Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
권호 표지
DOI QR코드

DOI QR Code

Erythromycin Withdrawal Time in Olive Flounder (Paralichthys olivaceus) after Oral Administration

양식 넙치(Paralichthys olivaceus)에 대한 Erythromycin 휴약기간 설정

  • Lee, Tae-Seek (Aquaculture Environment Research Center, NFRDI) ;
  • Park, Mi-Jung (National Fisheries Products Quality Inspection Service) ;
  • Choi, Hye-Sung (Aquaculture Environment Research Center, NFRDI) ;
  • Shim, Kil-Bo (Aquaculture Environment Research Center, NFRDI) ;
  • Park, Mi-Seon (Research and Development Planning Department, NFRDI) ;
  • Shin, Il-Shik (Faculty of Marine Bioscience & Technology, Kangnung-Wonju National University)
  • 이태식 (국립수산과학원 양식환경연구센터) ;
  • 박미정 (국립수산물품질검사원) ;
  • 최혜승 (국립수산과학원 양식환경연구센터) ;
  • 심길보 (국립수산과학원 양식환경연구센터) ;
  • 박미선 (국립수산과학원 연구기획부) ;
  • 신일식 (강릉원주대학교 해양생명과학부)
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The withdrawal time of erythromycin in cultured olive flounder was investigated to ensure the food safety of the fish treated with erythromycin. The oral administration of erythromycin was carried out using the experimental diet containing erythromycin (200 mg/kg) daily dose of 40 mg/kg body weight. The 45 day experimental period was broken into 7 days of habituation, 8 days of medication and 30 days of additional feeding without antibiotics. The erythromycin concentration in the flounder muscle had been increased gradually with medication. After 5 days of medication, the concentration increased to its maximum level of 6.05 mg/kg. After discontinuing the antibiotic, the erythromycin concentration decreased drastically and day 9 was below 0.1 mg/kg. The erythromycin concentration had slowly declined from the 6th to the 20th day after medication and disappeared completely after 25 days. From these results, the time needed to reduce the erythromycin level to the 0.2 mg/kg limit adopted by the ED and Japan was suspected to be 4-6 days. Therefore, a reasonable withdrawal time following ED and Japanese regulatory guidelines for erythromycin in the cultured flounder could be estimated to be 10 days.

Keywords

References

  1. EC (European Communities). 1999. COMMISSION REGULATION No 2593/1999 amending Annexes I, II and Ill of Council Regulation (EEC) No 2377/90 laying down Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Official J. Eur. Commun., Brussels, Belgium, L315/26-31
  2. Esposito, A., L. Fabrizi, D. Lucchetti, L. Marvasi, E. Coni and E. Guandalini. 2007. Orally administered erythromycin in rainbow trout (Oncorhynchus mykiss): Residues in edible tissues and withdrawal time. Antimierob. Agents Chemother., 51, 1043-1047 https://doi.org/10.1128/AAC.01002-06
  3. FAO (Food and Agriculture Organizaion of the United Nations). 2006a. Yearbook of fishery statistics. FAO Fisheries Department, 98, 1-560
  4. FAO (Food and Agriculture Organizaion of the United Nations). 2006b. State of world aquaculture 2006. FAO Fisheries Department, 1-129
  5. Hayama, T. 1998. Residues of animal drugs in food. J. Food Hyg. Soc. Japan, 39, 6-11
  6. KFDA (Korea Food & Drug Administration). 2004. Establishment antimicrobials management system for aquaculture. Gudeok Publ. Co., Busan, Korea, 1-184
  7. KFDA (Korea Food & Drug Administration). 2006. Approval of registration of the animal drug and usage status. Dongwon-Monhwasa, Seoul, Korea, 1-183
  8. KFDA (Korea Food & Drug Administration). 2007a. Food Code. Seoul, Korea, 1115pp.
  9. KFDA (Korea Food & Drug Administration). 2007b. MRLs for veterinary drugs in foods. pp. 1-310
  10. KMI (Korea Maritime Institute). 2007. Global maritime affairs & fisheries weekly 16th, Gihoek munhwasa, Seoul, Korea, pp.5-10
  11. MOMAF (Ministry of Maritime Affairs & Fisheries). 2002. Study on the development of HACCP system for fishery produets during produetion and before market. Gudeok Publ. Co., Busan, Korea, pp. 1-254
  12. MOMAF (Ministry of Maritime Affairs & Fisheries). 2006. Survey on the status of fish culture. Samsungelife, Seoul, Korea, pp.15-29
  13. NFRDI (National Fisheries Research and Development Institute). 2006. The guidance of aquatic drug use. pp.1-31
  14. Park, J.H. 2004. Analytical method for veterinary drug residues. In: International symposium & workshop on the control of the use of veterinary drug and management of residues in foods of animal origin. Lee, H.O, NVRQS, Korea, pp.137-167
  15. Park, M.S., B.Y. Jee, S.H. Jeong and J.W. Kim. 2002. Status and prospects of fish diseases in Korea. In: World Aquaculture, 586 pp
  16. Park, M.J., M.S. Park, T.S. Lee and I.S. Shin. 2008. A new analytical method for erythromycin in fish by liquid chromatography/tandem mass spectrometry. Food Sci. Biotechnol., 17, 508-513
  17. Ray, W.A., K.T. Murray, S, Meredith, S.S. Narasimhulu, K. Hall and C.M. Stein. 2004. Oral erythromycin and the risk of sudden death from cardiac causes. N. Engl. J. Med., 351, 1089-1096 https://doi.org/10.1056/NEJMoa040582
  18. Treves-Brown, KM. 2000. Applied fish pharmacology. eds. Dordrecht Boston, Kluwer Academic Publ., pp. 87-94

Cited by

  1. The Pharmacokinetic Characterization of Erythromycin thiocyanate in Cultured Olive Flounder by Single Intramuscular Administration vol.30, pp.6, 2018, https://doi.org/10.13000/JFMSE.2018.12.30.6.1930
  2. 경구투여에 의한 양식산 넙치내 Erythromycin의 약물동태학적 특성 분석 vol.26, pp.2, 2014, https://doi.org/10.13000/jfmse.2014.26.2.316