• Journal of the Korean Society for Precision Engineering
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• v.9 no.4
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• pp.136-146
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• 1992

This paper provides the end-point positioning of a single-link flexible robot arm by inverse dynamics. The system is composed of a flexible arm, the mobile ballscrew stage as an arm base, a DC servomotor as an actuator, and a computer. Actuator voltages required for the model of a flexible arm to follow a given tip trajectory are formulated on the basis of the Bermoullie-Euler beam theory and solved by applying the Laplace transform method, and computed by the numerical inversion method proposed by Weeks. The mobile stage as the arm base is shifted so that the end-point follows the desired trajectories. Then the trajectory of end-point is measured by the laser displacement sensor. Here, two kinds of functions are chosen for the given tip trajectories. One is what is called the bang-bang acceleration profile and the other is the Gaussian velocity profile.

• Molecules and Cells
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• v.39 no.10
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• pp.715-721
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• 2016

Plants have become physiologically adapted to a seasonally shifting environment by evolving many sensory mechanisms. Seasonal flowering is a good example of adaptation to local environmental demands and is crucial for maximizing reproductive fitness. Photoperiod and temperature are major environmental stimuli that control flowering through expression of a floral inducer, FLOWERING LOCUS T (FT) protein. Recent discoveries made using the model plant Arabidopsis thaliana have shown that the functions of photoreceptors are essential for the timing of FT gene induction, via modulation of the transcriptional activator CONSTANS (CO) at transcriptional and post-translational levels in response to seasonal variations. The activation of FT transcription by the fine-tuned CO protein enables plants to switch from vegetative growth to flowering under inductive environmental conditions. The present review briefly summarizes our current understanding of the molecular mechanisms by which the information of environmental stimuli is sensed and transduced to trigger FT induction in leaves.

• Journal of Plant Biology
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• v.25 no.1
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• pp.3-8
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• 1982

As a part of the studies on the regulatory mechanism of gene expression by gibbrellic acid, the effects of $GA_3$ on the protein biosynthesis and phosphorylation in maize seedlings were investigated in the presence of actinomycin D. The activities of protein biosynthesis and phosphorylation in germinating seeds treated with $GA_3$ were greater than those of the control at the 3-day point after germination. It is assumed that the enhancement of protein biosynthesis by $GA_3$ in the presence of actinomycin D is due to the effects of $GA_3$ on the translational processes in which protein is produced from the mRNA synthesized previously.

• 제어로봇시스템학회:학술대회논문집
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• 1998.10a
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• pp.484-489
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• 1998

In this paper, we examine the displacement characteristics of the parallel leaf spring mechanism with large-deflective elastic hinges, and the validity of this mechanism as a translational and rotational mechanism is confirmed with multi-input system. This study is focused on the linear driving force as an input force, which is applied to the large-deflective elastic mechanism, and the displacement characteristics are discussed with theoretically and experimentally. The motions of this mechanism due to large-deflective hinges are changed by the position of loading force regardless of a single driving force. The numbers of degree of freedom are increased with the hinges, and we can be used to a multiple driving force in order to obtain many types of Output.

• Structural Engineering and Mechanics
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• v.33 no.3
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• pp.339-355
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• 2009

The sealed, tuned liquid column gas damper (TLCGD) with gas-spring effect extends the frequency range of application up to about 5 Hz and efficiently increases the modal structural damping. In this paper the influence of several TLCGDs to reduce coupled translational and rotational vibrations of plan-asymmetric buildings under wind or seismic loads is investigated. The locations of the modal centers of velocity of rigidly assumed floors are crucial to select the design and the optimal position of the liquid absorbers. TLCGD's dynamics can be derived in detail using the extended non-stationary Bernoulli's equation for moving reference systems. Modal tuning of the TLCGD renders the optimal parameters by means of a geometrical transformation and in analogy to the classical tuned mass damper (TMD). Subsequently, fine-tuning is conveniently performed in the state space domain. Numerical simulations illustrate a significant reduction of the vibrations of plan-asymmetric buildings by the proposed TLCGDs.

• Molecules and Cells
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• v.41 no.8
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• pp.705-716
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• 2018

The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and modification, and lipid synthesis and calcium storage. Dysregulation of ER functions leads to the accumulation of misfolded- or unfolded-protein in the ER lumen, and this triggers the unfolded protein response (UPR), which restores ER homeostasis. The UPR is characterized by three distinct downstream signaling pathways that promote cell survival or apoptosis depending on the stressor, the intensity and duration of ER stress, and the cell type. Mammalian cells express the UPR transducers IRE1, PERK, and ATF6, which control transcriptional and translational responses to ER stress. Direct links between ER stress and immune responses are also evident, but the mechanisms by which UPR signaling cascades are coordinated with immunity remain unclear. This review discusses recent investigations of the roles of ER stress in immune responses that lead to differentiation, maturation, and cytokine expression in immune cells. Further understanding of how ER stress contributes to the pathogenesis of immune disorders will facilitate the development of novel therapies that target UPR pathways.

• Molecules and Cells
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• v.43 no.3
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• pp.203-214
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• 2020

Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology.

• Proceedings of the KIEE Conference
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• 2000.11b
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• pp.274-276
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• 2000

Recently, the demands of the ultra-precision stage system, such as wafer stepper stages for photolithography, are increasing in the field of manufacturing and test equipment. Since the mechanical elements which convert rotational motion into translational introduce backlash and elasticity in the system, better performance of the drive could be achieved by the linear BLDC motor with appropriate servo control. The analytical design and the FEM analysis about linear BLDC motor is described in this paper. The performance of the servo-drive system will be evaluated through the comparison of results between the designed data and the measured data in the future.

• Journal of Life Science
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• v.7 no.3
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• pp.172-175
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• 1997

Transgenic hybrid poplar subclones containing herbicide glyphosate resistant gene (aroA) were treated with ozone at the concentration of 100 nL L$^{-1}$ for 6 hr for 5 consecutive days. The foreign gene expression in leaves of all treated plants was reduced both at transcriptional and translational levels confirmed by Northern and Western blot analysis, respectively, as compared to non-treated control plants. These results indicated that the expression of foreign gene in transgenic plants could be affected by the environmental stresses. Thus, the performance of transgenic plants cultivated on field conditions may be lower than they are expected.

• BMB Reports
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• v.55 no.11
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• pp.535-540
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• 2022

Ribosomes, acting as the cellular factories for protein production, are essential for all living organisms. Ribosomes are composed of both proteins and RNAs and are established through the coordination of several steps, including transcription, maturation of ribosomal RNA (rRNA), and assembly of ribosomal proteins. In particular, diverse factors required for ribosome biogenesis, such as transcription factors, small nucleolar RNA (snoRNA)-associated proteins, and assembly factors, are tightly regulated by various post-translational modifications. Among these modifications, small ubiquitin-related modifier (SUMO) targets lots of proteins required for gene expression of ribosomal proteins, rRNA, and snoRNAs, rRNA processing, and ribosome assembly. The tight control of SUMOylation affects functions and locations of substrates. This review summarizes current studies and recent progress of SUMOylation-mediated regulation of ribosome biogenesis.