• Title/Summary/Keyword: Triple-well

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A Study on the Grain Size Dependence of Hardness in Nanocrystalline Metals (나노결정금속의 경도의 결정립도의존성에 관한 연구)

  • 김형섭;조성식;원창환
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 1997.03a
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    • pp.73-76
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    • 1997
  • Nanocrystalline materials have been modeled as a mixture of the crystallite and the grain boundary phases. The mechanical property has been calculated using the rule of mixtures based on the volume fractions. The critical grain size concept suggested by Nieh and Wadsworth and porous material model suggested by Lee and Kim were applied to the calculation. The theoretical results fit very well with the experimental values

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The Theory of Significant Structure of Liquids : A New Method of Fixing Parameters (액체의 구조에 관하여 -새로운 Parameter 결정법-)

  • Hyungsuk Park;Seihun Chang
    • Journal of the Korean Chemical Society
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    • v.7 no.2
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    • pp.174-178
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    • 1963
  • The new method to determine the parameters in the liquid partition function of H. Eyring and co-workers is proposed, in which method the equilibrium condition of the three phases and the boundary condition of the liquid partition function at the triple point are used. The calculated thermodynamic properties using the new determined parameters are agreed well with the observed values.

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Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells

  • Shin, Miyoung;Yang, Eun Gyeong;Song, Hyun Kyu;Jeon, Hyesung
    • BMB Reports
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    • v.48 no.6
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    • pp.342-347
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    • 2015
  • The expression of epidermal growth factor receptor (EGFR) is an important diagnostic marker for triple-negative breast cancer (TNBC) cells, which lack three hormonal receptors: estrogen and progesterone receptors as well as epidermal growth factor receptor 2. EGFR transactivation can cause drug resistance in many cancers including TNBC, but the mechanism underlying this phenomenon is poorly defined. Here, we demonstrate that insulin treatment induces EGFR activation by stimulating the interaction of EGFR with insulin-like growth factor receptor 1 (IGF-1R) in the MDA-MB-436 TNBC cell line. These cells express low levels of EGFR, while exhibiting high levels of IGF-1R expression and phosphorylation. Low-EGFRexpressing MDA-MB-436 cells show high sensitivity to insulinstimulated cell growth. Therefore, unexpectedly, insulin stimulation induced EGFR transactivation by regulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells. [BMB Reports 2015; 48(6): 342-347]

Behavior of the Edge Flame on Flame Extinction in Buoyancy minimized Methane-Air Non-premixed Counter Triple Co-flow Flames (부력을 최소화한 대향류 삼축 메탄-공기 비예혼합 화염 소화에서 에지화염의 거동)

  • Park, Jin Wook;Park, Jeong;Yun, Jin-Han;Keel, Sang-In
    • 한국연소학회:학술대회논문집
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    • 2014.11a
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    • pp.81-84
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    • 2014
  • A Experimental study on flame extinction behavior was investigated using He curtain flow with counter triple co-flow burner. Buoyancy force was suppressed up to a microgravity level of $10^{-2}-10^{-3}g$ by using He curtain flow. The stability maps were provided with a functional dependency of diluent mole fraction and global strain rate to clarify the differences in flame extinction behavior. The flame extinction curves had C-shapes at various global strain rates. The oscillation and extinction modes were different each other in terms of the global strain rate, and the flames extinction modes could be classified into five modes such as (I) and (II): an extinction through the shrinkage of the outmost edge flame forward the flame center after self-excitation and without self-excitation, respectively, (III): an extinction through rapid advancement of a flame hole while the outmost edge flame is stationary, (IV): self-excitation occurs in the outermost edge flame and the center edge flame and then a donut shaped flame is formed and/or the flame is entirely extinguished, (V): shrinkage of the outermost edge flame without self-excitation followed by shrinkage or survival of the center flame. These oscillation and extinction modes could be identified well to the behavior of edge flame. The result also showed that the edge flame was influenced significantly by the conductive heat losses to the flame center or ambient He curtain flow.

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Acceleration of Simulated Fault Injection Using a Checkpoint Forwarding Technique

  • Na, Jongwhoa;Lee, Dongwoo
    • ETRI Journal
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    • v.39 no.4
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    • pp.605-613
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    • 2017
  • Simulated fault injection (SFI) is widely used to assess the effectiveness of fault tolerance mechanisms in safety-critical embedded systems (SCESs) because of its advantages such as controllability and observability. However, the long test time of SFI due to the large number of test cases and the complex simulation models of modern SCESs has been identified as a limiting factor. We present a method that can accelerate an SFI tool using a checkpoint forwarding (CF) technique. To evaluate the performance of CF-based SFI (CF-SFI), we have developed a CF mechanism using Verilog fault-injection tools and two systems under test (SUT): a single-core-based co-simulation model and a triple modular redundant co-simulation model. Both systems use the Verilog simulation model of the OpenRISC 1200 processor and can execute the embedded benchmarks from MiBench. We investigate the effectiveness of the CF mechanism and evaluate the two SUTs by measuring the test time as well as the failure rates. Compared to the SFI with no CF mechanism, the proposed CF-SFI approach reduces the test time of the two SUTs by 29%-45%.

Heteronuclear NMR studies on 44 kDa dimer, syndesmos

  • Kim, Heeyoun;Lee, Inhwan;Han, Jeongmin;Cheong, Hae-kap;Kim, Eunhee;Lee, Weontae
    • Journal of the Korean Magnetic Resonance Society
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    • v.19 no.2
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    • pp.83-87
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    • 2015
  • Syndesmos, which is co-localized with syndecan-4 cytoplasmic domain ($Syn4^{cyto}$) in focal contacts, interacts with various cell adhesion adaptor proteins including $Syn4^{cyto}$ to control cell signaling. Syndesmos consists of 211 amino acids and it exists as a dimer (44kDa) in solution. Recently, we have determined the structure of syndesmos by x-ray crystallography, however, dynamics related to syndecan binding still remain elusive. In this report, we performed NMR experiments to acquire biochemical and structural information of syndesmos. Based on a series of three-dimensional triple resonance experiments on a $^{13}C/^{15}N/^2H$ labeled protein, NMR spectra were obtained with well dispersed and homogeneous NMR data. We present the sequence specific backbone assignment of syndesmos and assigned NMR data with combination structural information can be directly used for the studies on interaction with $Syn4^{cyto}$ and other binding molecules.

A Frequency Adjustable Double Lorentz CRLH Transmission Line using DGS (DGS를 이용한 주파수 가변 DL-CRLH 전송선로)

  • Lim, Jong-Sik;Lee, Jae-Hoon;Lee, Jun;Jeong, Yong-Chae;Han, Sang-Min;Ahn, Dal
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.59 no.8
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    • pp.1429-1435
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    • 2010
  • In this paper, a double lorentz composite right left handed(DL-CRLH) transmission line is designed using defected ground structure (DGS) and varactor diodes. Previously, the diode has been adopted only selectively for one of parallel or series resonators, and the balanced frequency as well as triple band frequencies were fixed. However in the proposed DL-CRLH transmission line, the balanced frequency, where the resonant frequencies of the series-connected parallel resonator and shunt-connected series resonator are the same, is adjustable. In addition, the triple band frequencies are controlled, too. The measured balanced frequency varies between 3.42~4.8GHz according to the controlled bias voltage. Under the same bias condition for the balanced frequency, the adjusted frequencies are 2.22~2.77GHz, 3.7~5.2GHz, 7.32~8.23GHz, 3.42~4.8GHz, and 4.44~5.92GHz for the conditions that ${\beta}d=+0.5{\pi}$, $-0.5{\pi}$, 2nd $+0.5{\pi}$, ${\omega}_{\infty}$, and ${\omega}_o$, respectively.

Mass Fragmentation Patterns as Fingerprints for Positive Identification of Polyphenolic Compounds in a Crude Extract

  • Manshoor, Nurhuda;Weber, Jean-Frederic F.
    • Mass Spectrometry Letters
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    • v.6 no.4
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    • pp.105-111
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    • 2015
  • Sixteen compounds of Neobalanocarpus heimii were successfully identified directly from their plant extract using a triple quadrupole LC-MS/MS system. In order to fulfil the objectives of this work, a series of stilbene oligomers of various degrees of condensation were isolated and their structure are characterized. Out of these, four are resveratrol dimers, three trimers, and nine tetramers. The isolation process was done on a fully automated semi-preparative HPLC system. Their structures were elucidated on the basis of 1D- and 2D-NMR as well as MS data. The mass fragmentation patterns of the compounds were recorded and a retrievable in-house library was built to keep the data. In order to demonstrate the potential of this approach, the polyphenolic crude extract was analysed with the LC-MS/MS system and the MS/MS spectra extracted for each chromatographic peak of interest. The fragmentation patterns were compared with those of anticipated pure compounds that were previously recorded. All compounds were successfully identified. It is therefore believed that the LC-MS/MS potential for dereplication of structurally similar compounds in a crude mixture was thus firmly established.

An Experimental Study of Turbulent Uniform Shear Flow in a Nearly Two-Dimensional $90^{\circ}$ Curved Duct (II) - Turbulent Flow Field- (2차원 $90^{\circ}$ 곡관에서 균일전단류의 특성에 대한 실험적 연구 (2) -난류유동장-)

  • 임효재;성형진;정명균
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.19 no.3
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    • pp.846-857
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    • 1995
  • An experimental study is made of turbulent shear flows in a nearly two-dimensional 90.deg. curved duct by using the hot-wire anemometer. The Reynolds normal and shear stresses, triple velocity products, integral length scales, Taylor micro length scales and dissipation length scales are measured and analyzed. For a positive shear at the inlet, the afore-mentioned turbulence quantities are all suppressed. However, when the inlet shear flow is negative, they are augmented, i.e., the convex curvature suppresses the turbulence whereas the concave curvature augments it. It is found that the curvature effects are rather sensitive to the triple velocity products than the Reynolds stresses. The evolution of turbulence under the curvature with the different shear conditions is well described by the modified curvature parameter S' and the non-dimensional development time ${\tau}$.'