Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.2.801

Is Sunlight a Predisposing Factor for Triple Negative Breast Cancer in Turkey?  

Mutlu, Hasan (Department of Medical Oncology, Acibadem Kayseri Hospital)
Buyukcelik, Abdullah (Department of Internal Medicine, Acibadem University School of Medicine)
Colak, Taner (Department of General Surgery, Akdeniz University School of Medicine)
Ozdogan, Mustafa (Department of Medical Oncology, Akdeniz University School of Medicine)
Erden, Abdulsamet (Department Internal Medicine, Kayseri Training And Research Hospital)
Aslan, Tuncay (Department Internal Medicine, Kayseri Training And Research Hospital)
Akca, Zeki (Department of Radiation Oncology, Zeki Akca, Mersin Government Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 801-803 More about this Journal
Abstract
Intraduction: There is known to be a relationship between vitamin D level and more aggresive breast cancer subtypes, especially triple-negative breast cancer (TNBC). It was reported that sunlight exposure has an effect on the prognosis of patients with cancer, possibly related to the conversion of vitamin D to its active form with sunlight. We aimed to evaluate the effect of sunlight exposure on patients with TNBC. Materials-Methods: A total of 1,167 patients with breast cancer from two different regions of Turkey (Antalya and Kayseri, regions having different climate and sunlight exposure intensity over the year) were analysed retrospectively. The ratio of patients with TNBC was identified in those two regions. Results: The ratio of patients with TNBC was 8% and 12% for Kayseri and Antalya regions, respectively, and this difference between the two groups was statistically significant (p=0.021). Discussion: Sunlight exposure may be associated with more prevalent TNBC. This finding should be investigated with a prospective study.
Keywords
Breast cancer; sunlight exposure; season; triple negative;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Abbas S, Linseisen J, Slanger T, et al (2008). Serum 25-hydroxy vitamin D and risk of postmenopausal breast cancer-results of a large case control study. Carcinogenesis, 29, 93-9.
2 Carey LA, Perou CM, Livasy CA, et al (2006). Race, breast cancer subtypes, and survival in the carolina breast cancer study. JAMA. 7, 2492-502.
3 Davoodi F, Brenner RV, Evans SRT, et al (1995). Modulation of vitamin D receptor and estrogen receptor by 1,25(OH)2-vitamin D3 in T47D human breast cancer cells. J Steroid Biochem Mol Biol, 54, 147-53.   DOI   ScienceOn
4 Freedman D, Dosemeci M, McGlynn K (2002). Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study. Occup Environ Med, 59, 2567-2.
5 Gonzalez-Angulo AM, Timms KM, Liu S, et al (2011). Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res, 17, 1082.   DOI
6 James SY, Mackey AG, Binderup L, Colston KW (1994). Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells. J Endocrinol, 141, 555-63.   DOI   ScienceOn
7 Lee HJ, So JY, DeCastro A, et al (2010). Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling. J Steroid Biochem Mol Biol. 121, 408-12.   DOI   ScienceOn
8 Lin NU, Vanderplas A, Hughes ME, et al (2012). Clinicopathologic features, patterns of recurrence, and survival among women with triple-negativebreast cancer in the national comprehensive cancer network. Cancer, 15, 5463-72
9 Mohr SB, Garland CF, Gorham ED, et al (2008). Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries. Breast J, 14, 255-60.   DOI   ScienceOn
10 Mutlu H, Colak T, Ozdogan M, Altuner TY, Akca Z (2011). The effect of seasonal differences on prognostic factors in Turkish patients with breast cancer. Eur J Cancer Prev. 20, 475-7.
11 Parkin DM, Pisani P, Ferlay J (1999). Global cancer statistics. CA Cancer J Clin. 49, 39.
12 Peng X, Jhaveri P, Hussain-Hakimjee EA, Mehta RG (2007) Overexpression of ER and VDR is not sufficient to make ER-negative MDA-MB231 breastcancer cells responsive to 1alpha-hydroxyvitamin D5. Carcinogenesis, 28, 1000-7.
13 Peppone LJ, Rickles AS, Janelsins MC, Insalaco MR, Skinner KA (2012). The association between breast cancer prognostic indicators and serum 25-OH vitamin D levels. Ann Surg Oncol. 19, 2590-9.   DOI   ScienceOn
14 Rainville C, Khan Y, Tisman G (2009).Triple negative breast cancer patients presenting with low serum vitamin D levels: a case series. Cases J, 21, 8390.
15 Rhee HV, Coebergh JW, Vries ED (2009). Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies. Eur J Cancer Prev, 18, 458-75.   DOI   ScienceOn
16 Swami S, Krishnan AV, Feldman D (2000). 1alpha,25-Dihydroxyvitamin D3 downregulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cells. Clin Cancer Res, 6, 3371-9.
17 Swami S, Raghavachari N, Muller UR, Bao YP, Feldman D (2003). Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. Breast Cancer Res Treat, 80, 49-62.   DOI   ScienceOn
18 Swain S (2008). Triple-Negative Breast Cancer: Metastatic Risk and Role of Platinum Agents 2008 ASCO Clinical Science Symposium, 2008.
19 Trivers KF, Lund MJ, Porter PL, et al (2009). The epidemiology of triple-negative breast cancer, including race. Cancer Causes Control. 20, 1071-82.   DOI   ScienceOn
20 Yao S, Ambrosone CB (2012). Associations between vitamin D deficiency and risk of aggressive breast cancer in African-American women. J Steroid Biochem Mol Biol, 12, 166-5.