• The Korean Journal of Pharmacology
• /
• v.32 no.2
• /
• pp.177-188
• /
• 1996

The effects of cytokines on the growth and differentiation of glial cells in culture were evaluated to confirm that cytokines could modify the number and function of glial cells. Proliferation of glial cells was determined by the $^3H-thymidine$ uptake and the double immunostain with anti-cell specific marker and anti-bromodeoxyuridine(BrdU) antibody. To check the effect on the differentiation of glial cells, the amount of glial fibrillar acidic protein(GFAP) and the activity of glutamine synthetase(GS) were measured in astrocytes. And also the amounts of myelin basic protein(MBP) and the activity of 2',3'-cyclic nucleotide phosphohydrolase(CNPase) were measured in oligodendrocytes. Among the cytokines used, only interleukin-$1{\beta}(IL-1{\beta})$ stimulated the growth of type 1 and type 2 astrocyte as well as 0-2A precursor cell. When the functional changes in these glial cells by cytokines were tested, $IL-1{\beta}$ did not increase GFAP content in type 1 and type 2 astrocyte, but $IL-1{\beta}$ increased GS activity in type 1 astrocyte, and slightly decreased this enzyme activity in type 2 astrocyte. Also interleukin-2(IL-2) and $interferon-{\gamma}$ $(IFN-{\gamma})$ inhibited the activity of GS in type 1 and type 2 astrocyte. On the other hand, all cytokines used did not modify the growth and differentiation in oligodendrocytes. From these results we could suggest that $IL-1{\beta}$ increases the growth of type 1 and type 2 astrocyte and also promotes the development for 0-2A precursor cell to type 2 astrocyte.

• Biomedical Science Letters
• /
• v.16 no.2
• /
• pp.75-82
• /
• 2010

The molecular epidemiological characteristics of methicillin-resistant Staphylococcus aureus (MRSA) isolates have demonstrated their genetic diversity and evolution. A total of 137 strains of MRSA clinical isolates was collected from Korean healthcare facility in 2007. The MRSA clinical isolates were analyzed by molecular typings (SCCmec element and agr locus typing), virule nce factor gene detections {(Panton-Valentine leukocidin (PVL), enterotoxin, exfoliative toxin and toxic shock syndrome toxin-1), and amplified fragment length polymorphism (AFLP)}. The MRSA clinical isolates were classified as SCCmec type II-agr type 1 (2 strains), type II-agr type 2 (79 strains), type III-agr type 1 (24 strains), type III-agr type 2 (2 strains), type IV-agr type 1 (27 strains), type IV-agr type 2 (2 strains), and non-typable (1 strain, agr type 3). Based on SCCmec types, SCCmec type II (95.1%) and III (88.5%) indicated higher multidrug resistance rate than SCCmec type IV (10.3%) (P<0.001). The most common enterotoxin genes were seg (83.8%), sei (83.1%), and sec (80.2%). The tst gene was present in 86 out of 137 (62.8%) MRSA isolates. All MRSA isolates were negative for PVL and exfoliative toxin genes. The combinations of toxin genes were observed in particular SCCmec types; 97.6% of SCCmec type II strains carried sec, seg, sei and tst genes, 73.0% of SCCmec type III strains carried sea gene, and 89.7% of SCCmec type IV strains carried sec, seg and sei genes. Each of the SCCmec types of MRSA isolates had distinct AFLP profile. In conclusion, SCCmec type II, agr type 1 and 2 have demonstrated to be the most common types in Korea, and the results indicated that the virulence factors are closely associated with their molecular types (SCCmec and agr types).

• Korean Journal of Child Studies
• /
• v.1
• /
• pp.28-39
• /
• 1980

I. OBJECTIVES The aim of this study lies in examining following items: 1. Difference in creativity between boys and girls 2. Inter correlation of the sub-variables of creativity 3. Correlation between parent-child relationship and creativity 4. The relationship between creativity and number of siblings 5. Creativity and birth-order II. METHODS & PROCED URES 1. Instruments: Standardized Creativity Test and Parent-Child Relationship Test for children 2. Objects: 118 boys and 97 girls enrolled in primary schools in Seoul who were selected by random sampling 3. Procedure: (1) The data of the boy group and the girl group were analized by means of M,t, SD. (2)The relationships between creativity and the number of siblings as well as the relationship between creativity and birth order were analyzed by M. (3) Inter-correlations among the sub-factors of creativity were obtained in boys and girls. (4) Complex-correlations between creativity and parent child relationship were produced. III. RESULTS 1. There were no significant differences between boy and girl in creativity. 2. Inter correlation among the sub-factors of creativity Boy: The highest scores were obtained in fluidity, and adaptability, the lowest in originality and openness. Girl: The highest score were obtained in world scribbling and fluidity, the comparatively low were in originality and a match-problem. 3. Inter-correlation between creativity and parent-child relationship a. Father-son: The positive refusal type has the most significant relation and conflict type, discrepancy type, negative type in turn have significant inter-coorelations. b. Mother-son: Discrepancy type, conflict type, positive refusal type have high correlations, while negative refusal type, anticipation type, and anxiety show significance in 5% level. c. Father-daughter: Positive refusal type shows correlation of 5% level significance, while indulgence type shows negative correlation in 1% level significance. d. Mother-daughter: Discrepancy type shows 5% level significance, while indulgence type shows negative correlation in 1% level. 4. Concerning the number of siblings, it was found that, boys and girls alike, those grown among 3 or 5 showed most creativity. 5. Concerning the birth order, it was found that, boys and girls alike, the first child showed the most creativity, and the youngest showed the next to the most, while the middle showed the least creativity.

• Child Health Nursing Research
• /
• v.25 no.4
• /
• pp.449-457
• /
• 2019

Purpose: The purpose of this study was to identify predictors of eating disorders in adolescents with type 1 diabetes, with the goal of providing data in support of nursing interventions to improve their health. Methods: A total of 136 adolescents aged 13-18 years with type 1 diabetes completed the Diabetes Eating Problem Survey-Revised, Rosenberg Self-Esteem Scale, and the Beck Depression Inventory-II, using structured self-reported questionnaires. The collected data were analyzed using the t-test, $x^2$ test, and binominal logistic regression with SPSS version 23.0 for Windows. Results: The prevalence of eating disorders in adolescents with type 1 diabetes was 39%. Four significant predictors of eating disorders were identified; absence of body satisfaction (odds ratio [OR]=3.87, 95% confidence interval [CI]=1.55~9.65), depression (OR=2.87, 95% CI=1.13~7.28), female gender (OR=2.67, 95% CI=1.09~6.54), and glycosylated hemoglobin type A1c levels (OR=1.47, 95% CI=1.10~1.97). Conclusion: In order to prevent eating disorders among adolescents with type 1 diabetes, programs for managing adolescents' depression and improving their body satisfaction should be developed. Futhermore, more attention should be directed towards programs aiming to prevent eating disorders in female adolescents.

• Journal of Korean Foot and Ankle Society
• /
• v.14 no.1
• /
• pp.66-72
• /
• 2010

Purpose: To evaluate the clinical efficacy of the minimally invasive posterior approach for the surgical treatment of intraarticular fracture of calcaneus. Materials and Methods: From March 2006 to October 2008, we studied retrospectively 45 patients, 56 cases who were treated with minimally invasive reduction and pin fixation treatment for displaced intraarticular calcaneal fracture and were followed up for more than 1 year. The clinical results were evaluated with Creighton-Nebraska score and AOFAS score, circle draw test after 1 year. We checked simple AP, lateral, axial and Broden's view preoperatively and 1 year after surgery, and compared Bohler angle and Gissane angle. Results: By Creighton-Nebraska score, Sanders type 1 was 81, type 2 was 75, type 3 was 69, type 4 was 61. By AOFAS score, Sanders type 1 was 88, type 2 was 82, type 3 was 78, type 4 was 63. And by circle draw test, type 1 was 8.8 cm, type 2 was 8.5 cm, type 3 was 8 cm, type 4 was 6.6 cm. Preoperative Bohler angle and Gissane angle were $7.2^{\circ}$, $98^{\circ}$, and it increased to $21.2^{\circ}$, $116^{\circ}$ after postoperative 1 year. Conclusion: Minimally invasive reduction and pin fixation treatment for displaced intraarticular calcaneal fracture was considered to be an effective treatment modality.

• Journal of radiological science and technology
• /
• v.42 no.6
• /
• pp.429-434
• /
• 2019

The gonads are directly affected by radiation exposure during radiography of the pelvis, abdomen, and spine. Exposure of the gonads to radiation can cause genetic mutations and can result in the occurrence of malignant tumors. In this study, we created three types of shielding material shapes for shielding of the ovaries, which are the gonads of female during radiography of the pelvis, and comparative evaluations using shadow shielding methods. The source surface distance(SSD) was 100 cm and the field size was 42 cm × 43 cm. The three types of shielding material shapes(type 1, 2 and 3) were assessed and the entrance surface dose in the ovaries were measured. The thickness of the shielding material was expanded from 0.3 mm to 2.4 mm and after five repetitions, radiation values were measured and mean values were calculated. The mean dose were 3.09 mGy for type 1, 3.54 mGy for type 2, and 3.19 mGy for type 3, indicating that the measurements were the lowest for type 1. When an additional filter of 0.2 Cu + 1 Al was used, the dose were 3.72 mGy for type 1, 5.43 mGy for type 2, and 4.05 mGy for type 3, indicating that the measurements were the lowest for type 1. The results show that, even if the shielding material is not thick, in other words, even with a thickness of 2.94 mGy for the SN 3(0.9 mm) of type 1, shielding can be achieved, with a patient dose lower than the diagnostic reference level(3.42 mGy). Additionally, among the three types of shielding material, the type 1 appeared to be the most appropriate shielding material. It is thought that the use of shielding material could reduce the risk factors for stochastic effects or critical effects of ionizing radiation during pelvic or lumbar radiography.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.21 no.3
• /
• pp.200-206
• /
• 2008

Objectives : This study was planned to find the character type of enneagram in patients with Bell's palsy. Methods : Author gave the 26 patients with Bell's palsy the Korean Enneagram Personality Type Indicator(KEPTI). After making out the questionnaire, we got back them. Then author graded questionnaire papers, and classified according to characte type. We finded that type 1 and type 9 show a higher ratio than any other charicter type. Results : The cause of Bell's palsy onset were over work 34.5%, stress 23.1%, over work and stress 19.2%, cold exposure 7.7%, dental treatment 3.8% pregnancy 3.8%, unknown 7.7%. We finded that type 1 and type 9 show higher ratio than any other charicter type. Conclusion : To find the interrelation between the character type of enneagram and Bell's palsy, further reseach is needed continuosly.

• Proceedings of the KIEE Conference
• /
• 2008.04a
• /
• pp.155-156
• /
• 2008

In this paper, an interval type-2 fuzzy logic system is designed and compared with a type-1 fuzzy logic system. To compare performance of a type-1 fuzzy logic system with the type-2 fuzzy logic system, we apply type-1 fuzzy logic system and type-2 system to modeling the noised data. Membership function of interval type-2 fuzzy logic system is designed consequents of rules including uncertainty. For general type-2 fuzzy logic system computational complexity is severe. On the other hand, theoretic and arithmetic computations for interval type-2 fuzzy logic systems are very simple.

• Bulletin of the Korean Mathematical Society
• /
• v.38 no.4
• /
• pp.753-761
• /
• 2001

We introduce the notion of Gauss map of pointwise 1-type on ruled surfaces in the Euclidean 3-space for which vector valued functions is neither trivial nor it extends or coincides with the usual notion of 1-type, in general. We characterize the minimal helicoid in terms of it and give a complete classification of the ruled surfaces with pointwise 1-type Gauss map.

• The Pure and Applied Mathematics
• /
• v.18 no.4
• /
• pp.369-377
• /
• 2011

In this article, we study generalized slant cylindrical surfaces (GSCS's) with pointwise 1-type Gauss map of the first and second kinds. Our main results state that GSCS's with pointwise 1-type Gauss map of the first kind coincide with surfaces of revolution with constant mean curvature; and the right cones are the only polynomial kind GSCS's with pointwise 1-type Gauss map of the second kind.