• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.479-483
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• 2016

Breast cancer is the first or second leading cancer among females across the globe. A large number of studies have been conducted to assess any relationship between vitamin D receptor (VDR) gene polymorphisms and breast cancer development. Epidemiological studies have indicated that ethnic traits exhibited by a group of people with a common ancestry and culture, alter the link between VDR gene and breast cancer. It has been hypothesized that VDR polymorphisms have the capacity to impact both on incidence of breast cancer occurrence and to predict its outcome. A survey was here conducted to assess and compare the impact of vitamin D receptor gene polymorphisms Fok1, Bsm1, Taq1, Apa1 and poly (A) on development of breast cancer. Information was obtained from electronic databases including PubMed and Google Scholar for articles published during the period from 1996 to 2015. This search was achieved by using the terms "genetics", "breast cancer", "VDR gene", "polymorphisms". However, due to inconsistent results, no conclusive statements could be presented about the significance of the VDR genotype as far as the development of breast carcinoma is concerned.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.801-803
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• 2013

Intraduction: There is known to be a relationship between vitamin D level and more aggresive breast cancer subtypes, especially triple-negative breast cancer (TNBC). It was reported that sunlight exposure has an effect on the prognosis of patients with cancer, possibly related to the conversion of vitamin D to its active form with sunlight. We aimed to evaluate the effect of sunlight exposure on patients with TNBC. Materials-Methods: A total of 1,167 patients with breast cancer from two different regions of Turkey (Antalya and Kayseri, regions having different climate and sunlight exposure intensity over the year) were analysed retrospectively. The ratio of patients with TNBC was identified in those two regions. Results: The ratio of patients with TNBC was 8% and 12% for Kayseri and Antalya regions, respectively, and this difference between the two groups was statistically significant (p=0.021). Discussion: Sunlight exposure may be associated with more prevalent TNBC. This finding should be investigated with a prospective study.

• 대한지역사회영양학회지
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• 제7권2호
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• pp.245-256
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• 2002

This study was carried out to examine Koreans preference in mushrooms, their nutritional knowledge of mushrooms as a source of Vitamin D, and five characteristics of six dishes consisting of common dishes and mushroom dishes. The data were collected from 2,777 subjects in various age ranges by means of a survey questionnaire. Variables, such as age, gender, diet quality and the degree of interest in diet were significant factors considered in relation to preference of mushrooms. Adults ate mushrooms because of their healthfulness, but this attibute was not a factor among adolescent students. The level of nutritional knowledge was relatively low and the ratio of "do not know" responses was higher than the ratio of "yes" or "no" . Generally, housewives, elementary school children and those who were healthy, ate floods because of health consciousness, and those who preferred mushrooms had better dietary habits. The characteristics of mushroom dishes, both as main and side dishes, had much more correlation with the factors considered for the subjects than the common dishes and one dish meals, respectively. Dietary altitudes, such as mushroom preference, frequency of mushroom intake and level of nutritional knowledge, were strongly correlated with the characteristics of the six dishes. It has been shown that mushroom dishes were recognized as nutritional, rather than delicious.

• Childhood Kidney Diseases
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• 제7권2호
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• pp.234-238
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• 2003

저자들은 3년 전부터 외반슬과 동요성 보행을 보인 6세 남아에서 특발성 Fanconi 증후군에 동반된 신석회화증의 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• International journal of thyroidology
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• 제11권2호
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• pp.88-91
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• 2018

After introducing tyrosine kinase inhibitors (TKIs) as promising treatments for radioactive iodine refractory advanced thyroid cancer patients, we more often meet patients with TKI-related hormone and electrolyte imbalances in clinics. Hypocalcemia associated with TKI is associated with an imbalance in calcium-vitamin D metabolism. TKI-related hypothyroidism is related to the metabolic rate of thyroid hormones. The two side effects usually occur in the early stages of TKI treatment, and if the imbalance is corrected appropriately, the effects are minor, but in severe cases, the TKI should be discontinued. The authors reported a case of severe hypocalcemia and thyroid dysfunction after TKI treatment. A 56-year-old man suffered from symptomatic hypocalcemia during TKI treatment, which was resolved after he stopped taking the TKI medication. Although calcium and vitamin D replacement have increased, hypocalcemia was recurred and TKI treatments have been permanently stopped due to serious weight loss in grade 3. After the interruption, his calcium levels normalized.

• Journal of Nutrition and Health
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• 제53권4호
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• pp.381-389
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• 2020

본 연구는 국내 비만과 고도비만 여성의 혈청 영양소 수준을 관찰하고자 시행하였다. 본 연구 결과를 통해 비만인과 고도비만인의 비만 예방 및 관리 지표로서의 혈청 영양소와의 관련성을 파악하고자 하였다. 본 연구의 대상자의 연령은 만18세 이상에서 59세 이하 성인 여성이며 서울 B 외과의원 비만클리닉에서 제공된 ID에 의하여 판별되는 2차 가공된 자료로 병원에서 환자의 동의를 받고 후향적으로 자료를 분석하여 총 44명을 대상자로 선정하였다. 본 연구는 BMI의 지표를 활용하여 BMI가 25.0-29.9 kg/㎡의 비만을 비만군, 30.0 kg/㎡ 이상의 고도 비만을 고도비만군으로 구분하여 비만군 23명, 고도비만군 21명을 분석하였다. 연구 대상자들의 신장과 체중, BMI, SMM, BFM, PFM을 체성분 분석을 통해 조사하였고, 혈중 생화학적 지표와 엽산, 비타민 B₁₂, 25(OH)D₃, 철, 페리틴 수준을 분석하였다. 비만군과 고도 비만군의 연령, 체중, BMI 및 체조성 중 체지방량, 체지방률은 비만군이 유의적으로 낮게 나타났으며 신장은 고도 비만군에서 유의적으로 낮게 나타났다. 생화학적 지표 검사결과 AST, ALT, 당화혈색소, 총 콜레스테롤, 중성지방은 대부분 정상 범위에 해당하였으며 두 군 사이의 유의적 차이가 나타나지 않았다. 비만과 관련된 혈청 영양소 수준을 조사한 결과 혈청 엽산, 비타민 B₁₂, 25(OH)D₃, 철, 페리틴의 수치는 대부분 정상 범위에 해당하며 두 군 간의 유의적인 차이는 없었다. 본 연구에서 비만과 고도비만 성인 여성의 혈청 영양소 수준은 유의적 차이가 없는 것으로 나타났다. 국내에서 비만 예방이나 치료를 위한 근거를 마련하기 위해서 비만과 영양소의 관련성에 대해 보다 심도 깊은 전향적 연구가 필요할 것으로 사료된다.

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2004년도 춘계학술대회
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• pp.434.2-435
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• 2004

본 연구는 마우스에 있어 규칙적인 수영훈련과 비타민 C 섭취가 운동스트레스를 부여하였을 때 항산화체계에 미치는 영향을 보고자 하였다. 수영훈련은 6주령의 Balb/c 마우스를 분양받아 1주간의 환경적응과 1주간의 수영적응 훈련을 (30 min/day) (5d/week) 실시하여 적응 여부를 가려 8주간의 본 수영훈련을 실시하였다(1 h/day) (5d/week). 실험군은 통제군(control: C), 수영훈련시킨 군(training: T), 수영훈련과 비타민 C를 투여한 군(training ＋ vitamin C (1.3 g/100 g diet) : TC}으로 나누었다.(중략)

• 한국식품영양과학회지
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• 제6권1호
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• pp.41-47
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• 1977

율무쌀의 영양적(營養的)인 가치(價値)를 평가(評價)하기 위하여 체중(體重) $55.6{\pm}3.5g$의 Leuise계(系) albino rats 암수 각(各) 40수(首)를 8 group으로 나누고 각(各) group에 casein 15%+starch 75%+oil 8.0% diet(A), 율무쌀 98% diet(B), 쌀 98% diet(C), 보리쌀 98% diet(D), 쌀 49%+율무쌀 49% 혼합 diet(E), 쌀 73.5%+율무쌀 24.5% 혼합 diet(F), 보리쌀 49%+율무쌀 49% 혼합 diet(G), 보리쌀 73.5%+율무쌀 24.5% 혼합 diet(H)의 8종류(種類)의 diet에 각각 비타민 mixture 1% 및 salt mixture 1% 씩을 첨가(添加)한 것을 7주간(週間) 급여(給與)하여 체중증가량(體重增加量), 소화율(消化率), liver의 중량(重量), liver 및 plasma중의 protein 양(量), plasma 중의 free amino acid양(量), hematocrit 및 hemoglobin양(量)을 측정(測定)한 바 다음과 같은 결과(結果)를 얻었다. 1. 체중증가량(體重增加量)은 율무쌀 98% diet(B) group 이 가장 낮았고, 다음이 쌀 49%+율무쌀49% 혼합 diet(E) group으로써 이들 사이에는 유의(有意)한 차(差)가 없었으나 쌀 98% diet(C) group, 보리쌀 98% diet(D) group 및 기타 혼식(混食) group과는 유의(有意)한 차(差)(P<0.01)가 있었다. 2. 율무 현미(玄米) 및 백미(白米)의 소화율(消化率)은 protein과 carbohydrate는 백미(白米)가 높았고 fat는 현미(玄米)가 높았다. 3. liver의 중량(重量)은 율무쌀 98% diet(B) group은 쌀 98% diet(C) group과는 유의(有意)한 차(差)(P<0.05)가 있었으나 기타 group과는 유의(有意)한 차(差)가 없었다. 그리고 단위체중(單位體重)에 대한 무게는 차이(差異)가 없었다. 4. live 및 plasma의 total protein과 plasma의 A/G ratio는 율무쌀 98% diet(B) group이 가장 낮았다. 5. plasma 중의 free amino acid 조성(組成)은 식이(食餌)의 조성(組成)과 비슷하였다. 6. hematocrit와 hemoglobin content는 율무쌀 98% diet(B) group이 가장 낮았다. 7. 혼식(混食) group에 있어서는 쌀과 율무쌀 및 보리쌀과 율무쌀의 혼합비율(混合比率)이 1:1보다 3:1이 더 좋은 결과(結果)이었다.

• Journal of Nutrition and Health
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• 제47권5호
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• pp.321-329
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• 2014

제5기국민건강영양조사 자료중 40세이상 남성을 대상으로 혈액 중 25(OH)D와 COPD의 상관관계를 조사하였다. 25(OH)D는 사분위로 군을 나누어 적용하였고, 2012년 개정된 진료지침에 따라 $FEV_1/FEV_6$ < 0.73인 경우를 COPD로 판정하였다. 다른 요인을 보정하지 않았을 경우에는 25(OH)D와 COPD 사이에 상관관계가 없었으나 흡연상태, 가계소득, 교육수준, 직업, BMI, 만연령및흡연지수를 보정하였을 때는 25(OH)D와 COPD사이에 유의한 상관관계를 보였다. 25(OH)D농도 17~21 ng/mL인 3/4분위군을 기준으로 1/4분위의 경우의 OR 1.643 (95% CI 1.161-2.236), 2/4분위는 OR 1.453 (95% CI 1.045-2.020)으로 유의하게 증가하였다. 결론적으로 40세 이상 남성에서 혈중 25(OH)D 농도는 COPD 유병가능성과 유의한 상관관계를 보였다. 즉, 3/4 분위군 [25(OH)D 17 ng/mL 이상 21 ng/mL 미만]을 기준으로 혈중농도가 낮을수록 COPD 유병가능성이 높았다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권5호
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• pp.742-752
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• 2020

Objective: This study investigated the effects of vitamin A (VA) supplementation during late-stage pregnancy on longissimus dorsi muscle tissue development, birth traits, and growth performance of postnatal Korean native calves. Methods: In the preliminary experiment, twenty-six pregnant cattle (initial body weight [BW] = 319 kg (standard deviation [SD] = 30.1; 1st parity) were randomly assigned to the control and treatment groups. The treatment group received VA supplementation at 24,000 IU/d from gestational day 225 until delivery. In the main experiment, twelve pregnant cattle (initial BW = 317 kg [SD = 31.3]; 1st parity) were treated with VA supplementation at 24,000 IU/d (gestational days 150 to 225) and at 78,000 IU/d (gestational day 225 until delivery). Serum VA levels were analyzed in pregnant cattle, and the growth performance, gene expression, and serum VA levels were analyzed in the offspring. Results: Serum VA levels in pregnant cattle decreased the late gestation in both experiments (p<0.001). In the main experiment, pregnant cattle at parturition and offspring at birth in the treatment group had higher serum VA levels than those in the control group (p<0.05). In the treatment groups, an increased birth weight was observed in the main experimental group (p = 0.022), and a tendency (p = 0.088) toward an increased birth weight was observed in the preliminary experimental group. However, no differences were observed in the feed intake, average daily gain, gain-to-feed ratio, or BW of 31-day-old calves. Gene expression was analyzed in longissimus dorsi muscles of 31-day-old calves. VA supplementation in pregnant cattle stimulated postnatal muscle development in offspring by elevating myogenic factor 5 (MYF5), MYF6, and myoblast determination levels (p<0.05). Moreover, preadipocyte-related marker genes such as extracellular signal-regulated kinase 2 and krüppel-like factor 2 were higher in the treatment group than in the control group (p<0.05). Conclusion: VA supplementation (78,000 IU/d) in late-stage pregnant cattle maintained serum VA levels. In addition, 78,000 IU/d VA supplementation increased the birth weight and expression of genes related to muscle and preadipocyte development in offspring. Overall, 78,000 IU/d VA supplementation in pregnant cattle is beneficial to newborn calves.