Browse > Article
http://dx.doi.org/10.4163/jnh.2020.53.4.381

Differences in serum ferritin and vitamin D levels of Korean women with obesity and severe obesity  

Kang, Nan Hui (Department of Food and Nutrition, Changwon National University)
Park, Ji Sook (Department of Food and Nutrition, Changwon National University)
Lee, Hongchan (B Clinic)
Yim, Jung-Eun (Department of Food and Nutrition, Changwon National University)
Publication Information
Journal of Nutrition and Health / v.53, no.4, 2020 , pp. 381-389 More about this Journal
Abstract
Purpose: This study examined the relationships among serum ferritin, vitamin D, folate, iron, and vitamin B12 as indicators of obesity. The results provide the basic data for the prevention and treatment of obese and severely obese people. Methods: This study selected 44 people from 18 years of age or older to 59 years. This study used the indicators of the body mass index (BMI) to analyze obesity as the obesity group (BMI of 25.0-29.9 kg/㎡) and as the severe obesity group (BMI ≥ 30.0 kg/㎡). Of the 44 subjects, 23 and 21 subjects were in the obesity and severe obesity groups, respectively. Their height, weight, body fat, skeletal muscle mass measured using bioimpedance analysis, and measured serum nutrients and biochemical parameters. Results: The obesity group showed a significantly lower age, body weight, BMI and body composition, body fat mass, and body fat percentage, and the height was significantly lower in the severe obesity group. The results of the biochemical parameters of the subjects showed that the levels of aspartate transaminase, alanine transaminase, hemoglobin A1c, total cholesterol, and triglyceride were within the normal range, and there was no significant difference between the 2 groups. The levels of folate, vitamin B12, 25-hydroxyvitamin D3, iron, and ferritin were almost normal, and there was no significant difference between the 2 groups. Conclusion: This study revealed an association with the serum nutrients and obesity, but there was no difference between the obesity group and severe obesity group. Observations of the nutrient levels in not only the blood in obesity and severe obesity but also in red blood cells and tissues will be necessary.
Keywords
obesity; ferritin; vitamin D;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 World Health Organization. Fact Sheets: Obesity and Overweight [Internet]. Geneva: WHO; 2017 [cited 2020 Apr 1]. Available from: http://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
2 Lim HS, Heo Y. Plasma total homocysteine, folate and vitamin B12 concentrations in patients with coronary stenosis. Korean J Community Nutr 2005; 10(6): 963-970.
3 Dierkes J, Kroesen M, Pietrzik K. Folic acid and vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women. Int J Vitam Nutr Res 1998; 68(2): 98-103.
4 Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19(2): 73-78.   DOI
5 Jung IK. Prevalence of vitamin D deficiency in Korea: results from KNHANES 2010 to 2011. J Nutr Health 2013; 46(6): 540-551.   DOI
6 Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANESVI-3). Cheongju: Korea Centers for Disease Control and Prevention; 2017.
7 Oh SW. Recent Epidemiological changes in Korean obesity. Korean J Helicobacter Up Gastrointest Res 2017; 17(2): 62-65.   DOI
8 Mohamed-Ali V, Pinkney JH, Coppack SW. Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 1998; 22(12): 1145-1158.   DOI
9 Na YK, Hong HS, Suk HJ. Blood biochemical parameters, physical activity, stress and sleep management by body mass index. J Korean Biol Nurs Sci 2014; 16(2): 133-140.   DOI
10 Combs GF, McClung JP. The Vitamins: Fundamental Aspects in Nutrition and Health. Cambridge: Academic Press; 2016.
11 WHO Scientific Group on the Prevention and Management of Osteoporosis. Prevention and Management of Osteoporosis: Report of a WHO Scientific Group. Geneva: WHO; 2003.
12 Park S, Lee BK. Vitamin D deficiency is an independent risk factor for cardiovascular disease in Koreans aged ${\geq}$ 50 years: results from the Korean National Health and Nutrition Examination Survey. Nutr Res Pract 2012; 6(2): 162-168.   DOI
13 Oh MG, Han MA, Park J, Ryu SY, Choi SW. The prevalence of vitamin D deficiency among cancer survivors in a nationwide survey of the Korean population. PLoS One 2015; 10(6): e0129901.   DOI
14 Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium (US). Dietary Reference Intakes for Calcium and Vitamin D. Washington, D.C.: National Academies Press; 2011.
15 Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985; 76(1): 370-373.   DOI
16 Park JY, Heo YR. Relationship of vitamin D status and obesity index Korean women. J Nutr Health 2016; 49(1): 28-35.   DOI
17 Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women. Am J Clin Nutr 1998; 68(5): 1104-1110.   DOI
18 Lee SR. Effect of high frequency and the consumption of catechin on the composition of the body, blood stroma, hormone and antioxidant activity in the management of abdominal obesity [dissertation]. Seoul: Sungshin Women's University; 2010.
19 Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257(1): 79-83.   DOI
20 Woodside JV, Yarnell JW, McMaster D, Young IS, Harmon DL, McCrum EE, et al. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr 1998; 67(5): 858-866.   DOI
21 de Luis DA, Pacheco D, Izaola O, Terroba MC, Cuellar L, Cabezas G. Micronutrient status in morbidly obese women before bariatric surgery. Surg Obes Relat Dis 2013; 9(2): 323-327.   DOI
22 Jurado RL. Iron, infections, and anemia of inflammation. Clin Infect Dis 1997; 25(4): 888-895.   DOI
23 Park SK, Choi WJ, Oh CM, Kim J, Shin H, Ryoo JH. Association between serum ferritin levels and the incidence of obesity in Korean men: a prospective cohort study. Endocr J 2014; 61(3): 215-224.   DOI
24 Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114(12): 1752-1761.   DOI
25 Schaich KM. Metals and lipid oxidation. Contemporary issues. Lipids 1992; 27(3): 209-218.   DOI
26 Jang SY, Lee JY, Bae JM, Lee C, Hong SN, Kim A, et al. 25-hydroxyvitamin D levels and body mass index in healthy postmenopausal women. Korean J Obstet Gynecol 2012; 55(6): 378-383.   DOI
27 Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690-693.   DOI
28 Blum M, Dolnikowski G, Seyoum E, Harris SS, Booth SL, Peterson J, et al. Vitamin $D_{3}$ in fat tissue. Endocrine 2008; 33(1): 90-94.   DOI
29 Wamberg L, Christiansen T, Paulsen SK, Fisker S, Rask P, Rejnmark L, et al. Expression of vitamin D-metabolizing enzymes in human adipose tissue -- the effect of obesity and diet-induced weight loss. Int J Obes 2013; 37(5): 651-657.   DOI
30 Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2007; 17(7): 517-524.   DOI
31 Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008; 112(10): 4292-4297.
32 Rock CL, Emond JA, Flatt SW, Heath DD, Karanja N, Pakiz B, et al. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity (Silver Spring) 2012; 20(11): 2296-2301.   DOI
33 Yoon JS, Song MK. Vitamin D intake, outdoor activity time and serum 25-OH vitamin D concentrations of Korean postmenopausal women by season and by age. Korean J Community Nutr 2015; 20(2): 120-128.   DOI
34 Lee OH, Chung YS, Moon JW. Iron status according to serum selenium concentration and physique in young female adults. Korean J Nutr 2010; 43(2): 114-122.   DOI
35 Stankowiak-Kulpa H, Kargulewicz A, Styszynski A, Swora-Cwynar E, Grzymislawski M. Iron status in obese women. Ann Agric Environ Med 2017; 24(4): 587-591.   DOI
36 Aeberli I, Hurrell RF, Zimmermann MB. Overweight children have higher hepcidin concentrations and lower iron status but have dietary iron intakes ancirculating and bioavailability comparable with normal weight children. Int J Obes (Lond) 2009; 33(10): 1111-1117.   DOI
37 Kim HK, Lim JH, Kwon ER, Park YJ, Kim NE, Noh WY, et al. Serum ferritin and risk of the metabolic syndrome in Korean adults. Korean J Obes 2010; 19(2): 48-55.
38 Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 2004; 27(10): 2422-2428.   DOI
39 Shiwaku K, Anuurad E, Enkhmaa B, Kitajima K, Yamane Y. Appropriate BMI for Asian populations. Lancet 2004; 363(9414): 1077.
40 Lecube A, Hernandez C, Pelegri D, Simo R. Factors accounting for high ferritin levels in obesity. Int J Obes 2008; 32(11): 1665-1669.   DOI
41 Khan A, Khan WM, Ayub M, Humayun M, Haroon M. Ferritin is a marker of inflammation rather than iron deficiency in overweight and obese people. J Obes 2016; 2016: 1937320.