• 동의신경정신과학회지
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• 제16권2호
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• pp.135-148
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• 2005

Objective : The purpose of this study is to take around the oriental medical treatment about substance related disorder in china. Method : We review the studies which are published by six different journal in China since 1992 to 2002 involved in substance related disorders. Result 1. The kinds of substance which is the subject of each study. It suggest that the narcotics-withdrawal patients in china take kinds of opium many more than phillopon or barbiturate, cocain etc. especially the heroine takes the most portion in the kinds of opium. 2. The type of chinese medicine demonstration which is about the addiction and withdrawal. There are many symptoms in the each period of withdrawal, According to the each period demonstration, the herbal formula must be different. 3. The formula used in treatment and the substance which is used in common Codonopsis radix is widely used, and pinellia ternata, aractylodes japonica, citrus nobilis, vegetable worms, angelica gigas, zizyphus jujuba, panax ginseng, astragalus membranaceus etc are also used in treatment. 4. The methods of acupunture treatment Hapkok(LI-4), Naegwan(PC6), and Sanyinjiao(SP6) are the widely used acu-points. in addition to these acupoints, there are waegwan(TE5) choksamli(ST36) hanggan(LR2)etc. Conclusion : We expect that this review about substance related disorders in TCM help the clinical study of substance related disorders in Korean medicine.

• 한국콘텐츠학회논문지
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• 제14권11호
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• pp.285-297
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• 2014

본 연구는 초기 청소년기의 주의력 결핍 및 과잉행동이 어떠한 경로를 통하여 우울에 영향을 미치는지, 그리고 그러한 경로에서 성별에 따른 차이가 존재하는지 검증하고자 하는 것이다. 이를 위하여 본 연구에서는 한국아동 청소년패널조사(KCYPS) 초등학교 4학년 3차년도 자료에 대하여 구조방정식 다집단분석을 이용하여 실증적 검증을 실시하였다. 분석 결과, 주의력 결핍 및 과잉행동은 사회적 위축과 교우관계를 통하여 직, 간접적으로 우울에 유의한 영향을 미치는 것으로 나타났으며, 이러한 경로 가운데 주의력 결핍 및 과잉행동과 우울 간의 관계에서 성별에 따른 차이가 존재하는 것으로 확인되었다. 이렇게 도출된 연구결과에 근거하여 주의력 결핍 및 과잉행동의 증상을 경험하고 있는 청소년의 우울에 대한 예방 및 개입과 관련된 함의가 제시되었다.

• The Korean Journal of Pain
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• 제23권3호
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• pp.172-178
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• 2010

Background: Tumor necrosis factor-alpha and other proinflammatory cytokines are becoming well recognized as key mediators in the pathogenesis of many types of neuropathic pain. Thalidomide has profound immunomodulatory actions in addition to their originally intended pharmacological actions. There has been debate on the analgesic efficacy of opioids in neuropathic pain. The aim of this study was to investigate the effect of thalidomide and morphine on a spinal nerve ligation model in rats. Methods: Male Sprague-Dawley rats weighing 100-120 g were used. Lumbar (L) 5 and 6 spinal nerve ligations were performed to induce neuropathic pain. For assessment of mechanical allodynia, mechanical stimulus using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of intraperitoneal thalidomide (6.25, 12.5, 25 and 50 mg/kg, respectively) and morphine (3 and 10 mg/kg, respectively) were examined on a withdrawal threshold evoked by spinal nerve ligation. Results: After L5 and 6 spinal nerve ligation, paw withdrawal thresholds on the ipsilateral side were significantly decreased compared with pre-operative baseline and with those in the sham-operated group. Intraperitoneal thalidomide and morphine significantly increased the paw withdrawal threshold compared to controls and produced dose-responsiveness. Conclusions: Systemic thalidomide and morphine have antiallodynic effect on neuropathic pain induced by spinal nerve ligation in rat. These results suggest that morphine and thalidomide may be alternative therapeutic approaches for neuropathic pain.

• 한국수산과학회지
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• 제42권3호
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• pp.204-208
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• 2009

The withdrawal time of erythromycin in cultured olive flounder was investigated to ensure the food safety of the fish treated with erythromycin. The oral administration of erythromycin was carried out using the experimental diet containing erythromycin (200 mg/kg) daily dose of 40 mg/kg body weight. The 45 day experimental period was broken into 7 days of habituation, 8 days of medication and 30 days of additional feeding without antibiotics. The erythromycin concentration in the flounder muscle had been increased gradually with medication. After 5 days of medication, the concentration increased to its maximum level of 6.05 mg/kg. After discontinuing the antibiotic, the erythromycin concentration decreased drastically and day 9 was below 0.1 mg/kg. The erythromycin concentration had slowly declined from the 6th to the 20th day after medication and disappeared completely after 25 days. From these results, the time needed to reduce the erythromycin level to the 0.2 mg/kg limit adopted by the ED and Japan was suspected to be 4-6 days. Therefore, a reasonable withdrawal time following ED and Japanese regulatory guidelines for erythromycin in the cultured flounder could be estimated to be 10 days.

• 한국수산과학회지
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• 제41권6호
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• pp.440-445
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• 2008

Ciprofloxacin is the most commonly used fluoroquinolones for treating bacterial disease in olive flounder (Paralichthys olivaceus) farming, but its withdrawal time for industrial-scale farming has not been established. The depletion of ciprofloxacin was investigated in the olive flounder under field conditions. Fish were kept in an inland fish farm and fed a commercial diet containing 5 mg/kg of ciprofloxacin for 13 days. Seven fishes per sampling time were examined during and after the treatment. Ciprofloxacin and its major metabolite, enrofloxacin, were analyzed using HPLC with a fluorescence detector. The concentrations of ciprofloxacin and enrofloxacin in muscle increased during the medication period, and then decreased rapidly. The ciprofloxacin and enrofloxacin concentration in the olive flounder peaked on days 11 and 13, respectively, with maximum concentrations in muscle of 0.58 and 0.73 mg/kg. Residual ciprofloxacin and enrofloxacin were eliminated rapidly; 6 days after treatment, the respective levels in muscle were 0.04 and 0.10 mg/kg and neither was detected 15 days post treatment. The level of ciprofloxacin accumulation at the beginning of oral administration was variable according to the farming conditions, but the overall exhaustion time was similar. In conclusion, an adequate withdrawal period for enrofloxacin is 15 days in the case of oral ciprofloxacin administration.

• Journal of Microbiology and Biotechnology
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• 제21권10호
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• pp.1088-1096
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• 2011

The purpose of this study was to evaluate whether wild ginseng (WG) administration could attenuate anxiety- and depression-like behaviors and expression of corticotrophin-releasing factor (CRF) and neuropeptide Y (NPY) following withdrawal from repeated morphine administration in rats. Male rats were administered daily doses of WG (50, 100, or 200 mg/kg, i.p.) for 5 days, 30 min before morphine injection (40 mg/kg, s.c). The anxiety- and depression-like behavioral responses were measured 72 h after the last morphine injection using an elevated plus maze (EPM) and forced swimming test (FST), respectively. Changes in hypothalamic CRF and NPY expressions were also examined by analyzing their immunoreactivities in the hypothalamus. Daily administration of WG significantly reduced anxiety- and depression-like behavior, and elicited the suppression of CRF expression and the stimulation of NPY expression in the hypothalamus. Our results demonstrated that WG extract might be effective at inhibiting the anxiety and depression responses due to morphine withdrawal by possibly modulating the hypothalamus CRF and NPY systems. Furthermore, these findings imply that WG extract can be used for developing new medication to cure or alleviate morphine withdrawal symptoms and to prevent relapses of morphine use.

• 전력전자학회논문지
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• 제8권4호
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• pp.321-327
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• 2003

연속주조 프로세스는 고온의 액체 용강을 고체 금속으로 만드는 프로세스로서, 스트랜드 구동롤의 역할은 운전자가 설정한 주조 속도 제어 패턴에 따라 정확하게 주편을 인발하는 것이다. 기존의 스트랜드 구동롤의 제어는 주조 속도만을 제어하였으나 전동기 드라이버 세팅의 부정확성 및 변동, 연속적인 주조에 의한 구동롤의 마모 및 변형에 의한 롤 직경의 변경, 주조 중 주편 벌징량의 변동 등의 요인에 의해 주조 중 주편을 인발하는 데 소요되는 전체 인발력이 각 구동롤에 적절하게 분배되지 않아 주편 코너부에 수평 크랙을 발생시켜 주조 속도를 증가하는데 있어서 결정적인 장애요인이었다. 본 논문에서는 스트랜드 구동롤에 인가되는 인발력 분포와 주편 품질과의 상관 관계를 도출하고 주조 중에 연속적으로 인발력을 분배할 수 있는 알고리즘을 제안하였다. 제안한 인발력 분배 알고리즘은 각 구동롤 전동기의 절대적인 토크를 제어하는 것이 아니라, 상위제어기에서 결정한 인발력 분배 비율에 따라 각 구동롤 전동기의 토크분 전류를 상호 비교하여 속도 설정치를 조정함으로써 이루어진다. 그리고 인발력 분배 알고리즘의 동작 확인을 위해 광양제척소 1연주공장 4연주기에 적용하여 양호한 결과를 확인하였다.

• 한국물환경학회지
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• 제23권5호
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• pp.591-599
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• 2007

The quality of water released from a stratified reservoir is dependent on various factors such as the location and shape of intake facility, structure of reservoir stratification, profile of water quality constituent, and withdrawal flux. Sometimes, selective withdrawal capabilities can provide the operational flexibility to meet the water quality demands both in-reservoir and downstream. The objective of this study was to evaluate the performance of a one-dimensional reservoir selective withdrawal model (SELECT) as a tool for supporting downstream water quality management for Daecheong and Imha reservoirs. The simulated water quality variables including water temperature, dissolved oxygen (DO), conductivity, turbidity were compared with the field data measured in tailwater. The model showed fairly satisfactory results and high reliability in simulating observations. The coefficients of determinant between simulated and observed turbidity values were 0.93 and 0.95 for Daecheong and Imha reservoirs, respectively. The outflow water quality was significantly influenced by water intake level under fully stratified condition, while the effect of intake amount was minor. In conclusion, the SELECT is simple but effective tool for supporting downstream water quality prediction and management for both reservoirs.

• 생물정신의학
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• 제11권1호
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• pp.33-39
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• 2004

Objective:Nitric oxide(NO) has been known to be associated with tolerance and preference to alcohol. It has also been known to affect various alcohol drinking behavior, alcohol withdrawal symptoms and alcohol- induced brain damage. The purpose of this study was to determine the difference, among alcohol dependence group, alcohol drinking group and abstinence group, in serum concentration of nitrite, a stable metabolite of NO, and it's relationship to clinical and biochemical markers of alcoholism. Methods:Forty subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated for the clinical characteristics and biochemical markers of alcohol dependence including nitrite with their CIWA-Ar scores checked just after admission. Thirty-nine healthy controls were also evaluated, divided into twenty-three alcohol drinking group and sixteen abstinence group. Clinical characteristics were evaluated by CIWA-Ar, CAGE and AUDIT questionnaires. Aspartate aminotransferase(AST), alanine aminotransferase (ALT), gamma glutamyltransferase(GGT) and mean corpuscular volume(MCV) were used as the biochemical markers of alcohol dependence. Serum nitrite concentrations were measured by Griess reaction. Results:1) The concentrations of nitrite in alcohol dependence patients were not different from those in the control subjects. 2) There were no significant association between the nitrite concentrations and the CIWA-Ar scores in alcohol dependence patients. 3) Nitrites are significantly increased in alcohol dependence group and alcohol drinking group compared with abstinence group. Conclusions:These findings suggest that serum nitrite concentration has no relation with alcohol withdrawal symptoms, but alcohol drinking increases serum nitrite concentration influenced by general condition of the body.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제2권1호
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• pp.150-154
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• 1991

연빈지구에 거주하는 한족과 조선민족아동들의 문제행동에서의 차이를 알아보기 위하여 유치원부터 고등학교 2학년 사이의 한족아동 500명과 조선민족아동 512명을 부모보고형 CBCL을 통하여 평가하였다. 그 결과 Social withdrawal, depressed, somatic complaints, aggressive 등의 행동문제는 연변지구의 두 민족 아동들에게서 공통적으로 많이 나타나는 행동문제이었으며, 미국이나 상해아동과 비교할 때 연변지구의 아동들이 social withdrawal 문제는 더 높은 빈도를 보인 반면 aggressive 행동문제는 상대적으로 더 낮은 빈도를 보였다. 한족과 조선민족 아동들을 비교하였을 때 uncommunicative, 분열성, 강박, 불안등의 내향성문제행동은 한족아동에게서 더 빈번히 나타났으나, 활동과다, 잔폭한 행위등은 조선족 아동들에게 더 많이 나타났다.