• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.3
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• pp.678-683
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• 2008

Aconitum pseudo-laeve var. erectum has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Aconitum pseudo-laeve var. erectum has the efficiency of anti-inflammatory activity and modulates the intestinal immune system. However, the mechanism of anti-inflammatory action of Aconitum pseudo-laeve var. erectum has not been clarified yet. In the present study, the effect of Aconitum pseudo-laeve var. erectum against LPS-stimulated expressions of COX-2 and iNOS in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription- polymerase chain reaction (RT-PCR), PGE2 immunoassay, and NO detection. The results of the present study indicate that Aconitum pseudo-laeve var. erectum is a potent inhibitor of the LPS-induced NO and $PGE_{2}$ production by blocking iNOS and $NF{\kappa}B$ activation in RAW 264.7 macrophages. These findings suggest that Aconitum pseudo-laeve var. erectum is a potential therapeutic for the treatment of inflammatory syndrome.

• Journal of Sensor Science and Technology
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• v.32 no.5
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• pp.267-274
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• 2023

LiDAR, one of the most important sensing methods used in mobile robots and cars with assistive/autonomous driving functions, is used to locate surrounding obstacles or to build maps. For real-time path generation, the detection of potholes or puddles on the driving surface is crucial. To achieve this, we used the coordinates of the reflection points provided by LiDAR as well as the intensity information to classify water areas, which was achieved by applying a linear regression method to the intensity distribution. The rationale for using the LiDAR index as an input variable for linear regression is presented, and we demonstrated that it is not affected by errors in the distance measurement value. Because of LiDAR vertical scanning, if the reflective surface is not uniform, it is divided into different groups according to the intensity distribution, and a mathematical basis for this is presented. Through experiments in an outdoor driving area, we could distinguish between flat ground, potholes, and puddles, and kinematic analysis was performed to calculate the maximum width that could be crossed for a given vehicle body size and wheel radius.

• Journal of Korean Home Economics Education Association
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• v.12 no.3
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• pp.53-63
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• 2000

The purpose of this study was quantitative and qualitative contents analysis of food and nutrition section in middle school textbooks of home economics, physical education and science. As a quantitative approach numbers of sentence lines tables, figures, photos, activities, and exercises were counted. As a qualitative approach, types of explanations were categorized by 7 criteria, and commons and differences of the contents of those subjects were compared. The conclusions of this study were summarized as follows: 1) Contents of food and nutrition section were divided into nutrients. water. energy, food groups, and nutritional problems. When average sentence lines of each were compared, those of nutrients were the longest in all 3 subjects. 2) When compared the numbers of tables, figures, and photos in 3 subjects of textbooks, there were more figures in home economics and science, and more tables in physical education. 3) There were more activities and exercises in home economics an science than in physical education. 4) The D(sentences with table) or E type(sentences with figure) was adapted for the explanation of nutrients functions, recommended dietary allowance, food sources, food groups, eating habits, and weight control in home economics: nutritions functions and energy metabolism in physical education : and digestion, body constituents, energy metabolism, and detection of nutrients in science. 5) Contents about classification and functions of nutrients. food sources deficiency water, energy contents of nutrients and obesity were shown in all 3 subjects. Food groups and eating habits were explained in detail in home economics whereas digestion of nutrients in the digestive tracts were explained in detail in science. Recommended dietary allowance for Koreans and basic food groups revised in 1995 were presented in home economics, whereas those revised in 1989 were presented in physical education. To avoid confusion, recommended dietary allowance for Koreans and food groups presented in physical education tex should be updated.

• Korean Journal of Ecology and Environment
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• v.44 no.3
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• pp.264-271
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• 2011

At the Jangheung multipurpose dam, which is on the Tamjin River, a trapping and trucking operation was established to maintain continuous upstream migration of fish,. To facilitate fish gathering, installation of an effective fishing trap was required. In this study, we evaluated the fish trap, established at the Jangheung dam, using PIT (Passive Integrated Transponder) telemetry. A total of 254 individuals from 15 species were monitored. Among these tagged species, 36 individuals from 6 species (Carassius auratus, C. cuvieri, Zacco temminckii, Z. platypus, Pungtungia herzi, and Pseudobagrus koreanus) were detected; a 14.2% detection rate. C. auratus recorded the highest detection rate of 44.2% while P. herzi was 14.3%. Z. temminckii and Z. platypus showed relatively low detection, 5% and 7.7% respectively. Some of individuals from C. auratus and Z. platypus did not pass through the antenna at the first attempt but were continuously detected on multiple days. There were no statistical differences in body size (total length, standard length and body weight) of individuals that did or did not swim into the trap (Mann-Whitney U test, p>0.05). Fish mainly swam into the trap during outflow of water from the dam (Mann-Whitney U test, p<0.001) and showed a higher detection frequency in daytime than nighttime (Mann-Whitney U test, p<0.001). Thus, for fish movement into the trap, external factors such as outflow from dam and time of day have important roles. Based on detection rate, not all fishes showed upstream migration but represented selective migration. Consequently, the establishment of flexible outflow strategies that take into consideration ecological characteristics of fishes should required for improving the efficiency of fishway.

• Korean Journal of Remote Sensing
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• v.38 no.2
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• pp.153-166
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• 2022

Waterstorage is one of the factorsthat most directly represent the amount of available water resources. Since the effects of drought can be more intuitively expressed, it is also used in variousstudies for drought evaluation. In a recent study, hydrological drought was evaluated through information on observing reservoirs with optical images. The short observation cycle and diversity of optical satellites provide a lot of data. However, there are some limitations because it is vulnerable to the influence of weather or the atmospheric environment. Therefore, thisstudy attempted to conduct a study on estimating the drought index using Synthetic Aperture Radar (SAR) image with relatively little influence from the observation environment. We produced the waterbody of Baekgok and Chopyeong reservoirs using SAR images of Sentinel-1 satellites and calculated the Reservoir Area Drought Index (RADI), a hydrological drought index. In order to validate the applicability of RADI to drought monitoring, it was compared with Reservoir Storage Drought Index (RSDI) based on measured storage. The two indices showed a very high correlation with the correlation coefficient, r=0.87, Area Under curve, AUC=0.97. These results show the possibility of regional-scale hydrological drought monitoring of SAR-based RADI. As the number of available SAR images increases in the future, it is expected that the utilization of drought monitoring will also increase.

• Journal of the Korean earth science society
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• v.31 no.6
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• pp.563-572
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• 2010

Both multi-channel temperature monitoring and geophysical electric survey were performed together for an embankment to assess the leakage zone. Temperature variation according to space and time on the inner parts of engineering constructions (e.g.: dam and slope) can be basic information for diagnosing their safety problem. In general, as constructions become superannuated, structural deformation (e.g.: cracks and defects) could be generated by various factors. Seepage or leakage of water through the cracks or defects in old dams will directly cause temperature anomaly. This study shows that the position of seepage or leakage in dam body can be detected by multi-channel temperature monitoring using thermal line sensor. For that matter, diverse temperature monitoring experiments for a leakage physical model were performed in the laboratory. In field application of an old earth fill dam, temperature variations for water depth and for inner parts of boreholes located at downstream slope were measured. Temperature monitoring results for a long time at the bottom of downstream slope of the dam showed the possibility that temperature monitoring can provide the synthetic information about flowing path and quantity of seepage of leakage in dam body. Geophysical data by electrical method are also added to help interpret data.

• Journal of Society of Preventive Korean Medicine
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• v.15 no.1
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• pp.37-47
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• 2011

Objectives : Previous studies have shown that Fructus mume (FM) has anti-platelet effects. The present study was performed to determine the acute oral toxicity and quality control of a crude extract of FM in ICR mice. Methods : We investigated the in vivo single dose acute toxicity of FM 95% ethanol extract. This test was orally administered once by gavage to 20 male and 20 female mice at dose levels of 0 (control group), 1250, 2500 and 5000mg/kg body weight, respectively. Mortalities, clinical findings, autopsy findings and body weight changes were monitored daily for the 14 days following the administration. HPLC analysis was performed for the simultaneous determination of ursolic acid and p-hydroxycinnamic acid in FM. Reverse-phase chromatography using a C18 column and photodiode array detection at 211 nm was used for quantification of the two maker components. The mobile phase for gradient elution consists of water and acetonitrile. Results : We observed survival rates, general toxicity, change of body weight, and autopsy. The mice did not die after single oral administration of maximum dose of FM. Autopsy of animal revealed no abnormal gross finding. Therefore, $LD_{50}$ value of FM for ICR mice was more than 5000mg/kg on oral route. The HPLC analysis showed that ursolic acid and p-hydroxycinnamic acid amounts to 9.75- and 0.12% in the extract with the retention times of 47.99- and 15.38 minutes, respectively. Conclusions : These results suggest that no toxic dose level of FM in mice is considered to be more than 5000mg/kg. Consequently, it was concluded that FM have no effect on acute toxicity and side effect in ICR mice. For the quality control of FM extract, simultaneous determination of ursolic acid and p-hydroxycinnamic acid was established.

• Journal of the Korean Society of Radiology
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• v.14 no.7
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• pp.857-862
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• 2020

In March 2011, a tsunami off Japan caused radioactive material that had seeped into the sea from the Fukushima nuclear accident to flow to the Pacific Ocean, causing pollution to sea life. For a comparative evaluation with the area surrounding the site of a nuclear power plant by the release of radioactive materials, an area 20 to 30 km away from the emergency protection plan area was selected as a comparative point considering weather conditions, population distribution, etc. In addition, the government intends to analyze the minimum detection radiation received by residents around the nuclear power plant and evaluate the effective dose. Analysis of tritium radiation from water samples showed that most of the samples were not detected and that 0.0014 % to 0.777 % of the annual legal standard of 1 mSv for the general public had little effect on the human body. Therefore, the measurement and analysis of water samples around the nuclear power plant site is expected to help relieve anxiety, such as exposure to the general public and neighboring residents due to radiation release.

• Progress in Medical Physics
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• v.27 no.3
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• pp.162-168
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• 2016

Proton therapy is increasingly being actively used in the treatment of cancer. In contrast to photons, protons have the potential advantage of delivering higher doses to the cancerous tissue and lower doses to the surrounding normal tissue. However, a range shifter is needed to degrade the beam energy in order to apply the pencil beam scanning technique to tumors located close to the minimum range. The secondary neutrons are produced in the beam path including within the patient's body as a result of nuclear interactions. Therefore, unintended side effects may possibly occur. The research related to the secondary neutrons generated during proton therapy has been presented in a variety of studies worldwide, since 2007. In this study, we measured the magnitude of the secondary neutron dose depending on the location of the detector and the use of a range shifter at the beam nozzle of the proton scanning mode, which was recently installed. In addition, the production of secondary neutrons was measured and estimated as a function of the distance between the isocenter and detector. The neutron dose was measured using WENDI-II (Wide Energy Neutron Detection Instruments) and a Plastic Water phantom; a Zebra dosimeter and 4-cm-thick range shifter were also employed as a phantom. In conclusion, we need to consider the secondary neutron dose at proton scanning facilities to employ the range shifter reasonably and effectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.785-791
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• 2005

Corydalis Tuber has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Corydalis Tuber has been known to be effective for the control of pain and treatment of arthritis. It was reported that Corydalis Tuber possesses anti-inflammatory activity and modulates the intestinal immune system. The effect of Corydalis Tuber against LPS-stimulated expressions of COX-2, iNOS, and $IL-1{\beta}$ in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), $PGE_2$ immunoassay, and NO detection. The aqueous extract of Corydalis Tuber was shown to suppress $PGE_2$ production by inhibition on the LPS-stimulated enhancement of COX-2 enzyme activity, $IL-1{\beta}$, and iNOS expression in the RAW 264.7 macrophages. Present results suggest that Corydalis Tuber exerts anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and $IL-1{\beta}$ expressions, resulting in inhibition of $PGE_2$ synthesis. Corydalis Tuber has anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and $IL-1{\beta}$ mRNA expressions, resulting in inhibition of $PGE_2$ and NO synthesis.