• The Korean Journal of Physiology and Pharmacology
• /
• 제16권4호
• /
• pp.273-279
• /
• 2012

Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h or 3.2 mg/kg daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women. Inter-individual random variabilities of CL and $V_d$ were 16% and 9%. Based on a CL estimate from the final PK model, a simple dosage scheme to achieve the target $AUC_{0-inf}$ (defined as median AUC0-inf with a once-daily dosage) of 26.18 $mg/l{\cdot}hr$, was proposed: $24.79{\cdot}ABW^{0.5}mg$ q24h, where ABW represents the actual body weight in kilograms. The dosing scheme reduced the unexplained interindividual variabilities of CL and Vd of iBu with ABW being a significant covariate affecting clearance of iBU. We propose a new simple dosing scheme for iBu based only on ABW.

• Toxicological Research
• /
• 제33권3호
• /
• pp.239-253
• /
• 2017

Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide ($Nd_2O_3$) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized $Nd_2O_3-containing$ aerosols via a nose-only inhalation system at doses of $0mg/m^3$, $0.5mg/m^3$, $2.5mg/m^3$, and $10mg/m^3$ for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the $2.5mg/m^3$ and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the $0.5mg/m^3$ treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the $0.5mg/m^3$ group, but were exacerbated in the $10mg/m^3$ group. The lowest-observed-adverse-effect concentration of nano-sized $Nd_2O_3$ was determined to be $0.5mg/m^3$, and the target organ was determined to be the lung, under the present experimental conditions in male rats.

• 콘크리트학회논문집
• /
• 제24권4호
• /
• pp.435-444
• /
• 2012

기준재령 염소이온 확산계수를 측정하기 위하여 고성능 콘크리트 배합을 선정하고 공시체를 제작하였다. 배합은 해양환경에 건설되는 교량에 적합하도록 선정되었으며 배합설계 변수는 결합재 종류, 물-결합재비, 광물질 혼화재 치환율, 잔골재 종류, 고강도 및 고유동성을 얻기 위한 화학 혼화제 종류, 목표 슬럼프 또는 슬럼프 플로우이다. 시험 결과로부터 기준재령 염소이온 확산계수는 결합재 종류와 그 치환율에 따라 크게 다름을 확인하고, 결합재 종류와 치환율을 고려한 기준재령 확산계수 모델을 개발하였다. 개발된 모델의 확산계수를 기존 모델의 확산계수 및 추가 확산 계수 측정시험 결과 비교하여 개발된 모델의 타당성을 확인하였다.

• 한국건축시공학회지
• /
• 제18권2호
• /
• pp.133-140
• /
• 2018

이 연구의 목적은 바텀애시 및 준설토 기반의 인공 경량골재 콘크리트의 합리적 배합설계 절차를 제시하는 것이다. 25 배합의 실험결과를 바탕으로 경량골재 콘크리트의 목표성능(압축강도, 절건 밀도, 초기 슬럼프, 공기량)에 대하여 물-시멘트 비, 단위 시멘트양, 경량 잔골재 치환율을 결정하는 식을 제시하였다. 제안된 식과 절대용적 배합의 개념으로부터 각 구성요소들의 단위용적중량을 산정하였다. 제시된 배합설계 절차는 기존 결정에 효율적으로 이용될 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1897-1900
• /
• 2015

Purpose: To evaluate acute toxicity in nasopharyngeal cancer (NPC) patients treated with intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) with or without cisplatin-based chemotherapy. Materials and Methods: A total of 45 newly diagnosed, histologically proven non-metastatic NPC patients treated with IMRT between May 2010 and December 2012, were evaluated retrospectively, 37 planned with Eclipse and 8 with Prowess Panther treatment planning system. The doses to the planning target volumes of primary tumor and involved lymph nodes, high risk region, and uninvolved regional nodal areas were 70 Gy, 60 Gy, and 54 Gy respectively and delivered simultaneously over 33 fractions to 39 patients. Another 6 patients irradiated with sequential boost technique. Some 84.4% of patients received chemotherapy. Acute toxicities were graded according to the Radiation Therapy Oncology Group scoring criteria and Common Terminology Criteria for Adverse Events (CTCAE) for chemotherapy side effects. Results: Median age was 43 years (14-79) and all patients were WHO type II. Grade 1 mucositis and dysphagia were observed in 17 (37.8%), and 10 (22.2%) patients, respectively. The incidence of acute grade 2 mucositis and dysphagia was 55.6% and 68.9%, respectively. The most common chemoradiotherapy related acute toxicities were nausea, leucopenia and thrombocytopenia. Grade 3 toxicity was detected in 13 (28.8%) cases. No grade 4 toxicity was occurred. Mean weight loss was 9%. None of the patients required the insertion of percutaneous endoscopic gastrostomy for nutritional support. Radiation therapy was completed without interruption in all patients. Conclusions: IMRT is a safe and effective treatment modality, and well tolerated by patients in the treatment of nasopharyngeal carcinoma. No unexpected side effects were observed.

• 대한지역사회영양학회지
• /
• 제12권1호
• /
• pp.68-79
• /
• 2007

Iron deficiency is the most common nutritional problem that affects people of all ages in both industrialized and developing countries. Especially, college women are the target population for dietary iron deficiency. Recent study showed that the nutritional status of college women was poor because of insufficient food consumption and repeatabled weight reduction. The purpose of this study was to investigate the effects of nutrition counseling on the diet quality, nutritional status of iron and hematic parameters in college women who have self-recognized anemic symptoms. Anthropometric and dietary assessments as well as blood analysis, were carried out before and after the 8 weeks of nutrition counseling. During the experimental period, the 31 subjects were given nutrition education by a clinical dietitian. Nutrition counseling consisted of pathology of anemia, nutrition information for iron deficient anemia, diet information of balanced meals and menu choices for eating out. As a result, the frequencies of consumption of legumen and vegetables significantly increased after nutrition counseling(p<0.05). Daily intakes of protein, especially animal protein, vitamin E, niacin, heme iron, and zinc significantly increased(p<0.05). After nutrition counseling, some self-reported clinical symptoms such as 'dizziness', 'fatigue', 'short of breath', 'headache', 'sleeplessness', and 'beating heart' were significantly improved. Serum levels of transferrin(p<0.01) and total iron binding capacity levels(p<0.05) significantly increased. It could be concluded that the 8 weeks of nutrition counseling might be effective on quality of diet as well as iron status and it might also improve the some hematic parameters in college women who have self-recognized anemic symptoms.

• 한국의류산업학회지
• /
• 제7권3호
• /
• pp.301-308
• /
• 2005

The purpose of this study is to design men's clothing pattern that supplemented the problems of body shapes, by grasping the physical characteristics of middle-aged men and classifying their body shapes through comparing measurements after carrying out the human-body measurement targeting 120 middle-aged men at the age of 35-49 in full. As to the technical-statistic analysis of the measurement items, it could be seen that the middle-aged people who are the research target, have the obese body shapes. As a result of carrying out the factor analysis by the measurement analysis, it was derived the totally five factors such as thickness and width, stature and height, weight and girth, the bust length, and the shoulder shape. The total communality is 78.47%, and as a result of the cluster analysis by the factor score, it was classified into three clusters. Type 1 is the body shape with the great stature, the waist region a little obese, and the biggest thickness, width and girth. It is a flat body shape with the narrow shoulder and the smallest difference between the breast width and the waist width. As type 2 is the body shape that is small stature and is relatively not fat, it is the shape with the biggest difference between the breast width and the waist width and with the wide shoulder. Type 3 is the body shape that belongs to the middle of type 1 and type 2, has the upper-part body longer than other body shapes, and has the developed breast region with the biggest bosom width and bosom thickness.

• 한국정보과학회논문지:시스템및이론
• /
• 제36권5호
• /
• pp.422-428
• /
• 2009

플래시 메모리는 부피가 작고, 가볍고, 소비전력이 낮으며 입출력이 빨라 최근 소형기기의 저장 장치로 널리 사용이 되고 있다. 그러나 플래시 메모리는 지움 연산을 수반하는 가비지 컬렉션을 수행해야 한다. 지움 연산은 속도가 느리고, 각 블록마다 지움 연산 횟수가 제한이 있다. 따라서 본 논문에서는 지움 연산 횟수와 각 블록의 지움 횟수 편차를 줄이는데 초점을 맞춘 균등화 정책을 제안한다. 따라서 플래시 메모리의 페이지 사용률에 기반을 둔 두 가지 가비지 컬렉션 수행 모드를 정의하고 그리고 각 모드에 대해 다른 지움 비용을 계산하여 전체 지움 연산 횟수와 각 블록의 지움 횟수 편차를 최소화하는 가비지 컬렉션 기법을 제안한다. 추가로 가비지 컬렉션 연산 시간을 최소화하기 위해 그룹 관리 기법을 제안해 보다 빠른 수행 시간을 가질 수 있도록 한다. 실험 결과 제안하는 정책은 기존의 Greedy 와 CAT 기법의 장점들을 동시에 나타내었고, 지움 횟수 편차를 평균 85% 감소 시켰고 가비지 컬렉션 수행 시간을 최대 6% 단축 시켰다

• International Journal of Naval Architecture and Ocean Engineering
• /
• 제3권4호
• /
• pp.274-285
• /
• 2011

The supercavitating vehicle is an underwater vehicle that is surrounded almost completely by a supercavity to reduce hydrodynamic drag substantially. Since the cruise speed of the vehicle is much higher than that of conventional submarines, the drag force is huge and a buckling may occur. The buckling phenomenon is analyzed in this study through static and dynamic approaches. Critical buckling load and pressure as well as buckling mode shapes are calculated using static buckling analysis and a stability map is obtained from dynamic buckling analysis. When the finite element method (FEM) is used for the buckling analysis, the solver requires a linear static solver and an eigenvalue solver. In this study, these two solvers are integrated and a consolidated buckling analysis module is constructed. Furthermore, Particle Swarm Optimization (PSO) algorithm is combined in the buckling analysis module to perform a design optimization computation of a simplified supercavitating vehicle. The simplified configuration includes cylindrical shell structure with three stiffeners. The target for the design optimization process is to minimize total weight while maintaining the given structure buckling-free.

• 대한지역사회영양학회지
• /
• 제16권6호
• /
• pp.683-696
• /
• 2011

This study compared levels of health beliefs and health behavior practices according to lifestyle pattern among adults in Seoul. A self-administered survey questionnaire was collected from a total of 1,004 Seoul residents aged 30-59 years. The levels of perceived benefit, perceived barrier, and self-efficacy from health belief model and health behavior practices were measured across multiple health behavior areas including dietary behavior, drinking, smoking, exercise, functional food consumption, and weight control behavior. Factor analysis and subsequent cluster analysis based on 28 lifestyle questions divided the subjects into four lifestyles of society-, economy-, trend-, and health-oriented lifestyle. Some general characteristics were significantly different by lifestyles. The society-oriented lifestyle was significantly higher in proportions of men and overweight. The trend-oriented lifestyle was significantly younger and spent more monthly allowance. Health-oriented lifestyle was older. The levels of health belief variables and health behavior practices significantly differed by lifestyles. Overall the health-oriented lifestyle showed more desirable levels of health belief variables and health behavior practice in various health behavior areas compared to the other lifestyles, whereas the society-oriented lifestyle was found the other way. Health belief model variables including perceived benefit, perceived barrier, and self-efficacy were generally significant in predicting the levels of various health behavior practice, with somewhat differences by lifestyle pattern and health behavior type. The study findings suggest it may be useful to segment target subjects according to lifestyle pattern in planning and administering health education programs.