• Clinical and Experimental Pediatrics
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• 제55권6호
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• pp.206-211
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• 2012

Purpose: The increasing prevalence of breast feeding has led to concerns about vitamin D deficiency (VDD) and iron deficiency anemia (IDA) in children. We evaluated the prevalence of VDD in a population of Korean children with IDA and assessed the risk factors for VDD in these children. Methods: A total of 79 children who were diagnosed with IDA were prospectively surveyed from April 2010 to March 2011. Data were collected by questionnaire, medical assessment, and laboratory tests, including measurement of 25-hydroxyvitamin D (25OHD), hemoglobin, and wrist radiography. Results: The median age was 22 months and 30% of the subjects were female. Over a half of subjects (58%) had subnormal vitamin D level (25OHD<30 ng/mL), and VDD (25OHD<20 ng/mL) was present in 39% of children. There was no difference in serum hemoglobin level between IDA patients with VDD and those without VDD. Most subjects (89%) were currently or had recently been breastfed and almost all subjects (97%) who had VDD received breastfeeding. Children with VDD were more likely to be younger than 2 years, to have been breastfed, and to have been tested in winter or spring. Multivariable analysis indicated seasonal variation was a significant independent risk factor for VDD in our IDA patients. Conclusion: Our results demonstrated that VDD has a high prevalence in Korean children with IDA. Primary care physicians should be aware of the possibility of VDD in children with IDA and should supplement the vitamin D as well as iron.

• 전기전자학회논문지
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• 제5권2호
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• pp.182-189
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• 2001

Single-pass VDD 심장 박동기(pacemaker)는 하나의 리드만 이식하는 수술 과정의 단순함과 하나의 리드만으로 심방 탈분극파를 적절히 검출하여 심방-심실 탈분극의 연속성(A-V sequence)을 이를 수 있다는 이유로 널리 사용되고 있으나, 검출의 신뢰도에 대해서는 여전히 논의의 대상이 되고 있다. 본 논문에서는 논의의 대상이 되고 있는 심방 탈분극파 검출을 개선하기 위하여 자동화된 심장 박동기 심파 검출 알고리즘을 9명의 환자로부터 얻은 Single-pass VDD 심파에 적용하고, 실제 심파 검출과정에서의 동작 특성을 관찰하였다. 자동화된 검출 알고리즘은 최근에 검출된 두 개의 intrinsic 탈분극파 진폭의 평균치를 계산하여 그 평균치의 50%로 검출 문턱치를 매 박동마다 조정하는 매우 단순한 방법으로, 자동화된 검출 알고리즘의 핵심인 문턱 전압 검출치의 자동적 조정만으로도 Single-pass VDD 심방 탈분극파 검출을 개선할 수 있음을 확인하였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권4호
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• pp.403-412
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• 2021

Purpose: This study aimed to determine the serum 25-hydroxy-vitamin D (25(OH)D) status of breastfed infants less than six months old and their mothers, and factors affecting the status. Methods: This cross-sectional study was done on breastfed, term, Filipino infants less than six months old who were seen at local health centers and clinics in an urban area. The serum 25(OH)D levels of these infants and their mothers were determined, and their demographic data, nutritional status, sun exposure behavior, and maternal vitamin D intake were analyzed for correlation using regression models. Results: Among the 131 infants, 101 (77%) had vitamin D deficiency (VDD), which was defined as having 25(OH)D levels <37.5 nmol/L, and 13 (10%) had vitamin D insufficiency (VDI), with levels >37.5-50 nmol/L. Conversely, maternal VDD with levels <50 nmol/L was seen in 31 (24%) mothers and maternal VDI with levels 50-75 nmol/L, in 63 (48%) mothers. Infant age and maternal 25(OH)D status were independent predictors of infant VDD. Infants less than three months old were found to have a six-time increased risk of infant VDD (p=0.004). Infants who had mothers with VDD had a six-time increased risk, whereas those with maternal VDI had a four-time increased risk of infant VDD (p=0.049 and p=0.020, respectively). Conclusion: Both infant and maternal VDD and VDI were seen to be highly prevalent in this tropical, urban community. Young infants and maternal VDD/VDI independently increased the risk of infant VDD, whereas lack of sun exposure of the mothers increased the risk for maternal VDI.

• Journal of Nutrition and Health
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• 제46권6호
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• pp.540-551
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• 2013

Vitamin D deficiency (VDD) is becoming an epidemic and thereby a global health problem. Further, VDD adversely affects calcium metabolism and skeletal health, and is associated with increased risk of several diseases, e.g., autoimmune diseases, several types of cancers, type 2 diabetes mellitus, cardiovascular diseases, infectious diseases, asthma, psoriatic arthritis, and etc. To evaluate the prevalence of VDD in Korea, and then to evaluate the association of several factors with serum 25(OH)D level, the author analyzed the data of 14,456 individuals who were 10 years of age and over from the Fifth Korea National Health and Nutrition Examination Survey 1 & 2 (KNHANES V-1 & 2) conducted by the Korean Centers for Disease Control & Prevention. As a result, among Koreans (age $${\geq_-}$$ 10years), 65.9% of males and 77.7% of females were below optimum blood serum 25(OH)D (20 ng/mL). VDD is more severe in female than in male at all age groups. In addition, the younger generations had less 25(OH)D level than older generations in Korea. The analysis by complex sample general linear model (CSGLM) suggested that blood 25(OH)D concentration was related with gender (p < .001), residence (p = .030), occupation (p < .001), anemia (p < .001) and physical activity (p < .001). In conclusion, VDD is pandemic and it is more severe in younger generations in Korea. Further, from the results by CSGLM, serum 25(OH)D status is closely related with the life style of Koreans.

• 전기전자학회논문지
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• 제17권3호
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• pp.284-293
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• 2013

본 논문에서는 열전에너지 하베스팅을 위한 저전압 DC-DC 부스트 변환기를 설계하였다. 설계된 변환기는 열전소자의 작은 출력전압으로부터 시동회로를 통해 일정 전압까지 승압된 VDD를 얻으며, 이는 내부 컨트롤 블록을 동작시키는데 사용된다. VDD가 원하는 전압 값에 도달하면 전압감지기가 이를 감지하고 시동회로에 공급되는 전류를 차단하여 전류소모를 최소화한다. 이후 비교기의 출력에 따라 VDD를 위한 DC-DC 변환기와 최종출력 VOUT을 위한 DC-DC 변환기를 번갈아가며 동작시켜서 최종적으로 승압된 VOUT을 얻는다. 모의실험 결과, 설계한 변환기는 200mV의 입력으로부터 2.65V의 VOUT을 출력하며, 최대 전력효율은 63%이다. $0.35{\mu}m$ CMOS 공정을 사용하여 설계한 칩의 크기는 PAD를 포함하여 $1.3mm{\times}0.7mm$이다.

• 대한전자공학회논문지SD
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• 제40권6호
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• pp.442-446
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• 2003

본 논문에서는 몸체효과와 문턱전압 손실이 제거된 새로운 2-단계 2-위상 VPP 전하펌프 발생기를 제안하였다. 새롭게 제안된 회로의 동작을 검증하기 위하여 0.18um Triple-Well CMOS 공정을 사용하였으며, VPP의 전압 레벨은 VDD가 문턱전압 이상일 때 3VDD가 공급되는 결과를 얻었다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권6호
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• pp.664-670
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• 2015

A four-times-VDD switch that supports high and low voltage mode operations is demonstrated in a generic 65 nm logic process. The proposed switch shows the robust operation for supply voltages ranging from VDD to $4{\times}VDD$. A cascaded voltage switch and a voltage doubler based charge pump generate the intermediate supply voltage levels required for the proposed high voltage switch. All the high voltage circuits developed in this work can be implemented using standard logic transistors without being subject to any voltage overstress.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2002년도 봄 학술발표회 논문집
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• pp.433-450
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• 2002

The concept of VDD(Virtual Design & Development) based on high performance computing technology is introduced. The whole process of design and development could be carried out in cyber space through VDD technology in which high-precision simulation technology is combined with virtual reality technology. Therefore, time for design and development of a new product can be shorten and quality of product can be also improved. However, efficient simulation technology must be developed and appropriate supercomputing system must be available to realize VDD technology. In this work, several technologies for obtaining cost-effective supercomputing systems for VDD technology are introduced and investigated. The detail informations about optimization technology for PC(Personal Computer) computing, clustering technology, Internet Supercomputing technology, and Piggyback technology are provided and numerical results are also presented.

• 방송공학회논문지
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• 제14권3호
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• pp.342-356
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• 2009

본 논문에서는 비월 주사 영상을 하나의 필드만을 사용하여 순차 주사 영상으로 변환시키는 투표 결정 기반 디인터레이싱 보간방법(VDD)을 제안한다. VDD는 투표 결정 방법을 이용하여 4단계 보간 과정을 거치게 된다. 1단계는 MM-ELA방법을 이용하여 거짓 에지 의심영역을 검출하는 과정이다. 검출된 영역은 상위 주변 화소 정보를 이용한 다수결 투표 결정 방법인 2단계 과정으로 에지 방향을 결정하며 미결정 방향은 3단계 과정인 상, 하위 주변 화소 정보를 이용한 다수결 투표 및 방향성 평균으로 에지 방향을 보존하고 화질 열화를 최소화한다. 마지막으로 위 단계에서 결정되지 못한 화소는 세밀한 방향을 고려할 수 있는 DOI를 이용하여 보간한다. 계층 구조의 VDD는 복잡도가 높지만 계조도 변화에 취약한 기존 방법들에 비하여 정교한 에지를 추출할 수 있으며 실험결과를 통해 객관적, 주관적 우수성을 나타낸다.

• Nutrition Research and Practice
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• 제14권1호
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• pp.12-19
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• 2020

BACKGROUND/OBJECTIVES: Vitamin D is a pleiotropic hormone that affects various body organ systems. We evaluated the prevalence of a vitamin D deficiency (VDD) and its potential role in the clinical condition of critically ill Korean children. SUBJECTS/METHODS: Patients under 18 years old with a 25(OH) vitamin D measurement on the first day of PICU admission were included from among the children admitted to the pediatric intensive care unit (PICU) of our tertiary children's hospital between October 2017 and January 2019. RESULTS: A total of 172 pediatric patients were enrolled. The mean 25(OH) vitamin D level was 17.5 ± 12.8 ng/mL. There was a 65.1% prevalence of VDD (25(OH) vitamin D level < 20 ng/mL). VDD was associated with age at PICU admission, gastrointestinal/hepatobiliary disorders, International Society of Thrombosis and Hemostasis disseminated intravascular coagulation (ISTH DIC) score, pediatric multiple organ dysfunction syndrome (pMODS) score and with several laboratory test findings including hemoglobin, platelet, C-reactive protein, serum albumin, total bilirubin, prothrombin time, and anti-thrombin III levels. Most of these parameters also showed significant linear correlations with the 25(OH) vitamin D level (P < 0.05). However, no statistically meaningful association was found between VDD and other clinical conditions such as the need for a mechanical ventilator, requirement for vasoactive drugs, duration of the PICU and hospital stays, or PICU mortality. CONCLUSION: There is a high prevalence of VDD in critically ill Korean children. There were significant associations between the 25(OH) vitamin D level and gastrointestinal/hepatobiliary disorders, the pMODS score and with coagulation related factors. Further large-scale studies with more specific subgroup analyses are required to more precisely assess the clinical implications of VDD in critically ill pediatric patients.