• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.28 no.3
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• pp.115-122
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• 2016

In this study, 21 energy reduction factors were selected as architecture, system & operation, and lighting and equipment parts to analyze reduction method of the load occurring in office buildings. Energy consumption simulation was performed. In the architecture part, saving rate (1.53%) of "occupant density" factor was the most efficient. In the system and operation part, saving rate (1.28%) of "interior VAV and exterior FPU type" factor was the most efficient. In case of lighting and equipment part, saving rate (12.42%) of "schedule" factor was the most efficient. In the three parts, saving rate of the lighting and equipment part was 27.32%. This was caused by the "schedule" factor. Saving rates of the architecture part and the system and operation part were 3.39% and 1.20%, respectively.

• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 1995.05a
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• pp.88-93
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• 1995

The purpose of this study is to introduce the energy simulation program BLDSYM, verify the approach. and demonstrate the energy saving opportunities. A case study model for Hoover Middle School, OK USA has been introduced as a base case simulation. Air-side variable air volume (VAV) and water-side variable flow hydronic (VFH) system have been recommended, modeled and simulated to quantify the energy savings compared with the base system, which is typically constant air and water flow system. More than 30 % of energy savings could be obtained with the optimum variable flow system.

• Journal of Cadastre & Land InformatiX
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• v.50 no.2
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• pp.169-187
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• 2020

In Korea, Switzerland has been known as a country that integrates the Cadastral System (hereafter as CS.) and the registration system(hereafter as RS.) according to a research report by the Ministry of Home Affairs since 1975. However, I found that Switzerland's CS. and RS. were separately managed by the Dept. of Defense, Civil Protection & Sports(hereafter as DDPS.) and the Dept. of Justice & Police(hereafter as DJP.). Therefore, I have a question about where is the institution in charge of the CS. and RS. in Switzerland, what are the relevant laws and regulations, and what are the related public records, and the background and purpose of this study is to resolve this. Research Results First, cadastral affairs are handled by the Cadastral Surveying Division at the Federal Office for Topography (Swisstopo) under the DDPS, and the registered affairs are handled by the Private Law Division at the Federal Office for Justice under the DJP. Second, Cadastral-related laws include 'VAV' and 'TVAV' newly enacted in 1993, and Registration-related laws include 'Civil Act(ZGB)' and 'Order on Land Registration(GbVO)' etc. which have been in effect since 1912. Third, the cadastral record includes the Cadastral Books, Cadastral Maps & Numerical Cadastral Books etc, and the register includes the Hauptbuch, Tagebuch, Pläne, Liegenschaftsbeschreibung etc. It is hoped that the results of this study will provide an accurate understanding of the fact that Switzerland's CS. is managed separately by the DDPS, and the RS. is managed by the DJP.

• Molecular & Cellular Toxicology
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• v.3 no.4
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• pp.231-237
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• 2007

Exposure to DNA-damaging agents can elicit a variety of stress-related responses that may alter the expression of genes associated with numerous biological pathways. We used 19 k whole human genome chip to detect gene expression profiles and potential signature genes in human normal hepatocytes (THLE-3) by treatment of five direct acting mutagens, furylfuramide (AF-2), N-nitroso-N-methylurea (MNU), methylmethanesulfonate (MMS), 4-nitroquinoline-N-oxide (4-NQO) and 2-nitrofluorene (2NF) of the $IC_{20}$ concentration for 3 h. Fifty one up-regulated common genes and 45 down-regulated common genes above 1.5-fold by five direct-acting mutagens were identified by clustering analysis. Many of these changed genes have some association with apoptosis, control of cell cycle, regulation of transcription and signal transduction. Genes related to these functions, as TP73L, E2F5, MST016, SOX5, MAFB, LIF, SII3, TFIIS, EMR1, CYTL1, CX3CR1 and RHOH are up-regulated. Down-regulated genes are ALOX15B, xs155, IFITM1, BATF, VAV2, CD79A, DCDC2, TNFSF8 and KOX8. We suggest that gene expression profiling on mutagens by toxicogenomic analysis affords promising opportunities to reveal potential new mechanistic markers of genotoxicity.

• International Journal of Aeronautical and Space Sciences
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• v.10 no.1
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• pp.30-36
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• 2009

Many formation guidance laws have been proposed for VAV formation flight. Since most autonomous formation flight methods require various active communication links between the vehicles to know motion information of other vehicles, damage to the receiver or the transmitter and communication delay are critical problem to achieve a given formation flight mission. Therefore, in this point of view, the method that does not need an inter-vehicle communication is preferred in the autonomous formation flight. In this paper, we first summarize the formation guidance law without an inter-vehicle communication using feedback linearization and sliding mode control proposed in previous study. We also propose the modified formation guidance law with robust disturbance observer, which can provide significantly better performance than previously mentioned guidance law in case that other vehicles maneuver with large accelerations. The robust disturbance observer can estimate uncertainties generated by acceleration of leader vehicle. By eliminating the uncertainties using the estimated uncertainties, VAVs are able to achieve the tight formation flight. The performance of the proposed approach is validated by numerical simulations.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2016.05a
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• pp.93-95
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• 2016

In recent years, attention of ship owners for the energy saving of the vessel is being collected due to the volume decline. Ship accommodation consists of watertight type windows and is closed, Ship HVAC is used to promote a comfortable environment for the crew. In addition requirements for comfort of the crew is getting stronger with the improvement of living standards, there is a need for HVAC improvements. In this paper, propose method to save energy and improve HVAC controls by using the HVAC structure of the variable air volume.

• Journal of the Korean Solar Energy Society
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• v.25 no.2
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• pp.63-69
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• 2005

This study is the survey of a transition procedure of building services systems(heat source, HVAC, water supply) through the survey of existing office buildings, building design documents. The preference & major consideration of system selection is the engineer's opinions. The results of this survey can be used in selection of building services system design. In this survey, "Hot & cold water generator system" and "single duct CAV+FCU system", "Elevated water tank system" are selected. The most important consideration in system selection is the energy saving in heat source system, and comfort in HVAC system, and water pressure in water supply system. They prefer "steam boiler+absorption chiller system" for heat source system, "steam boiler+ice thermal storage system", "hot & cold water generator system", "district heating+absorption chiller system" : "single duct CAV+FCU system" and "single duct VAV+convector system" for HVAC system: and "booster pump system" for water supply system.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.13 no.10
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• pp.947-959
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• 2001

We propose a control scheme to control the indoor zone temperature via variable air volume (VAV) unit. To control the room temperature, state space model of the conditioned zone which is partitioned into nine artificial sectional regions is derived. The nonlinearity of the damper motion and actuator are considered for the practical use in the state space system description. The temperature control of the room temperature is performed by manipulating the degree of openness of the damper in relation to the local room temperature and the supplied air flow rate. In general, since a local temperature in the conditioned zone is measured, it is required to estimate the temperature values in each regions for the precise temperature control. We thus design a state observer to estimate the regional temperature, and use these values in the controller. The overall control system consists of the state observer based state feedback with the integral control. We compared the control results of the proposed scheme with those of cascade proportional and integral (PI) control, and showed that the scheme achieved precise control of the conditioned system.

• Molecules and Cells
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• v.37 no.8
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• pp.628-635
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• 2014

2-(Trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient megakaryopoiesis. Here, we show that (R)-TEMOSPho blocks osteoclast maturation from progenitor cells of hematopoietic origin, as well as blocking the resorptive function of mature osteoclasts. The inhibitory effect of (R)-TEMOSPho on osteoclasts was due to a disruption of the actin cytoskeleton, resulting from impaired downstream signaling of c-Fms, a receptor for macrophage-colony stimulating factor linked to c-Cbl, phosphoinositol-3-kinase (PI3K), Vav3, and Rac1. In addition, (R)-TEMOSPho blocked inflammation-induced bone destruction by reducing the numbers of osteoclasts produced in mice. Thus, (R)-TEMOSPho may represent a promising new class of antiresorptive drugs for the treatment of bone loss associated with increased osteoclast maturation and activity.

• Molecules and Cells
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• v.41 no.6
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• pp.545-552
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• 2018

Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex with two newly developed inhibitors possessing 4-aminopyrido[4,3-D]pyrimidine moieties (SKI-G-618 and SKI-O-85). One SYK inhibitor (SKI-G-618) exhibited moderate inhibitory activity against SYK, whereas the other inhibitor (SKI-O-85) exhibited a low inhibitory profile against SYK. Binding mode analysis indicates that a highly potent SYK inhibitor might be developed by modifying and optimizing the functional groups that interact with Leu377, Gly378, and Val385 in the G-loop and the nearby region in SYK. In agreement with our structural analysis, one of our SYK inhibitor (SKI-G-618) shows strong inhibitory activities on the ${\beta}$-hexosaminidase release and phosphorylation of SYK/Vav in RBL-2H3 cells. Taken together, our findings have important implications for the design of high affinity SYK inhibitors.