• Journal of Life Science
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• v.20 no.12
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• pp.1889-1895
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• 2010

The purpose of this present study was to investigate the effects of long-term treadmill running and aged garlic extract supplementation on weight, adipose tissue mass, lipid profiles and oxidative stress after exhaustion in high fat diet-induced obese rats. Thirty male Sprague-Dawley rats (3 weeks old) were used as subjects. High fat diets were fed to all subjects for 6 weeks in order to induce obesity. The subjects were divided into five groups - N (normal diet group), HD (high fat diet group), E (exercise group), EA (exercise with AGE diet group) and A (AGE diet group). Aerobic exercise was performed through treadmill running and AGE at a dosage of 2.86 kg/g was administered to rats 30 min before every exercise for 4 weeks. After 4 weeks, all groups completed acute treadmill running (speed increasing gradually to 25 m/min, 15% uphill grade) until exhaustion. Immediately after exhaustive treadmill exercise, the weight, adipose tissue mass, lipid profiles and oxidative stress of the rats were assayed. At the end of 6 weeks of high fat diets, body weight and body weight gain were significantly higher in the high fat diet groups than in the normal diet group (p<0.001). At the end of treadmill exercise with AGE intake for 4 weeks, body weight gain, visceral and epididymal fat of the E and EA groups were significantly decreased compared to other groups (p<0.05). There were no significant differences in gastrocnemius and soleus. T-C, HDL-C, TG and LDL-C were not significant in any of the groups. TBARS was significantly lower in the A group than in the E group (p<0.05). These results indicated that body weight gain, visceral and epididymal fat decreased in the E and EA groups, and TBARS levels were lower in the A group than the E group. Regular aerobic exercise intervention with AGE supplementation may also modify the adipose weight and improve the oxidant stress in obese rats.

• Exercise Science
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• v.21 no.2
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• pp.243-254
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• 2012

This study tried to suggest the applicapability of soy protein supplementation and treadmill running exercise for the replacement theraphy on negative effects to estrogen metabolism in menopause. This study was analyzed the effects of 8 week soy protein supplementation and treadmill running exercise on the changes of body composition, blood concentrations of glucose, insulin, triglycerides, C-reactive protein (CRP) and estradiol, estrogen receptor gene expression of liver in ovariectomized rats. Ovariectomized groups showed the increasing responses of body weight, body fat percentage, and blood concentration of triglycerides, but these groups showed the decreasing responses of blood estradiol level and estrogen receptor gene expression in liver. Ovariectomized groups showed the positive responses of blood concentrations of lipid markers, insulin, estradiol, and estrogen receptor gene expression of liver except bone mineral contents after 8 week soy protein supplementation and treadmill running exercise. I could find the positive effects of 8 week soy protein supplementation and treadmill running exercise on the estrogen and lipid metabolism in ovariectomized rats, but this study could not confirmed the detailed replacement program of exercise intensity, duration, and soy protein volume for estrogen metabolism in ovariectomized rats.

• Journal of Korean Physical Therapy Science
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• v.26 no.3
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• pp.37-43
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• 2019

Purpose: The purpose of this study is to determine the effect of load and speed of treadmill exercise impact on muscle activity and muscle strength. Design: Randomized controlled trial. Methods: The study was conducted for 12 female student from G University. Treadmill exercise was divided into four groups (ULS, LLS, UHS, LHS). Results: 1) There was significant difference in muscle activity of tibialis anterial, medial head of gastrocnemius, rectus femoris, biceps femoris muscle in ULS, UHS (p<0.05). 2) There was significant difference in muscle activity of tibialis anterial, medial head of gastrocnemius, rectus femoris, biceps femoris muscle in LLS, LHS (p<0.05). 3) There was significant difference in muscle activity of tibialis anterial, medial head of gastrocnemius, rectus femoris, biceps femoris muscle in ULS, LLS (p<0.05). 4) There was significant difference in muscle activity of tibialis anterial, medial head of gastrocnemius, rectus femoris, biceps femoris muscle in UHS, LHS (p<0.05). 5 There was significant difference in muscle strength in LHS (p<0.05). Conclusion: Exercising with high speed and load has more influence on the muscle activity and muscle strength of the lower extremities.

• The Journal of Korean Physical Therapy
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• v.22 no.6
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• pp.65-70
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• 2010

Purpose: Exercise has been shown to be a simple and economical therapeutic modality that may be considered as an effective aid for diabetic mellitus. For example, exercise training increases insulin sensitivity in type 2 diabetes. But we found no reported of how exercise affect type 1 diabetes. This study investigated the impact of aerobic and graduated treadmill exercise regimens on body weight, glucose and insulin concentrations, lipid profiles, and oxidative stress indicators in rats with streptozotocin (STZ) induced diabetes. Glycosylated hemoglobin ($HbA_{1c}$) was determined as an indicator of glucose control during exercise. Methods: In our study, a total of 40 rats were used. Three groups of 10 rats each were given STZ to induce diabetes. The remaining 10 rats became the normal group. After 28 days we determined biochemical parameters such as glucose, glycosylated hemoglobin ($HbA_{1c}$), insulin concentration, serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL). Superoxide dismutase (SOD) and catalase activities were also measured. Results: Concentrations of blood glucose and $HbA_{1c}$ in the moderated exercise groups were significantly decreased after 28 days compared with the control group (p<0.05). There was a significant reduction in serum TC and TG in the experimental groups. The activity of SOD increased significantly by 17.70% and 48.25% respectively. Conclusion: These results indicate that physical training and exercise training affects body weight, fasting blood glucose, $HbA_{1c}$, insulin, lipid profiles, and antioxidant status in rats with streptozotocin-induced diabetes. We suggest that graduated treadmill exercise may have therapeutic, preventative, and protective effects against diabetes mellitusby improving glycemic control, oxidant defenses, and lipid metabolism.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.2
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• pp.73-88
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• 2009

Objectives : Neuronal changes that result from treadmill exercise for patients with Parkinson's disease(PD) have not been well documented, although some clinical and laboratory reports suggest that regular exercise may produce a neuroprotective effect and restore dopaminergic and motor functions. However, it is not clear if the improvements are due to neuronal alterations within the affected nigrostriatal region or result from a more general effect of exercise on affect areas and motivation. In this study, we demonstrate that motorized treadmill exercise improves the neuronal outcomes in rodent models of PD. Methods : We used a chronic mouse model of parkinsonism, which was induced by injecting male C57BL/6 mice with 10 doses(Every 12 hour) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (30 mg/kg) and probenecid (20 mg/kg) over 5 days. These mice were able to sustain an exercise training program on a motorized rodent treadmill at a speed of 18 m/min, $0^{\circ}$ of inclination, 40 min/day, 5 days/week for 4 weeks. At the end of exercise training, we extracted the brain and compared their neuronal and neurochemical changes with the control(saline and sedentary) mice groups. Synphilin protein is the substance that manifestly reacts with ${\alpha}$-synuclein. In this study, we used Synphilin as a manifest sign of recovery from neurodegeneration. We analyze the brain stems of the substantia nigra and striatum region using the western blotting technique. Results : There were no expression of synphilin in the saline-induced groups. The addition of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) greatly accelerated synphilin expression which meant an aggregation of ${\alpha}$-synuclein. But, the MPTP-induced treadmill exercise group showed significantly lower expression than the MPTP-induced sedentary group. This means treadmill exercise has a definite effect on the decrease of ${\alpha}$-synuclein aggregation. Conclusions : In this study, our results suggest that treadmill exercise promoted the removal of the aggregation of ${\alpha}$-synuclein, resulting in protection against disease development and blocks the apoptotic process in the chronic parkinsonian mice brain with severe neurodegeneration.

• Journal of Korean Physical Therapy Science
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• v.16 no.4
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• pp.67-74
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• 2009

Background: This study had been carried out with 20 elderly subjects as its object for about one month from November 3, 2008 to December 14, 2008 in order to observe the effect of Underwater Treadmill on the elderly's walking and balance ability. Methods: Subjects were assigned either experimental group (n=10) or the control group (n=10), experimental group received Underwater Treadmill program (30 min per course, 3days a week for 6weeks). Subjects were assessed for muscle power (Nicolas Manual Muscle Test), balance (Functional Reach Test), gait ability (Time Up and Go, 10M walking test) before experiments and after experiments. Results: The results of this study were as follows; 1. After underwater treadmill exercise, the change of isometric contraction indicated a beneficial increase on lower extremity muscle power of experimental group and functional test of balance function; FRT, TUG indicated beneficial difference between groups. 2. beneficial difference between groups in walking speed of hourly index change of walking function. 3. between muscle power and balance, gait ability, we could find out there's high correlation ship between lower extremity muscle power increasing and balance and gait ability of the elderly. Conclusion: Aerobic exercise using underwater treadmill effects on muscle power strengthening of the elderly, and because of this, increase of lower extremity muscle power is very helpful not only to improvement of balance ability, but also to improvement of gait ability, so it will be used as a physical therapy program on clinic and used as an exercise program for protecting the elderly from falling down very well.

• Korean Journal of Exercise Nutrition
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• v.23 no.2
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• pp.1-6
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• 2019

[Purpose] Strenuous exercise often induces skeletal muscle damage, which results in impaired performance. Sphingolipid metabolism contributes to various cellular processes, including apoptosis, stress response, and inflammation. However, the relationship between exercise-induced muscle damage and ceramide (a key component of sphingolipid metabolism), is rarely studied. The present study aimed to explore the regulatory role of sphingolipid metabolism in exercise-induced muscle damage. [Methods] Mice were subjected to strenuous exercise by treadmill running with gradual increase in intensity. The blood and gastrocnemius muscles (white and red portion) were collected immediately after and 24 h post exercise. For 3 days, imipramine was intraperitoneally injected 1 h prior to treadmill running. [Results] Interleukin 6 (IL-6) and serum creatine kinase (CK) levels were enhanced immediately after and 24 h post exercise (relative to those of resting), respectively. Acidic sphingomyelinase (A-SMase) protein expression in gastrocnemius muscles was significantly augmented by exercise, unlike, serine palmitoyltransferase-1 (SPT-1) and neutral sphingomyelinase (N-SMase) expressions. Furthermore, imipramine (a selective A-SMase inhibitor) treatment reduced the exercise-induced CK and IL-6 elevations, along with a decrease in cleaved caspase-3 (Cas-3) of gastrocnemius muscles. [Conclusion] We found the crucial role of A-SMase in exercise-induced muscle damage.

• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.79-84
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• 2019

The purpose of this study was to examine the effects of treadmill exercise on the aerobic function of dance majors in their 20s. The subjects consisted of 10 female Korean dance majors in their 20s as an experimental group and 10 normal female college students as a control group, and both groups conducted treadmill gait training. Their heart rate recovery (HRR), maximal oxygen uptake (MOU), maximal voluntary ventilation (MVV), and lactate recovery rate (LRR) were measured before and after the experiment. The comparison of changes in the subjects' aerobic function before and after the experiment showed that the experimental group gained more significant effects on HRR and LRR than the control group. Therefore, treadmill gait training may help Korean dance majors to improve their basic physical strength by enhancing their aerobic function, and the findings of this study are likely to provide basic data to support scientific exercise prescriptions.

• Journal of Korean Physical Therapy Science
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• v.31 no.1
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• pp.70-87
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• 2024

Background: This study aimed to investigate the effect of Y-balance exercise on spatio-temporal gait parameters in subjects with chronic ankle instability. Design: Randomized Controlled Trial. Method: A study was conducted on 43 people with chronic ankle instability. Subjects performed modified Y-balance exercise 3 times a week for 50 minutes, 4 weeks. Gait parameters were measured using a gait analysis treadmill before exercise, 2 weeks after exercise, and 4 weeks after exercise. A gait analysis treadmill (FDM-T AP1171, Zebris, Germany) was used to measure gait parameters. Mean values were compared using Repeated measured two-way ANOVA. Result:: When comparing the results of three measurements taken before exercise, 2 weeks after exercise, and 4 weeks after exercise, there were significant differences in the qualitative and quantitative aspects of gait in gait variables such as step distance, step time, step ratio, and sway ratio. Conclusions: These results suggest that the Y-balance exercise and various exercises combining balance and proprioception are effective for subjects with chronic ankle instability.

• The Journal of Korean Medicine
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• v.26 no.4
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• pp.62-73
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• 2005

Objectives: This study was designed to identify the ergogenic effects of Red ginseng and Paeonia radix mixtures and optimal ratios. Materials and Methods: This study was conducted by administering treatments of Red ginseng and Paeonia radix mixtures to rats and by measuring the time to exhaustion by treadmill running. Results: The treatment of Red ginseng and Paeonia radix mixtures to the rats increased the time to exhaustion by treadmill running. The most potent inhibition of Red ginseng and Paeonia radix mixtures on the 5-HT synthesis and the TPH expression in the dorsal raphe was observed at the dose of 200 mg/kg and the optimal ratio of Red ginseng and Paeonia radix for the maximum efficacy was 50:50. Under normal conditions (not exercise), long-term treatment of Red ginseng and Paeonia radix mixtures did not affect the 5-HT synthesis and the TPH expression in the dorsal raphe, suggesting that Red ginseng and Paeonia radix mixtures does not alter serotonin level in the normal rats. The suppressive effect of Red ginseng and Paeonia radix mixtures on the 5-HT synthesis and the TPH expression during exercise is a possible ergogenic mechanism of these mixtures. Conclusions : Red ginseng and Paeonia radix mixtures reduce exercise-induced fatigue, and have the effect of acting as ergogenic aids on the time to exhaustion by treadmill exercise and on 5-HT synthesis and TPH expression.