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http://dx.doi.org/10.7314/APJCP.2014.15.22.9593

Ursolic Acid Promotes Apoptosis of SGC-7901 Gastric Cancer Cells through ROCK/PTEN Mediated Mitochondrial Translocation of Cofilin-1  

Li, Rui (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
Wang, Xia (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
Zhang, Xiao-Hong (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
Chen, Hong-Hai (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
Liu, Yan-Dong (Department of Clinical Laboratories, the Fifth People's Hospital of Shenyang and Tumor Hospital of Shenyang)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.22, 2014 , pp. 9593-9597 More about this Journal
Abstract
Ursolic acid, extracted from the traditional Chinese medicine bearberry, can induce apoptosis of gastric cancer cells. However, its pro-apoptotic mechanism still needs further investigation. More and more evidence demonstrates that mitochondrial translocation of cofilin-1 appears necessary for the regulation of apoptosis. Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis. These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.
Keywords
Ursolic acid; apoptosis; ROCK/PTEN; cofilin-1; mitochondrial translocation; gastric cancer;
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