• 한국지하수토양환경학회지:지하수토양환경
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• 제15권6호
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• pp.122-127
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• 2010

Constructing the national inventory that can be used as a tool to identify and assess existing or potential contamination is necessary for efficiently managing the soil and groundwater contamination. In order to start this construction, the first step is how we define and classify potential contamination sources of soil and groundwater. After selecting the basic classification model of contamination sources from developed countries, we suggested the classification and list of the potential contamination sources of soil and groundwater which are appropriate for specific conditions of South Korea. In addition, we investigated several databases to confirm the existence of available data sources and then examined established attribute data through chemical accident response information system (CARIS) and water information system (WIS) in National Institute of Environmental Research and mine geographic information system (MGIS) in Mine Reclamation Corporation. All sorts of attribute data in the existing databases can be utilized as significant assessment factors for determining the management priority of potential contamination sources in the future. Therefore, it is required the expanded investigation of additional database sources and the continual modification so that the classification system of potential contamination sources can be improved.

• 약학회지
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• 제41권1호
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• pp.30-37
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• 1997

In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by th e method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50 ${\mu}$m. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.

• Bulletin of the Korean Chemical Society
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• 제29권4호
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• pp.785-789
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• 2008

The present study is the first report of utilizing $TiO_2$ photocatalyst to analytically calibrate the hydroperoxyl radical ($HO_2\;^{\cdot}$). An in-situ calibration method of $HO_2\;^{\cdot}$ is proposed for air monitoring by using an 2-methyl-6-(pmethoxyphenyl)- 3,7-dihydroimidazo-[1,2-a]pyrazin-3-one (MCLA)-chemiluminescence (CL) technique. In this method, $HO_2\;^{\cdot}$($pK_a$ = 4.80) is produced by the ultraviolet (UV) photolysis of immobilized $TiO_2$ using a constant flow rate of air equilibrated water, in which $HO_2\;^{\cdot}$ is controlled by using various lengths of knotted tubing reactor (KTR). The principle of the proposed calibration is based on the experimentally determined halflife ($t_{1/2}$) of $HO_2\;^{\cdot}$ and its empirically observed pH-dependent rate constant, $k_{obs}$, at a given pH. The concentration of $HO_2\;^{\cdot}$/$O_2\;^{\cdot}$− is increased as pH increases. This pH dependence is due to the different disproportionative reactivities between $HO_2\;^{\cdot}$/$O_2\;^{\cdot}$− and $HO_2\;^{\cdot}$/$O_2\;^{\cdot}$−. Experimental results indicate the practical feasibility of the approach, producing very promising method.

• BMB Reports
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• 제36권3호
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• pp.326-331
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• 2003

The fission yeast cells that contained the cloned glutathione synthetase (GS) gene showed 1.4-fold higher glutathione (GSB) content and 1.9-fold higher GS activity than the cells without the cloned GS gene. Interestingly, $\gamma$-glutamylcysteine synthetase activity increased 2.1-fold in the S. pombe cells that contained the cloned GS gene. The S. pombe cells that harbored the multi copy-number plasmid pRGS49 (containing the cloned GS gene) showed a higher level of survival on solid media with cadmium chloride (1 mM) or mercuric chloride ($10\;{\mu}M$) than the cells that harbored the YEp357R vector. The 506 bp upstream sequence from the translational initiation point and N-terminal8 amino acid-coding region were fused into the promoteriess $\beta$-galactosidase gene of the shuttle vector YEp367R to generate the fusion plasmid pUGS39. Synthesis of $\beta$-galactosidase from the fusion plasmid pUGS39 was significantly enhanced by cadmium chloride and NO-generating S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SN). It was also induced by L-buthionine-(S,R)-sulfoximine, a specific inhibitor of $\gamma$-glutamylcysteine synthetase (GCS). We also found that the expression of the S. pombe GS gene is regulated by the Atf1-Spc1-Wis1 signal pathway.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2002년도 학술대회지
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• pp.72-77
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• 2002

미국에서는 품질 관리 문제를 해결할 수 있는 아이디어로 지급(Pay) Factor가 사용되어왔으며 현재는 생애주기비용까지 고려한 한층 진보된 지급조정모델 개발에 많은 관심을 가지고 있다. 하지만 이러한 지급조정모델절차의 개발은 품질특성변수 선택의 문제, 품질특성변수의 확률적 분포와 도로 공용성간의 관계 분석의 문제, 그리고 하나의 전체 지급조정모델 개발의 문제 등으로 미 교통부에서 어려움을 가지고 있다. 본 논문에서는 이러한 점을 극복하기 위한 방법론으로 생애주기비용분석을 고려한 몬테카를로 시뮬레이션 접근 방식이 사용되었다. 미 여러 교통부에서 적용 가능한 견본이 될 수 있도록 현 위스콘신 교통국에서 사용중인 도로관리 관련 시스템들에서 데이터를 축출하여 지급조정을 격정하기 위한 분석 절차를 제시하고 이를 근간으로 지급조정모델 결정 지원 시스템을 개발하였으며 민감도 분석을 실행하여 실제 데이터를 사용하여 개발된 지급조정모델의 적정성을 평가하였다. 본 논문에서 사용된 지급조정모델 개발 절차는 한층 정확성을 높인 도로공용성예측모델과 생애주기비용모델을 사용함으로써 실제 프로젝트에 사용 가능할 것으로 판단된다.

• Environmental Analysis Health and Toxicology
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• 제25권1호
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• pp.41-55
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• 2010

The aims of this study were to develop the suitable "system software" in chemical ranking and scoring (CRS) for the food hazardous chemicals associated with environmental emission and to suggest the priority lists of food contamination by environmental-origined pollutants. Study materials were selected with reference to the priority pollutants list for environment and food management from domestic and foreign research and the number of study materials is 103 pollutants (18 heavy metals, 10 PBTs, 10 EDs, and 65 organic compounds). The Food-CRS-Korea system consisted of the environmental fate model via multimedia, transfer environment to food model, and health risk assessment by contaminated food intake. We have established that health risks of excess cancer risks, hazard quotients (HQs) by chronic toxicity and HQs by reproductive toxicity convert to score, respectively. The creditable scoring system was designed to consider uncertainty of quantitative risk assessment based on VOI (Value-Of-Information). The predictability of the Food-CRS-Korea model was evaluated by comparing the presumable values and the measured ones of the environmental media and foodstuffs. The priority lists based on emissions with background-level-correction are 15 pollutants such as arsenic, cadmium, and etc. The priority lists based on environmental monitoring date are 17 pollutants including DEHP, TCDD, and so on. Consequently, we suggested the priority lists of 13 pollutants by considering the several emission and exposure scenarios. According to the Food-CRS-Korea system, arsenics, cadmium, chromes, DEHP, leads, and nickels have high health risk rates and reliable grades.

• The Korean Journal of Physiology and Pharmacology
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• 제20권6호
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• pp.621-628
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• 2016

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.

• Journal of the Korean Wood Science and Technology
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• 제43권5호
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• pp.600-612
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• 2015

We investigated the optimization of the organosolv pretreatment of yellow poplar for bioethanol production. Response surface methodology was used to determine the optimal conditions of three independent variables (reaction temperature, reaction time, and sulfuric acid (SA) concentration). Reaction temperature is the most significant variable in the degradation of xylan and lignin in the presence of an acid catalyst, and ethanol production increased with a decrease in the lignin content. The highest ethanol concentration ($42.80g/{\ell}$) and theoretical ethanol yield (98.76%) were obtained at $152^{\circ}C$ (2.5 bar) with 1.6% SA for 16 min. However, because of excessive degradation of the raw material, the overall ethanol yield was less than under other pretreatment conditions which has approximately 50% of WIS recovery rate after pretreatment. The optimal conditions for the maximum overall ethanol yield ($146^{\circ}C$ with 1.22% SA for 15.9 min) were determined with a predicted yield of 17.11%, and the experimental values were very close (17.15%). Therefore, the quadratic model is reliable.

• 대한물리치료과학회지
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• 제13권3호
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• pp.77-84
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• 2006

The purpose of this study is to introduce the effect of attentional focus on performance of task. Previous studies has shown that motor learning can be enhanced by directing performers's attention to the effects of their movements(external focus), rather than to the body movement producing the effects(internal focus). Wulf and colleagues have invoked the 'constrained action hypothesis' to explain the comparative benefits of adopting an external rather than an internal focus of attention. This hypothesis proposed that when performers utilize an internal focus of attention, they may actually constrain or interfere with automatic control processes that would normally regulate the movement, whereas an external focus of attention allows the motor system to more naturally self-organize. Electromyography(EMG) was used to determine neuromuscular correlates of external versus internal focus differences. EMG activity was lower with an external relative to an internal focus. This suggest that an external focus of attention enhances movement economy, and presumably reduces 'noise' in the motor system that hampers fine movement control. Focusing on a more remote effect seems to facilitate the discriminability of the effect from the body movements that produced it and to be more beneficial than focusing on a very close effects. There might be an optimal distance of the effect, at which ti wis easily distinguishable from the body movement but at which it is also still possible for the performer to relate this effect to the movement techniques. Future Studies of motor learning of patient need to accommodate these new finding and account for the role of the learner's attentional focus and its influencing on learning.

• Archives of Plastic Surgery
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• 제35권2호
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• pp.201-204
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• 2008

Purpose: Now the CT scanner and PACS program proved to be an excellent instrument for detection and localization of most facial foreign bodies above certain minimum levels of detectability. The severity of injury in penetrating trauma on the face is often underestimated in physical examination. Wood, with its porous consistency and organic nature, provides a good medium for microbial agents. This is a report of our recent experience with wooden foreign bodies in the parotid gland imaged with CT. Methods: A 9-year-old boy was referred for evaluation of possible retained foreign body within his face. One day earlier, he had fallen, face down approximately 1 miter onto ground. He had subsequently undergone an exploration of his right parotido-masseteric area at an outside hospital with repair of a right facial laceration. Enhanced 2 mm axial and coronal CT scans were obtained through the face. Axial and coronal CT images were obtained with a General Electric(Milwaukee, Wis) 9800 CT scanner at 130 kV, 90 mA, with a 2 mm section thickness. Results: We finally decided the linear "gas" attenuation was a foreign body because of its linear configuration, which did not conform to that of an anatomic structure, and on the basis of articles that described a wood foreign body in the orbit as having the appearance of air. We found that wood was hypoattenuating($-464{\pm}27HU$). Conclusion: We recommend this type of software program for CT scanning for any patient with an injury on the face in which a foreign body is suspected.