• 시스템엔지니어링학술지
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• 제19권2호
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• pp.92-116
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• 2023

Emerging Industries often do not match the structures and contents of existing regulations, and regulations that impose excessive burdens compared to the regulatory purpose are continuously created. These results, the emerging industries struggle to growth. In order to respond to these regulatory problems, the regulatory management policies are establishing in each country, and research on the reasonable regulatory methods and its effects on industry has continued. But companies still complain of difficulties in business due to regulations. In the background, it is analyzed that there are limitations in response to regulatory issues of the emerging industry, such as the lack of standards and expertise that can be judged as 'problems', and delay in recognizing and improving the problems of the competent ministries, over-interpretation of the risks of new technologies, and vague concerns about accidents etc., the regulation corresponding limitations is existed. In this regard, this study seeks to lay the groundwork for analysis of the major regulatory conflict issues and the reasonable countermeasures by identifying the regulatory conflict issues arising from the emergence of the innovative technologies and services, and analyzing studies to resolve them.

• 한국보육지원학회지
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• 제10권6호
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• pp.265-289
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• 2014

본 연구의 목적은 맞벌이가정 초등학교 저학년 아동의 성별로 입학후 3년간 방과후 보호자부재의 변화, 그리고 방과후보호, 가정환경(가구소득, 부모감독)과 자기조절학습능력 및 정서 행동문제 간의 관계 분석이었다. 한국아동 청소년패널조사의 초1패널 3학년으로 입학 후 3년간 맞벌이 양친부모 가정에 속한 남아 526명, 여아 483명을 대상으로, 3년간의 방과후 보호자부재와 방과후보호를 분류하고 연구변인별 점수를 산출한 후 Friedman검증, t 검증, 상관분석, 회귀분석을 하였다. 입학 후 3년간 방과후 보호자재 상태는 남아와 여아 약 45%, 50% 수준이며, 점차 일시적 또는 지속적 보호자부재 상태로 변화를 보였다. 방과후보호에 따라 가구소득과 자기조절학습능력은 남녀 모두에서, 부모감독은 여아, 정서 행동문제는 주로 남아의 경우에 차이가 있었다. 남녀 모두에서 가정환경은 자기조절학습 능력, 정서 행동문제와 유의한 관계가 있고, 자기조절학습능력과 정서 행동문제에 대한 방과후보호와 가정환경의 상대적 영향은 차이가 있었다. 아동의 성을 고려한 방과후보호, 고소득가정 자기보호 아동에의 관심이 필요함을 시사해 주었다.

• Interdisciplinary Bio Central
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• 제1권1호
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• pp.4.1-4.7
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• 2009

Introduction: Histone modifications and DNA methylation are the major factors in epigenetic gene regulation. Especially, revealing how histone modifications are related to DNA methylation is one of the challenging problems in this field. In this paper, we address this issue and propose several plausible mechanisms for precise controlling of DNA methylation status at CpG islands. Materials and Methods: To establish the regulatory relationships, we used 38 histone modification types including H2A.Z and CTCF, and DNA methylation status at CpG islands across chromosome 6, 20, and 22 of human CD4+ T cell. We utilized Bayesian network to construct regulatory network. Results and Discussion: We found several meaningful relationships supported by previous studies. In addition, our results show that histone modifications can be clustered into several groups with different regulatory properties. Based on those findings we predicted the status of methylation level at CpG islands with high accuracy, and suggested core-regulatory network to control DNA methylation status.

• 한국전자통신학회논문지
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• 제12권5호
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• pp.725-730
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• 2017

원전의 안전 유지를 위한 계측제어계통에 일반적인 IT 자원을 활용하는 사례가 증가하고 있다. 이에 따라 기존 IT 자원이 갖는 잠정적인 보안 취약점으로 인해 원전 사이버 보안 침해 사고가 발생할 수 있으며, 원전의 가동 중단뿐만 아니라 국가적 재난에 이르는 심각한 사고를 야기할 수 있다는 문제가 제기되고 있다. 국내 원자력 규제기관에서는 이에 대응하기 위해 원전 사이버 보안 규제지침을 개발하고 규제 대상 및 범위를 확대시키고 있지만, 원전의 일반적인 보안 문제뿐만 아니라 원전 취약점에 특화된 공격에도 대응할 수 있는 방안이 필요하다. 이에 본 논문에서는 R.G.5.71에서 규정하고 있는 내용 중 취약점 점검과 관련된 42개 항목을 선별하여 5가지의 유형으로 분류 분석하였다. 제안된 분석 내용을 바탕으로 취약점 점검 도구를 개발한다면 원전 사이버 보안 취약점 점검 효율성을 향상시킬 수 있을 것으로 판단된다.

• 한국IT서비스학회지
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• 제22권1호
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• pp.15-27
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• 2023

As the number of users of the Metaverse platform increases and virtual assets in the Metaverse can be converted into reality, various commercial trading activities are occurring within the Metaverse. Considering that users can earn profits through selling digital products and the profits can be converted into fiat money or virtual assets, the commerce activities within Metaverse are similar to existing e-commerce. However, due to the peculiarity of transactions performed in Metaverse platform, the current legal system is insufficient to apply to Metaverse commerce, and many researches have been conducted for this purpose. But, regulatory research on NFT(Non-Fungible Token) digital products that can be applied to all types of physical products is inadequate. Therefore, This study investigated the types of digital products commerce in Metaverse, investigated the issues of commerce transactions related to NFT digital products and the regulations related to them. Based on this, research results can be used as the development direction of NFT digital products trading and consideration of related policy to protect NFT digital products.

• 보건의료산업학회지
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• 제11권4호
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• pp.189-202
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• 2017

Objectives : This study aims to present a new classification system using evaluation standards to ensure the safety of transport ventilators used in Korea. Due to the rapid advancement of technology, various types of ventilators have been developed and as the range of application increases, so does demand. With quick access to information and a growing economy, the technology used in Korean hospitals is equivalent to that of other countries; however, regulatory and safety consciousness are still lagging in Korea. Methods : Based on researching overseas cases, reference data and standards for improving the current system in Korea are proposed. Results : According to the review of transport ventilator use in Korea, it was found that concerns about safety is due to the absence of a standardized classification system for evaluating the safety and effectiveness of transport ventilators. Conclusions : In order to improve the safety of patients and the quality of medical care, it is essential to establish guidelines and assessment standards guaranteeing the safety of transport ventilators in Korea. Clear definitions and classifications for devices must precede the application of such standards. In addition, effective evaluation standards should be developed in order to resolve problems and improve upon the current system through continuous validation.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.344-347
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• 2005

Helper T(Th) cells regulate immune response by producing various kinds of cytokines in response to antigen stimulation. The regulatory functions of Th cells are promoted by their differentiation into two distinct subsets, Th1 and Th2 cells. Th1 cells are involved in inducing cellular immune response by activating cytotoxic T cells. Th2 cells trigger B cells to produce antibodies, protective proteins used by the immune system to identify and neutralize foreign substances. Because cellular and humoral immune responses have quite different roles in protecting the host from foreign substances, Th cell differentiation is a crucial event in the immune response. The destiny of a naive Th cell is mainly controlled by cytokines such as IL-4, IL-12, and IFN-${\gamma}$. To understand the mechanism of Th cell differentiation, many mathematical models have been proposed. One of the most difficult problems in mathematical modeling is to find appropriate kinetic parameters needed to complete a model. However, it is relatively easy to get qualitative or linguistic knowledge of a model dynamics. To incorporate such knowledge into a model, we propose a novel approach, fuzzy continuous Petri nets extending traditional continuous Petri net by adding new types of places and transitions called fuzzy places and fuzzy transitions. This extension makes it possible to perform fuzzy inference with fuzzy places and fuzzy transitions acting as kinetic parameters and fuzzy inference systems between input and output places, respectively.

• Journal of Plant Biotechnology
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• 제45권4호
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• pp.299-305
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• 2018

Although new plant breeding technologies facilitate efficient plant breeding without introducing a transgene, they are creating indistinct boundaries in the regulation of genetically modified organisms (GMOs). The rapid advancement in plant breeding by genome-editing requires the establishment of a new global policy for the new biotechnology, while filling the gap between process-based and product-based GMO in terms of regulations. In this study recent developments in producing major crops using new plant breeding technologies were reviewed, and a regulatory model that takes into account the various methodologies to achieve genetic modifications as well as the resulting types of mutation were proposed. Moreover, the communication process were discussed in order to understand consumers' current situation and problems of new plant breeding technology, establish social acceptance well, and understand consumers' disputes such as GMO crops.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7645-7652
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• 2014

Neuroblastoma (NB), the most common extracranial solid tumor, accounts for 10% of childhood cancer. To date, scientists have gained quite a lot of knowledge about microRNAs (miRNAs) and their genes in NB. Discovering inner regulation networks, however, still presents problems. Our study was focused on determining differentially-expressed miRNAs, their target genes and transcription factors (TFs) which exert profound influence on the pathogenesis of NB. Here we constructed three regulatory networks: differentially-expressed, related and global. We compared and analyzed the differences between the three networks to distinguish key pathways and significant nodes. Certain pathways demonstrated specific features. The differentially-expressed network consists of already identified differentially-expressed genes, miRNAs and their host genes. With this network, we can clearly see how pathways of differentially expressed genes, differentially expressed miRNAs and TFs affect on the progression of NB. MYCN, for example, which is a mutated gene of NB, is targeted by hsa-miR-29a and hsa-miR-34a, and regulates another eight differentially-expressed miRNAs that target genes VEGFA, BCL2, REL2 and so on. Further related genes and miRNAs were obtained to construct the related network and it was observed that a miRNA and its target gene exhibit special features. Hsa-miR-34a, for example, targets gene MYC, which regulates hsa-miR-34a in turn. This forms a self-adaption association. TFs like MYC and PTEN having six types of adjacent nodes and other classes of TFs investigated really can help to demonstrate that TFs affect pathways through expressions of significant miRNAs involved in the pathogenesis of NB. The present study providing comprehensive data partially reveals the mechanism of NB and should facilitate future studies to gain more significant and related data results for NB.

• 기록학연구
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• 제79호
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• pp.33-82
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• 2024

2006년 UN PRI를 계기로 확산된 ESG 경영에 대한 관심이 최근에는 우리 사회 전반에 걸쳐 확산되고 있다. 소비자는 기업의 ESG 분야에 있어서의 적극성 여부를 소비행위의 기준으로 삼고 있으며, 국제사회는 다양한 규제조치들을 정비하여 강화하고 있다. 투자시장에서는 비재무성과(ESG 정보)가 재무성과(신용등급)와 함께 중요한 투자지표로 활용되고 있다. 이러한 기업평가 패러다임의 변화와 시장압력으로 인해 기업이 ESG 대응활동을 소홀히 할 경우 시장선택에서 배제될 가능성이 높아지고 있으며, 이에 따라 ESG 경영의 중요성도 높아져가고 있다. 기업은 이런 시장압력에 대응하여 정당성을 확보하기 위해 다양한 노력을 하고 있지만 그 과정에서 ESG 경영의 근거가 되는 기록/데이터를 체계적으로 관리하고 활용하는데 어려움을 겪고 있다. 본 논문에서는 ESG 경영에 대한 기본적인 이해를 위해 ESG의 대두 과정과 현재 기업에 적용되는 ESG 관련 규제들을 정리하였다. 이를 통해 ESG 경영은 기업의 선한 의지로 이뤄지는 것이 아니라 기업 평가 패러다임의 변화에 따라 기업의 생존을 위한 경영 전략으로 수용되고 있는 점을 알 수 있다. 그리고 기업의 ESG 관련 업무 담당자 면담을 통해 기업의 ESG 대응 과정을 수동적 커뮤니케이션과 능동적 커뮤니케이션으로 구분하였고, 각 커뮤니케이션 유형별로 면담 과정에서 확인된 문제점을 정리하였다. 그리고 ESG 경영정보를 기업 내외부 이해관계자(Stakeholders)와 수동적/능동적으로 커뮤니케이션하는 과정에서 ESG 아카이브가 각 커뮤니케이션 유형별 문제점을 극복할 수 있는 도구로서 기능할 수 있는 가능성을 제기하고, 이러한 역할을 할 수 있는 ESG 아카이브의 유형을 5가지로 제시하였다.