• Journal of Acupuncture Research
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• v.31 no.1
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• pp.7-21
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• 2014

Objectives : To observe the regenerative effects of indirect moxibustion, a traditional Korean medical treatment on skeletal muscles using mouse model of skeletal muscle adiposity. Methods : Twenty seven ICR male mice were randomly assigned into Intact control(n=3), glycerol treatment together without moxibustion(n=12), and glycerol treatment together with moxibustion (n=12) groups. Mice of glycerol treatment groups were injected with 50 ${\mu}l$ DW(distilled water) containing 50 % of glycerol into the two tibialis anterior. After injection, moxibustion was applied at 'Shenshu'($BL_{23}$) and 'Zusanli'($ST_{36}$) acupoints three times per each session, every days for twelve days(total 12 treatments). Phospho-Erk1/2, Myostatin protein levels were analyzed by western blotting and immunofluo-rescence staining techniques for tissues of the tibialis anterior muscle. Smad, phospho-Smad were analyzed by immunofluorescence staining. Results : 1. Histological analysis of sections from injected TA muscles showed that glycerol induced rapidly muscle necrosis, with a maximum at day 3. 6 days and 9 days after injection, muscle was regenerating. 2. According to western blotting and immunofluorescence staining, phospho-Erk1/2 protein signals in glycerol treatment with moxibustion group were stronger compared to Intact and glycerol treatment without moxibustion group. 3. According to western blotting and immunofluorescence staining, myostatin protein signals in glycerol treatment without moxibustion group were stronger compared to Intact and glycerol treatment with moxibustion group. 4. According to immunofluorescence staining, Smad protein signals in glycerol treatment without moxibustion group were stronger compared to Intact and glycerol treatment with moxibustion group. 5. According to immunofluorescence staining, phospho-Smad protein signals in glycerol treatment without moxibustion group were stronger compared to Intact and glycerol treatment with moxibustion group. Conclusions : These results confirm that indirect moxibustion of 'Shenshu'($BL_{23}$) and 'Zusanli'($ST_{36}$) influences muscle regeneration in mouse models of skeletal muscle adiposity. Further discussion, and the establishment of moxibustion mechanism will prompt clinical application of moxibustion.

• Journal of Pharmacopuncture
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• v.16 no.4
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• pp.14-21
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• 2013

Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-Persica$^{(R)}$) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the treatment group after treatment compared with that before treatment and with that in the control group after treatment was statistically different (P < 0.05). The post-prandial glucose in the treatment group after treatment was significantly different from that before treatment and from that in the control group after treatment (P < 0.05); the post-prandial blood sugar in the treatment group was reduced by 8.98%. Conclusions: The results revealed that the botanical compound (Glyco-Persica$^{(R)}$) has significant hypoglycemic properties which affect main clinical symptoms in diabetes type 2. Body weight, blood pressure, heart rate, routine blood, stool and urine tests showed no meaningful negative changes after the course of treatment. There was no significant adverse reaction during the trial.

• The Journal of Korean Society for School & Community Health Education
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• v.1 no.1
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• pp.1-9
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• 2000

The purpose of this study were to assess the effect on health promotion behavior of health instruction in elementary school and to provide a basis of school health education. Subjects of this study were random sampled 80 students for control group in elementary 6th grade students. the treatment group systematically studied five sphere instruction: individual hygiene, disease prevention, first-aid & safety, oral health, health & nutrition in two hours a week, from April 20, till July 10. Each group was pre-tested and post-tested by health behavior promotion questionnaire. The conclusions as follows; 1. Compare analysis of control group and treatment group in the pre-test according to health condition of children were no significant difference physical health condition, health anxiety, disease-absent(P>.05). 2. Health promotion behaviors in the post-test according to concern quotient significantly correlated with individual hygiene(r=.249, P<.05), disease prevention(r=.477, P<.01), oral health(r=.228, P<.05), health & nutrition(r=.323, P<.01) in the treatment group, on the contrary the disease prevention, first-aid & safety, oral health, health & nutrition(P>.05). 3. The difference of health promotion behavior within & between group were as follow; 1) The difference of individual health hygiene with in the treatment group was significant in pre-post test, the comparison of the two groups was significant difference in post-test(treatment group: $3.965{\pm}.568$, control group: $3.645{\pm}.573$). 2) The difference of disease prevention with in the treatment group was significant in pre-post test, the comparison of the two groups was significant difference in post-test(t group : $3.475{\pm}.619$, c group: $3.964{\pm}.600$). 3) The difference of first-aid & safety with in the treatment group was significant in pre-post test, the comparison of the two groups was significant difference in post-test(t group : $3.700{\pm}.466$, c group: $4.140{\pm}.545$). 4) The difference of oral health with in the treatment group was significant in pre-post test, the comparison of the two groups was significant difference in post-test(t group: $3.163{\pm}.665$, c group: $3.753{\pm}.544$). 5) The difference of health & nutrition with in the treatment group was significant in pre-post test, the comparison of the two groups was significant difference in post-test(t group : $3.255{\pm}.515$, c group: $3.698{\pm}.558$).

• Journal of Preventive Medicine and Public Health
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• v.21 no.1 s.23
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• pp.47-60
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• 1988

The monthly ambulatory treatment days in newly detected hypertension group and known hypertension group were analyzed. The population was identified through the records of screening examination given by Korea Medical Insurance Corporation during the period from April to July, 1986. From the records of screening examination, 11,614 hypertensive patients were identified. By random sampling,959 patients were selected : among them, 544 fell under the category of known hypertension group and the other 415 fell under the newly detected hypertension group. The monthly ambulatory treatment days of these patients during the period from the April, 1985 to September, 1987 were analyzed in order to compare the exents of medical care utilization as well as to define and analyze the determinants responsible for the ambulatory treatment days between the two groups. The following results were obtained. 1) In the known hypertension group, no statistically significant changes in the ambulatory treatment days was observed after, in comparision to before, the screening examination. However, in the newly detected hypertension group the medical care utilization increased after the screening examination because of hypertension. 2) The ambulatory treatment days for hypertension of the known hypertension was statistically significant and higher than that of the newly detected hypertension group after screening examination. 3) There was no statistically significant change in the ambulatory treatment days in association with diseases other than hypertension in either group before and after the screening examination. 4) There was no statistically significant variable responsible for ambulatory treatment days in the known hypertension group. However, the income was a statistically significant variable in the newly detected hypertension group. 5) After the screening examination, the variables determining the ambulatory treatment days were the age of the patient and the diastolic blood pressure in the known hypertension group. These variables responsible for 2.02% of the total ambulatory treatment days. In the newly detected hypertension group, the income was a statistically significant variable which was responsible for 2.10% of total ambulatory treatment days. The above results satisfied the hypothesis that there would be no significant changes in the ambulatory treatment days before and after the screening examination in the known hypertension group. Also the hypothesis that there would be no significant change in the exents of medical care utilization for the diseases other than hypertension before and after the screening examination in either group was satisfied Also the medical care utilization was significantly higher in the known hypertension group than the newly detected hypertension group after the screening examination. This finding satisfied the hypothesis. This study was limited by the lack of considering fully the variables reponsible for the clinical symptoms of hypertension as well as for the individual characteristics. Thus, the result of this study are not fully adequate to define the determinants responsible for the exents of medical care utilization. In the future studies on medical rare utilization, additional variables should be considered.

• Journal of Veterinary Clinics
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• v.22 no.2
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• pp.144-147
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• 2005

This study was performed to investigate that electro-acupuncture might relieve chronic back pain in horses. Twenty horses with chronic back pain were chosen from referring to College of Veterinary Medicine, University of Florida. They were assigned the patients referred to 2 treatment groups and 1 control group. The treatment group I was electrostimulated to 4 acupoints. The acupuncture points of Lumbosacral point, GV-6, BL26, and BL54 were used.; The treatment group II was taken the phenylbutazone orally. Control group was administered the normal saline per oral. Back pain score system was used to evaluate the degree of back pain. The treatment group r had significant lower back pain score from two times of electroacupuncture treatment. However, the treatment group II and control group did not change back, pain scores during experimental periods. Thus, Electroacupuncture treatment might be effective therapy for chronic back pain in horses.

• Journal of Acupuncture Research
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• v.29 no.3
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• pp.115-120
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• 2012

Objectives : This study was done for reporting the effect of acupuncture treatment on Ryodoraku score of the patients with chronic low back pain due to the kidney deficiency Methods : We investigated 37 cases of patients with chronic low back pain due to the kidney deficiency, and devided patients into two groups : We specially treated one group by acupuncture treatment, which was not applied to the other group we analyzed of each group the Ryodoraku score(F3) of each group before and after acupuncture treatment and compared it. Results : 1. In acupuncture treatment group compared with baseline, at final, Ryodoraku score(F3) was significantly increased. 2. At final, acupuncture treatment group showed significant increase on Ryodoraku score(F3) score compared with non acupuncture treatment group. Conclusions : It is suggested that Ryodoraku score(F3) should be available for diagnosing kidney deficiency-induced chronic low back pain as a promising diagnostic index and a outcome measurement.

• Journal of Korean Physical Therapy Science
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• v.4 no.2
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• pp.421-432
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• 1997

To find out the actual status of treatment of physically handicapped who were stayed of home, 320 physically handicapped persons were selected among total 6,264 physically handicapped registered in Taejon city, surveyed from January 1st to March 30, 1997. Following are the results ana lysed of collected data from 201 samped persons. 1. For the cause of physically handicapped, 36.3% was congenital, 26.9% was cerebralvascular acciednt(CVA). and 14.9% was infectious diseases and others in that orders. The must frequest cause of below 20 years age group was congenital cause, but that of $20{\sim}30$ years age group and $40{\sim}50$ years age group were accident and CVA repectively. 30.0% of respondents caused by infection and others earned household living expenses. Household living expenses were higher among the respondents caused by congenital cause but those were lowest in the accidental couse group. Handicap durations were longer in the accidental cause group and infections and others group than the congenital cause group and CVA group. 2. 54.7% of studied handicapped were under treatment. But 36.3% of them were stopped treatment, and 8.9 % of them answered not treated. Most handicapped, coused by congenital and CAV, were under treatment, but most of them caused by accidental and others were stopped treatment. 3. For the medical facilities, 54.5% of them utilized welfare facility, but 25.5% utilized general hospital and 20.0% of them utilized oriental medical hospital and health centers. Congenital cause group frequently selected welfare facility for the treatment facility. But accidental cause group frequently seleced general hospitals and CVA gruop frequently selected oriental medical hospital and others. The medical cost of welfare facility, oriental medical hospitals and others were lower than that of general hospitals. 4. The proportions of under treatment were higher among yonger age higher monthly living expenses group shorter handicapped duration groups, congenital cause group and handicap grade II group. But that of stop treatment were higher among congenital cause group, infectious and others cause group, and handicap grade I & then III group. 5. For the feelings satisfacion about medical treatment, only 35.3% of under treated group responed satisfation. 55.5% of them responded so-so, but 9.1 % responed dissatisfaction. The proportion of satisfaction was higher among shorter handicap duration group.

• The Journal of Korean Medicine
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• v.24 no.1
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• pp.41-53
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• 2003

The effect of Banhasasim-tang extracts on the hepatic, splenic and cardiac toxicity induced by doxorubicin administration (three injection protocol) were monitored using male ICR mice. Changes of body weight, clinical signs, necropsy findings and organ weights of liver, spleen and heart were observed with blood GOT and GPT levels. The results were as follows: 1. Decrease of body weight after doxorubicin treatment was dose-dependently inhibited by Banhasasim-tang extracts. 2. The degrees of anorexia, ataxia and dehydration that were observed in doxombicin treatment groups were dose-dependently inhibited by Banhasasim-rang extracts. 3. Increase of absolute and relative liver weight observed in the doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of liver congestion and necrotic spot were significantly and dose-dependently decreased in the Banhasasim-rang extracts dosing group compared to that of the doxorubicin-only treatment group. It is also demonstrated that elevated serum GOT and GPT levels in the doxorubicin treatment group were significantly decreased in the Banhasasim-rang extracts dosing group. 4. Decrease of absolute and relative spleen weight observed in doxorubicin treatment groups were dose-dependently inhibited by Banhasasim-rang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased in the Banhasasim-rang extracts dosing group compared to that of doxorubicin-only treatment group. 5. Increase of absolute and relative heart weight observed in doxorubicin treatment groups were dose-dependently inhibited by Banhasasim-rang extracts. In addition, the degrees of heart congestion and enlargement were significantly and dose-dependently decreased in the Banhasasim-rang extracts dosing group compared to that of the doxorubicin-only treatment group. In conclusion, the toxicity of doxorubicin treatment (decrease of body weight, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of liver, spleen and heart, elevation of serum GOT and GPT levels) was inhibited and/or prevented by Banhasasim-rang extracts. According to these results, it is considered that Banhasasim-rang has some preventive effect against the toxicity induced by doxorubicin.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.8 no.1
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• pp.87-96
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• 2013

Objectives : The purpose of this study is to investigate the effect of Chuna treatment for neck pain patients caused by traffic accident. Methods : 64 patients were divided into two groups, experimental group and control group, of 32 patients each. Control group was treated with general korean medical treatment three times per week for 2 weeks. Experimental group was treated with Chuna treatment and general korean medical treatment three times per week for 2 weeks. We evaluated the treatment effect of each group with the visual analog scale(VAS) and neck disability index(NDI). Results : 1. In both two groups, VAS were decreased significantly in statistics after treatment. 2. In both two groups, NDI were decreased significantly in statistics after treatment. 3. There were significant reduction of the VAS in experimental group than control group, but, there were not significant reduction of the NDI in experimental group than control group. Conclusions : We suggest that Chuna treatment could be recommended as a useful therapy to neck pain patients caused by traffic accident.

• Journal of Veterinary Clinics
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• v.19 no.1
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• pp.43-48
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• 2002

This study was performed to investigate the effects of recombinant BST formulation treatment on the milk yield, milk components, mastitis, and general cow health condition when the formulations of retinyl palmitate, cholecalciferol and rBST were administered after the peak period of milk production. The milk yields of treatment groups (Group I, II, III and IV) were increased from 21.5% to 29.0% than that of control group. There was significant difference in milk production between treatment group II, IV and control group (P<0.05). However, there was no significant difference in milk production between treatment group I, III and control group (P<0.05). And the addition of retinyl palmitate and cholecalciferol into rBST formulation did not increase the milk yield. The milk of treatment groups with sustained-release rBST did not show significant difference in milk components (milk fat, protein, lactose, and solid not fat). However, there were minor changes, primarily in fat content of milk, during the first few weeks of rBST administration. There was no incidence of clinical mastitis between rBST treatment groups and control group. Addition of high and medium concentration of retinyl palmitate and cholecalciferol into sustained-release rBST formulation was efficient in reduction of somatic cell count in milk. There was great energy deficit in all treatment groups compared with control group during the early study period. Thus, the body condition score of all treatment groups showed lower value than control group. No evidences of metabolic health problems, such as ketosis, milk fever, and downer cow were observed. Incidence of general lameness did not appear on all treatment groups during 140 days of this study.