• Title/Summary/Keyword: Traditional oriental medicines

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Oriental medicines with anti-anaphylactic effect

  • Jeong, Hyun-Ja;Hong, Seung-Heon;Kim, Hyung-Min
    • Advances in Traditional Medicine
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    • v.4 no.3
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    • pp.125-136
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    • 2004
  • The pharmacological mechanisms of most Oriental medicines have not been clearly defined in spite of their effective use in treating many diseases throughout the world. Many Oriental medicines have been used against various allergic diseases for generations, and still occupy an important place in traditional medicine in far eastern countries including Korea. It is also still unclear how Oriental drugs prevent allergic disease in vivo or in vitro models. Some Korean folk medicine inhibited the mast cell-mediated allergic reaction. This review summarizes the effective folk medicine in experimental effect on systemic or local anaphylaxis reaction. Potential anti-anaphylactic folk medicines include: Poncirus trifoliata; Siegesbeckia glabrescence; Solanum lyratum; Aquilaria agallocha; Ulmi radicis; Polygonum tinctorium; Hwanglyun-Haedok-Tang; Rehmannia glutinosa; Kum-Hwag-San; Syzygium aromaticm; Spirulina platensis; Sosiho-Tang; Sinomenium acutum; Schizonepta tenuifolia; Shini-San; Magnoliae flos; Sochungryong-Tang; Oryza sativa; Cryptotympana atrata; Salviae radix; Rosa davurica; Asiasari radix; Chung-Dae-San; Cichorium intybus; Perilla frutescens; Vitex rotundifolia; Terminalia chebula; Siberian Ginseng; Solanum melongena; Gahmi-Shini-San; Alpinia oxyphylla; Acanthopanax senticosus root; Prunella vulgaris; Allergina; Ixeris dentate; Acanthopanax senticosus stem; Tongkyutang; Salvia plebeia; Rubus coreanus; Sinpo- Tang; Dodutang; Forsythia fructus; Xanthii fructus; and Purple bamboo slat. Ensuring the effects and understanding the mechanisms of action for these Oriental medicines can permit drug development and laying of the ground-work for evaluating potential synergistic effects by addition and subtraction of prescriptions.

Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (IV) (중국, 베트남산 약용식물의 최종당화산물 생성저해활성 검색 (IV))

  • Kim, Jong-Min;Kim, Young-Sook;Kim, Joo-Hwan;Yoo, Jeong-Lim;Kim, Jin-Sook
    • Korean Journal of Pharmacognosy
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    • v.40 no.4
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    • pp.388-393
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    • 2009
  • Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines ($IC_{50}$<50 ${\mu}g$/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, $IC_{50}$=75.98 ${\mu}g$/ml; 28 days, $IC_{50}$=88.27 ${\mu}g$/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.

Screening of Korea Traditional Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (한약재의 최종당화산물 생성저해활성 검색)

  • Jang, Dae-Sik;Lee, Yun-Mi;Kim, Young-Sook;Kim, Jin-Sook
    • Korean Journal of Pharmacognosy
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    • v.37 no.1 s.144
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    • pp.48-52
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    • 2006
  • Advanced glycation end products (AGEs) are largely involved in the pathogenesis of diabetic complications. As part of our ongoing project directed toward the discovery of preventive and/or delay agents for diabetic complications from natural sources, 92 Korean traditional herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 17 herbal medicines exhibited a significant inhibitory activity against AGEs formation. Particularly, 9 herbal medicines, i.e., Cinnamomi Cortex, Artemisiae Argyi Herba, Ammoni Tsao-ko Fructus, Menthae Herba, Amomi Semen, Polygoni Avicularis Herba, Lycopi Herba, Salviae Radix, and Nelumbinis Semen showed more potent inhibitory activity (2-4 fold) than the positive control aminoguanidine.

A review of allergic rhinitis in traditional Chinese medicine

  • Lee, Sang-Chang;Kim, Min-San;Seong, Man-Jun;Choi, Mi-Sun;Kang, Suk-Hoon;Lee, Sheng-Ho;Kim, Jong-Hak;Lee, Young-Seob;Kwon, Dong-Yeul
    • Journal of Evidence-Based Herbal Medicine
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    • v.1 no.2
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    • pp.27-33
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    • 2008
  • Allergic rhinitis comes within snuffle in Chinese medicine. For generations, physicians have believed that the internal factors that cause this disease are pulmonary tuberculosis, splenic hypofunction and loss of virility, and its external factors are a cold, an uncommon atmosphere and an uncommon flavor. From the viewpoint of Chinese medicine, this symptom was fundamentally cured by "abidance by individuality, locality and seasons", on the basis of demonstration. In result, visceral function was recovered. In Chinese medicine, a disease is etiologically cured by the principles of Wholism and by discriminating among symptoms. In particular, "method for replenishing Qi and securing Exterior" has been widely used among the foregoing therapeutics. According to modern pharmacology, Astragli Radix, Atractylodis Macrocephalae Rhizoma and Ledebouriellae Radix all have antihistaminic effects and strengthen of the masticating and swallowing function of the recticuloendothelial system. This disease can be cured by controlling immunity and allergic reactions. Besides, it is necessary to take moderate exercise, to strengthen constitution, to avoid causative substances, to control ingesting flesh, meat and shrimps, to eat little, and to avoid what is cold and raw.

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Eliminatory Effect of Mixed Extract of Hovenia Dulcis Thunb and Gastrodia Elata on Ethanol-Induced Hangover in Rats (랫드에서 헛개나무와 천마 혼합 추출물의 에탄올 섭취에 의한 숙취 제거 효과)

  • Jeon Tae Won;Lee Eun Sil;Lee Young Sun;Han Ok Kyung;Bae Jae Chil;Kim Kwang Joong;Kim Hyo Jung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.5
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    • pp.905-910
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    • 2002
  • To investigate an eliminatory effect of mixed extract of Hovenia dulcis Thunb, Gastrodia elata and Alnus japonica etc., on the ethanol-induced hangover, 12 hr-fasted male Sprague-Dawley rats weighing 220±20 g were given mixed extract (10 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12 hr and then the animals were sacrificed at 24 hr after the ethanol treatment. From 0 to 12 hr, the administration of mixed extract significantly decreased the area under the serum alcohol concentrations-vs.-time curves by 21 % compared with control group. In these experiments, liver function indices, such as alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenase activities, showed unaltered results in all treated groups compared with the normal group. These results suggest that oral intake of the mixed extract may be effective on elimination of ethanol-induced hangover.

Effect of Mixture of Gastrodiae rhizoma on Blood Amelioration in High Cholesterol-diet Rats (고콜레스테롤 식이 랫드에서 천마혼합액의 혈액개선 효과)

  • Lee Young Sun;Han Ok Kyung;Jean Tae Won;Lee Eun Sil;Kim Kwang Joong;Bae Jae Chil;Kim Hyo Jung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.2
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    • pp.226-232
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    • 2002
  • This study was carried out to investigate the effect of mixture of Gastrodiae rhizoma (GM) on blood amelioration in high cholesterol-diet rats. Sprague-Dawley male rats were randomly assigned to one normal diet and three high cholesterol-diet groups which contained 1 % (w/w) cholesterol diet. The groups of high cholesterol-diet were classified to control (high cholesterol-diet only), GM-1 (high cholesterol-diet and GM) and ST-1 (high cholesterol-diet and Statin drug). The body and organs weight were not significantly changed among the tested groups. Contents of serum total cholesterol and LDL-cholesterol were significantly increased in cholesterol-diet groups compared with normal diet group but significantly decreased in the group of GM-1. Morphology of red blood cell in GM-1 group was similar to normal diet group but the control group had many crystals of cholesterol. Hepatic xanthine oxidase activity in the rats of high cholesterol-diet was decreased up to the levels of normal diet group according to oral administration of GM. The results of the present study demonstrate that the orally injection of GM can ameliorate the status of total cholesterol and LDL-cholesterol, and repress xanthine oxidase in liver in high cholesterol-diet rats. These finding suggest that GM is expected to be an effective tea for the blood amelioration in high cholesterol-diet rats.

The Methodology of DB Construction of the Traditional Prescription Medicines Before the Song Dynasty (송대(宋代) 이전 한의학(韓醫學) 처방(處方) 약물(藥物) DB 구축 방법에 대한 연구(硏究))

  • Baik, You-Sang
    • Journal of Korean Medical classics
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    • v.22 no.2
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    • pp.305-313
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    • 2009
  • With the recent increase of social demand of knowledge on traditional medicine, the construction of database is becoming a pressing matter. The reality is that while the social desire to adapt the high quality knowledge is growing fast, the field of Oriental Medicine has yet to organize its system. The number of Oriental Medical Doctors are limited, and there is no structured means of communication to expand the professional knowledge of these specialists to the public. Accordingly, an effective and structured knowledge system is in great need. In the process of building an Oriental Medicine database, prescription[方劑] and medicines[本草] are first in line. Consequently, we have taken the first step by organizing various methods to build the database containing information such as the formula, ingredients, composition, handling methods of herbal medicine written in traditional medical publications and herbal texts before the Song(宋) dynasty.

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Proposed Mechanisms and Further study for Korean Traditional medicines-Drug Interaction in a view of Toxicology (한약의 약물상호작용 기전과 연구방향 - 독성학적인 측면을 중심으로 -)

  • Park, Yeong-Chul;Kim, Myung-Dong;Lee, Sun-Dong
    • Journal of Society of Preventive Korean Medicine
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    • v.15 no.1
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    • pp.1-16
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    • 2011
  • Objectives : The mechanisms for korean traditional medicine-drug interaction has not been well reviewed in spite that the chance for co-administration with western drugs or diet supplements has been increased. Especially, it is well known that various cytochrome P450s play a major role in drug-drug interaction. Of course, Korean traditional medicines is not excluded in a view of metabolism or biotransformation by cytochrome P450. This article was focused on reviewing the possible roles of cytochrome P450 in Korean traditional medicine-drug interaction, Also, the directions for further studies were suggested in terms of Korean traditional medicine-drug interaction. Methods : New studies for korean traditional medicine-drug interaction were reviewed and summarized in terms of cytochrome P450 activities by various Korean traditional medicines and western drugs. Results and Conclusions : Even if a few studies related to Korean traditional medicine-drug interactions was carried out, almost no studies for Korean traditional medicine-drug interactions has been found in a view of cytochrome P450. It was suggested that Korean traditional medicines and their decoction should be analyzed that how they effects on cytochrome P450, expecially CYP 1, 2, 3 families and how they interact with western drugs.

A Survey of the Status of Management and Prices of Herbal Medicines: Traditional Korean Medicine Institutions (한방의료기관의 한약 관리 및 가격 현황에 대한 연구)

  • Huang, Dae-Sun;Shin, Hyeun-Kyoo
    • The Journal of Korean Medicine
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    • v.32 no.5
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    • pp.90-99
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    • 2011
  • Objectives: Comparison of the status of herbal medicine management carried out by traditional Korean medicine hospitals and clinics, and changes in the prices of the herbal medicines offered by them. Methods: A questionnaire survey was conducted for 126 traditional Korean medicine hospitals and 4,200 traditional Korean medicine clinics. Questionnaire sheets were dispatched to them by mail in 2008. Rate of response: 57 hospitals (45.2%) and 465 clinics (11.0%) Results: 1. Concerning the herbal medicines kept by them, the hospitals and the clinics kept 295 and 147 kinds of medicine, respectively, on average. As for their monthly expenditure on the purchase of herbal medicines, the hospitals spent an average of KRW 28.38 million while the clinics spent an average of KRW 1.64 million. 2. The average monthly expenditure of the clinics on the purchase of herbal medicines decreased by 32% from 2006, which can be interpreted as a reduction of their business. 3. The prices of herbal medicines for disease treatment ranged from KRW 140,000~190,000 per jae(dosage form) in the hospitals compared to KRW 140,000~168,000 in the clinics. 4. Compared to 1994, the prices of herbal medicines used for disease treatment have risen, whereas the prices of herbal medicines used as tonics have decreased. Conclusions: There are no conspicuous differences between the hospitals and the clinics in terms of the prices charged for herbal medicines, regardless of whether they are used to treat diseases or prescribed as tonics.

The Comparative Study of Oriental Medicine in Korea, Japan and China (한국(韓國)과 일본(日本) 및 중국(中國)의 동양의학(東洋醫學)에 대한 비교연구(比較硏究))

  • Cho, Ki-Ho
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.271-298
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    • 1998
  • During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.

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