Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Eliminatory Effect of Mixed Extract of Hovenia Dulcis Thunb and Gastrodia Elata on Ethanol-Induced Hangover in Rats

랫드에서 헛개나무와 천마 혼합 추출물의 에탄올 섭취에 의한 숙취 제거 효과

  • Jeon Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark) ;
  • Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark) ;
  • Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark) ;
  • Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark) ;
  • Bae Jae Chil (Cheonma Natural Food. Kyongbuk) ;
  • Kim Kwang Joong (College of Oriental Medicine, Kyungsan, University) ;
  • Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University. Kyongbuk Technopark, College of Oriental Medicine, Kyungsan, University)
  • 전태원 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 이은실 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 이영선 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 한옥경 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 배재칠 (천마자연식품) ;
  • 김광중 (경산대학교 한의과대학) ;
  • 김효정 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원, 경산대학교 한의과대학)
  • Published : 2002.10.01
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Abstract

To investigate an eliminatory effect of mixed extract of Hovenia dulcis Thunb, Gastrodia elata and Alnus japonica etc., on the ethanol-induced hangover, 12 hr-fasted male Sprague-Dawley rats weighing 220±20 g were given mixed extract (10 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12 hr and then the animals were sacrificed at 24 hr after the ethanol treatment. From 0 to 12 hr, the administration of mixed extract significantly decreased the area under the serum alcohol concentrations-vs.-time curves by 21 % compared with control group. In these experiments, liver function indices, such as alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenase activities, showed unaltered results in all treated groups compared with the normal group. These results suggest that oral intake of the mixed extract may be effective on elimination of ethanol-induced hangover.

Keywords

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