• Title/Summary/Keyword: Two-wavelength Raman scattering

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Non-Invasive HbA1c Measurement Using Two-Wavelength Raman Scattering (2 파장 라만 산란을 이용한 비침습적 HbA1c 측정)

  • Yang, Jooran;Kim, Hyungpyo
    • Journal of Sensor Science and Technology
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    • v.28 no.5
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    • pp.305-310
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    • 2019
  • The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

Development of a Raman Lidar System Using the Photon-counting Method to Measure Carbon Dioxide (이산화탄소 원격 계측을 위한 광 계수 방식의 라만 라이다 장치 개발)

  • Sun Ho Park;In Young Choi;Moon Sang Yoon
    • Korean Journal of Optics and Photonics
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    • v.35 no.2
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    • pp.71-80
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    • 2024
  • We developed a Raman lidar system for remote measurement of carbon dioxide present in atmospheric space. An air-cooled laser with 355-nm wavelength and a 6-inch optical receiver was used to miniaturize the Raman lidar system, and a scanning Raman lidar system was developed using a two-axis scanning device and a photon counter. To verify the performance of the developed Raman lidar system, a gas chamber capable of maintaining a concentration was located at a distance of about 87 m, and the change in Raman signal according to the change in the concentration of carbon dioxide was measured. As a result, it was confirmed that the change in the Raman scattering signal of carbon dioxide that appeared for a change in carbon dioxide concentration from about 0.67 to 40 vol% was linear, and the coefficient of determination (R2) value, which indicates the correlation between the carbon dioxide concentration and Raman scattering signal, showed a high linearity of 0.9999.

Broad Wings around Hα and Hβ in the S-type Symbiotic Stars

  • Chang, Seok-Jun;Lee, Hee-Won;Lee, Ho-Gyu
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.86.4-87
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    • 2017
  • Symbiotic stars are binary systems composed of a hot white dwarf and a mass losing giant. Many symbiotic stars are known to exhibit broad wings around Balmer emission line. We show high resolution spectra of S-type symbiotic stars, Z Andromedae and AG Draconis, obtained with the ESPaDOnS and the 3.6 m Canada-France-Hawaii Telescope, in which we find prominent broad wings around Balmer lines. We adopt Monte-Carlo technique to consider two types of wing formation mechanisms, which are Thomson scattering by free electron in H II region and Raman scattering by atomic hydrogen in H I region. We find that Thomson wings of $H{\alpha}$ and $H{\beta}$ have the same widths in the Doppler space due to the cross section independent of wavelength. In contrast, Raman $H{\alpha}$ wings are 3 times broader widths than $H{\beta}$ counterparts, which is attributed to the different cross sections and branching ratios. Our CFHT data show that $H{\alpha}$ wings of Z Andromedae and AG Draconis are broader than $H{\beta}$ wings, lending strong support to the Raman scattering origin of Balmer wings in these objects.

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Wideband Hybrid Fiber Amplifier Using Er-Doped Fiber and Raman Medium

  • Seo, Hong-Seok;Ahn, Joon-Tae;Park, Bong-Je;Chung, Woon-Jin
    • ETRI Journal
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    • v.29 no.6
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    • pp.779-784
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    • 2007
  • In this paper, we report the experimental results of a hybrid wideband fiber amplifier. The amplifying medium is a concatenated hybrid fiber consisting of Er-doped fiber (EDF) and dispersion compensating fiber (DCF). The gain mechanisms are based on stimulated emission in the EDF and stimulated Raman scattering (SRS) in the DCF. Since we simultaneously use optical amplification by the two processes, the gain bandwidth is easily expanded over 105 nm by a two-tone pumping scheme. Using an experimental setup constructed with a hybrid structure of EDF-DCF-EDF, we analyzed the spectral behavior of amplified spontaneous emission for pumping powers. We achieved an optical gain of over 20 dB in the wavelength range from 1,500 to 1,600 nm under optimized pumping conditions to make the spectral gain shape flat.

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Selecting Characteristic Raman Wavelengths to Distinguish Liquid Water, Water Vapor, and Ice Water

  • Park, Sun-Ho;Kim, Yong-Gi;Kim, Duk-Hyeon;Cheong, Hai-Du;Choi, Won-Seok;Lee, Ji-In
    • Journal of the Optical Society of Korea
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    • v.14 no.3
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    • pp.209-214
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    • 2010
  • The Raman shift of water vapor is 3657 $cm^{-1}$, and this Raman signal can be easily separated from other Raman signals or elastic signals. However, it is difficult to make simultaneous Raman measurements on the three phases of water, namely, ice water, liquid water, and water vapor. This is because we must consider the overlap between their Raman spectra. Therefore, very few groups have attempted to make Raman simultaneous measurements even on two elements (water vapor and liquid water, or water vapor and ice water). We have made an effort to find three characteristic Raman wavelengths that correspond to the three phases of water after measuring full Raman spectra of water on particular days that are rainy, snowy or clear. Finally, we have found that the 401-nm, 404-nm, and 408-nm wavelengths are the most characteristic Raman wavelengths that are representative of the water phases when we are using the 355-nm laser wavelength for making measurements.

Calculation of Multiple Scattering in Water Cloud and Application in Remote Measurement of Cloud Physical Properties (구름에서의 다중산란효과 계산 및 이를 이용한 구름 물리변수 원격 추출 방법 연구)

  • Kim, Dukhyeon;Park, Sunho;Choi, Sungcheol
    • Korean Journal of Optics and Photonics
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    • v.25 no.1
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    • pp.1-7
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    • 2014
  • Multiple scattering effects in cloud are important error sources of the Mie scattering Lidar inversion method, which should be measured to correct the Lidar equation in single wavelength Mie Lidar. We have calculated the multiple scattering effects in liquid water clouds by using a Monte Carlo method, and we have applied these multiple scattering effects in measuring water cloud effective size and LWC (Liquid Water Content). When cloud effective size is less than $2.5{\mu}m$, we can easily extract cloud effective size and LWC by using two wavelength Lidar such as extinction coefficients measured at 355nm and 1064nm. For a larger size cloud, we can find that saturated degree of linear polarization is strongly correlated with cloud effective size, LWC, and extinction coefficients. From these correlations we know that we can measure LWC and cloud effective size if we use single wavelength Rotational Raman Lidar and Mie scattering polarization Lidar.

The Study of Two-dimensional Chemical Distribution about Soil using Laser Spectroscopy (레이저 분광법을 활용한 토양 2차원 화학적 분포도 검출 연구)

  • Yang, Jun-Ho;Yoh, Jai-Ick
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.45 no.6
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    • pp.523-530
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    • 2017
  • Laser-Induced Breakdown Spectroscopy (LIBS) which a plasma is irradiated at a specific wavelength depending on the material when a high-energy laser is irradiated, and a Raman spectroscopy which measures rotation and vibration in molecules as light-scattering phenomenon occurs, are attracting attention as a space exploration technology because of the advantages of high accuracy and real-time analysis, and the ability to perform long-range detection. In this study, the tendency of the laser spectrum according to the change of the soil component was analyzed by laser spectroscopy and the two - dimensional chemical distribution was conducted based on the trend of laser spectrum. We have also established the environment of Mars (4-7 torr) and lunar atmosphere (<1 torr) in experimental setup, to prove that it is possible to measure by difference of soil chemical composition using LIBS and Raman spectroscopy even in artificial space environment.

Analysis of Xe Plasma by LAS (레이저 흡수법을 이용한 제논 플라즈마 분석)

  • Yang, Jong-Kyung;Her, In-Sung;Lee, Jong-Chan;Choi, Yong-Sung;Park, Dae-Hee
    • Proceedings of the KIEE Conference
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    • 2005.11a
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    • pp.220-222
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    • 2005
  • We can classify two cases in a way to observe an atom of gas state or a molecule using the laser. First case is way to use dispersion phenomenon like Rayleigh scattering, Thomson scattering, Mie scattering, Raman Scattering. And Second case is a way to use change phenomenon like a LAS (Laser Absorption Spectroscopy), LIF (Laser Induced Fluorescent). In this paper, we have measured the meta-stable density and the distribution by using a LAS method in Xe discharge lamp. The laser absorption spectroscopy (LAS) is useful to investigate the behavior of such species. The xenon atoms in the $1S_4$ and $1S_5$ generate excited $Xe^*$(147nm) and $Xe_{2}^*$(173nm) dimers in Xe plasma. It is found that the intensity of VUV 147nm emission is proportional to that of the IR 828nm emission, and the VUV 173nm emission is roughly proportional to that of the IR 823nm emission. The laser is used CW laser that consist of AlGaAs semiconductor and energy level is used 823.16nm wavelength. We measured signal of monochrometer from the lamp center while will change a discharge electric current by 6mA in 3mA and calculated meta-stable state density of a xenon atom through a measured value.

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Multimodal Nonlinear Optical Microscopy for Simultaneous 3-D Label-Free and Immunofluorescence Imaging of Biological Samples

  • Park, Joo Hyun;Lee, Eun-Soo;Lee, Jae Yong;Lee, Eun Seong;Lee, Tae Geol;Kim, Se-Hwa;Lee, Sang-Won
    • Journal of the Optical Society of Korea
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    • v.18 no.5
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    • pp.551-557
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    • 2014
  • In this study, we demonstrated multimodal nonlinear optical (NLO) microscopy integrated simultaneously with two-photon excitation fluorescence (TPEF), second-harmonic generation (SHG), and coherent anti-Stokes Raman scattering (CARS) in order to obtain targeted cellular and label-free images in an immunofluorescence assay of the atherosclerotic aorta from apolipoprotein E-deficient mice. The multimodal NLO microscope used two laser systems: picosecond (ps) and femtosecond (fs) pulsed lasers. A pair of ps-pulsed lights served for CARS (817 nm and 1064 nm) and SHG (817 nm) images; light from the fs-pulsed laser with the center wavelength of 720 nm was incident into the sample to obtain autofluorescence and targeted molecular TPEF images for high efficiency of fluorescence intensity without cross-talk. For multicolor-targeted TPEF imaging, we stained smooth-muscle cells and macrophages with fluorescent dyes (Alexa Fluor 350 and Alexa Fluor 594) for an immunofluorescence assay. Each depth-sectioned image consisted of $512{\times}512$ pixels with a field of view of $250{\times}250{\mu}m^2$, a lateral resolution of $0.4{\mu}m$, and an axial resolution of $1.3{\mu}m$. We obtained composite multicolor images with conventional label-free NLO images and targeted TPEF images in atherosclerotic-plaque samples. Multicolor 3-D imaging of atherosclerotic-plaque structural and functional composition will be helpful for understanding the pathogenesis of cardiovascular disease.