world is skin cancer and its prevalence is growing. The present research sought to estimate relative risk of morbidity and mortality due to skin cancer. Materials and Methods: In this cross-sectional study. The required data were gathered from the registered cancer reports of Cancer Control Office in the Center for Non Communicable Disease of the Iranian Ministry of Health (MOH). The data were extracted at province level in the time span of 2008-10. WINBUGS software was used to analyze the data and to identify high risk regions. ArcGIS10 was utilized to map the distribution of skin cancer and to demonstrate high risk provinces by using classic and fully Bayesian models taking into account spatial correlations of adjacent regions separately for men and women. Results: Relative risk of morbidity for women in Yazd and for men in Kurdistan and relative risk of mortality for women in Bushehr and for men in Kohgiluyeh were found to be the highest. Bayesian model due to regarding adjacent regions correlation, have precise estimation in comparing to classical model. More frequent epidemiological studies to enact skin cancer prevention programs. Conclusions: High risk regions in Iran include central and highland regions. Therefore it is suggested that health decision makers enact public education, using anti UV creams and sunglasses for those parts as a short preventing program.

• Smart Media Journal
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• v.5 no.4
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• pp.90-95
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• 2016

Recently, the quality of cultural experience can be improved through a stereoscopic information service provided by the latest mobile-based Information Telecommunication technology without the human cultural commentators, which was used in order to enhance the understanding of our cultural heritage. The purpose of this paper is to produce contents that introduce cultural heritage using the Android-based GPS and augmented reality. In this paper we propose a culture content creation method that is based on location information such as user/cultural anomalies using GPS and augmented reality based on Markerless Tracking. Marker Detection Technology and Markerless Tracking Technology are used for smart phone's rapid recognition of augmented real world and accurate recognition according to the state of the cultural heritage. Also, the Google Map of Android is used to locate the user. The strength of this method lies in that it can be used for a variety of subjects while the existing methods are limited to certain kinds of augmented reality contents.

• Journal of the Korean Institute of Intelligent Systems
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• v.23 no.4
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• pp.332-340
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• 2013

This paper reports a programming toolkit for implementing localization and navigation of a mobile robot both in real world and simulation. Many of the previous function libraries are difficult to use because of their complexity or lack of usability. The proposed toolkit consist of functions for dead reckoning, motion model, measurement model, and operations on directions or heading angles. The dead reckoning and motion model deals with differential drive robot and bicycle type robot driven by front wheel or rear wheel. The functions can be used for navigation in both real environment and simulation. To prove the feasibility of the toolkit, simulation results are shown along with the results in real environment. It is expected the proposed toolkit is used for test of algorithms for mobile robot navigation such as localization, map building, and obstacle avoidance.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.15 no.2
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• pp.141-148
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• 1997

Continuous development of Personal Computer(PC) combined with the decrease of price and the expansion of operating system in PC like Windows 95, and Windows N/T makes it possible for the user to consider PC-bas-ed Automated Happing/Facilities Management (AM/FM) system. Therefore, the purpose of this study is to establish a PC-based data automation system of pipe infrastructures-water, sewer, and drainage-and road in Korea Land Corporation. In order to achieve this goal, relevant literature survey was done first. Secondly, the study site was determined by discussion with Korea Land Institute. Thirdly, PC-based CAD software for AM/FM in the world market were surveyed, and AutoCAD Map was selected because KLC had been using hundreds of AutoCAD copies already. After that user needs assessment was done to visit on-site office, local branch office, and the corresponding city office for the system design and database design. After the graphic data were digitized and the attribute data were entered into the batabase, the data automation system was established, and tested for application. Finally, the guidelines and problems for PC-based data automation in AM/FM was discussed.

• Journal of KIISE
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• v.43 no.8
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• pp.910-918
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• 2016

A tensor is a multi-dimensional array that represents many data such as (user, user, time) in the social network system. A tensor generator is an important tool for multi-dimensional data mining research with various applications including simulation, multi-dimensional data modeling/understanding, and sampling/extrapolation. However, existing tensor generators cannot generate sparse tensors like real-world tensors that obey power law. In addition, they have limitations such as tensor sizes that can be processed and additional time required to upload generated tensor to distributed systems for further analysis. In this study, we propose TeT, a distributed tera-scale tensor generator to solve these problems. TeT generates sparse random tensor as well as sparse R-MAT and Kronecker tensor without any limitation on tensor sizes. In addition, a TeT-generated tensor is immediately ready for further tensor analysis on the same distributed system. The careful design of TeT facilitates nearly linear scalability on the number of machines.

• Journal of Korean Society for Geospatial Information Science
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• v.20 no.4
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• pp.135-143
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• 2012

Remote sensing which observes repeatedly the whole Earth and GIS-based decision-making technology have been utilized widely in disaster management such as early warning monitoring, damage investigation, emergent rescue and response, rapid recovery etc. In addition, various countermeasures of national level to collect timely satellite imagery in emergency have been considered through the operation of a satellite with onboard multiple sensors as well as the practical joint use of satellite imagery by collaboration with space agencies of the world. In order to respond heavy snowfall disaster occurred on the east coast of the Korean Peninsula in February 2011, snow-covered regions were analyzed and detected in this study through NDSI(Normalized Difference Snow Index) considering reflectance of wavelength for MODIS sensor and change detection algorithm using satellite imagery collected from International Charter. We present the application case of National Disaster Management Institute(NDMI) which supported timely decision-making through GIS spatial analysis with various spatial data and snow cover map.

• Journal of Korean Society of Forest Science
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• v.86 no.1
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• pp.25-34
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• 1997

The optimum global natural vegetation mapping(GNVM) system was selected as a series of the study to estimate potential forest area of the globe. To select the system, three types of GNVM systems which are simple system with Light Climatic Dataset(LCD), altitude-allowed system with LCD and altitude-allowed system with Heavy Climatic Dataset(HCD) were established and compared. The three GNVM systems spherically interpolate such spotty climate data as those observed at weather stations the world over onto $1^{\circ}{\times}1^{\circ}$ grid points, product vegetation type classification, and produce a potential natural vegetation(PNV) map and a PNV area. As a result of comparison with three GNVM systems, altitude-allowed LCD system represented natural vegetation distribution better than other versions. The difference between the simple system versus the one with altitude allowance indicated that the simple version tends to over-represent the warmer climate areas and under-represent cold and hostile climate areas. In the difference between altitude-allowed versions of LCD and HCD, HCD version tended to overestimate moist climate areas and to underestimate dry climate areas.

• Journal of Environmental Health Sciences
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• v.35 no.1
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• pp.1-10
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• 2009

This study assessed the relationships between levels of $PM_{10}$ and hospitalization rates for asthma among children from 2003 to 2005 at four major cities in Korea. In addition, we estimated the reduced number of asthma hospitalization associated with an ambient $PM_{10}$ improvement to the acceptable levels as recommended by the World Health Organization (WHO). The Generalized Additive Model (GAM) was used to estimate the relative risks (RR) of asthma hospitalization associated with changes in $PM_{10}$ The RRs of children's asthma hospitalization for every $10{\mu}g/m^3$ increment in $PM_{10}$ were 1.009(95% CI = 1.004-1.014) in Seoul, 1.013(95% CI = 1.006-1.021) in Incheon, 1.009(95% CI = 1.002-1.016) in Busan, and 1.021(95% CI = 1.005-1.037) in Ulsan. We assessed $PM_{10}$ related health benefits from implementing the WHO's guidelines (24-hour average $50{\mu}g/m^3$) using the U.S. Environmental Protection Agency's Environmental Benefits Mapping and Analysis Program. The estimated benefits were 439(95% CI = 216-666) reduced asthma hospitalization in Seoul, 720(95% CI = 304-1,151) in Incheon, 260(95% CI = 66-459) in Busan, and 126(95% CI = 30-228) in Ulsan. It was concluded that improving $PM_{10}$ condition to the WHO guideline would make a significant contribution to the reduction in asthma hospitalization among children. Therefore, public health measures are still needed to improve air quality in Korea.