• Journal of the Korean Institute of Gas
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• v.26 no.1
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• pp.1-6
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• 2022

This paper is a purpose to study and analyze the engine starting failure examples for LPG car. The first example, the researcher verified the phenomenon that didn't supply the fuel because of filter clogging by fine alien substance in the gas valve line when he inspected the emergency cutting valve. The second example, there was no the influence of gas leakage when the solenoid operated at first. But the damage part of solenoid assemblying face wad downed a durability according to running a valve. Eventually, the researcher checked on the phenomenon of engine stopping by no gas feeding in solenoid because of leaking of gas. The third example, the researcher sought that the wiring sheaths of connector fin between EGR 10A fuse and LPG switch verified the burn-out phenomenon due to the bad contacting as tension damage produced the overheating. Therefore, the manager of a car has to do pre-inspection no producing electric failure and he must maintain his car with optimum condition.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.4
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• pp.63-74
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• 2022

Objectives : Skin aging is generally characterized by wrinkles, sagging, loss of elasticity roughness, pigmentation and dryness. This changes is caused by reducing the elements constituting the extracellular matrix contributing to the physiological properties of the skin, such as collagen fiber, elastic fiber, and hyaluronic acid. Adequate skin hydration is important to maintain normal skin function and reduce skin aging. The present study is objective to observe skin moisturizing effects of Unripe apple(UA, Immature fruit of Malus pumila Mill) in vivo and its underlying molecular mechanisms. Methods : ICR mice were orally administerd UA(100, 200 and 400mg/kg/day) for 8 weeks, and skin water contents and the expression of transforming growth factor (TGF)-𝛽1, ceramide, hyaluronan and collagen type I(COL1) were measured in dorsal back skin of the mice. Gene expression of hyaluronan synthase(HAS1, HAS2, HAS3), collagen synthase(COL1A1, COL1A2) and TGF-𝛽1 were also determined by realtime RT-PCR. Results : Skin water contents and the expression of TGF-𝛽1, ceramide, COL1 and hyaluronan were significantly increased in UA group(100, 200 and 400mg/kg/day) compared to vehicle control. The mRNA expression of HAS isoform(HAS1, HAS2, HAS3), COL1A1, COL1A2, and TGF-𝛽1 were also significantly increased by UA. Conclusions : UA has skin moisturizing effects and enhancement activities in skin function related components(COL1, hyaluronan, ceramide and TGF-𝛽1). These results suggested that UA can be a developing candidate for developing alternative skin protective agent or functional food ingredient.

• Journal of Life Science
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• v.33 no.9
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• pp.754-765
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• 2023

Exosomes are a type of extracellular vesicle containing proteins and messenger and microRNAs; they are secreted by all cell types. Once released, exosomes are selectively taken up by other cells adjacent or at a distance, releasing their contents and reprogramming the target cells. Since exosomes are natural vesicles produced by cells as small sizes, it is generally accepted that exosomes have a non-toxic nature and non-immunogenic behaviors. Recently, exosomes have elicited scientific attention as drug delivery vehicles to the central nervous system. The central nervous system has a blood-brain barrier that makes it difficult for drugs to penetrate. Thus, the blood-brain barrier has been a major obstacle to the development of drugs for treating neurodegenerative diseases. However, accumulating evidence suggests that exosomes can cross the blood-brain barrier primarily through transcytosis. Consequently, exosomes are expected to become a new delivery vehicle that can cross the blood-brain barrier and deliver drugs into the brain parenchyma. In addition, since different types of exosomes are secreted depending on the cell type and disease state, exosomes can also be utilized as biomarkers for the diagnosis of diseases in the central nervous system. In this review, we summarized recent research trends on exosomes, including clinical trials as biomarkers and treatment options for diseases in the central nervous system.

• Restorative Dentistry and Endodontics
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• v.48 no.1
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• pp.6.1-6.14
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• 2023

Objectives: This study evaluated the effects of high-plasticity mineral trioxide aggregate (MTA-HP) on the activity of M1 and M2 macrophages, compared to white MTA (Angelus). Materials and Methods: Peritoneal inflammatory M1 (from C57BL/6 mice) and M2 (from BALB/c mice) macrophages were cultured in the presence of the tested materials. Cell viability (MTT and trypan blue assays), adhesion, phagocytosis, reactive oxygen species (ROS) production, and tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β production were evaluated. Parametric analysis of variance and the non-parametric Kruskal-Wallis test were used. Results were considered significant when p < 0.05. Results: The MTT assay revealed a significant decrease in M1 metabolism with MTA-HP at 24 hours, and with MTA and MTA-HP later. The trypan blue assay showed significantly fewer live M1 at 48 hours and live M2 at 48 and 72 hours with MTA-HP, compared to MTA. M1 and M2 adherence and phagocytosis showed no significant differences compared to control for both materials. Zymosan A stimulated ROS production by macrophages. In the absence of interferon-γ, TNF-α production by M1 did not significantly differ between groups. For M2, both materials showed higher TNF-α production in the presence of the stimulus, but without significant between-group differences. Likewise, TGF-β production by M1 and M2 macrophages was not significantly different between the groups. Conclusions: M1 and M2 macrophages presented different viability in response to MTA and MTA-HP at different time points. Introducing a plasticizer into the MTA vehicle did not interfere with the activity of M1 and M2 macrophages.

• Journal of the Korean Society of Propulsion Engineers
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• v.26 no.4
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• pp.54-63
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• 2022

A 3-tonf class liquid rocket engine that powers the upper stage of a small launcher and lifts 500 kg payload to 500 km SSO is designed. The small launcher is to utilize the flight-proven technology of the 75-tonf class engine for the first stage. A combination of liquid oxygen and liquid methane has been selected as their cryogenic states can provide an extra boost in specific impulse as well as enable a weight saving via the common dome arrangement. An expander cycle is chosen among others as the low-pressure operation makes it robust and reliable while a specific impulse of over 360 seconds is achievable with the nozzle extension ratio of 120. Key components such as combustion chamber and turbopump are designed for additive manufacturing to a target cost. The engine system provides an evaporated methane for the autogenous pressurization system and the reaction control of the stage. This upper stage propulsion system can be extended to various missions including deep space exploration.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.20-37
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• 2023

Although traffic signal installations are continuously expanding, the effect of preventing traffic accidents remains unverified. Totally, 7,045 traffic accident data (such as signal violations) registered with TCS were manually searched for a 7-year period from 2013 to 2019 for 1,602 traffic signals in Daejeon Metropolitan City. The top 20 traffic accident intersections were identified, the traffic accident investigation records and field maps were viewed to compare the driving direction and signal phase of the violated vehicle, and the cause of the traffic accident was divided into insufficient signal operation design (operation) and driver negligence (intentional). Results of the analysis revealed that 75% of traffic accidents occurred in thru-left-turn traffic signals and overlap; moreover, extending the yellow time or operating all red signals due to countermeasures against traffic accidents occurring in yellow signals resulted in reduced traffic accidents. Data indicated that Permissive Left Turn requires improvement with the signal operation. In addition, since The Korean National Police Agency is not computerized for traffic accident sites and signal-related data, the lack of manpower necessitates improvement and utilization of TCS when establishing traffic accident prevention measures. It is believed that it will contribute to signal operation by analyzing vast amounts of data collected in the field and presenting improvement measures.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.73-87
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• 2023

Furnishing traffic safety information can contribute to providing hazard warnings to drivers, thereby avoiding crashes. A smart road lighting platform that instantly recognizes road conditions using various sensors and provides appropriate traffic safety information has therefore been developed. This study analyzes the short-term traffic safety improvement effects of the smart road lighting's tunnel traffic safety information service using surrogate safety measures (SSM). Individual driving behavior was investigated by applying the vehicle trajectory data collected with RADAR in the Anin Avalanche 1 and 2 tunnel sections in Gangneung. Comparing accumulated speeding, speed variation, time-to-collision, and deceleration rate to avoid the crash before and after providing traffic safety information, all SSMs showed significant improvement, indicating that the tunnel traffic safety information service is beneficial in improving traffic safety. Analyzing potential crash risk in the subdivided tunnel and access road sections revealed that providing traffic safety information reduced the probability of traffic accidents in most segments. The results of this study will be valuable for analyzing the short-term quantitative effects of traffic safety information services.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.12
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• pp.1846-1854
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• 2022

The sophistication and diversification of mission equipment for surveillance and reconnaissance is leading to a demand for large-capacity public data links. Overseas, a T4 class(274Mbps) common data link was applied to the Global hwak, a high-altitude unmanned aerial vehicle, and various research and development are being conducted in Korea. In this paper, we propose a structure in which pilot is additionally applied to improve SNR performance while minimizing data transmission rate loss in the DVB-S2 frame structure, which is a european satellite broadcasting standard, for high-capacity transmission of T4 class or higher in the common data link. For the performance evaluation of the proposed structure, the performance of the DVB-S2 was compared and analyzed by simulating the UAV data link channel environment. As a result of simulation, 0.15% of transmission rate loss occurred at T4 class transmission rate compared to DVB-S2 in the proposed structure, but improved SNR reception performance of 0.2~0.3dB was confirmed in the UAV channel environment.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5D
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• pp.821-829
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• 2006

Traffic load comprise primary input to pavement design causing pavement damage. therefore it should be proceeded suitable traffic load distribution modeling for pavement design and analysis. Traffic load have been represented by equivalent single axle loads (ESALs) which convert mixed traffic stream into one value for design purposes. But there are some limit to apply ESALs to other roads because it is empirical value developed as part of the original AASHO(American Association of State Highway Officials) road test. There have been many efforts to solve these problems. Several leading country have implemented M-E(Mechanistic-Empirical) design procedures based on mechanical concept. As a result, they established traffic load quantification method using load distribution model known as Axle Load Spectra. This paper details Axle Load Spectra and presents axle load distribution model based on normal mixture distribution function using truck load data collected by WIM system installed in national highway. Axle load spectra and axle load distribution model presented in this paper could be useful for basic data when making traffic load quantification plan for pavement design, overweight vehicle permit plan and pavement maintenance cost plan.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4D
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• pp.469-476
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• 2008

Recently, TOD gains popularity as a traffic solution measure of high density urban regeneration projects. The purpose of this study is to investigate traffic impacts of high density TOD projects, and to identify the issues to be resolved. For a case study, it chooses Gangnamgucheong station in Gangnam area served by two subway lines, and designates 400m radius from the station as a site for high-density development. The MOEs chosen for this study is traffic volume, time, distance, speed, and mode share. The SECOM model is adopted for traffic simulation. The analysis results show that high-density TOD is an effective tool for traffic improvement even with only one station area being implemented. It is found that the traffic volume increases near the station in nature where high-density development occurs, but it declines overall in the rest of Gangam area. The total travel time and distance of passenger vehicles decline, meaning that the traffic condition becomes better than before. With regulation on parking supply, the improvement becomes more vivid. In terms of the changes of traffic speed, both alternatives show 4.1% increase in speed, but the difference between alternatives is not quite noticeable because of the induced vehicle demand driven to the streets with improved traffic condition. The mode share changes occur for the benefit of subway ridership, because the study station is equipped with two subway line services. When mixed with parking supply restriction, the impact becomes clearer.