• YAKHAK HOEJI
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• v.58 no.3
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• pp.171-180
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• 2014

To enhance the in vitro permeation of lovastatin through excised hairless mouse and human cadaver skins, solubility was determined in various hydrophilic and lipophilic vehicles, and the effects of vehicles and penetration enhancers on the skin permeation from solution formulations were investigated. Solubility of lovastatin was highest in N-methyl-2-pyrrolidone (NMP) ($278.2{\pm}10.1$ mg/ml) and dimethyl sulfoxide (DMSO) ($162.2{\pm}9.7$ mg/ml). Among different pure vehicles used, NMP, DMSO, propylene glycol and isopropyl myristate provided some drug permeation ($6.9{\pm}1.1$, $5.9{\pm}1.6$, $3.0{\pm}0.5$ and $2.2{\pm}0.3{\mu}g/cm^2$ at 24 hr, respectively) through hairless mouse skin. The addition of oleic acid, linoleic acid and oleyl alcohol to DMSO showed the maximum permeation at around 5 v/v%, however, capric acid and caprylic acid had no enhancing effect. The increase of enhancer concentrations showed bell-shaped permeation rate, suggesting the presence of optimal concentration in lovastatin penetration. Increasing donor concentration from 10 mg/ml to 80 mg/ml in DMSO and a cosolvent of DMSO, NMP and DGME (3 : 3 : 4 v/v) did not show significant dose dependent permeation in both hairless mouse and human cadaver skins. The maximum lovastatin flux through human cadaver skin was found to be $0.87{\pm}0.46{\mu}g/cm^2$/hr with 5 v/v% linoleic acid and donor dose of 4 mg/0.64 $cm^2$ in the cosolvent. These results suggest that transdermal delivery of lovastatin would be feasible by establishing the optimal concentrations of donor dose and unsaturated fatty acids in appropriate vehicles.

• Journal of Nutrition and Health
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• v.51 no.1
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• pp.60-72
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• 2018

Purpose: The purpose of this study was to determine differences in eating-out, dietary life styles, and healthy dietary competencies among middle-aged consumers according to obesity status and gender for implications of consumer education. Methods: Data were drawn from the 2016 Food Consumption Behavior Survey, and 3,022 subjects (mail 1,388; female 1,634) who were middle-aged adults were investigated. Analysis of variance with $Scheff\acute{e}$ test, t-test, $x^2$-test, and factor analysis were performed using SPSS v.24. Results: Males showed less interest in diet than females. For both males and females, higher BMI degrees were associated with higher levels of interest in diet. For frequency, monthly average consumption expenditure, one-time cost for eating out, and drinking frequency, males showed higher levels than females. Especially for the male group, higher obesity status was associated with higher levels of eating out and drinking. Dietary lifestyles of males and females turned out to be very similar. For the male group, normal weight group was more likely to show 'health and high quality pursuit dietary life-style' than the other groups. For females, the normal weight group were more likely to show 'health and high quality pursuit dietary life-style' and 'safety pursuit dietary life-style' than the other groups. The level of 'healthy dietary competence' for females was found to be higher than that for males. For the female group, there were significant differences according to obesity status, and practice was more important than knowledge in determining a healthy dietary life. Conclusion: For dietary life-related education for obese middle-aged consumers, it is important to emphasize less eating-out and drinking and less overeating while eating-out based on the results that eating-out, drinking, and overeating in the obesity group were significantly higher than in the normal group. It is important to focus on the value of dietary life and diverse foods, based on the results that the obesity group was less likely to be have healthy dietary lifestyles and consume less diverse foods than the normal group.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.11a
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• pp.332-333
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• 2022

Recently, SpaceX, private enterprise dealing in space development company, has reported a plan for launching of 42,000 low earth orbit satellites until 2031 through Starlink Business, and launched 900 satellites until now. Concretely, it plans tp operate Ku/Ka band satellite, and launch 7,518 of V band satellites for broadband communication. Therefore, we can utilize wireless communication in an ocean, and various solutions through the low earth orbit satellites. This paper deals in a realization of wireless control system employing FPGA (Field Programmable Gate Array) for vessel applications.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2022.11a
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• pp.390-391
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• 2022

Recently, SpaceX, private enterprise dealing in space development company, has reported a plan for launching of low earth orbit satellites via Starlink Business, and launched 900 satellites until now. Concretely, it plans tp operate Ku/Ka band satellite, and launch 7,518 of V band satellites for broadband communication. Therefore, wireless communication service for ship will be provided, and various solutions will be offered through the low earth orbit satellites. In this work, we investigated RF characteristics of coplanar waveguide employing periodic 3D coupling structures, and examined its potential for a development of marine radio communication FISoC (fully-integrated system on chip) semiconductor device.

• Analytical Science and Technology
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• v.22 no.5
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• pp.407-414
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• 2009

A simultaneous determination method for cholesterol, lanosterol and desmosterol was developed using gas chromatography/mass spectrometry. Urine was enzymatically hydrolyzed with ${\beta}$-glucuronidase/arylsulfatase. Samples were prepared using extractions with a mixture of ethyl acetate-hexane (2:3, v/v), followed by derivatization with a mixture of MSTFA/TMSI/TMCS (100:2:5 v/v/v). All analyses were performed using GC/MS in selective ion monitoring mode. Good linearities ($r^2=0.998{\sim}0.999$) in calibration curve and a satisfactory recovery (80.0%~113%) were achieved. Accuracy and precision values within ${\pm}15%$ in the concentration range of 5 to 200 ng/mL were also observed for all compounds. The developed method was applied to pravastatin-treated (70 and 250 mg/kg/day for 7 days, oral) hyperlipidemia rats. Those sterols were significantly lower in drug-treated rats compared to the controls, which justifies the drug efficacy. Therefore, these results indicate that the developed method was successfully applied to examine statin drug efficacy with urine sample.

• Journal of the Korean Operations Research and Management Science Society
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• v.25 no.3
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• pp.17-33
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• 2000

We consider the Steiner tree packing problem. For a given undirected graph G =(V, E) with positive integer capacities and non-negative weights on its edges, and a list of node sets(nets), the problem is to find a connection of nets which satisfies the edge capacity limits and minimizes the total weights. We focus on the switchbox routing problem in knock-knee model and formulate this problem as an integer programming using Steiner tree variables. The model contains exponential number of variables, but the problem can be solved using a polynomial time column generation procedure. We test the algorithm on some standard test instances and compare the performances with the results using cutting plane approach. Computational results show that our algorithm is competitive to the cutting plane algorithm presented by Grotschel et al. and can be used to solve practically sized problems.

• Proceedings of the KIEE Conference
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• 1987.11a
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• pp.234-238
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• 1987

In this paper, the used specimen composition was added basic additives ($Bi_2O_3\;lmol%$, $Sb_2O_3\;lmol%$, CoO 0.5 mol%, MnO 0.5mol%) to ZnO powder, and $TiO_2$ (1,2,3,4 mol%) to the above basic composition. It appears that there are four regions of conduction current depended upon the strength of the applied electric field ; Ohimic region, Poole-Frenkel region, Schottky region and Tunneling region. Increasing of $TiO_2mol%$, the breakdown voltages of ZnO ceramic varistors are decreased. The decrease of breakdown voltages was explained with the decrease of potential barrier height. Moreover, V-I characteristics with temperature dependence are decreased with increasing of $TiO_2mol%$.

• YAKHAK HOEJI
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• v.42 no.5
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• pp.473-479
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• 1998

Lovastatin (LOVA), a fungal metabolite isolated from cultures of Aspergillus terreus, is a competitive HMG-CoA reductase inhibitor used for the treatment of primary hyper cholesterolemia, and has also been shown to suppress growth in a variety of non-glioma tumor cell lines. A sensitive reversed-phase high-perfonnance liquid chromatographic method with ultraviolet (UV) absorbance detection has been developed to quantitate LOVA in human plasma and urine samples using liquid-liquid extraction procedure. Baseline separation of LOVA and internal standard, simvastatin was achieved on a Novapak $C_{18}$ analytical column with a mobile phase containing 0.025M $NaH_2PO_4$: CAN (35:65, v/v%), adjusted pH to 4.5. The flow rate was set at 1.5ml/min, and the column effluent was monitored by a UV detection at 238nm. The limit of quantification was determined to be 0.5${\mu}$g/ml while extraction efficiency of LOVA ranged from 73.4-82.9% at LOVA concentrations of 0.5 to 10${\mu}$g/ml. Good linearity with correlation coefficients greater than 0.999 was obtained in the range of LOVA concentrations from 0.5 to 10${\mu}$g/ml. The accuracy and the precision were proven excellent with relative standard deviation (RSD, %) and relative error (RE, %) of less than 4.2 and 4.0, respectively. Intraday precision, evaluated at five LOVA concentrations (0.5, 1, 2, 5, 10${\mu}$g/ml) and expressed as RSD ranged from 0-1.82% while the interday precision at the same concentrations ranged from 0.7-10.5%. The analytical method described was then successfully employed for the determination of LOVA concentrations in plasma samples obtained during a phase II clinical trial using high doses of LOVA (30-40mg/kg/day). This method could be further utilized for the ongoing pharmacolkinetic studies and therapeutic drug monitoring of the high-dose LOVA therapy in adenocarcinoma patients.

• Journal for History of Mathematics
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• v.26 no.2_3
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• pp.163-176
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• 2013

This study concerns Stanojevic's academic works on the $\mathfrak{L}^1$-convergence of Fourier series from 1973 to 2002. We review his academic works. Also, we briefly investigate a simple academic lineage for the researchers of $\mathfrak{L}^1$-convergence of Fourier series until 2012. First, we introduce the classical lineage of the researchers for $\mathfrak{L}^1$-convergence Fourier series in section 2. Second, we investigate the backgrounds of Stanojevic's study at Belgrade University and University of Missouri-Rolla respectively. Finally, we compare and consider the $\mathfrak{L}^1$-convergence theorems of Stanojevic's results from 1973 to 2002 successively. In addition, we compose a the simple lineage of $\mathfrak{L}^1$-convergence of Fourier series from 1973 to 2012.

• Proceedings of the KIEE Conference
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• 1999.07f
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• pp.2597-2600
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• 1999

Semiconductor devices can be series stacked for the application of high voltage switching. It can provide high reliability and long lifetime by the safe design with a reasonable margin. The equal voltage distribution at solid-state switches in series should be guaranteed. Static and dynamic voltage division, over current protection must be considered carefully in the design stage. A fast switching thyristor is a good candidate for the high power pulse applications. A high voltage switching module is designed and tested. Its specifications are working voltage of 70 kV, switching pulse width of 120${\mu}s$, peak switching current of 220A, maximum repetition rate of 200pps. The module can be series connected to get higher working voltage. This paper presents the design details and the test results are compared with expected circuit simulations.