Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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In Vivo Anti-Nociceptive and Anti-Inflammatory Effect of the Two Triterpenes, Ursolic Acid and 23-Hydroxyursolic Acid, from Cussonia bancoensis

  • Tapondjou, L.A. (Department of Chemistry, Faculty of Science, University of Dschang) ;
  • Lontsi, David (Department of Organic Chemistry, Faculty of Science, University of Yaounde) ;
  • Sondengam, Beiban-Luc (Department of Organic Chemistry, Faculty of Science, University of Yaounde) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University) ;
  • Lee, Kyung-Tae (College of Pharmacy, Kyung Hee University) ;
  • Jung, Hyun-Ju (Division of Applied Plant Sciences, Sangji University) ;
  • Park, Hee-Juhn (Division of Applied Plant Sciences, Sangji University)
  • Published : 2003.02.01
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Abstract

Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test anti nociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1％-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the antinociceptive and anti-inflammatory effect of C. bancoesnsis.

Keywords

References

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