• Annals of Clinical Neurophysiology
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• v.1 no.2
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• pp.112-117
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• 1999

Background : Posterior tibial nerve somatosensory evoked potentials (PTSEP) have cortical potentials on primary sensory area of foot around 40 msec. The direct cortical recordings of the cortical potentials shows high voltage positive wave on medial hemisphere, especially on paracentral lobule (PCL). However, it is so difficult to record the potential directly on PCL that the cortical potential of PTSEP is not well understood. We investigated the cortical potential of PTSEP on subdural electrodes. Methods : We recorded cortical potentials to posterior tibial nerve stimulation on subdural electrodes which were on medial hemisphere near PCL in 15 intractable neocortical epilepsy patients. The numbers of subdural electrodes were 8 in 10 subjects ($1{\times}8array$) and 16 in 5 subjects ($2{\times}8arrays$). Seven subjects had three-dimensional imaging fusion (3D-fusion) of MRI and the electrodes using Analyze program. We investigated the amplitude, latency, polarity, and phase of the waves regarding location. Results : The waves had maximal amplitude on PCL in 4 subjects, precuneus in 1, cingulate gyrus nearest to PCL in 2 among 7 subjects with 3D-fusion. Also the electrodes were located on posterior area of PCL (2 out of 2 subjects with more than two electrodes put on PCL in 3D-fusion) and superior area of it (5 out of 5 subjects with $2{\times}8arrays $). All the high (more than 20 uV) amplitude around 40msec had positive polarity in 7 subjects. The phase reversals were detected between the electrodes with the highest amplitude and the just posterior (2 subjects) or anterior (6 subjects) located electrodes. The just posterior located electrodes had sharper phase reversal than the anterior one. Conclusion : PTSEP might have maximal amplitude of cortical potentials on the more superior and posterior area of PCL. The highest amplitude potential has positivity. The wave with maximal amplitude could have phase reversal of cortical potentials with surrounding electrodes, especially shaper with posterior part than with anterior one.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.1
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• pp.7-11
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• 2006

Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of -60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward current. Also, when the holding potentials were changed from +20 mV to -80 mV with intervals of 20 mV, there was little difference in inward current. In pacemaker activity, the resting membrane potential (RMP) was depolarized (In pH 5.5, $23{\pm}1.5$ mV depolarized) and the amplitude was decreased by a decrease of the extracellular pH. However, in case of increase of extracellular pH, the RMP was slightly hyperpolarized and the amplitude was decreased a little. The melastatin type transient receptor potential (TRPM) channel 7 has been suggested to be required for intestinal pacemaking activity. TRPM7 produced large outward currents and small inward currents by voltage ramps, ranging from +100 to -100 mV from a holding potential of -60 mV. The inward current of TRPM7 was dramatically increased by a decrease in the extracellular pH. At pH 4.0, the average inward current amplitude measured at -100 mV was increased by about 7 fold, compared with the current amplitude at pH 7.4. Changes in the outward current (measured at +100 mV) were much smaller than those of the inward current. These results indicate that the resting membrane potential of pacemaking activity might be depolarized by external acidic pH through TRPM7 that is required for intestinal pacemaking activity.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.1-7
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• 2021

In this paper, a method of extending 1 bit by adding an external device to a parallel interface type Digital-to-Analog conversion(D/A C) circuit is presented. To do this, the principle of the D/A C circuit was examined, and the problems that occur when extending one bit by adding individual devices were analyzed, and a bit extension method of the D/A devices using an OP-Amp. circuit was presented. As the proposed method uses the high-precision characteristics of the OP-Amp., even if an error occurs in the device, only the overall size of the output waveform is affected, and the voltage reversal phenomenon that occurs between each bit does not occur. In order to confirm the effect of the proposed method, an experimental circuit was constructed and the absolute voltage of the output and the relative error were measured. As a result, a voltage error of 0.0756% appeared, confirming that the 0.195% requirement for one bit expansion by adding individual devices was sufficiently satisfied.

• Corrosion Science and Technology
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• v.19 no.5
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• pp.265-280
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• 2020

External corrosion of buried pipes can be controlled using both coating and cathodic protection. However, deterioration of the coating can occur due to several reasons. The detection reliabilty of coating flaw detection methods is affected by interference such as metal objects connected to rectifiers and copper grids. When performing parallel direct current voltage gradient (DCVG) inspection, a sine wave form without potential reversal in voltage gradient appears in the area where the interference exists. However, this area may be not identified using existing methods. The objective of this study was to determine the effect of analyzing direction on the reliability of coating flaw detection of pipes buried in soil using a multi-electrode detector. DCVG on the buried pipe was measured along the buried pipe. This measurement parallel to the pipe was repeated. Measured data were analyzed for parallel, vertical, and diagonal directions. The reliability of coating flaw detection was improved by up to 46.4% compared to the conventional method.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.131-135
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• 2008

The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed at least 4 different currents: a tetrodotoxin (TTX)-sensitive $Na^+$ current, a hyperpolarization-activated inward current, and A-type and delayed rectifier-type $K^+$ outward currents. Both types of $K^+$ outward currents were blocked by either 5 mM tetraethylammonium (TEA) or 5 mM 4-aminopyridine (4-AP). The hyperpolarization-activated current resembled the classical $K^+$ inward current in that it exhibited a voltage-dependent block in the presence of external $Ba^{2+}$ (30 ${\mu}$M) or $Cs^+$ (3${\mu}$M). However, the reversal potentials did not match well with the predicted $K^+$ equilibrium potentials, suggesting that it was not a classical $K^+$ inward rectifier current. The other $Na^+$ inward current resembled the classical $Na^+$ current observed in pharmacological studies. The expression of these channels may contribute to generation and repolarization of action potential and might be regarded as functional markers for hNSCs-derived neurons.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07b
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• pp.585-588
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• 2002

The USM uses friction between a mobile part (rotor) and a vibration part(stator), which is different from the principle of the conventional motor based on the interaction of electric and magnetic fields. In this thesis, a flat-type $L_1-B_8$ mode USM was designed and fabricated the characteristics of an ultrasonic vibration. The results of fabricated USM are as follows: (1) In case of ultrasonic motor with elastic-body of stainless, when applied voltage, frequency, pressing force of rotor were 50 [V], 27.9 [kHz], 1.5 [N], 5.0[mN m] respectively, the speed of revolution could be presented up to 0 [cm/s]. (2) In case of ultrasonic motor with elastic-body of brass, when applied voltage, frequency, pressing force of rotor were 50 [V], 21.4 [kHz], 1.5 [N], 1.4[mN m]respectively, the speed of rotor revolution was presented up to 0 [cm/s]. (3) The USM of elastic-body of stainless showing 1.17[%], somewhat low, in the maximum efficiency according to torque was superior to the USM of elastic-body of brass showing 0.34 [%]. The Flat-type $L_1-B_8$ mode USM had characteristics of typical drooping torque-speed, large torque and high speed, and operating in both directions by phase reversal.

• The Korean Journal of Physiology
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• v.28 no.2
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• pp.143-150
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• 1994

The whole-cell mode of the patch clamp technique was used to study $Ca^{2+}-activated\;Cl^-\;current$ $(I_{Cl_{Ca}})$ in gastric antral myocytes. Extracellular application of caffeine evoked $Ca^{2+}-activated\;current$. In order to isolate the chloride current from background current, all known systems were blocked with specific blockers. The current-voltage relationship of caffeine-induced current showed outward rectification and it reversed at around $E_{Cl^-}$. The shift of reversal potential upon the alteration of external and internal chloride concentrations was well fitted with results which were calculated by the Nernst equation. Extracellular addition of N-phenylanthranilic acid and niflumic acid which are known anion channel blockers abolished the caffeine induced current. Intracellular application of a high concentration of EGTA also abolished this current. Application of c-AMP, c-GMP, heparin, or $AIF^-_4$ made no remarkable changes to this current. Sodium replacement with the impermeable cation N-methylglucamine or with $Cd^{2+}$ rarely affected this current. From the above results it is suggested that the caffeine induced current was a $Cl^-$ current and it was activated by intracellular $Ca^{2+}$.

• Journal of Power Electronics
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• v.10 no.5
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• pp.451-460
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• 2010

This paper presents a new kind of digital control metal halide lamp electronic ballast. A zero-voltage-switch quasi-square-wave (ZVS-QSW) dual Buck converter is adopted here. In this paper, a digital control method is proposed to achieve ZVS for the converter. This ZVS can be realized during the whole working condition. Single-cycle-peak-current control is proposed to solve the problem of excessive inductor current during a low-frequency reversal transient. Power loop control is also realized and its consistency for different lamps is good. An AVR special microcontroller for a HID ballast is used to raise the control performance, and the low-frequency square-wave control method is adopted to avoid acoustic resonance. A 70W prototype was built in the laboratory. Experimental results show that the electronic ballast works reliably. Furthermore, the efficiency of the ballast can be higher than 92%.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.147-150
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• 2006

Neurotoxic shellfish poisoning (NSP) can result from eating filter-feeding shellfish carrying brevetoxins produced by the marine dinoflagellate Krenia brevis (formally Gymnodinium breve). Brevetoxins enhance sodium entry into cells via voltage-sensitive sodium channels and have an excitatory effect. The incubation period is three hours (range 15 minutes-18 hours). NSP is characterized by gastroenteritis combined with neurologic symptoms. Gastrointestinal (GI) symptoms include abdominal pain, nausea, diarrhea and burning pain in the rectum. Neurologic symptoms are paresthesia, reversal of hot and cold temperature sensation, myalgia, headache, vertigo, and ataxia. Other symptoms may include malaise, tremor, dysphagia, bradycardia, decreased reflexes, dilated pupils, seizure, and coma. The health problem caused by K. breviscan be associated with a red tide bloom. We encountered 3 cases of neurotoxic shellfish poisoning. They all presented with GI and neurologic symptoms andrecovered after conservative treatment.

• The Transactions of the Korean Institute of Power Electronics
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• v.20 no.4
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• pp.375-387
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• 2015

This study investigates an economic and highly efficient power-converter topology and its modulation scheme for 60 kW rapid EV charger system. The target system is a three-phase three-switch buck-type rectifier topology. A new carrier-based PWM scheme, which is characterized by simple implementation using logic gates, is introduced in this paper. This PWM scheme replaces the diode rectifier equivalent switching state with an active switching state to produce the same effective current flowing path. As a result, the distortion of input current during the polarity reversal of capacitor line voltage can be mitigated. The proposed modulation technique is confirmed through simulation verification. The proposed modulation technique and its implementation scheme can expand the operation range of the three-phase three-switch buck-type rectifier with high-quality AC input and capacitor ripple current.