• Bulletin of the Korean Chemical Society
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• 제30권1호
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• pp.119-123
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• 2009

Structural modifications were performed on the C-3 and C-28 positions of ursolic acid and oleanolic acid and the NO production inhibitory activities of the resulting derivatives were evaluated. The SAR revealed that the ursolic acid and oleanolic acid derivatives 3a and 4a, which possessing methoxy group at C-3 position exhibit improved NO production inhibitory activity on LPS-induced RAW247 cells while showing less cytotoxicity than the parent compounds.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.280-284
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• 2002

Six compounds were isolated from the fruits of Acanthopanax sessiliflorus. Their structures were elucidated as (-)-sesamin, scoparone, protocatechuic acid, ursolic acid, hyperin and 5-hydroxymethylfurfural by physicochemical and spectroscopic analysis. Among them, scoparone, ursolic acid and 5-hydroxymethylfurfural were isolated for the first time from Acanthopanax species.

• Natural Product Sciences
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• 제3권2호
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• pp.108-110
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• 1997

A new pentacyclic triterpene acid, elliptic acid was isolated from the ethanolic extract of the leaves of Rubus ellipticus. On the basis of physical evidences coupled with chemical investigations, the structure of elliptic acid was given as, 3,7, 11-trihydroxy ursolic acid.

• 한국자원식물학회지
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• 제32권4호
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• pp.264-269
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• 2019

쉽싸리(L. lucidus)가 가지는 효능의 하나로 알려진 항염증효과의 활성물질을 파악하기 위하여 본 연구를 수행하였다. 항염효과는 LPS로 활성화한 macrophage 264.7이 생산하는 NO의 감소효과를 측정함으로써 평가하였다. 쉽싸리 추출물에서 얻은 비극성 분획물인 $CHCl_3$ 분획물은 농도의존적으로 현저히 NO 생산을 감소시켰다. 이에 비해 극성 분획물인 BuOH 분획물은 그 효과가 약하였다. Silica gel column chromatography에 의해 이 $CHCl_3$ 분획물로부터 주요 화합물인 ursolic acid를 분리하고 분광학적 방법으로 동정할 수 있었다. 효과가 약하였던 BuOH 분획물로부터 diaion HP-20 column chromatography와 sephadex LH-20 column chromatography로 이 분획의 주요 화합물인 rosmarinic acid를 분리하고 역시 분광학적 방법으로 동정하였다. Ursolic acid는 농도의존적으로 NO 생산을 억제하였으나 rosmarinic acid는 그 효과가 상대적으로 약하였다. 이러한 사실로부터 쉽싸리의 항염효과는 주로 ursolic acid의 존재 때문임을 알 수 있었다.

• 한국약용작물학회지
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• 제3권2호
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• pp.91-95
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• 1995

국내(國內)에서 생산(生産)된 백화사설초(百花蛇舌草) Oldenlandia diffusa(WiIId.) Roxb. 의 전초로 부터 얻은 MeOH extract를 $CHCl_3, EtOAc$ 및 BuOH로 분획하여 얻은 fraction으로 부터 column chromatography를 실시하여 3종의 화합물을 분리하였다. 이들의 이화학적(理化學的) 및 분광학적(分光學的) data를 종합하여 화합물 I의 화학구조는 ${\beta}-sitosterol$에 소양(小量)의 stigmasterol이 함유된 sterol이며, 화합물 II는 ursolic acid이고, 화합물 III은 ${\beta}-sitostero\;3-0-{\beta}-D-glucoside$임을 밝혔다. 이 식물은 다양한 생리활성(生理活性)이 보고(報告)된 ursolic acid의 중요한 자원식물(資源植物)이 될 수 있음을 본실험을 통하여 밝혔으며 문헌(文獻)에 보고(報告)된 oleanolic acid는 함유(含有)되어 있지 않음을 알았다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9593-9597
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• 2014

Ursolic acid, extracted from the traditional Chinese medicine bearberry, can induce apoptosis of gastric cancer cells. However, its pro-apoptotic mechanism still needs further investigation. More and more evidence demonstrates that mitochondrial translocation of cofilin-1 appears necessary for the regulation of apoptosis. Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis. These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.

• Biomolecules & Therapeutics
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• 제16권4호
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• pp.364-369
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• 2008

Anti-hyperlipidemic effect of red ginseng (RG; the steamed root of Panax ginseng C.A. Meyer) and Crataegii fructus (CF, the fruit of Crataegus pinnatifida BGE), which are used frequently in China and Korea as herbal medicines to treat arteriosclerosis, were investigated. Treatments of RG and CF significantly reduced blood triglyceride (TG) and total cholesterol (TC) levels in Triton WR-1339-induced hyperlipidemic mice and serum TG levels in corn oil-induced hypertriglyceridemic mice. Ginsenoside Rg3 and ursolic acid, the main constituents of RG and CF, respectively, also reduced TG and TC levels in hyperlipidemic mice. RG and CF significantly lowered the high blood TG and TC levels and body and epididymal mass weights induced by long-term feeding of a high-fat diet and increased the high-fat diet-induced decrease in blood HDL cholesterol levels. RG and Rg3 reduced the blood TC levels more than CF and ursolic acid. However, blood TG level were reduced by CF and ursolic acid more than RG and Rg3. RG, CF, and their constituents also inhibited pancreatic lipase and HMG-CoA reductase activities. The most potent inhibitor was Rg3. These findings suggest that RG and CF may be suitable for the therapies of hypercholesterolemia and triglyceridemia, respectively.

• Archives of Pharmacal Research
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• 제23권2호
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• pp.155-158
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• 2000

Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.

• Archives of Pharmacal Research
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• 제26권2호
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• pp.143-146
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• 2003

Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test anti nociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1％-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the antinociceptive and anti-inflammatory effect of C. bancoesnsis.

• 생약학회지
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• 제29권3호
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• pp.187-192
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• 1998

The ethyl acetate fraction of Uncariae Ramulus et Uncus, which showed anticonvulsant effects against pentylenetetrazole (PTZ) treated mice, were subjected to column chromatography to isolate ursolic acid and hyperin from active eluate. Hyperin decreased the elevated activities of GABA-T and xanthine oxidase and lipid peroxide level dose-dependently in PTZ treated mice brain tissue in vitro, but no effect on superoxide dismutase activity. The effects on such enzyme and component seemed to be related with biosynthesis or metabolism of neurotransmitters.