• Parasites, Hosts and Diseases
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• 제46권1호
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• pp.1-15
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• 2008

Introduction of double-stranded RNA (dsRNA) into some cells or organisms results in degradation of its homologous mRNA, a process called RNA interference (RNAi). The dsRNAs are processed into short interfering RNAs (siRNAs) that subsequently bind to the RNA-induced silencing complex (RISC), causing degradation of target mRNAs. Because of this sequence-specific ability to silence target genes, RNAi has been extensively used to study gene functions and has the potential to control disease pathogens or vectors. With this promise of RNAi to control pathogens and vectors, this paper reviews the current status of RNAi in protozoans, animal parasitic helminths and disease-transmitting vectors, such as insects. Many pathogens and vectors cause severe parasitic diseases in tropical regions and it is difficult to control once the host has been invaded. Intracellularly, RNAi can be highly effective in impeding parasitic development and proliferation within the host. To fully realize its potential as a means to control tropical diseases, appropriate delivery methods for RNAi should be developed, and possible off-target effects should be minimized for specific gene suppression. RNAi can also be utilized to reduce vector competence to interfere with disease transmission, as genes critical for pathogenesis of tropical diseases are knockdowned via RNAi.

• Journal of Power Electronics
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• 제16권2호
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• pp.542-552
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• 2016

Central 60° synchronous modulation is an easy pulse-width modulation (PWM) method to implement for the traction inverters of urban rail trains at a very low switching frequency. Unfortunately, its switching patterns are determined by a Fourier analysis of assumed steady-state voltages. As a result, its transient responses are not very good with over-currents and high instantaneous torque pulses. In the proposed solution, the switching patterns of the conventional central 60° modulation are modified according to the dynamic error between the target and actual stator flux. Then, the specific trajectory of the stator flux and current vector can be guaranteed, which leads to better system transients. In addition, stator flux control is introduced to get smooth mode switching between the central 60° modulation and the other PWMs in this paper. A detailed flow chart of the control signal transmission is given. The target flux is obtained by an integral of the target voltage. The actual PMSM flux is estimated by a minimum order flux state observer based on the extended flux model. Based on a two-level inverter model, improved rules in the α-β stationary coordinate system and equations of the switching patterns amendment are proposed. The proposed method is verified by simulation and experimental results.

• 한국통신학회논문지
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• 제25권1B호
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• pp.112-119
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• 2000

Two-color 적외선 탐색기는 표적의 대응 능력과 배경 잡음이 존재하는 상황에서 효율적인 표적 추적을 위해 두 개의 검출 대역을 사용한다. 본 논문은 Two-color 탐색기의 검출 대역 선정에 관한 연구이다. 검출 대역을 선정하기 위해, 표적, 섬광탄, 및 배경 잡음의 적외선 방사 특성을 분석하고, 수신 전력과 깊이 관련된 대기 투가 특성, 검출 가능 거리, 배경 잡음의 영향, 신호 대 잡음비 등의 특성을 분석한다. 분석 결과, two-color 적외선 탐색기의 적절한 대역은 표적 검출을 위한 3$\mu\textrm{m}$~5$\mu\textrm{m}$ 대역과 반대응 능력을 위한 $1.5\mu\textrm{m}$~1.7$\mu\textrm{m}$ 대역으로 나타났다. 본 논문의 연구 결과는 two-color 탐색기의 추후 연구에 중요한 역할을 할 것이다.

• ETRI Journal
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• 제38권1호
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• pp.70-80
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• 2016

This paper addresses the problem of robust waveform design for distributed multiple-radar systems (DMRSs) based on low probability of intercept (LPI), where signal-to-interference-plus-noise ratio (SINR) and mutual information (MI) are utilized as the metrics for target detection and information extraction, respectively. Recognizing that a precise characterization of a target spectrum is impossible to capture in practice, we consider that a target spectrum lies in an uncertainty class bounded by known upper and lower bounds. Based on this model, robust waveform design approaches for the DMRS are developed based on LPI-SINR and LPI-MI criteria, where the total transmitting energy is minimized for a given system performance. Numerical results show the effectiveness of the proposed approaches.

• 한국전산구조공학회논문집
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• 제26권2호
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• pp.123-130
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• 2013

본 논문에서는 주파수 선택적 투과막(FSS)이 결합된 복합재료 구조에서 구성 재료 간의 열팽창계수 차이로 잔류응력이 발생하므로 이로 인한 층간분리나 FSS의 손상 등 구조적인 파손 가능성과 잔류응력으로 인하여 변형된 FSS가 전파투과특성에 미치는 영향에 대하여 연구하였다. FSS는 단위요소의 종류, 설계변수, 배열에 따라 전파특성이 다르게 나타나므로, PSO 알고리즘을 이용하여 다이폴이 목표주파수에서 투과특성을 갖도록 설계하고 그 설계치수를 다른 N-pole 종류 단위요소(Tripole, Cross dipole, Jerusalem cross)에 적용하여, 복합재료 구조에 발생하는 잔류응력과 그로인한 구조적 손상과 전파 특성을 영향성을 관찰하고 FSS패턴과 복합재료의 적층 변화에 따라 비교하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권1호
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• pp.39-48
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• 2023

Spinal nerve injury causes mechanical allodynia and structural imbalance of neurotransmission, which were typically associated with calcium overload. Storeoperated calcium entry (SOCE) is considered crucial elements-mediating intracellular calcium homeostasis, ion channel activity, and synaptic plasticity. However, the underlying mechanism of SOCE in mediating neuronal transmitter release and synaptic transmission remains ambiguous in neuropathic pain. Neuropathic rats were operated by spinal nerve ligations. Neurotransmissions were assessed by whole-cell recording in substantia gelatinosa. Immunofluorescence staining of STIM1 with neuronal and glial biomarkers in the spinal dorsal horn. The endoplasmic reticulum stress level was estimated from qRT-PCR. Intrathecal injection of SOCE antagonist SKF96365 dose-dependently alleviated mechanical allodynia in ipsilateral hind paws of neuropathic rats with ED₅₀ of 18 ㎍. Immunofluorescence staining demonstrated that STIM1 was specifically and significantly expressed in neurons but not astrocytes and microglia in the spinal dorsal horn. Bath application of SKF96365 inhibited enhanced miniature excitatory postsynaptic currents in a dosage-dependent manner without affecting miniature inhibitory postsynaptic currents. Mal-adaption of SOCE was commonly related to endoplasmic reticulum (ER) stress in the central nervous system. SKF96365 markedly suppressed ER stress levels by alleviating mRNA expression of C/ EBP homologous protein and heat shock protein 70 in neuropathic rats. Our findings suggested that nerve injury might promote SOCE-mediated calcium levels, resulting in long-term imbalance of spinal synaptic transmission and behavioral sensitization, SKF96365 produces antinociception by alleviating glutamatergic transmission and ER stress. This work demonstrated the involvement of SOCE in neuropathic pain, implying that SOCE might be a potential target for pain management.

• 전기학회논문지
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• 제64권7호
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• pp.1031-1039
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• 2015

Present guided missiles are equipped with infrared seeker to find the infrared sources radiating from target plane and then chase, which results in an improvement of the hitting success rate when in striking target objects. To interrupt the chases from the guided missile, the target plane spreads the flare, avoiding the missile attracts. Our research is to develop a 2-color infrared identification technique to discern the flare and real thermal source from target plane. Considering flare radiation properties and EM atmosphere transmission rates, two channels were selected, in which main channel (MC) was in a range of 3.7 μm∼4.8 μm and auxiliary channel (AC) in 1.7 μm∼2.3 μm. A 2500K heat source was used for an artificial flare source, while a 570K heat source was utilized for airplane infrared source in experimental testing. Two infrared sensors detectable only at each chanel were employed in order to measure the voltage ratio from two channels, identifying the flare and real target plane via comparison the voltage ratio. Several experimental conditions were imported in order to prove that our proposed 2-color infrared identification technique is very efficient way to discern heat sources from aircraft and flare, demonstrating that our proposed technique is very promising means for our force’s InfraRed Counter Counter Measure (IRCCM) in order to countermeasure opposite force’s InfraRed Counter Measures (IRCM).

• 대한한의학방제학회지
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• 제31권4호
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• pp.295-313
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• 2023

Objectives : While treatments for cancer are advancing, the development of effective treatments for cancer metastasis, the main cause of cancer patient death, remains insufficient. Recent studies on Dichroae Radix have revealed that its active ingredients have the potential to inhibit cancer metastasis. This study aimed to investigate the cancer metastasis inhibitory effect of Dichroae Radix using network pharmacological analysis. Methods : The active compounds of Dichroae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : In total, 25 active compounds and their 62 non-redundant targets were selected through the TCMSP database and analysis platform. The target genes underwent gene ontology and pathway enrichment analysis. The gene list applied to the gene ontology analysis revealed associations with various biological processes, including signal transduction, chemical synaptic transmission, G-protein-coupled receptor signaling pathways, response to xenobiotic stimulus, and response to drugs, among others. A total of eleven genes, including HSP90AB1, CALM1, F2, AR, PAKACA, PTGS2, NOS2, RXRA, ESR1, ESR2, and NCOA1, were found to be associated with biological pathways related to cancer metastasis. Furthermore, nineteen of the active compounds from Dichroae Radix were confirmed to interact with these genes. Conclusions : The results provide valuable insights into the mechanism of action and molecular targets of Dichroae Radix. Notably, Berberine, the main active ingredient of Dichroae Radix, plays a significant role in degrading AR proteins in advanced prostate cancer. Further studies and validations can provide crucial data to advance cancer metastasis prevention and treatment strategies.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2002년도 학술대회 논문집
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• pp.35-36
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• 2002

High temperature super conducting(HTS) cable system for power transmission are under development that will be cooled by sub-cooled liquid nitrogen to provide cooling of the cable and termination. The target of the development during the first 3-years stage is 22.9kV/50MVA class and 30m length cold dielectric type 3-phase power cable. The essential features of the HTS cable cryogenic system and performance conditions for the design of power cable will be discussed.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 통신소사이어티 추계학술대회논문집
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• pp.251-254
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• 2003

In this paper, we develop an effective method for estimating and predicting interference power strength using the IMM(Interacting Multiple Model) algorithm. Based on the proposed interference prediction algorithm, we adjust transmission power of mobile terminals to maintain a certain level of target signal - to - interference- plus -noise- ratio ( SINR ) at the base station. Results of numerical experiments are presented to show a performance profile of the proposed algorithm.