• Korean Journal of Environmental Biology
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• v.25 no.4
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• pp.289-296
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• 2007

Di-(ethyhexyl) phthalate (DEHP), commonly used as a plasticizer for manufacturing flexible vinyl products, has been the topic of extensive research, especially concerning endocrine disrupting properties. Metallothionein (MT) is a low molecular weight (6,000$\sim$7,000 Da), cysteine-rich (22$\sim$23%), metal-binding protein and is known to be induced by extrinsic factors such as chemical agents and stresses. Some of the known function of MT include detoxification of heavy metals and alkylating agents and neutralization of free radicals. Nonetheless, the definitive physiological function of MT are still unknown. This study was carried out to investigate the effects of DEHP on the ultrastructural changes and the expression of MT of the rat liver. The rats were orally intubated with either corn oil (experimental control) or 0.5 mg, 1.5 mg and 4.5 mg DEHP kg$^{-1}$ day$^{-1}$ in 0.5 mL of corn oil for 15 days before sacrificing and sampling. DEHP induced mild ultrastrctural changes of some cell organelles such as rough endoplasmic reticulum, mitochondria, lysosomes and peroxisomes in the rat liver treated with DEHP. In the respect of immunogold labelling and Western blotting, MT expression of the liver tissue was up-regulated by DEHP. In conclusion, DEHP has effects on the ultrastructures and hepatic function for MT expression in rat.

• Archives of design research
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• v.16 no.1
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• pp.103-116
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• 2003

As the globalization become the main stream in our world, there is no exception also on the cultural section. And we are En the midst of this rapid transition. In the case of advertising market, we opened to those agencies in abroad in the early year of 1990 and now completely opened. On this thesis, the multinational corporation advertising was studied and researched by empirical case study. The main topic is the value expression in the advertising creativity viewed on the cultural level. The multinational corporations that have an eminent, powerful brands produces much of goods wend widely with their powerful brands and extend their marketing activities to abroad. For example, those non-alcoholic beverages, pharmaceutical products, cosmetics, electronic appliances, vehicles, sports shoes, clothes are their main exports, and they broaden the product category, market size to the global market. They also use an expert marketing skill accumulated for a long time. The advertising activities is one of the useful method to extend their global market abroad enhacing continuously brand value. And much of the multinational corporation's advertising are suspected of negative effects that advertisements works on a tool which curies so called uniformed ideology - various ruling ideology - with commercial messages. These advertising affect an developing country's moral value, life style, social value, and others. And they weaken those developing country's unique tradition, culture by putting their own ideology. Those who have a critical position on the advertising activities have been careful in judging it's effects. The result of this study which of the value system is expressed in the multinational corporation's advertisements are; First, the self - esteem value is classified by western value, and it was founded out much more in the domestic corporation's advertisements then multinational ones. Second, the security value system is classified by western value system, and it's outcome was much the same as former one. Consequently, the multinational corporation's advertisements have less of an western value expression relative to korean advertisements. Those outcomes may infer that the multinational corporations prefer to an compromise creative strategy in korea for avoiding cultural conflicts.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.353-365
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• 2019

The purpose of this research is to guide the development of the program for the Directive Individual Sand Box Play for the improvement of the self-esteem of children of the dissolved multicultural families. For quantitative analysis data, the scores from before and after the program were compared. The SPSS 18.0 Package was used for statistical analysis. For the qualitative analysis, the linguistic changes in B children during the session were collected and analyzed using the self-expression scale. The research period lasted for around 3 months from February 2017 to May 2017, for a total of 12 sessions which included individual activities, 1 session of group activities, and 1 night and 2 days of family camp activities featuring a total of 6 children. The main results of this research include quantitatively through the program of the Directive Individual Sand Box Play in relation to the social self-esteem capability at z=-2,200 on the level of p<.05, the significant difference was shown. Qualitatively, positive expression increased as sessions proceeded and negative expression reduced regarding the linguistic expressions by session of children B. This means that the method of the Directive Individual Sand Box which presents the topic and in addition, the process of visiting the house of a child which is the most secure environment had shown the effectiveness that increases the improvement of the self-esteem of the children of the dissolved multi-cultural families. According to the diverse special characteristics of clients, a preliminary basic framework for the mobile individual sand box program through the directive approach method will be prepared.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2607-2610
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• 2013

Malignant glioma, also known as brain cancer, is the most common intracranial tumor, having an extremely high mortality and recurrence rate. The survival rate of the affected patients is very low and treatment is difficult. Hence, growth inhibition of glioma has become a hot topic in the study of brain cancer treatment. Among the various isothiocyanate compounds, it has been confirmed that benzyl isothiocyanate (BITC) can inhibit the growth of a variety of tumors, including leukemia, glioma and lung cancer, both inside and outside the body. This study explored inhibitory effects of BITC on human glioma U87MG cells, as well as potential mechanisms. It was found that BITC could inhibit proliferation, induce apoptosis and arrest cell cycling of U87MG cells. In addition, it inhibited the expression of SOD and GSH, and caused oxidative stress to tumor cells. Therefore, it is believed that BITC can inhibit the growth of U87MG cells outside the body. Its mechanism may be related to the fact that BITC can cause oxidative stress to tumor cells.

• BMB Reports
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• v.48 no.3
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• pp.139-146
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• 2015

Adaptive brain function and synaptic plasticity rely on dynamic regulation of local proteome. One way for the neuron to introduce new proteins to the axon terminal is to transport those from the cell body, which had long been thought as the only source of axonal proteins. Another way, which is the topic of this review, is synthesizing proteins on site by local mRNA translation. Recent evidence indicates that the axon stores a reservoir of translationally silent mRNAs and regulates their expression solely by translational control. Different stimuli to axons, such as guidance cues, growth factors, and nerve injury, promote translation of selective mRNAs, a process required for the axon's ability to respond to these cues. One of the critical questions in the field of axonal protein synthesis is how mRNA-specific local translation is regulated by extracellular cues. Here, we review current experimental techniques that can be used to answer this question. Furthermore, we discuss how new technologies can help us understand what biological processes are regulated by axonal protein synthesis in vivo.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2591-2600
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• 2015

Breast cancer is the most common cancer worldwide among women and the second most common cancer. Approximately 15-23% of breast cancers over-express human epidermal growth factor receptor2 (HER2), a 185-kDa transmembrane tyrosine kinase, which is mainly found at the cell surface of tumor cells. HER2-positive breast cancer, featuring amplification of HER2/neu and negative expression of ER and PR, has the three following characteristics: rapid tumor growth, lower survival rate, and better response to adjuvant therapies. Clinically, it is notable for its role in a pathogenesis that is associated with increased disease recurrence and acts as a worse prognosis. At the same time, it represents a good target for anti-cancer immunotherapy despite the prevalence of drug resistance. New treatments are a major topic of research, and a brighter future can be expected. This review discusses the role of HER2 in breast cancer, therapeutic modalities available and prognostic factors.

• International Journal of High-Rise Buildings
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• v.5 no.4
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• pp.319-326
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• 2016

The ingenuity of structural engineers in the field of tall and super-tall buildings has led to some of the most remarkable inventions. During this evolution of structural engineering concepts in the last 100 years, the technical challenges that engineers encountered were extraordinary and the advances were unprecedented. However, as the accomplishments of structural engineers are progressing, the desire for taller and safer structures is also increasing. The diagrid structural system is part of this evolving process as it develops a new paradigm for tall building design combining engineering efficiency and new architectural expression. The first appearances of this type of tall buildings have already been constructed and the interest of both engineering and architectural communities is growing mainly due to the many advantages compared to other structural systems. This paper presents a simple approach on optimizing member sizes for the diagonals of steel diagrid tall buildings. The optimizing method is based on minimizing the volume of the diagonal elements of a diagrid structure. The constraints are coming from the stiffness-based design, limiting the tip deflection of the building to widely accepted regulative limits. In addition, the current paper attempts to open the discussion on the important topic of optimization and robustness for tall buildings and also studies the future of the diagrid structural system.

• Journal of the Korean Home Economics Association
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• v.43 no.5 s.207
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• pp.249-265
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• 2005

Creative application in elaborate techniques can not only make design constructs productive but also can widen designers' figurative perspectives. There are many techniques applied in fashion design such as folds, patchworks, embroidery, dyeing, industrial treatment, etc. In particular, folds play a significant part in enlightening clothes uniqueness in contemporary fashion design. The primary purpose of this study was to make new suggestion for the production of high value-added fashion goods by reviewing and synthesizing fold expressions. Diverse fold designs were retrieved through a comprehensive literature review on topic-related books, fashion dictionaries, and fashion encyclopedias. Significant cases of fashion designs using folds were retrieved from fashion magazines uploaded from 2000. There are three types of folds applied in fashion design. (1) The folds by needlework like tucks, smocking, shirring, and trimming type folds(ruffle, frill, flounce, and ruche). (2) The folds by chemical or mechanical treatment like permanent pleats and crinkle. (3) The folds of formative dress like drape. From a comprehensive review of the folds design cases after 2000, the following characteristics of folds design were identified: (1) a highlighted role in the whole, (2) mixture and deformation of techniques and materials, (3) 3-D surface effect, (4) creation of a unique figurative beauty, and (5) expression of diverse fashion image.

• International Journal of Knowledge Content Development & Technology
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• v.3 no.1
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• pp.81-95
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• 2013

Through a series of precise text handling processes, including automatic extraction of information from documents with knowledge from various fields, recognition of entity names, detection of core topics, analysis of the relations between the extracted information and topics, and automatic inference of new knowledge, the most efficient knowledge base of the relevant field is created, and plans to apply these to the information knowledge management and service are the core requirements necessary for intellectualization of information. In this paper, the knowledge base, which is a necessary core resource and comprehensive technology for intellectualization of science and technology information, is described and the usability of academic information services using it is evaluated. The knowledge base proposed in this article is an amalgamation of information expression and knowledge storage, composed of identifying code systems from terms to documents, by integrating terminologies, word intelligent networks, topic networks, classification systems, and authority data.

• Journal of the Korea Society for Simulation
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• v.24 no.2
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• pp.11-17
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• 2015

Although systems with finite capacities have been the topic of much study, there are as of yet no analytic expressions for (higher) moment and tail probability of stationary waiting times in systems with even constant processing times. The normal queueing theory cannot properly handle such systems due to the difficulties caused by finite capacity. In this study, for a DBR (Drum-Buffer-Rope) line production system with constant processing times, we introduce analytic expressions by using previous results obtained using a max-plus algebraic approach.