• Korean Journal of Microbiology
• /
• v.37 no.1
• /
• pp.92-99
• /
• 2001

High-cell-density cultivation of Ralstonia eutopha KHB 8862 by fed-batch fermentation in a 200 l pilot plant was carried out for the mass production of poly(3-hydroxybutyrate) (PHB). After 80 h of cultivation, the dry cell weight (DCW), PHB concentration, and PHB yield from fructose syrup reached 168 g/l, 74%DCW, and 0.27 (w/w), respectively, resulting in a productivity of 1.6 g of PHB/L/h. Based on these results, the PHB production cost from bacterial fermentation was analyzed and economic evaluation was performed. In the case of new investment being implemented or not, the production cost of PHB was US$ 3.15/kg and US$ 2.41/kg, respectively. PHB productivity and PHB yield on a carbon substrate were both important factors to be optimized. The increase of PHB yield on a carbon sources significantly decreased the PHB production cost but the increase in productivity had a relatively slight effect on the decrease in PHB production cost because the cost of carbon sources (37%) for PHB was larger in proportion to total cost than the depreciation cost (17%). These results suggest that the increased PHB yield from carbon sources and the development of new cheaper substrates would be more effective in decreasing PHB production cost than the increase in productivity. It was demonstrated that PHB is not in competition with consumable plastics such as PET in present market. Therefore, it is essential to lower production cost to be used as a bulk product and desirable to develop new application fields for PHB such as biomedical and cosmeceuticals.

• IE interfaces
• /
• v.16 no.4
• /
• pp.450-462
• /
• 2003

In this paper, we deal with a process and layout design for producing a planned amount of Sikhye in a given limited time period under a reasonable production schedule. We represent a Sikhye production line as a vector N, the element of which denotes the number of tanks required in each process and our objective is to find an appropriate vector which minimizes the total investment cost. We suggest a systematic method for finding an appropriate N and an appropriate layout to N. In detail, first, we decide the required sequence of processes and the required operations for each process and we estimate standard operating times. Second, constructing a precedence diagram, we find a critical path in order to reduce the total production lead time for a batch of Sikhye. Third, given a limited N space, we manage to construct manually each production schedule using both the processing times of the critical operations and transfer times. Finally, we find an optimal vector N which gives a minimum investment cost and meets both the time constraint and quantity constraint. In addition, with the estimated relative size of each tank, we suggest an appropriate conceptual layout design including an expansion area for future demands, based on the span technique used in the field of architectural design.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.31 no.4
• /
• pp.35-47
• /
• 2006

This paper considers an integrated scheduling problem for consecutive production and delivery stages in a two-stage supply chain. The Production is performed on a single facility and then the finished products are delivered to the customer by capacitated multiple vehicles. The objective of this paper is to obtain job sequencing and delivery batching minimizing the total cost of the associated WIP inventory, finished product inventory and delivery. The inventory cost is characterized by the sum of weighted flowtime. The delivery cost is proportional to the required number of delivery batches. Some polynomial-solvable cases are derived. For the general case, two efficient heuristic algorithms are suggested, and then the heuristics are tested through some numerical experiments.

• Journal of Korean Institute of Industrial Engineers
• /
• v.18 no.1
• /
• pp.11-24
• /
• 1992

The performance of Storage assignment policies is traditionally evaluated with the storage capacity of and AS/RS taken as given. However, the storage capacity is closely related to the inventory model used in real situations. This paper presents a model of evaluating the performance of three storage policies(random storage, class-based storage, and full turnover-based storage) considering production lot-sizing simultaneously with storage assignment of inventory items. The objective of the model is to achieve a balance of warehouse throughput and space requirements such that a total of material handling cost, production ordering cost, and inventory holding cost is minimized. The effects of the parameters involved in the model are investigated on the performance of each storage policy through example problems.

• Asian-Australasian Journal of Animal Sciences
• /
• v.28 no.1
• /
• pp.1-13
• /
• 2015

Feed is single most expensive input in commercial pork production representing more than 50% of the total cost of production. The greatest proportion of this cost is associated with the energy component, thus making energy the most important dietary in terms of cost. For efficient pork production, it is imperative that diets are formulated to accurately match dietary energy supply to requirements for maintenance and productive functions. To achieve this goal, it is critical that the energy value of feeds is precisely determined and that the energy system that best meets the energy needs of a pig is used. Therefore, the present review focuses on dietary supply and needs for pigs and the available energy systems for formulating swine diets with particular emphasis on the net energy system. In addition to providing a more accurate estimate of the energy available to the animal in an ingredient and the subsequent diet, diets formulated using the this system are typically lower in crude protein, which leads to additional benefits in terms of reduced nitrogen excretion and consequent environmental pollution. Furthermore, using the net energy system may reduce diet cost as it allows for increased use of feedstuffs containing fibre in place of feedstuffs containing starch. A brief review of the use of distiller dried grains with solubles in swine diets as an energy source is included.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2001.10a
• /
• pp.150-153
• /
• 2001

The selection of the optimal partners in supply chain management is one of the most critical success factors. In the past, partners for outsourcing production were selected repeatedly within a closed group of candidates due to the limited information and location of partners. But, the wide use of internet and the development of electronic commerce make it possible that the partners capable of providing the optimal services are selected regardless of their location or nationality. And the concept of partners was limited to the provider of production resources. In the supply chain management, the concept should be extended to the provider of transportation and warehouse due to the high portion of transportation cost among the total production cost Therefore, In this study, we propose an analytical approach to the selection of Production and transportation partners in supply chain management. For this purpose a mathematical model is developed, and then a heuristic algorithm based on tabu search is presented since the model belongs to the NP hard problem.

• Journal of Korean Society of Forest Science
• /
• v.98 no.4
• /
• pp.504-511
• /
• 2009

This study to understand the production cost of cultivation in chestnut tree (Castanea spp.) as a result of a survey conducted of 227 farmers is as follows. In full-time farmer, average cultivation area was 5.5 hectares and average chestnut production was 1.6 tons per hectare. In chestnut sale type, more than 73% of total production was sold by Nong-hyup (7an agricultural cooperative association) and intermediaries, and also proportion of nut size grade was 18% in special-large nut, following 49% in large nut, 25% in middle nut and 8% in small nut. There was considerable difference among cultivated regions in gross income, whereas total average gross income was 2,103 thousand KRW per hectare and 66.4% of it was used in management expenses. Finally the chestnut cultivated farmers have a yearly income of 706 thousands KRW (net income rate 33.6%). As peculiarity of regional production cost, a low tree farm in height and a labor intensive growing helped the improved quality of the chestnut so, on average, 2,161 thousand KRW per hectare of the income of the Chungnam was raised. However caused by an old-age of chestnut trees, there was a little input to management expenses and it resulted in low productivity in the Jeonnam and the Gyeongnam.

• Journal of Preventive Medicine and Public Health
• /
• v.39 no.6
• /
• pp.499-504
• /
• 2006

Objectives : The aim of the study was to estimate the annual socioeconomic cost of diseases in Korea. Methods : We estimate both the direct and indirect costs of diseases in Korea during 2003 using a prevalence-based approach. The direct cost estimates included medical expenditures, traffic costs and caregiver's cost, and the indirect costs, representing the loss of production, included lost workdays due to illness and lost earnings due to premature death, which were estimated based on the human capital theory. The cost estimates were reported at three different discount rates (0, 3 and 5%). Results : The cost of diseases in Korea during 2003 was 38.4 trillion won based on 0% discount rate. This estimate represents approximately 5.3% of GDP The direct and indirect costs were estimated to be 22.5 trillion (58.5% of total cost) and 15.9 trillion won (41.5%), respectively. It was also found that the cost for those aged $40\sim49$ accounted for the largest proportion (21.7%) in relation to age groups. The cost of diseases for males was 23.5% higher than that for females. For major diseases, the total socioeconomic costs were 16.0, 13.4, 11.3 and 11.19% for neoplasms, and diseases of the digestive, respiratory and circulatory systems, respectively. Conclusions : This study can be expected to provide valuable information for determining intervention and funding priorities, and for planning health policies.

• Asian-Australasian Journal of Animal Sciences
• /
• v.30 no.2
• /
• pp.187-191
• /
• 2017

Objective: An experiment was conducted to examine the effect of dietary supplementation of dried and ground foliage of black gram (Vigna mungo L.) on feed intake and utilization, and production performance of crossbred lactating cows. Methods: Eighteen lactating crossbred (Bos taurus${\times}$Bos indicus) cows (body weight $330.93{\pm}10.82kg$) at their second and mid lactation (milk yield $6.77{\pm}0.54kg/d$) were randomly divided into three groups of six each in a completely randomized block design. Three supplements were formulated by quantitatively replacing 0, 50, and 100 per cent of dietary wheat bran of concentrate mixture with dried and ground foliage of black gram. The designated supplement was fed to each group with basal diet of rice straw (ad libitum) to meet the requirements for maintenance and milk production. Daily feed intake and milk yield was recorded. A digestion trial was conducted to determine the total tract digestibility of various nutrients. Results: The daily feed intake was increased (p<0.05) with the supplementation of black gram foliage. Although the digestibility of dry matter, organic matter, crude protein, and ether extract did not vary (p>0.05), the fibre digestibility was increased (p<0.05), which ultimately improved (p<0.05) the total digestible nutrients content of composite diet. Although, the average milk yield (kg/animal/d) and composition did not differ (p>0.05) among the groups, milk yield was increased by 10 per cent with total replacement of wheat bran in concentrate mixture with of black gram foliage. The economics of milk production calculated as feed cost per kg milk yield (INR 10.61 vs 7.98) was reduced by complete replacement of wheat bran with black gram foliage. Conclusion: Black gram foliage could be used as complete replacement for wheat bran in concentrate mixture of dairy cows in formulating least cost ration for economic milk production in small holders' animal production.

• Journal of the Korean Data and Information Science Society
• /
• v.21 no.6
• /
• pp.1051-1060
• /
• 2010

In the plating process of the IC chips for the printed circuit board manufacturing, specification limits for the plating thickness are usually given but its target is not specified in most cases. When the target is not specified, the center point of the specification limits is used instead. When the process capability is large, however, the use of the center point for the target is not the best choice in the context of the total cost. In this paper, the total cost is defined in terms of the production cost and the loss function, and then the optimal choice for target is studied in order to minimize the expected loss. As a consequence, the optimal choice of the target reduces the expected loss significantly, while reducing the process capability slightly.