• East Asian Economic Review
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• v.20 no.4
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• pp.493-517
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• 2016

This paper examines the persistent properties of 12 sectoral relative prices between Korea and Japan obtained following the Classification of Individual Consumption according to Purpose (COICOP) over the period of 1985-2016. Applying a new econometric method developed by Pesaran which controls for the cross-section dependence in a panel, we are not able to reject the hypothesis that the sectoral real exchange rates contain a common stochastic trend. On the other hand, the well-known panel unit root tests such as the IPS and LLC tests widely used by previous studies strongly reject the unit root hypothesis. Since the error term of the regression for our panel exhibits significant cross-section dependence, these opposite results justify that the use of the new econometric method is appropriate.

• Journal of the Korean Mathematical Society
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• v.56 no.3
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• pp.825-855
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• 2019

We establish the existence of $C^1$ stable invariant manifolds for differential equations $u^{\prime}=A(t)u+f(t,u,{\lambda})$ obtained from sufficiently small $C^1$ perturbations of a nonuniform exponential dichotomy. Since any linear equation with nonzero Lyapunov exponents has a nonuniform exponential dichotomy, this is a very general assumption. We also establish the $C^1$ dependence of the stable manifolds on the parameter ${\lambda}$. We emphasize that our results are optimal, in the sense that the invariant manifolds are as regular as the vector field. We use the fiber contraction principle to establish the smoothness of the invariant manifolds. In addition, we can also consider linear perturbations, and thus our results can be readily applied to the robustness problem of nonuniform exponential dichotomies.

• Journal of Preventive Medicine and Public Health
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• v.51 no.1
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• pp.1-5
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• 2018

Smokers keep smoking despite knowing that tobacco claims many lives, including their own and others'. What makes it hard for them to quit smoking nonetheless? Tobacco companies insist that smokers choose to smoke, according to their right to self-determination. Moreover, they insist that with motivation and willpower to quit smoking, smokers can easily stop smoking. Against this backdrop, this paper aims to discuss the addictive disease called tobacco use disorder, with an assessment of the addictiveness of tobacco and the reasons why smoking cessation is challenging, based on neuroscientific research. Nicotine that enters the body via smoking is rapidly transmitted to the central nervous system and causes various effects, including an arousal response. The changes in the nicotine receptors in the brain due to continuous smoking lead to addiction symptoms such as tolerance, craving, and withdrawal. Compared with other addictive substances, including alcohol and opioids, tobacco is more likely to cause dependence in smokers, and smokers are less likely to recover from their dependence. Moreover, the thinning of the cerebral cortex and the decrease in cognitive functions that occur with aging accelerate with smoking. Such changes occur in the structure and functions of the brain in proportion to the amount and period of smoking. In particular, abnormalities in the neural circuits that control cognition and decision-making cause loss of the ability to exert self-control and autonomy. This initiates nicotine dependence and the continuation of addictive behaviors. Therefore, smoking is considered to be a behavior that is repeated due to dependence on an addictive substance, nicotine, instead of one's choice by free will.

• International Commerce and Information Review
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• v.16 no.2
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• pp.199-218
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• 2014

The study was focused on the Energy Efficiency of Korea. Thus this study calculates Energy Intensity and Energy Dependence, Energy Independence rate using data Korea Energy Statistics. This study calculate 'Energy Intensity', 'Energy Dependence', 'Energy Independence rate', which is making use of the Gross Domestic product, Energy Consumption, Energy Export and Import, Energy Gross Input. The analysis of the pater suggests that this goal can be achieved throuth improved efficiency of Energy consumption and Energy Independence.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.65.3-66
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• 2020

We use the IllustrisTNG cosmological hydrodynamical simulation to study the evolution of star formation rate (SFR)-density relation over cosmic time. We construct several samples of galaxies at different redshifts from z=2.0 to z=0.0, which have the same comoving number density. The SFR of galaxies decreases with local density at z=0.0, but its dependence on local density becomes weaker with redshift. At z≳1.0, the SFR of galaxies increases with local density (reversal of the SFR-density relation), and its dependence becomes stronger with redshift. This change of SFR-density relation with redshift still remains even when fixing the stellar masses of galaxies. The dependence of SFR on the distance to a galaxy cluster also shows a change with redshift in a way similar to the case based on local density, but the reversal happens at a higher redshift, z~1.5, in clusters. On the other hand, the molecular gas fraction always decreases with local density regardless of redshift at z=0.0-2.0 even though the dependence becomes weaker when we fix the stellar mass. Our study demonstrates that the observed reversal of the SFR-density relation at z≳1.0 can be successfully reproduced in cosmological simulations. Our results are consistent with the idea that massive, star-forming galaxies are strongly clustered at high redshifts, forming larger structures. These galaxies then consume their gas faster than those in low-density regions through frequent interactions with other galaxies, ending up being quiescent in the local universe.

• The Journal of the Korea Contents Association
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• v.22 no.10
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• pp.827-839
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• 2022

The severity of smartphone dependence among early adolescents, known as the most vulnerable group to smartphone addiction, is increasing. In this study, the factors affecting the smartphone dependence of early adolescents were analyzed by separating into elementary school and middle school students. For this purpose, the 1st data from Korean Children and Youth Panel Survey(2018) was used. The subjects of the study were 2,607 4th grade from elementary school and 2,590 1st grade from middle school. Factors that affect to smartphone dependence of both elementary and middle school students in common were gender, self-esteem, aggression, time spent with parents, and negative parenting attitude. On the other hand, region(city size), economic level, health status, school life satisfaction, and relationship with teachers were significant in the smartphone dependence of elementary school students, but not in middle school students. In middle school students, positive parenting attitudes were significant. Based on the results of the analysis, implications for policy establishment and social service provision were drawn to encourage the proper use of the by early youth.

• Journal of the Korean Society for Library and Information Science
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• v.48 no.1
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• pp.329-343
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• 2014

This research investigated the effects of university library users' use patterns and their recognition of service benefits on the magnitude of service value assessments derived from users' statements using contingent valuation method (CVM). Library users' use patterns were operationalized by the number of library visits, library website visit counts and the degree of dependence on their own libraries. User benefits variables were measured by the level of satisfaction on the benefits of library use for teaching & instruction, research & writings, and employment & external activities. University library services were divided into circulation, journal articles (domestic & foreign), reference service, user education, reading room service and WTPs for each service were measured. The results from hypotheses testing show that the number of library visits affect WTP amounts for circulation, foreign article use, reference service and user education. The degree of library dependence seems to affect WTP amounts for circulation and user education. With regards to the hypotheses related to the recognition of library service benefits, the degree of satisfaction for teaching & instruction benefits seems to affect WTP amounts for reading room use.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4973-4977
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• 2012

Introduction: Tobacco use is a global health care problem. Repetitive exposure to nicotine produces neuroadaptation resulting in nicotine dependence. Smoking is associated with a range of diseases, causing high levels of morbidity and mortality and is one of the leading causes of preventable deaths, with more than 4.6 million smokers worldwide dying each year from smoking related illnesses. Stopping smoking has major health benefits. Quitting at any age provides both short and long term benefits. Materials and methods: 45 patients attending the outpatient department at the Oxford Dental College, Bangalore, were randomly allocated to three groups of interventions namely placebo, counseling and nicotine replacement therapy (NRT). Initially each one was assessed for carbon monoxide levels using a breath analyser (pico smokerlyser bedfont UK). They were followed up for six months and the carbon monoxide levels were again assessed using the same instrument. The paired t test was used to compare the results before and after the intervention. Results: The scores before the initiation of intervention and after treatment were compared and all three interventions were found to be statistically significant after six months. It was noticed that patients with very low or low dependence followed by high dependence had good response in the placebo group (68% and 47.6% respectively), in the counseling group maximum response was seen in the medium followed by the very low group (61% and 59% respectively), and maximum response was seen in very high followed by the very low group with NRT (78.7% and 60.5% respectively). Conclusion: The inference that can be drawn from the present study is that non-invasive, non pharmacological methods like placebo and counseling are effective in low to medium groups, and NRT is effective with higher nicotine dependence.

• Biomolecules & Therapeutics
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• v.19 no.1
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• pp.45-51
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• 2011

These experiments were designed to use typical makers from behaviors and molecular basis in addicted animals of morphine and cocaine. Morphine has been widely abused with a high physical dependence liability. Morphine withdrawal activates the intracellular cAMP signaling pathway and further leads to changes in the expression of the cAMP response element binding protein (CREB), which may be important to the development and expression of morphine dependence. From these experiments, repeated morphine (10 mg/kg, twice per day for 7 days) developed physical dependence. Withdrawal signs were precipitated by naloxone and also increased the expression of the CREB. In addition, repeated exposure of cocaine (15 mg/kg) to mice develops locomotor sensitization and produced lasting behavioral sensitivity. Cocaine- and amphetamine-regulated transcript peptide (CART) peptide was up-regulated by repeated administration of cocaine in the striatum. Therefore, repeated morphine induced the development of physical dependence and increased pCREB. In addition, repeated cocaine induced locomotor sensitization and over-expressed CART peptide. In conclusion, the development of physical dependence and pCREB for morphine, and locomotor sensitization and CART peptide over-expression for cocaine would be useful markers to predict the abuse potential of opioid analgesics and pychostimulant drugs in animals, respectively.

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.677-684
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• 2006

Morphine has been used widely on the treatment of many types of chronic pain. However the development of tolerance to and dependence on morphine by repeat application is a major problem in pain therapy. The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to and dependence on morphine. We hypothesize that the use of nalbuphine, ${\kappa}-agonist$ may prove to be useful adjunct therapy to prevent morphine-induced undesirable effects in the management of some forms of chronic pain. Morphine (10 mg/kg) was injected to rats intraperitoneally for 5 day. The variable dose of nalbuphine (0.1, 1.0 and 5.0 mg/kg) was administered (i.p.) in combination with morphine injection. The development of morphine tolerance was assessed by measuring the antinociceptive effect with the Randall-Selitto apparatus. The development of dependence on morphine was determined by the scoring the precipitated withdrawal signs for 30 min after injection of naloxone (10 mg/kg, i.p.). Nalbuphine did not attenuate antinociceptive effect of morphine in rats. Interestingly, combined administration of morphine with nalbuphine (10:1) significantly attenuated the development of dependence on morphine. The elevation of $[^3H]MK-801$ binding in frontal cortex, dentate gyrus, and cerebellum after chronic morphine infusion was suppressed by the coadministration of nalbuphine. In addition, the elevation of NR1 expression by morphine was decreased by the coadministration of nalbuphine in rat cortex. These results suggest that the coadministration of nalbuphine with morphine in chronic pain treatment can be one of therapies to reduce the development of tolerance to and dependence on morphine.