• Journal of Nutrition and Health
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• v.31 no.9
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• pp.1394-1403
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• 1998

The study was designed to observe the effect of dietary calcium and fats on plasma cholesterol level, hepatic microsomal fluidity and HMG-CoA reductase activity as well as the excretion of fecal bile acids and neutral sterols in 1, 2-dimethylhydrazine(DMH)-treated rats. Male Sprague Dawley rats, at 7 weeks of age, were divided into 2 groups, 0.3% and 1.0% Ca levels and each group again subdivided into 2 groups of corn oil and perilla oil. Each rat was intramuscularly infused with DMH for 6 weeks to give total dose of 180mg/kg body weight and also fed experimental diet containing 15%(w/w) different fit and Ca(0.3% or 1.0%) for 20 weeks. High dietary calcium(1.0%) did not significantly influence on plasma cholesterol as well as hepatic microsomal fluidity and HMG CoA reductase activity, but significantly reduced the excretion of total bile acid per gram of faces and increased the excretion of total neutral sterol. However, high dietary Ca reduced the excretion of secondary bile acid(deoxycholic and lithocholic acids) which was known as promoter for colon cancer. Perilla oil rich in n-3 ${\alpha}$-linolenic acid significantly decreased plasma cholesterol by increasing hepatic microsomal fluidity compared with corn oil, but did not influence on HMG CoA reductase activity. Perilla oil did not influence on fecal excretion of total and primary bile acids, but reduced the excretion of secondary bile acids. Therefore, it could be recommended to consume more fish product and food rich in calcium and use more perilla oil in meal preparation to prevent from coronary hear disease and colon cancer especially when high fit diet has been practiced. (Korean Nutrition 31(9) : 1394-1403, 1998)

• Journal of Society of Preventive Korean Medicine
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• v.6 no.2
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• pp.95-103
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• 2002

In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.

• Journal of Nutrition and Health
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• v.38 no.5
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• pp.344-351
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• 2005

The purpose of this study was to examine the impact of isoflavones on lipid concentrations and hepatic LDL receptor mRNA level in growing female rats. Twenty four rats (body weight $75\pm5g$) were randomly assigned to one of two groups, consuming control diet or isoflavones supplemented diet (57mg isoflavones/100g diet). All rats has been fed on experimental diet and deionized water ad libitum for 9 weeks. The concentration of triglyceride and total cholesterol were measured in serum and liver. Serum HDL cholesterol was measured. Hepatic LDL receptor mRNA level was tested by RT-PCR. Supplementation of isoflavones did not affect weight gain, mean food intake and food efficiency ratio. Serum total cholesterol and non-HDL cholesterol of isoflavones supplemented rats were significantly lower than those of control rats (p<0.05). But hepatic cholseterol was not influenced by supplementation of isoflavones. Hepatic LDL receptor mRNA level not significantly different between control group and isoflavones supplemented group. Therefore, isoflavones may be beneficial on serum cholesterol and non-HDL cholesterol lowering in growing female rats.

• Journal of Food Hygiene and Safety
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• v.14 no.1
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• pp.122-128
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• 1999

The cholesterol-lowering effect of a fermented milk was studied for long-term period (56 weeks) in 206 Korean adults (106 normal cholesterol group and 100 hypercholesterol group) 300 $m\ell$ of the fermented milk was taken daily to all subjects for 10 weeks. 24 subjects drinking the fermented milk for 56 weeks and 42 subjects no-drinking for 40 weeks and then re-drinking from 50 th week for 6 weeks were followed up. Paired t-test, Duncan's multiple range test, and GLM repeated measure were used for statistical analysis. The level of total blood cholesterol and LDL after drinking the fermented milk for 10 weeks were decreased significantly in both group and affected by total cholesterol level at baseline, BMI, smoking and drinking. there is no significant change in triglyceride, HDL, and LDL/HDL ratio by drinking the fermented milk. The fermented milk intake for long-term period (56 weeks) did not show any more effect after 10 week on the level of TC, TG, HDL, LDL.

• Journal of Digital Convergence
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• v.18 no.12
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• pp.615-630
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• 2020

This study analyzes the difference in total cholesterol blood concentration according to dietary characteristics and health characteristics, as well as general characteristics, and the relationship between that factor and total cholesterol level according to the diagnostic criteria for dyslipidemia, and then compares and analyzes the relative risk ratio of significant factors for the occurrence of dyslipidemia. As a result, the total cholesterol blood concentration increases with age, so continuous management is necessary. Mainly, waist circumference level in early adulthood, regular exercise of appropriate intensity in late adulthood, and subjective health level management in the elderly are necessary. It was found that it was necessary to manage BMI level and eating-out level overall.

• Journal of the Korean Society of Food Culture
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• v.25 no.1
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• pp.91-99
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• 2010

To elucidate the effects of an obesity control program on body composition and serum lipid levels, 31 obese elementary students (male: 25, female: 6) residing in the Gyeonggi area were evaluated and their body composition, serum total cholesterol, HDL-cholesterol, LDL-cholesterol and TG (triglyceride) were analyzed. The average age, height, weight and BMI (body mass index) were $11.52{\pm}1.00\;yrs$, $151.96{\pm}8.04\;cm$, $68.21{\pm}9.03\;kg$ and $29.40{\pm}1.79\;kg/m^2$ for the males, respectively, and $11.17{\pm}1.17\;yrs$, $147.83{\pm}5.15\;cm$, $65.05{\pm}10.86\;kg$ and $29.62{\pm}3.24\;kg/m^2$ for the females, respectively. There was a significant decrease in BMI for males (p<0.001) and females (p<0.05). There were also significant changes in all of the biochemical levels evaluated before and after the study. Specifically, the total cholesterol, LDL-cholesterol and TG level decreased after the obesity control program, while the HDL-cholesterol level increased after the program. These results indicate that obesity control programs do change the BMI, serum total cholesterol, HDL-cholesterol, LDL-cholesterol and TG levels in obese elementary students. Thus, obesity control programs are urgently needed to prevent degenerative disease and decrease obesity among children in elementary school.

• Journal of the East Asian Society of Dietary Life
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• v.8 no.2
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• pp.93-106
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• 1998

This study was designed to find out the effects on the lipid metabolism of two herbs used in folk treatment in Korea The two herbs were A: Equisetum arvense L. (Seddugi), B: Eunymus alatus Siebold (Hwasalnamoo). The experiment was performed with the male rats of Sprague-Dawley which fed on high calorie and animal fat supplemented diets from which 30% of the total calories can from lard. Experimental groups were divided into standard (ST) and two other(A, B) groups for the each herb. Each of the two experimental groups consisted of three subgroups (I, II, III) according to the three different doses of the folk remedy used, which were five times and ten times the dose commonly used in a folk remedy. During the experimental period, total food intake and body weight gains were measured, and FER, CER, PER were calculated at the same times. Serum levels of triglyceride, total lipid, ttal cholesterol, HDL-cholesterol, and total lipid as well as cholesterol contents of the liver were measured at the time of sacrifice. Epididymal fat pads were weighted and an indes was calculated. The results of the effects on the lipid metabolism were as follows : 1.Total food intake and body weight gains increased in group A & B. 2. The serum levels of the total lipid and triglyceride decreased in AIII, BI and BIII.3. The serum level of cholesterol decreased in group B, while level of HDL-Cholesterol were increased in all groups and most effectively in group B. 4. The contents of total liver lipid increased in groups A&B. cholesterol decreased in groups A&B. In conclusion, effects on the lipid metabolism associated with the kinds of herbs a diet were the increase of body weighta and the decrease of total lipid and cholesterol levels in serum and liver.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.372-376
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• 2006

In order to study the effects of Cervi pantotrichum on hyperlipidemia, we divided the rats into three groups (normal group, control group & sample group) and perfomed the experimental research. Hyperlipidemia rat was induced by olive oil $1m{\ell}$(involved cholesterol 0.05g)/1200g for 10 days. The sample group was administerd the extract of Cervipantotrichum 10.8mg/200g for 5 days. and control group was administerd equal dose of saline. And then we measured the amount of serum total cholesterol, triglyceride, HDL-cholesterol, and phospholipid. Cervi pantotrichum showed decreasing effects on total cholesterol, LDL-cholesterol and phospholipid level, and increasing effects on HDL-cholesterol level in serum significantly. According to the above results, Cervi pantotrichum showed significant decreasing effects on hyperlipidemia, and it is considered that it is appropriate to apply for hyperlipidemia.

• Nutritional Sciences
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• v.9 no.2
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• pp.74-81
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• 2006

The present study examined the effect of soy isoflavones on lipid metabolism in growing female rats. Rats were randomly assigned to three different groups and provided experimental diets for 9 weeks. The experimental groups were classified into 1) a control group, 2) a soy protein isolate group: soy (+)) group and 3) a soy protein concentration group: soy (-)) group. Diets contained either casein or one of two soy proteins with (soy (+)) or without isoflavones (soy (-)). Serum triglyceride concentration showed no significant differences among the experimental groups. Serum total cholesterol concentration was significantly lower in both the soy (+) and soy (-) groups than in the control group and LDL-cholesterol concentration was significantly lower in the soy (+). Serum HDL-cholesterol concentration was significantly higher in the control group than in the soy protein groups but the HDL-cholesterol share rate in total cholesterol tended to be lower in the control group than in the soy protein groups, insignificant as it was. Hepatic IDL receptor mRNA level was significantly increased in the soy (+) group when compared to the other two groups to be 20% higher than the control group. In conclusion, soy protein isolate, soy protein rich with isoflavones reduced serum total cholesterol and LDL-cholesterol concentration and increased hepatic IDL receptor mRNA expression in growing female rats. Therefore, it is considered that the intake of soy isoflvones during puberty can be advantageous in terms of the long-tenn control of serum lipid.

• Journal of the East Asian Society of Dietary Life
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• v.9 no.1
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• pp.27-34
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• 1999

This study was carried out to investigate the effects of the kinds and the amounts of dietary fiber on serum lipid composition in rats. Seventy-two male Sprague-Dawley rats weighting 160$\pm$10g were fed diets containing 1.0%, 3.6%, 6.0% and 10.0% $\alpha$-cellulose, pectin and alginic acid fer 4 weeks. Daily food intake of experimental groups was significantly higher in the u-cellulose 10.0% group than in the other groups. Increasing the dietary fiber level decreased the food efficiency ratio of the $\alpha$-cellulose, pectin and alginic acid groups. Serum triglyceride concentration was significantly lower in the rats fed the alginic acid diet. Serum total cholesterol concentration showed no significant difference in the kind and the amount of three dietary fibers. Serum HDL-cholesterol concentration was higher in $\alpha$-cellulose and pectin diet. HDL-cholesterol/total cholesterol ratio was higher in u-cellulose and pectin diet than alginic acid diet. In conclusion, alginic acid is good for the serum triglyceride decrease, pectin is good for HDL-cholesterol increase, $\alpha$-cellulose and alginic acid are good for HDL-cholesterol/total cholesterol ratio increase. But the different effects according to the dietary fiber's contents did not show a significant trend.