• 약학회지
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• 제36권2호
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• pp.173-179
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• 1992

The rhizoma of Zingiber officinale has been used as antiemetic, expectorants, stomachache relieving drugs and digestive accelerators. From the observation of antigastritic action of the methanol extract of the rhizoma, it was fractionated with hexane, chloroform, ethyl acetate and butanol, followed by bioassay on antigastritic and antiulcerative activity. The hexane and the chloroform fraction reduced significantly HCl ethanol induced gastric lesion at the dose of 370 and 210 mg/kg, p.o., respectively. On the gastric ulceration and gastric secretion in pylorus-ligated rats, the hexane fraction decreased the volume of gastric secretion and acid output, and also increased pH at the dose of 370 mg/kg, i.d.. It showed considerable curative ratio of acetic acid induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000 mg/kg, p.o. in mice. In conclusion, Zingiberis rhizoma exhibited antigastric and antiulcerative activity which might be attributable to inhibition of gastric secretion. It is revealed that the active component may be present in the hexane fraction.

• 약학회지
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• 제36권2호
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• pp.115-119
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• 1992

The possibility as an anti-inflammatory drug of Prunus davidiana which have been used in Korean folk medicine for treatment of neuritis and rheumatism was investigated on carrageenin-induced paw edema in rats. The MeOH extract exhibited potent inhibitory effect on carrageenin-edema rats when topically applicated. On the other hand, it did not show any effect when orally tested. It also had no influences on isolated ileum of guinea pig and anti-platelet aggregating activities. Thus, it appears from the present findings that the MeOH extract of P. davidiana may be utilizable only for the external treatment of inflammed sites. This study was also conducted to further isolation of flavonoids from the EtOAc soluble fraction and characterized as persiconin and isosakuranin by spectrometric analysis.

• 산학경영연구
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• 제13권
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• pp.31-47
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• 2000

지금까지 신뢰는 연구 목적과 분야에 따라 여러 각도에서 조망되어 봤다. 본 연구에서는 조직 행동적 차원에서의 신뢰에 대한 기존 연구들을 살펴보는 한편, 최근 제안되고 있는 신뢰 형성 모형의 타당성을 한국적 조직 현실 속에서 실증코자 시도하였다. 신뢰 개념에 대한 여러 시각과 연구 경향을 간략히 소개하였으며, 특히 실증 연구를 통해 신뢰 형성의 4가지 선행 요인으로 제안되어 온 능력, 선의, 신실성 및 개인 신뢰성향의 실재성를 검토하였다.

• 대한안전경영과학회지
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• 제14권1호
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• pp.101-108
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• 2012

In this study was conducted numerical analysis to evaluate the stability of BTR(Built-in Timber Roof Tunneling Method), which is one of construction methods of underground structures in the non-opening state. The discretion method was applied to individually model reinforcing members of BTR, and the homogeneity analysis technic by area ratio was used to verify the feasibility comparing this result with that from conventional analysis method. The parameter study was performed to evaluate the effect varying ground depth, distance length of reinforcing supports and to verify the field applicability of new analysis method. The results showed the very precise value with allowable error, so this method can be applied in the field, The more length of supporting members caused the more vertical displacement and the top displacement increment of support members is larger than that of ground surace. The effect of ground depth was more impressive than that of distance length of reinforcing supports.

• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1310-1316
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• 2012

Novel antibacterial oxazolidinones bearing pyrrolidinone ring system at the C-5 side chain were synthesized and their in vitro antibacterial activities were evaluated. Most of the synthesized oxazolidinones showed good antibacterial activity against the Gram-positive and Gram-negative bacteria tested.

• Bulletin of the Korean Chemical Society
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• 제28권6호
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• pp.953-958
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• 2007

Anchoring quantum dots (QDs) onto thermodynamically stable, large band gap oxide semiconductors is a very important strategy to enhance their quantum yields for solar energy conversion in both visible and near-IR regions. We describe a general procedure for anchoring a few chalcogenide QDs onto the titanium oxide layer. To anchor the colloidal QDs onto a mesoporous TiO2 layer, linker molecules containing both carboxylate and thiol functional groups were initially attached to TiO2 layers and subsequently used to capture dispersed QDs with the thiol group. Employing the procedure, we exploited cadmium selenide (CdSe) and cadmium telluride (CdTe) quantum dots (QDs) as inorganic sensitizers for a large band gap TiO2 layer of dye-sensitized solar cells (DSSCs). Their attachment was confirmed by naked eyes, absorption spectra, and photovoltaic effects. A few QD-TiO2 systems thus obtained have been characterized for photoelectrochemical solar energy conversion.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1425-1428
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• 2013

The proteasome, which is highly evolutionarily conserved, is responsible for the degradation of most short-lived proteins in cells. Small-molecule inhibitors targeting the proteasome's degradative activity have been extensively developed as lead compounds for various human diseases. An exemplified molecule is bortezomib, which was approved by FDA in 2003 for the treatment of multiple myeloma. Here, using transiently and stably expressed N-end rule model substrates in mammalian cells, we evaluated and identified that salinosporamide A and salinosporamide B effectively inhibited the proteasomal degradation. Considering that a variety of proteasome substrates are implicated in the pathogenesis of many diseases, they have the potential to be clinically applicable as therapeutic agents.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2010년도 정기 학술대회
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• pp.678-681
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• 2010

최근 건설 기술의 비약적인 발전으로, 국내외적으로 장대교량의 건설이 증가하고 있다. 이러한 장대교량들은 지속적인 안전성 관리가 필요하며 현재 국내 다수의 장대교량들에는 다양한 센서로 이루어진 구조건전성 모니터링 시스템이 설치, 운용되고 있다. 장대교량과 같은 대형 구조물의 물리적 상태를 정확하게 파악하기 위해서는 다수의 센서배치가 필요로 하지만, 이는 센서 자체의 비용뿐만 아니라 센서와 데이터 서버를 연결하는 케이블의 설치비용으로 인하여 상당히 제약을 받을 수 밖에 없다. 실례로 홍콩의 Tsing Ma 대교의 경우 350개의 센서를 설치하는데 약 8 백만불이 넘는 금액이 들었으며(Farrar 등, 2004), Celeby(2002)의 보고에 의하면 각 센서의 채널 당 케이블의 설치비용으로 약 5000불의 비용이 소모되고 있다. 본 연구에서는 이러한 센서와 이러한 불편함을 극복하기 위하여 자체 연산기능을 가지고 있는 스마트 무선 센서를 개발하고, 이를 해남과 진도를 잇는 연육교인 제 2 진도대교에 적용, 사장교의 구조 건전성을 저비용 및 높은 편의성으로 모니터링 하기 위한 테스트베드를 구축하였다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2010년도 제34회 춘계학술대회논문집
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• pp.105-112
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• 2010

이중 펄스 로켓 추진기관은 하나의 연소관 안에 특성이 다른 2개의 추진제가 격벽에 의해 2개의 공간에 분리되어 있는 고체 추진기관이다. 유한요소법을 이용한 탄소성 동적거동해석에 의하여 펄스분리장치 파열판의 파열해석을 수행하였다. 파열판의 슬릿 크기를 변경한 해석을 수행하여 파열형상, 파열시점을 해석함으로써 슬릿의 설계 변수가 파열판에 미치는 영향을 검토하였다. 해석 결과는 펄스분리장치 파열판 슬릿 크기의 변경을 통한 파열압력의 조절에 사용할 수 있다.

• 한국정밀공학회지
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• 제24권6호
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• pp.113-120
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• 2007

Chemical vapor deposition (CVD) is one of the various synthesis methods that have been employed for carbon nanotube (CNT) growth. In particular, Ren et al reported that large areas of vertically aligned multi-wall carbon nanotubes could be grown using a direct current (dc) PECVD system. The synthesis of CNT requires a metal catalyst layer, etchant gas, and a carbon source. In this work, the substrates consists of Si wafers with Ni-deposited film. Ammonia $NH_3$) and acetylene ($C_2H_2$) were used as the etchant gases and carbon source, respectively. Pretreated conditions had an influence on vertical growth and density of CNTs. And patterned growth of CNTs could be achieved by lithographical defining the Ni catalyst prior to growth. The length of single CNT was increased as niclel dot size increased, but the growth rate was reduced when nickel dot size was more than 200 nm due to the synthesis of several CNTs on single Ni dot. The morphology of the carbon nanotubes by TEM showed that vertical CNTs were multi-wall and tip-type growth mode structure in which a Ni cap was at the end of the CNT.