• Title/Summary/Keyword: V.K.T.

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Interleukin-7 Receptor is Indispensable for Proliferation and Survival in Thymic ${\gamma}{\delta}$T Cell Development

  • Kim, Dong-Hyun;Yoon, Byung-Hak;Jung, Joo-Eun;Kim, Hoog-Sook;Ko, Seong-Hee;Choi, Eun-Young;Lee, Kwang-Ho;Kim, Kyung-Jae;Ye, Sang-Kyu;Chung, Myung-Hee
    • IMMUNE NETWORK
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    • v.5 no.1
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    • pp.23-29
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    • 2005
  • Background: Interleukin-7 receptor (IL-7R) ${\alpha}$-deficient mice have small numbers of B cells and ${\alpha}{\beta}$T cells in periphery, they totally lack ${\gamma}{\delta}$T cells. In addition, the V-J recombination and transcription of TCR ${\gamma}$ genes is also severely impaired in IL-7R ${\alpha}$-deficient mice. Stat5, a signaling molecule of the IL-7R, induces germline transcription in the TCR ${\gamma}$ locus, and promotes V-J recombination and ${\gamma}{\delta}$T cell development. However, the roles for IL-7R signaling pathway in thymic or extrathymic ${\gamma}{\delta}$T cell development are largely unknown. Methods: To clarify the role of the IL-7 receptor in proliferation and survival of ${\gamma}{\delta}$T cells, we introduced the TCR ${\gamma}{\delta}$ transgene, $V_{{\gamma}2}/V{\delta}_5$, into IL-7R ${\alpha}$-deficient mice, and investigated the development of ${\gamma}{\delta}$T cells. Results: We found that $V_{{\gamma}2}/V{\delta}_5$ transgene restored ${\gamma}{\delta}$T cells in the epithelium of the small intestine (IEL) but not in the thymus and the spleen. Further addition of a bcl-2 transgene resulted in partial recovery of ${\gamma}{\delta}$T cells in the thymus and the spleen of these mice. Conclusion: Taken together, this study revealed that the IL-7R ${\alpha}$ is indispensable for proliferation and survival mainly in thymic ${\gamma}{\delta}$T cell development.

Photocurrent study on the splitting of the valence band and growth of $CdGa_2Se_4$ single crystal thin film by hot wall epitaxy (Hot Wall epitaxy(HWE)법에 의한 $CdGa_2Se_4$ 단결정 박막의 성장과 가전자대 갈라짐에 대한 광전류 연구)

  • Park, Chang-Sun;Hong, Kwang-Joon
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.17 no.5
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    • pp.179-186
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    • 2007
  • Single crystal $CdGa_2Se_4$ layers were grown on a thoroughly etched semi-insulating GaAs(100) substrate at $420^{\circ}C$ with the hot wall epitaxy(HWE) system by evaporating the polycrystal source of $CdGa_2Se_4$ at $630^{\circ}C$. The crystalline structure of the single crystal thin films was investigated by the photoluminescence and double crystal X-ray diffraction(DCXD). The carrier density and mobility of single crystal $CdGa_2Se_4$ thin films measured with Hall effect by van der Pauw method are $8.27{\times}10^{17}cm^{-3},\;345cm^2/V{\cdot}s$ at 293 K, respectively. The photocurrent and the absorption spectra of $CdGa_2Se_4/SI$(Semi-Insulated) GaAs(100) are measured ranging from 293 K to 10 K. The temperature dependence of the energy band gap of the $CdGa_2Se_4$ obtained from the absorption spectra was well described by the Varshni's relation $E_g(T)=2.6400eV-(7.721{\times}10^{-4}eV/K)T^2/(T+399K)$. Using the photocurrent spectra and the Hopfield quasicubic model, the crystal field energy(${\Delta}cr$) and the spin-orbit splitting energy(${\Delta}so$) far the valence band of the $CdGa_2Se_4$ have been estimated to be 106.5 meV and 418.9 meV at 10 K, respectively. The three photocurrent peaks observed at 10 K are ascribed to the $A_{1^-},\;B_{1^-},\;and\;C_{11}-exciton$ peaks.

Insulation design for KEPCO 765kV Transmission Lines (한전 765 kV 송전선로의 절연설계)

  • Koo, B.M.;Won, Y.J.;Hwang, J.I.
    • Proceedings of the KIEE Conference
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    • 1994.07b
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    • pp.1628-1632
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    • 1994
  • KEPCO is now promoting the new project of upgrading its highest system voltage from 345kV to 765kV. The main reason of this project is an insurance of bulk power transmission from power complexes at coast to power demand center at Kyoung-In area. The new system needs a careful approach to basic design to secure its reliability and to reduce the increase of investment cost. So, We introduced the basic philosophy of insulation design in spring meeting of this transaction. This paper, after preceding paper, deals with the insulation design example for 765kV transmission lines.

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ON PATHOS BLOCK LINE CUT-VERTEX GRAPH OF A TREE

  • Nagesh, Hadonahalli Mudalagiraiah
    • Communications of the Korean Mathematical Society
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    • v.35 no.1
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    • pp.1-12
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    • 2020
  • A pathos block line cut-vertex graph of a tree T, written P BLc(T), is a graph whose vertices are the blocks, cut-vertices, and paths of a pathos of T, with two vertices of P BLc(T) adjacent whenever the corresponding blocks of T have a vertex in common or the edge lies on the corresponding path of the pathos or one corresponds to a block Bi of T and the other corresponds to a cut-vertex cj of T such that cj is in Bi; two distinct pathos vertices Pm and Pn of P BLc(T) are adjacent whenever the corresponding paths of the pathos Pm(vi, vj) and Pn(vk, vl) have a common vertex. We study the properties of P BLc(T) and present the characterization of graphs whose P BLc(T) are planar; outerplanar; maximal outerplanar; minimally nonouterplanar; eulerian; and hamiltonian. We further show that for any tree T, the crossing number of P BLc(T) can never be one.

Psychophysiological Characteristics of Insomnia Patients Measured by Biofeedback System (바이오피드백을 이용하여 측정한 불면증 환자의 정신생리적 특징)

  • Huh, Sung-Young;Lee, Jin-Seong;Kim, Sung-Gon;Kim, Ji-Hoon;Jung, Woo-Young
    • Sleep Medicine and Psychophysiology
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    • v.22 no.2
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    • pp.70-76
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    • 2015
  • Background and Objectives: Insomnia is the most prevalent sleep disorder in the general population and is considered to be a disorder of hyperarousal. The aim of this study was to measure the psychophysiological responses in insomnia patients using a biofeedback system, and to compare them with results from normal healthy subjects. Materials and Methods: Eighty patients with primary insomnia (35 males and 45 females, average age $49.71{\pm}12.91years$) and 101 normal healthy controls (64 males and 37 females, average age $27.65{\pm}2.77$) participated in this study. Electromyography (EMG), heart rate (HR), skin conductance (SC), skin temperature (ST), and respiratory rate (RR) were recorded using a biofeedback system during 5 phases (baseline, stress 1, recovery 1, stress 2, recovery 2) of a stress reactivity test, and average values were calculated. Difference in values between the two groups in each corresponding phase was analyzed with independent t-test, and change in values across phases of the stress reactivity test was analyzed with paired t-test (all two-tailed, p<0.05). Results: Compared to normal controls, insomnia patients had higher EMG in all 5 phases (baseline : $7.72{\pm}3.88{\mu}V$ vs. $4.89{\pm}1.73{\mu}V$, t = -6.06, p<0.001 ; stress 1 : $10.29{\pm}5.16{\mu}V$ vs. $6.63{\pm}2.48{\mu}V$, t = -5.84, p<0.001 ; recovery 1 : $7.87{\pm}3.86{\mu}V$ vs. $5.17{\pm}2.17{\mu}V$, t = -5.61, p<0.001 ; stress 2 : $10.22{\pm}6.07{\mu}V$ vs. $6.98{\pm}2.98{\mu}V$, t = -4.37, p<0.001 ; recovery 2 : $7.88{\pm}4.25{\mu}V$ vs. $5.17{\pm}1.99{\mu}V$, t = -5.27, p<0.001). Change in heart rate across phases of the stress reactivity test were higher in normal controls than in insomnia patients (stress 1-baseline : $6.48{\pm}0.59$ vs. $3.77{\pm}0.59$, t = 3.22, p = 0.002 ; recovery 1- stress 1 : $-5.36{\pm}0.0.59$ vs. $-3.16{\pm}0.47$, t = 2.91, p = 0.004 ; stress 2-recovery 1 : $8.45{\pm}0.61$ vs. $4.03{\pm}0.47$, t = 5.72, p<0.001 ; recovery 2-stress 2 : $-8.56{\pm}0.65$ vs. $4.02{\pm}0.51$, t = -5.31, p<0.001). Conclusion: Psychophysiological profiles of insomnia patients in a stress reactivity test were different from those of normal healthy controls. These results suggest that the sympathetic nervous system is more highly activated in insomnia patients.

EXISTENCE OF POSITIVE SOLUTIONS FOR SINGULAR IMPULSIVE DIFFERENTIAL EQUATIONS WITH INTEGRAL BOUNDARY CONDITIONS

  • Miao, Chunmei;Ge, Weigao;Zhang, Zhaojun
    • The Pure and Applied Mathematics
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    • v.21 no.3
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    • pp.147-163
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    • 2014
  • In this paper, we study the existence of positive solutions for singular impulsive differential equations with integral boundary conditions $$\{u^{{\prime}{\prime}}(t)+q(t)f(t,u(t),u^{\prime}(t))=0,\;t{\in}\mathbb{J}^{\prime},\\{\Delta}u(t_k)=I_k(u(t_k),u^{\prime}(t_k)),\;k=1,2,{\cdots},p,\\{\Delta}u^{\prime}(t_k)=-L_k(u(t_k),u^{\prime}(t_k)),\;k=1,2,{\cdots},p,\\u=(0)={\int}_{0}^{1}g(t)u(t)dt,\;u^{\prime}=0,$$) where the nonlinearity f(t, u, v) may be singular at v = 0. The proof is based on the theory of Leray-Schauder degree, together with a truncation technique. Some recent results in the literature are generalized and improved.

nBn Based InAs/GaSb Type II Superlattice Detectors with an N-type Barrier Doping for the Long Wave Infrared Detection (InAs/GaSb 제2형 응력 초격자 nBn 장적외선 검출소자 설계, 제작 및 특성평가)

  • Kim, Ha Sul;Lee, Hun;Klein, Brianna;Gautam, Nutan;Plis, Elena A.;Myers, Stephen;Krishna, Sanjay
    • Journal of the Korean Vacuum Society
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    • v.22 no.6
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    • pp.327-334
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    • 2013
  • Long-wave infrared detectors using the type-II InAs/GaSb strained superlattice (T2SL) material system with the nBn structure were designed and fabricated. The band gap energy of the T2SL material was calculated as a function of the thickness of the InAs and GaSb layers by the Kronig-Penney model. Growth of the barrier material ($Al_{0.2}Ga_{0.8}Sb$) incorporated Te doping to reduce the dark current. The full width at half maximum (FWHM) of the $1^{st}$ satellite superlattice peak from the X-ray diffraction was around 45 arcsec. The cutoff wavelength of the fabricated device was ${\sim}10.2{\mu}m$ (0.12 eV) at 80 K while under an applied bias of -1.4 V. The measured activation energy of the device was ~0.128 eV. The dark current density was shown to be $1.0{\times}10^{-2}A/cm^2$ at 80 K and with a bias -1.5 V. The responsivity was 0.58 A/W at $7.5{\mu}m$ at 80 K and with a bias of -1.5 V.

쌍끌이 중층트롤어업의 연구 ( IV ) ( a Study on the Midwater Pair Trawling ( IV )

  • Jang, Chung-Sik;Lee, Byeong-Gee
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.32 no.1
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    • pp.7-15
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    • 1996
  • Full scale experiment was carried out in the southern sea of Korea to compare some important factors tested in the model experiment. The results obtained can be summarized as follows ; 1. The changing aspect of mouth performance of the full scale net was almost coincided with the results obtained by the model experiment. The vertical opening(H) and the opening area(S) can be expressed as a function of the towing velocity(V) as H=48.78. $e^0.38V$(unit: m, k't) S= 1,443 .$e^-0.25V$(unit: $m^2V$, k't) 2. The changing aspect of working depth of the full scale net was almost coincided with the results obtained by the model experiment. The depth(D) can be expressed as a function of the towing velocity(V) and the warp length(L) as D=92.49.$V^1.37$(unit: m, k't, L= 150m) D= 12.07+0.32. L (unit: m, V=2k't) [)= - 7.90+0.22 . L (unit: m, V=3k't) 3. Some problems were found to operate A - type full scale net by common bottom pair trawlers. The problems can be summarized as follows; (1) Entangling of wing and square head ropes while net casting.(2) Man power needed and time spent for net hauling by common bottom trawlers increased considerably.( 3) Tearing of nettings caused by over -load of tension and entangling of net pendant while net hauling. To solve these problems, the trawlers are favorable to be equipped with variable pitch propeller and llet drum. While the net is favorable to be constructed with trifurcated net pendant in stead of quadrifurcated net pendant used at present.

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THE STUDY OF THE SYSTEM OF NONLINEAR WAVE EQUATIONS

  • Jung, Tacksun;Choi, Q-Heung
    • Journal of the Chungcheong Mathematical Society
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    • v.20 no.3
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    • pp.261-267
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    • 2007
  • We show the existence of the positive solution for the system of the following nonlinear wave equations with Dirichlet boundary conditions $$u_{tt}-u_{xx}+av^+=s{\phi}_{00}+f$$, $$v_{tt}-v_{xx}+bu^+=t{\phi}_{00}+g$$, $$u({\pm}\frac{\pi}{2},t)=v({\pm}\frac{\pi}{2},t)=0$$, where $u_+=max\{u,0\}$, s, $t{\in}R$, ${\phi}_{00}$ is the eigenfunction corresponding to the positive eigenvalue ${\lambda}_{00}=1$ of the eigenvalue problem $u_{tt}-u_{xx}={\lambda}_{mn}u$ with $u({\pm}\frac{\pi}{2},t)=0$, $u(x,t+{\pi})=u(x,t)=u(-x,t)=u(x,-t)$ and f, g are ${\pi}$-periodic, even in x and t and bounded functions in $[-\frac{\pi}{2},\frac{\pi}{2}]{\times}[-\frac{\pi}{2},\frac{\pi}{2}]$ with $\int_{-\frac{\pi}{2}}^{\frac{\pi}{2}}f{\phi}_{00}=\int_{-\frac{\pi}{2}}^{\frac{\pi}{2}}g{\phi}_{00}=0$.

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Correlation Effects in Superconducting $Sr_2VO_3FeAs$ (초전도 $Sr_2VO_3FeAs$에서 상관효과)

  • Lee, K.W.
    • Progress in Superconductivity
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    • v.12 no.1
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    • pp.46-50
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    • 2010
  • In the superconducting $Sr_2VO_3FeAs$, containing bimetallic layers, with maximum $T_c{\approx}\;46\;K$ correlation effects on V ions have been investigated using LDA+U method. Within the local density approximation (LDA) this system has the one-third filled $t_{2g}$ manifold of V, decomposed into $d_{xy}$ of bandwidth W=2 eV and nearly degenerate $d_{zx}d_{yz}$ of W=1 eV. Consideration of correlation effects leads to a metal-insulator transition on V ions $t^{2\uparrow}_{2g}\;{\rightarrow}\;d^{1\uparrow}_{xz}\;d^{1\uparrow}_{yz}$ at the critical on-site Coulomb repulsion $U_c$= 3.5 eV. At U=4 eV, the electronic structure, in which V ions are insulating, leads to several van Hove singularities near $E_F$ and similar Fermiology with other pnictides. Applying U to V ions results in increasing Fe moment as well as V moment, indicating somewhat hybridization between Fe and V ions even though this system is strongly 2-dimesional. Our results show possible importance of correlation effects on this system.