• Journal of Oral Medicine and Pain
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• 제31권1호
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• pp.27-36
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• 2006

개인식별에서 치과적 방법의 유용성과 중요도에 대해서는 잘 알려져 있다. 그러나 우리나라에서 개인의 신원확인을 위하여 법치의학적 방법을 이용한 포괄적 자료에 대하여는 발표된 예가 드물다. 본 논문은 2002년에서 2005년까지 국립과학수사연구소 법치의학실로 의뢰된 신원불상 변사자의 개인식별건을 분석하여 법치의학적 방법의 활용성에 대하여 연구하였다. 그 결과 4년 동안 법치의학실로 의뢰된 신원불상 변사자 관련 개인식별 건은 405건으로 전체 의뢰 493건의 약 82%에 이르렀다. 두개골을 비롯한 유골이 전체 의뢰되는 건과 치아나 상, 하악만으로 연령감정을 의뢰한 건은 각각 2002년에 58건과 42건, 2003년에 52건과 37건, 2004년에 91건과 27건, 2005년에 78건과 20건이었다. 2005년에는 개인식별을 위해 유골 전체에 대한 종합적 검사를 의뢰하는 건이 연령감정만 의뢰하는 건보다 4배에 이르렀다. 두개골과 사진을 겹치는 중첩법에 의한 동일인 식별은 접수된 24건 중 15건에서 활용되었고 나머지 9건에서는 유전자 검사로만 결과가 판정되었다. 법치의학적 방법에 의한 개인식별을 위하여 23건이 접수되었으며, 그 결과 9건이 동일인으로 판정되었고, 7건은 배제되었으며, 동일인으로 추정되는 4건에서는 유전자 검사 결과로 보완되어 확인되었으며, 3건은 의뢰된 자료가 충분하지 않았다. 법치의학적 방법에 의하여 신원이 확인된 신원불상 변사자 수는 2002년 9%에서 2005년 46%로 증가되었다. 개인식별에 있어서 법치의학적 방법은 지문이나 유전자검사와는 달리 일반인과 경찰에 비교적 덜 알려진 측면이 있으나, 점차 중요성에 대한 인식이 높아지고 있다. 치과기록이나 방사선 사진 등에 관한 정보가 잘 보존됨으로써 법치의학적 개인식별의 활용성이 점차 증가하고 있다. 유전자처럼 혈연 관계를 증명하는 것이 아니라 본인의 기록으로 남아있는 자료에 대한 비교 분석이기 때문에 분석이 용이하고 신속하며, 유전자 검사에 비해 고가의 장비를 필요로 하지 않고 비용이 저렴하다는 장점이 있다. 또한 뼈 조직이나 조직이 부패되어 핵 유전자의 추출이 어려울 때 이용되는 미토콘드리아 유전자의 개인식별률이 높지 않은 단점을 보완할 수 있다. 그러므로 개인식별에 있어서 유전자 분석과 두개골 사진 중첩법의 단점을 극복할 수 있는 법치의학적 방법의 활용성과 중요도는 더 증가될 것이다. 향후 개인식별률을 높이기 위하여 경찰과 법의학자와의 긴밀한 협조가 중요하며, 가출자와 실종자의 치과기록과 변사자의 치아기록을 전산자료화 할 수 있도록 관련 법과 체계의 확립이 시급한 실정이다.

• 대한화학회지
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• 제13권4호
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• pp.333-339
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• 1969

Synthesis and chemical properties of 1,4-bisdiazo-2-butene have been studied. 1,4-Bisdiazo-2-butene which was very unstable produced in protic solvents 1,3-butadiene and one unidentified substance instead of ring compounds. The reaction in aprotic solvents remains for further investigations.

• 건축역사연구
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• 제18권5호
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• pp.25-39
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• 2009

The examples of developing a building site after the Woongjin period are mainly found in temple sites, tile-roofed building sites of unidentified features, and palace remains including the pavilion site with the river in the front(임류각지) inside the Castle of Gongsan, Gongjoo. In case of the Hanseong period, a glimpase of the features has gained in Poongnab mud castle and Mongchon mud castle, but the excavated relics are not yet enough to make some date out of them. After the Woongjin period of Baejae, the earth-ramming development method was used mostly to construct a building site, which is divided into horizontal and slant raising of the ground level. Both are used simultaneously, but there are the significant differences in the way of raising the ground level between them. Particularly, in case of the Wanggoong-ri relics in Iksan, the ground level was raised in a narrow line slantly, which is differentiated from other slant raising of the ground level, and its time of construction also is after that of others. In addition, the board-building development method used for narrow space is usually found in the remains since the seventh century. However, there are not enough the relics of Baekjae to reveal the whole aspect of building site development. It should be studied later through the subsequent excavation and research.

• BMB Reports
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• 제36권5호
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• pp.508-513
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• 2003

The bacterium Bacillus thuringiensis produces toxin inclusions that are deleterious to target insect larvae. These toxins are believed to interact with a specific receptor protein(s) that is present on the gut epithelial cells of the larvae. In various insect species (in particular those belonging to the lepidopteran class), aminopeptidase N (APN) is one of the two receptor proteins that are considered to be involved in toxin-receptor interactions. However, in mosquitoes, the nature and identity of the receptor protein is unknown. Here, using RT-PCR, we identified two isoforms of the APN transcripts in the Aedes aegypti mosquito larval midgut. These results are congruent with a previous report of multiple isoforms of the APN gene expression in lepidopteran larvae. Which of the two isoforms (or other yet unidentified receptor proteins) is involved in the killing of mosquito larvae remains to be elucidated.

• 여성건강간호학회지
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• 제9권1호
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• pp.61-69
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• 2003

Fatigue is a universally common word. The subject has been studied in different disciplines, but the basic concept of the term still remains unidentified. It becomes especially important for the medical communications between nurses and clients. Based on the framework outlined by Walker and Avant (1995), this analysis attempts to clarify and examine the symptoms of fatigue. The attributes of fatigue identified in this paper were exhaustion, weighted psychological burden, shortage in capacity or lack of energy, shortage incapacity(motivation and excitement), and imbalance of energy. Therefore, the definition of fatigue refers to a subjective feeling from various internal or external stresses. The consequences of fatigue bring reduced capacity and imbalance of energy. The symptoms show a homeostatic disability or shortage of capacity (physical, psychological, environmental and physiological factors). A precise understanding of "fatigue" will be utilized in defining the causes and measuring outcomes. Also, it will enhance the effective medical communications with client s and nurses. In conclusion, more work is needed to develop objective measurement and effect ivenursing intervention.

• Journal of Genetic Medicine
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• 제9권2호
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• pp.84-88
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• 2012

Purpose: Neurofibromatosis type 1 (NF1), which is caused by mutations of the NF1 gene, is the most frequent single gene disorder to affect the nervous system. Unidentified bright objects (UBOs) are commonly observed on brain magnetic resonance imaging (MRI) in patients with NF1. However, their clinical and pathologic significance is not well understood. The purpose of this study was to investigate the correlation between UBOs and cerebral glucose metabolism measured by $^{18}F$-2-Fluoro-2-deoxy-D-glucose ($^{18}F$-FDG) positron emission tomography (PET) in Korean patients with NF1. Materials and Methods: Medical records of 75 patients (34 males and 41 females) with NF1 who underwent brain MRI and PET between 2005 and 2011 were evaluated retrospectively. Clinical data including demographics, neurological symptoms, and brain MRI and PET findings, were reviewed. Results: UBOs were detected in the brain MRI scans of 31 patients (41%). The region most frequently affected by UBOs was the basal ganglia. The most frequent brain PET finding was thalamic glucose hypometabolism (45/75, 60%). Of the 31 patients with UBOs, 26 had thalamic glucose hypometabolism on brain PET, but the other 5 had normal brain PET findings. Conversely, of the 45 patients with thalamic glucose hypometabolism on brain PET, 26 showed UBOs on their brain MRI scans, but 19 had normal findings on brain MRI scans. Conclusion: UBOs on brain MRI scans and thalamic glucose hypometabolism on PET appear to be 2 distinctive features of NF1 rather than correlated symptoms. Because the clinical significance of these abnormal imaging findings remains unclear, a longitudinal follow-up study of changes in clinical manifestations and imaging findings is necessary.

• 건축역사연구
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• 제25권6호
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• pp.17-25
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• 2016

Simgok Seowon is the commemorative shrine and academy established for scholar Jo Gwangjo (pen name : Jeongam). The shrine (sangnyangsik) and the east and west dormitories (Dongjae and Seojae) were built in 1636. The lecture hall, Imsimnu Pavilion, Sananggak and Munhyanggak buildings were built successively. Simgok Seowon is the only one that survived through the abolishment of seowon ordered by Regent Heungseon in the 19th century. The original seowon was renowned as a representative example showing the typical lecture hall in front and dormitory at the back (jeondanghujae) layout of the Giho School built in 1650. Two archaeological excavations were conducted in the lecture hall courtyard in 2004 and 2007~2008, which prompted debates the position of the dormitories in respect to the lecture hall, whether the dormitories should be placed in front, or at the back of the lecture hall. Simgok Seowon had been long known as a representative example of the lecture hall in front layout, but the excavations revealed contrasting evidence, suggesting the possibility for a dormitories in front layout. Recent studies and evidence show that the architecture of Simgok Seowon can be grouped into three phases. The first phase was when the shrine and both dormitories were built to the rear of the lecture hall, the second phase was when the lecture hall, Imsimnu Pavilion, Sananggak and Munhyanggak buildings were built, and lastly the third phase when the east, west dormitories were reconstructed in front of the lecture hall. The large scale construction of Simgok Seowon is related to the education based management of the academy by Doam Yi Jae, and the 17~18th century remains confirmed from the archaeological excavations are evidence of this. Remains for Imsimnu Pavilion, Sananggak, and Munhyanggak buildings have yet to be confirmed, and spaces to the south and east of the seowon are unidentified. Therefore, it is necessary to conduct investigations and research for the unexcavated spaces of the seowon, to conduct in-depth studies and for the effective adaptive re-use of the seowon.

• BMB Reports
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• 제51권9호
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• pp.425-426
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• 2018

As highly conserved signaling cascades of multicellular organisms, Wnt and Hippo pathways control a wide range of cellular activities, including cell adhesion, fate determination, cell cycle, motility, polarity, and metabolism. Dysregulation of those pathways are implicated in many human diseases, including cancer. Similarly to ${\beta}-catenin$ in the Wnt pathway, the YAP transcription co-activator is a major player in Hippo. Although the intracellular dynamics of YAP are well-known to largely depend on phosphorylation by LATS and AMPK kinases, the molecular effector of YAP cytosolic translocation remains unidentified. Recently, we reported that the Dishevelled (DVL), a key scaffolding protein between canonical and non-canonical Wnt pathway, is responsible for nuclear export of phosphorylated YAP. The DVL is also required for YAP intracellular trafficking induced by E-cadherin, ${\alpha}-catenin$, or metabolic stress. Note that the p53/LATS2 and LKB1/AMPK tumor suppressor axes, commonly inactivated in human cancer, govern the reciprocal inhibition between DVL and YAP. Conversely, loss of the tumor suppressor allows co-activation of YAP and Wnt independent of epithelial polarity or contact inhibition in human cancer. These observations provide novel mechanistic insight into (1) a tight molecular connection merging the Wnt and Hippo pathways, and (2) the importance of tumor suppressor contexts with respect to controlled proliferation and epithelial polarity regulated by cell adhesion.

• Archives of Plastic Surgery
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• 제42권2호
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• pp.214-217
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• 2015

Blepharoptosis is a common indication for surgery in plastic surgery units, yet its possible underlying pathology frequently remains unidentified. A 52-year-old man with a 20-year history of progressive bilateral ptosis (right>left) presented with recurrent ptosis of both eyes; he had undergone an operation on the levator aponeurosis 12 years prior. Due to the suspicion of an underlying disease, he was evaluated further. Chronic progressive external ophthalmoplegia in transition to the more severe syndromic variant Kearns-Sayre syndrome, a mitochondrial disorder causing myopathy, was diagnosed. The patient was treated with coenzyme Q10, and he underwent ptosis surgery on both eyes. This case illustrates a potentially multi-systemic disease that was diagnosed by a further evaluation of a common symptom, in this case worsening blepharoptosis. Awareness of myopathic symptoms is necessary to prevent overlooking serious yet improvable conditions.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5625-5629
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• 2013

Occurrence of breast cancer is related to genetic as well as cultural, environmental and life-style factors. Variations in diversity of these factors among different ethnic groups and geographical areas emphasize the immense need for studies in all racial-ethnic populations. The incidence of breast cancer in Pakistan is highest in Asians after Jews in Israel and 2.5 times higher than that in neighboring countries like Iran and India, accounting for 34.6% of female cancers. The Pakistani population is deficient in information regarding breast cancer etiology and epidemiology, but efforts done so far had suggested consanguinity as a major risk factor for frequent mutations leading to breast cancer and has also shed light on genetic origins in different ethnic groups within Pakistan. World-wide research efforts on different ethnicities have enhanced our understanding of genetic predisposition to breast cancer but despite these discoveries, 75% of the familial risk of breast cancer remains unexplained, highlighting the fact that the majority of breast cancer susceptibility genes remain unidentified. For this purpose Pakistani population provides a strong genetic pool to elucidate the genetic etiology of breast cancer because of cousin marriages. In this review, we describe the known breast cancer predisposition factors found in the local Pakistani population and the epidemiological research work done to emphasize the importance of exploring factors/variants contributing to breast cance, in order to prevent, cure and decrease its incidence in our country.