• Journal of Welding and Joining
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• 제9권2호
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• pp.37-43
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• 1991

In order to analyze the mechanical phenomena of three dimensional elato-plastic behavior caused by welding of thick plate, it is necessary to solve exactly the three dimensional unstationary heat conduction problem considering the moving effect of heat source and the temperature-dependence of material properties. In this paper, the three-dimensional unstationary heat conduction problem is formulated by using an isoparametric finite element method. Thereafter, the transient temperature distributions, according to time, of thick plate during welding are defined from the results calculated by the developed computer program.

• Structural Engineering and Mechanics
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• 제80권6호
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• pp.701-709
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• 2021

The paper aims at improving the understanding and mitigating the effects of tunnel fires that may breakout due to the burning fuel and/or explosion within the tunnel. This study particularly focuses on the behavior of the commonly used horse shoe geometry of tunnel systems. The problem has been obtained using an adequate well-established program incorporating the Lagrangian approach. A transient-thermo-coupled static structural analysis is carried out. The effects of radiation and convection to the outer walls of the tunnel is studied. The paper also presents the impact of the hazard on the structural integrity of the tunnel. A methodology is proposed to study the tunnel fire using a model which uses equivalent steel sheet to represent the presence of reinforcements to improve the computational efficiency with adequate validation. A parametric study has been carried out and the effect of suitable lining property for mitigating the fire hazard is arrived at. Detailed analysis is done for the threshold limits of the properties of the lining material to check if it is acceptable in all aspects for the integrity of the tunnel. The study may prove useful for developing insights for ensuring tunnel fire safety. To conduct such studies experimentally are tremendously costly but are required to gain confidence. But, scaled models, as well as loading and testing conditions, cannot be studied by many trials experimentally as the cost will shoot up sharply. In this context, the results obtained from such computational studies with a feasible variation of various combinations of parameters may act as a set of guidelines to freeze the adequate combination of various parameters to conduct one or two costly experiments for confidence building.

• 한국환경과학회지
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• 제21권12호
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• pp.1435-1447
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• 2012

The present study was conducted to determine the effect of hexaconazole (HEX), a triazole fungicide, on the growth, yield, photosynthetic response and antioxidant potential in cucumber (Cucumis sativus L.) plants subjected to UV-B stress. UV-B radiation and HEX were applied separately or in combination to cucumber seedlings. The growth parameters were significantly reduced under UV-B treatment, however, this growth inhibition was less in HEX treated plants. HEX caused noticeable changes in plant morphology such as reduced shoot length and leaf area, and increased leaf thickness. HEX was quite persistent in inhibiting shoot growth by causing a reduction in shoot fresh and dry weight. HEX noticeably recovered the UV-B induced inhibition of biomass production. Significant accumutation in anthocyanin and flavonoid pigments in the leaves occurred as a result of HEX or UV-B treatments. HEX permitted the survival of more green leaf tissue preventing chlorophyll content reduction and higher quantum yield for photosystemII under UV-B exposure. HEX treatment induced a transient rise in ABA levels in the leaves, and combined application of HEX and UV-B showed a significant enhancement of ABA content which activates $H_2O_2$ generation. UV-B exposure induced accumulation of $H_2O_2$ in the leaves, while HEX prevented UV-B induced increase in $H_2O_2$, indicating that HEX serves as an antioxidant agent able to scavenge $H_2O$ to protect cells from oxidative damage. An increase in the ascorbic acid was observed in the HEX treated cucumber leaves affecting many enzyme activities by removing $H_2O_2$ during photosynthetic processes. The activities of antioxidant enzymes including catalase(CAT), ascorbate peroxidase(APX), superoxide dismutase(SOD) and peroxidase(POD) in the leaves in the presence of HEX under UV-B stress were higher than those under UV-B stress alone. These findings suggest that HEX may participate in the enhanced tolerance to oxidative stress. From these results it can be concluded that HEX moderately ameliolate the effect of UV-B stress in cucumber by improving the components of antioxidant defense system.

• 설비공학논문집
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• 제22권2호
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• pp.78-85
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• 2010

A dynamic model has been developed to investigate the operability of a single and double-effect solar energy assisted parallel type absorption chiller. In the study, main components and fluid transport mechanism were modeled. And solar radiation and the solar collector were also modeled along with its control design. The model was run for the single mode with solar energy supply only and the solar/gas driving double effect mode. From the simulation results, it was found that the present configuration of the chiller is not capable of regulating solution flow rates according to variable solar energy input. And the issues of the excessive circulation flow rate and the mismatch between available solar power and cooling load discourages the use of the single mode, but the dual use of gas and solar power is recommendable in view of controllability and enhanced COP.

• Molecules and Cells
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• 제21권3호
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• pp.367-375
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• 2006

We previously identified a novel cancer/testis antigen gene CAGE by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera of gastric cancer patients. CAGE is expressed in many cancers and cancer cell lines, but not in normal tissues apart from the testis. In the present study, we investigated its role in the motility of cells of two human cancer cell lines: HeLa and the human hepatic cancer cell line, SNU387. Induction of CAGE by tetracycline or transient transfection enhanced the migration and invasiveness of HeLa cells, but not the adhesiveness of either cell line. Overexpression of CAGE led to activation of ERK and p38 MAPK but not Akt, and inhibition of ERK by PD98059 or p38 MAPK by SB203580 counteracted the CAGE-promoted increase in motility in both cell lines. Overexpression of CAGE also resulted in a reduction of ROS and an increase of ROS scavenging, associated with induction of catalase activity. Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines. Inhibition of ERK and p38 MAPK reduced the induction of catalase activity resulting from overexpression of CAGE, and inhibition of catalase reduced CAGE-promoted motility. We conclude that CAGE enhances the motility of cancer cells by activating ERK and p38 MAPK, inducing catalase activity, and reducing ROS levels.

• Radiation Oncology Journal
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• 제11권1호
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• pp.97-102
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• 1993

1983년 4월부터 1991년 9월까지 가톨릭 의과대학 강남성모병원 치료방사선과에서 국한된 폐소세포암으로 확진되어 방사선치료받은 32명의 환자를 대상으로 치료성적을 후향 분석하였다. 이중 5명은 방사선 치료 단독으로 치료받았으며 27명은 화학요법과 방사선치료 병용요법을 하였다. 남녀의 비는 4.3:1 이었으며 연령분포는 24세에서 78세였다(중앙값 : 63세). 6 MV X 선에의한 방사선치료선량은 일일 160-180 cGy씩 치료하여 총 1000-6660 cGy (중앙값 4500 cGy)였다. 치료 후 완전관해율은 $37.5{\%}$ (12/32), 부분관해율은 $34.4{\%}$(11/32)였고, 무반응은 $28.1{\%}$(0/32)였다. 생존기간의 중앙값은 10개월이었고 1년생존율과 2년생존율은 각각 $59.4{\%}$와 $28.1{\%}$였다. 1년생존율을 유의하게 증가시키는 요소로서는 70이상의 Karnofsky수행상태(p<0.04), 화학요법의 병행(CAV, PV, CAV+PV) (p<0.04), 화학요법 6회 이상(p<0.007) , 45 Gy 이상의 방사선량(p<0.03)와 방사선치료에 반응있었던 경우(CR+PR) (p<0.003)등이었다. 나이, 성별, 상대정맥증후군, 예방적 전뇌조사 및 방사선 치료기간은 유의한 영향을 미치지 않았다. 방사선 치료에의한 부작용은 식도염이 $34{\%}$(11명), 전신피로 $28{\%}$(9명)에서 있었으며 오심 구토 같은 위장관 증상은 $15{\%}$(5명) 그리고 백혈구감소증이 $3{\%}$(1명)에서 관찰되었다.

• 대한기계학회논문집B
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• 제27권10호
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• pp.1377-1384
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• 2003

An analysis has been performed for active thermal control of the KOMPSAT monopropellant rocket engine assembly, i.e., dual thruster module(DTM). The main efforts of this work have been directed at determining proper heater sizes for propellant valves and catalyst beds necessary to maintain their temperatures within specified temperature ranges under KOMPSAT environment and operational conditions. The TAS incorporated with TRASYS thermal radiation analyzer was used to establish a complete heat transfer model which allows to predict the DTM temperature as a function of time. The thermal analysis has been performed in transient mode to verify the appropriate power for catalyst bed heaters necessary to increase catalyst bed temperature to the required value within a specified period of time. Similar analysis has been executed to validate the heater power for the thermostatically controlled primary and redundant heater circuits used to prevent hydrazine freezing, i.e., single fault. Moreover the effect of the radiative property of thermal control coating of heat shield was examined. Thruster firing condition was also simulated for the heat soakback condition. As a consequence, all thermal analysis results for DTM satisfactorily met the thermal requirements for the KOMPSAT DTM under the worst case average voltage, i.e. 25 volt.

• 한국전자파학회논문지
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• 제11권3호
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• pp.437-444
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• 2000

본 논문에서눈 빠른 모델링과 정확한 계산을 위하여 상용 CAD인 PATRAN을 이용하여 3차원으로 설계한 휴대폰을 1 mm 해상도의 FDTD 모델령으로 직접 변환시키는 방법을 제안하였다. 이 방법의 우수성을 확인하기 위하여 3차원 과도 원거리 영역 변환법으로 계산한 복사패턴과 무반사실에서 이득비교법으로 측정한 결과를 비 교하였을 때 그 차이는 0.5 dB 이내이다. 또한,SAR과 직접적으로 관련한 물리량을 찾기 위해서 휴대폰의 전면 부에 형성되는 자기장을 계산하였다. 그 결과, 휴대폰 내부로부터 전면 방향으로 복사되거나 휴대폰 본체 길이 방향의 자기장 성분보다는 너비방향으로 흐르는 자기장 성분이 전체자기장에 가장 큰 영향을 주었다.

• 한국정보통신학회논문지
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• 제17권7호
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• pp.1558-1563
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• 2013

본 논문에서는 시간영역에서 완전도체 접지평면 위 수직 전기 다이폴에서 방사되는 전자기해석을 통해 전파의 거리에 따른 전파경로손실을 해석하였다. 자유공간에서 수직 전기 다이폴의 해석은 시간영역과 주파수영역에서 많은 연구가 이루어졌으나 본 논문에서는 특히 접지면 위 수직 다이폴을 기지국으로 가정한 전파경로손실특성을 시간영역에서 해석하였으며 접지면의 영향으로 나타나는 근접장의 위치변화와 모바일에서 수신되는 과도응답을 관찰하였다. 본 논문의 결과는 지표면 레이더 및 신호처리 분야에 응용될 수 있을 것이다.

• Radiation Oncology Journal
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• 제12권2호
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• pp.191-199
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• 1994

Purpose : This study was undertaken to show the clinical results of combined radiotherapy and hyperthermia in primary hepatoma Materials and Methods : Between December 1989 and March 1993, 50 patients with hepatomas were treated by combined radiotherapy and hyperthermia. Among them, we analyzed retrospectively 33 patients who received the complete course of treatment. The ages of the patients ranged from 36 to 75(mean age: 55.5 years). Twenty-six patients ($78.8\%$) were men, and 7 ($21.2\%$ were women. According to Child's classification, nine patients ($27.3{\%}$) were A group, 9 ($27.3\%$) were B group, 15 ($45.4\%$) were C group. Radiation therapy was done by a 6 MV and 15 MV linear accelerator. Patients were treated with daily fractions of 150-180 cCy to doses of 2550 cGy -4950 cGy (median : 3000 cGy). Local hyperthermia was done by 8 MHZ RF capacitive heating device (Cancermia. Green Cross Co., Korea), 50-60 min/session, 1-2 sessions/wk, and 8.5 sessions (median number)/patient. We analyzed the prognostic factors including age, sex, tumor type, Child's classification, $\alpha$-fetoprotein, liver cirrhosis, ascites, portal vein invasion, esophageal varix, number of hyperthermia, chemotherapy, total bilirubin level, Karnofsky perfomance status. Results : The overall 1-year survival was $24.2\%$, with a mean survival of 10months. Of 33 patients, tumor regression (PR+MR) was seen in $30.4\%$, no response was seen in $52.2\%,\;17.4\%$ patient was progressed. In patients who had tumor regression, the overall 1-year survival was $42.1\%$ with a mean survival of 14 months. Factors influencing the survival were sex (p=0.05), tumor type (p=0.0248), Child's classification (p=0.0001), liver cirrhosis (p=0.0108), ascites (p=0.0009), and Karnofsky perfomance status (p=0.0028). Complications developed in 28 patients, including 18 hot pain,5 fat necrosis, 3 transient fever, 2 nausea and vomiting. Conclusion : In this study, the results suggests that combined radiotherauy and hyperthermia may improve the survival rate of hepatoma.