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Eliminatory Effect of Mixed Extract of Hovenia Dulcis Thunb and Gastrodia Elata on Ethanol-Induced Hangover in Rats  

Jeon Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark)
Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark)
Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark)
Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark)
Bae Jae Chil (Cheonma Natural Food. Kyongbuk)
Kim Kwang Joong (College of Oriental Medicine, Kyungsan, University)
Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark, College of Oriental Medicine, Kyungsan, University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 905-910 More about this Journal
Abstract
To investigate an eliminatory effect of mixed extract of Hovenia dulcis Thunb, Gastrodia elata and Alnus japonica etc., on the ethanol-induced hangover, 12 hr-fasted male Sprague-Dawley rats weighing 220±20 g were given mixed extract (10 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12 hr and then the animals were sacrificed at 24 hr after the ethanol treatment. From 0 to 12 hr, the administration of mixed extract significantly decreased the area under the serum alcohol concentrations-vs.-time curves by 21 % compared with control group. In these experiments, liver function indices, such as alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenase activities, showed unaltered results in all treated groups compared with the normal group. These results suggest that oral intake of the mixed extract may be effective on elimination of ethanol-induced hangover.
Keywords
Hovenia dulcis Thunb; Gastrodia elata; hangover; ethanol; area under the curves;
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