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http://dx.doi.org/10.7314/APJCP.2016.17.2.479

Do VDR Gene Polymorphisms Contribute to Breast Cancer?  

Shaikh, Fouzia (Ziauddin University)
Baig, Saeeda (Ziauddin University)
Jamal, Qamar (Ziauddin University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.2, 2016 , pp. 479-483 More about this Journal
Abstract
Breast cancer is the first or second leading cancer among females across the globe. A large number of studies have been conducted to assess any relationship between vitamin D receptor (VDR) gene polymorphisms and breast cancer development. Epidemiological studies have indicated that ethnic traits exhibited by a group of people with a common ancestry and culture, alter the link between VDR gene and breast cancer. It has been hypothesized that VDR polymorphisms have the capacity to impact both on incidence of breast cancer occurrence and to predict its outcome. A survey was here conducted to assess and compare the impact of vitamin D receptor gene polymorphisms Fok1, Bsm1, Taq1, Apa1 and poly (A) on development of breast cancer. Information was obtained from electronic databases including PubMed and Google Scholar for articles published during the period from 1996 to 2015. This search was achieved by using the terms "genetics", "breast cancer", "VDR gene", "polymorphisms". However, due to inconsistent results, no conclusive statements could be presented about the significance of the VDR genotype as far as the development of breast carcinoma is concerned.
Keywords
Breast cancer; VDR gene; polymorphisms; impact on development;
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1 Abbas S, Nieters A, Linseisen J, et al (2008). Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk. Breast Cancer Res, 10, 31.
2 Alimirah F, Peng X, Murillo G, et al (2011). Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS One, 6, 16024.   DOI
3 Banerjee P, Chatterjee M (2003). Antiproliferative role of vitamin D and its analogs - a brief overview. Mol Cell Biochem, 253, 247-54.   DOI
4 Barroso E, Fernandez LP, Milne RL, et al (2008). Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies. BMC Cancer, 8, 385   DOI
5 Bhanushali AA, Lajpal N, Das BR, et al (2009). Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25hydroxyvitamin D levels. Indian J Hum Genet, 15, 108-113.   DOI
6 Bhurgri Y, Bhurgri A, Nishter S, et al (2006). Pakistan - country profile of cancer and cancer control, 1995-2004. J Pak Med Assoc, 56, 124-30.
7 Bid H K, Mittal R D (2003). Study of vitamin-D receptor (VDR) gene start codon polymorphism (Fok I) in healthy individuals from North India. Indian J Hum Genet, 9, 51-4.
8 Breast cancer incidence statistics $\mid$ Cancer Research UK [Online].
9 Bretherton WD, Given WR, Mansi JL, et al (2001). Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer, 85, 171-5.   DOI
10 Buyru N, Tezol A, Yosunkaya-Fenerci E, et al (2003). Vitamin D receptor gene polymorphisms in breast cancer. Exp Mol Med, 35, 550-5.   DOI
11 Chakraborty A, Mishra AK, Soni A, et al (2009). Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians. Cancer Detect Prev, 32, 386-94.   DOI
12 Chen WY, Bertone-Johnson ER., Hunter DJ, et al (2005). Associations between polymorphisms in the vitamin D receptor and breast cancer risk. Cancer Epidemiol. Biomarkers Prev, 14, 2335-9.   DOI
13 Collins ES, Guyer MS, Chakravarti A, et al (1997). Variations on a theme; cataloging human DNA sequence variation. Science, 278, 1580-1.   DOI
14 Curran JE, Vaughan T, Lea RA, et al (1999). Association of A vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer, 83, 723-726.   DOI
15 Dalessandri KM, Mike R, Wiencke JK, et al (2011). Vitamin D receptor polymorphisms and breast cancer risk in a highincidence population: a pilot study. J Am Coll Surg, 215, 652-7.
16 Ditsch N, Toth B, Mayr D, et al (2012). The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. Journal of Histochemistry & Cytochemistry, 60(2), 121-129   DOI
17 Du Y, Hu L, Kong F, et al (2014). Lack of association between vitamin D receptor gene BsmI polymorphism and breast cancer risk: an updated meta-analysis involving 23,020 subjects. Tumor Biol, 35, 2087-93.   DOI
18 Engel LS, Orlow I, Sima CS, et al (2012). Vitamin D receptor gene haplotypes and polymorphisms and risk of breast cancer: a nested case-control study. Cancer Epidemiol Biomarkers Prev, 21, 1856-67.   DOI
19 Fuhrman BJ, Freedman DM, Bhatti P, et al (2013). Sunlight, Polymorphisms of Vitamin D-related Genes and Risk of Breast Cancer. Anticancer Res, 33, 543-51.
20 Giovannucci E (2005). The epidemiology of vitamin D and cancer incidence and mortality: a review. Cancer Causes Control, 16, 83-95.   DOI
21 Gombart AF, Luong QT, Koeffler HP, et al (2006). Vitamin D compounds activity against microbes and cancer. Anticancer Res, 26, 2531-42.
22 Guy M, Lowe LC, Bretherton-Watt D, et al (2004). Vitamin D receptor gene polymorphisms and breast cancer risk. Clin Cancer Res, 10, 5472-81.   DOI
23 Hou MF, Tien YC, Lin GT, et al (2002). Association of vitamin D receptor gene polymorphism with sporadic breast cancer in Taiwanese patients. Breast Cancer Res Treat, 74, 1-7.   DOI
24 Huang YZ, Lu H, Bai YH, et al (2012). Relationship between genotypes and halpotypes of vitamin d receptor gene and breast cancer risk. J Med Res, 41, 89-92.
25 Ingles SA, Garcia DG, Wang W, et al (2000). Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control, 11, 25-30.   DOI
26 Iqbal MuN, Khan TA, Maqbool SA (2015). Vitamin d receptor cdx-2 polymorphism and premenopausal breast cancer risk in southern pakistani patients. PLoS ONE, 10, 122657.
27 Jinjiang Xu, Hongyu Li , Lixue Gu, et al (2014). Association between vitamin D receptor poly(A) polymorphism and breast cancer risk: a meta-analysis. Tumor Biol, 35, 589-93.   DOI
28 John EM, Schwartz GG, Koo J, et al (2007). Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. Am J Epidemiol, 166, 1409-19.   DOI
29 Khan MI, Bielecka FZ, Najm ZM, et al (2014). Vitamin D receptor gene polymorphisms in breast and renal cancer. current state and future approaches (Review). Int J Oncol, 44, 349-63.   DOI
30 Kostner K, Denzeri N, Cornelia SL, et al (2009). The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res, 29, 3511-36.
31 Lowe LC, Guy M, Mansi JL, et al (2005). Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population. Eur J Cancer, 41, 1164-9.   DOI
32 McCullough ML, Bostick RM, Mayo TL, et al (2009). Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu Rev Nutr, 29, 111-32.   DOI
33 McKay JD, Mc Cullough ML, Ziegler RG, et al (2009). Vitamin d receptor polymorphisms and breast cancer risk: results from the national cancer institute breast and prostate cancer cohort consortium. Cancer Epidemio Biomarkers Prev, 18, 297-305.   DOI
34 Mishra DK, Wu Y, Sarkissyan M, et al (2013). Vitamin d receptor gene polymorphisms and prognosis of breast cancer among african-american and hispanic women. PLoS ONE, 8, 57967.   DOI
35 Naveed S, Kamal A, Shamshad D, et al (2014). Frequency and Risk Factors of Breast Cancer in Karachi, Pakistan. Int J Med Sciences (DHR-IJMS), 5, 52-60.
36 Norman AW (2008). From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr, 88, 491-9.   DOI
37 Perna L, Butterbach K, Haug U, et al (2013). Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis. Cancer Epidemiol Biomarkers Prev, 22, 437-42.   DOI
38 Raimondi S, Johansson H1, Maisonneuve P, et al (2009). Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 30, 1170-80.   DOI
39 Rollison DE, Cole AL, Tung KH, et al (2011). Vitamin D intake,vitamin D receptor polymorphisms, and breast cancer risk among women living in the southwestern U.S. Breast Cancer Res Treat, 132, 683-91.
40 Shahbazi S, Alavi S, Majidzadeh A K, et al (2013). BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer. Med Oncol, 30, 393.   DOI
41 Sillanpaa P, Hirvonen A, Kataja V, et al (2004). Vitamin D receptor gene polymorphism as an important modifier of positive family history related breast cancer risk. Pharmacogenetics, 14, 239-45.   DOI
42 Silvagno F, De Vivo E, Attanasio A, et al (2010). Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes. PLoS ONE, 5, 8670.   DOI
43 Sinotte M, Rousseau F, Ayotte P, et al (2008). Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian population. Endocr Relat Cancer, 15, 975-83.   DOI
44 Tang C, Chen N, Wu M, et al (2009). FokI polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat, 117, 391-9.   DOI
45 Trabert B, Malone KE, Daling JR, et al (2007). Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case control study of Caucasian and African-American women. Breast Cancer Res, 9.
46 Uitterlinden AG, Fang Y, van Meurs JB, et al (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene, 338, 143-56.   DOI
47 Wang J, He Q, Yu-guo, et al (2013). Associations between vitamin D receptor polymorphisms and breast cancer risk. Tumor Biol, 34, 3823-30.   DOI
48 Welsh J (2007). Vitamin D and prevention of breast cancer. Acta Pharmacol Sin, 28, 1373-82.   DOI
49 Yang B, Liu S, Yang X, et al (2014). Current evidence on the four polymorphisms of VDR and breast cancer risk in Caucasian women. Meta Gene, 2, 41-49.   DOI
50 Zhang K, Song L (2014). Association between Vitamin D receptor gene polymorphisms and breast cancer risk: a metaanalysis of 39 Studies. PLoS ONE, 9, 96125.   DOI
51 Zhou H, Xu C, Gu M (2009). Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis. Clin Endocrinol (Oxf), 70, 938-45.   DOI
52 Zinser GM, Welsh JE (2004). Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol,18, 2208-23.   DOI
53 Zmuda JM, Cauley JA, Ferell RE, et al (2000). Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev, 22, 203-17.   DOI