• 한국인터넷방송통신학회논문지
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• 제19권3호
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• pp.165-171
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• 2019

컴퓨터 구조의 연구 결과, 특정 영역의 하드웨어를 개발하는 과정에서 가격 대 에너지 성능의 획기적인 개선이 이뤄진다고 알려져 있다. 본 논문은 인공신경망(NN)의 추론을 가속화시킬 수 있는 텐서 처리부(TPU) ASIC에 대한 분석을 수행하였다. 텐서 처리부의 핵심장치는 고속의 연산이 가능한 MAC 행렬곱셈기와 소프트웨어로 관리되는 온칩 메모리이다. 텐서 처리부의 실행모델은 기존의 CPU와 GPU의 실행모델보다 인공신경망의 반응시간 요구사항을 제대로 충족시킬 수 있으며, 수많은 MAC과 큰 메모리를 장착함에도 불구하고 면적이 작고 전력 소비가 낮다. 텐서플로우 벤치마크 프레임워크에 대하여 텐서 처리부를 활용함으로써, CPU 또는 GPU보다 높은 성능과 전력 효율을 나타낼 수가 있다. 본 논문에서는 텐서 처리부를 분석하고, 파이썬을 이용하여 모델링한 OpenTPU에 대하여 모의실행을 하였으며, 그 핵심장치인 행렬 곱셈부에 대한 합성을 시행하였다.

• 한국해양공학회지
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• 제33권3호
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• pp.214-221
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• 2019

A series of model tests was performed to evaluate the survivability of an articulated tower-type buoy structure under harsh environmental conditions. The buoy structure consisted of three long pipes, a buoyancy module, and top equipment. The scale model was made of acrylic pipe and plastic with a scale ratio of 1/22. The experiments were carried out at the ocean engineering basin of KRISO. The performance of the buoy structure was investigated under waves only and under combined environmental conditions from sea state (SS) 5 to 7. A nonlinear time-domain numerical simulation was conducted using the mooring analysis program OrcaFlex. The survivability of the buoy was analyzed based on three factors: the pitch motion, submergence of the top structure, and anchor reaction force. The model test results were directly compared to the results of numerical simulations. The effects of the sea state and combined environment on the performance of the buoy structure were investigated.

• BMB Reports
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• 제52권6호
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• pp.373-378
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• 2019

The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis (OA). We investigated whether NOD2 was involved in 29-kDa FN-f-induced pro-catabolic gene expression in human chondrocytes. The expression of mRNA and protein was measured using quantitative real-time polymerase chain reaction (qrt-PCR) and Western blot analysis. Small interfering RNAs were used for knockdown of NOD2 and toll-like receptor 2 (TLR-2). An immunoprecipitation assay was performed to examine protein interactions. The NOD2 levels in human OA cartilage were much higher than in normal cartilage. NOD1 and NOD2 expression, as well as pro-inflammatory cytokines, including interleukin-1beta (IL-$1{\beta}$) and tumor necrosis factor-alpha (TNF-${\alpha}$), were upregulated by 29-kDa FN-f in human chondrocytes. NOD2 silencing showed that NOD2 was involved in the 29-kDa FN-f-induced expression of TLR-2. Expressions of IL-6, IL-8, matrix metalloproteinase (MMP)-1, -3, and -13 were also suppressed by TLR-2 knockdown. Furthermore, NOD2 and TLR-2 knockdown data demonstrated that both NOD2 and TLR-2 modulated the expressions of their adaptors, receptorinteracting protein 2 (RIP2) and myeloid differentiation 88, in 29-kDa FN-f-treated chondrocytes. 29-kDa FN-f enhanced the interaction of NOD2, RIP2 and transforming growth factor beta-activated kinase 1 (TAK1), an indispensable signaling intermediate in the TLR-2 signaling pathway, and activated nuclear factor-${\kappa}B$ (NF-${\kappa}B$), subsequently leading to increased expressions of pro-inflammatory cytokines and cartilage-degrading enzymes. These results demonstrate that 29-kDa FN-f modulated pro-catabolic responses via cross-regulation of NOD2 and TLR-2 signaling pathways.

• 지질공학
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• 제31권3호
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• pp.257-267
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• 2021

Constraints on the structure and composition of the active layer are important for understanding permafrost evolution. Soil convection owing to repeated moisture-induced freeze-thaw cycles within the active layer promotes the formation of self-organized patterned ground. Here we present the results of ground penetrating radar (GPR) surveys across a selected sorted circle near King Sejong Station, Antarctica, to better delineate the active layer and its relation to the observed patterned ground structure. We acquire GPR data in both bistatic mode (common mid-points) for precise velocity constraints and monostatic mode (common-offset) for subsurface imaging. Reflections are derived from the active layer-permafrost boundary, organic layer-weathered soil boundary within the active layer, and frozen rock-fracture-filled ice boundary within the permafrost. The base of the imaged sorted circle possesses a convex-down shape in the central silty zone, which is typical for the pattern associated with convection-like soil motion within the active layer. The boundary between the central fine-silty domain and coarse-grained stone border is effectively identified in a radar amplitude contour at the assumed active layer depth, and is further examined in the frequency spectra of the near- and far-offset traces. The far-offset traces and the traces from the lower frequency components dominant on the far-offset traces would be associated with rapid absorption of higher frequency radiowave due to the voids in gravel-rich zone. The presented correlation strategies for analyzing very shallow, thin-layered GPR reflection data can potentially be applied to the various types of patterned ground, particularly for acquiring time-lapse imaging, when electric resistivity tomography is incorporated into the analysis.

• Journal of Microbiology and Biotechnology
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• 제31권11호
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• pp.1591-1600
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• 2021

Streptomyces coelicolor is a filamentous soil bacterium producing several kinds of antibiotics. S. coelicolor abs8752 is an abs (antibiotic synthesis deficient)-type mutation at the absR locus; it is characterized by an incapacity to produce any of the four antibiotics synthesized by its parental strain J1501. A chromosomal DNA fragment from S. coelicolor J1501, capable of complementing the abs- phenotype of the abs8752 mutant, was cloned and analyzed. DNA sequencing revealed that two complete ORFs (SCO6992 and SCO6993) were present in opposite directions in the clone. Introduction of SCO6992 in the mutant strain resulted in a remarkable increase in the production of two pigmented antibiotics, actinorhodin and undecylprodigiosin, in S. coelicolor J1501 and abs8752. However, introduction of SCO6993 did not show any significant difference compared to the control, suggesting that SCO6992 is primarily involved in stimulating the biosynthesis of antibiotics in S. coelicolor. In silico analysis of SCO6992 (359 aa, 39.5 kDa) revealed that sequences homologous to SCO6992 were all annotated as hypothetical proteins. Although a metalloprotease domain with a conserved metal-binding motif was found in SCO6992, the recombinant rSCO6992 did not show any protease activity. Instead, it showed very strong β-glucuronidase activity in an API ZYM assay and toward two artificial substrates, p-nitrophenyl-β-D-glucuronide and AS-BI-β-D-glucuronide. The binding between rSCO6992 and Zn²⁺ was confirmed by circular dichroism spectroscopy. We report for the first time that SCO6992 is a novel protein with β-glucuronidase activity, that has a distinct primary structure and physiological role from those of previously reported β-glucuronidases.

• 한국정보통신학회논문지
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• 제25권11호
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• pp.1619-1626
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• 2021

증분형 아날로그 디지털 변환기는 전통적인 델타 시그마 아날로그 디지털 컨버터와 달리 리셋 동작을 통한 입력과 출력의 1:1 매핑이 가능하며 이는 멀티플렉싱에 매우 용이하게 사용될 수 있다. 또한, 증분형 아날로그 디지털 변화기는 전통적인 델타 시그마 변환기에 비해 간단한 디지털 필터 설계가 가능하다. 따라서, 본 논문에서는 아날로그 디지털 컨버터 설계에 기본이 되는 딜레이가 있는 적분기와 딜레이가 없는 적분기의 시간 영역에서의 분석을 시작으로 2차 입력 피드 포워드, 확장된 카운팅, 2+1 매쉬, 2+2 매쉬 구조를 갖는 증분형 아날로그 디지털 변환기의 설계 방정식을 유도한다. 이를 통해 설계 이전에 증분형 아날로그 디지털 변환기의 성능을 예측할 수 있을 뿐만 아니라 각각의 아날로그 디지털 변화기에 적합한 디지털 필터를 설계할 수 있다. 또한, 아날로그 디지털 변환기의 정확도를 향상 시키기 위한 확장된 카운팅, MASH의 설계 기술들을 제안하였다.

• Steel and Composite Structures
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• 제43권1호
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• pp.79-90
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• 2022

In this study, the dynamic behavior of functionally graded layered deep beams with viscoelastic core is investigated including the porosity effect. The material properties of functionally graded layers are assumed to vary continuously through thickness direction according to the power-law function. To investigate porosity effect in functionally graded layers, three different distribution models are considered. The viscoelastically cored deep beam is exposed to harmonic sinusoidal load. The composite beam is modeled based on plane stress assumption. The dynamic equations of motion of the composite beam are derived based on the Hamilton principle. Within the framework of the finite element method (FEM), 2D twelve -node plane element is exploited to discretize the space domain. The discretized finite element model is solved using the Newmark average acceleration technique. The validity of the developed procedure is demonstrated by comparing the obtained results and good agreement is detected. Parametric studies are conducted to demonstrate the applicability of the developed methodology to study and analyze the dynamic response of viscoelastically cored porous functionally graded deep beams. Effects of viscoelastic parameter, porosity parameter, graduation index on the dynamic behavior of porous functionally graded deep beams with viscoelastic core are investigated and discussed. Material damping and porosity have a significant effect on the forced vibration response under harmonic excitation force. Increasing the material viscosity parameters results in decreasing the vibrational amplitudes and increasing the vibration time period due to increasing damping effect. Obtained results are supportive for the design and manufacturing of such type of composite beam structures.

• Smart Structures and Systems
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• 제29권2호
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• pp.267-278
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• 2022

Pre-stressed concrete circular spun piles are widely used in various infrastructure projects around the world and offer an economical deep foundation system with consistent and superior quality compared to cast in-situ and other concrete piles. Conventional methods for measuring the lateral response of piles have been limited to conventional instrumentation, such as electrical based gauges and pressure transducers. The problem with existing technology is that the sensors are not able to assist in recording the lateral stiffness changes of the pile which varies along the length depending on the distribution of the flexural moments and appearance of tensile cracks. This paper describes a full-scale bending test of a 1-m diameter spun pile of 30 m long and instrumented using advanced fibre optic distributed sensor, known as Brillouin Optical Time Domain Analysis (BOTDA). Optical fibre sensors were embedded inside the concrete during the manufacturing stage and attached on the concrete surface in order to measure the pile's full-length flexural behaviour under the prescribed serviceability and ultimate limit state. The relationship between moments-deflections and bending moments-curvatures are examined with respect to the lateral forces. Tensile cracks were measured and compared with the peak strains observed from BOTDA data which corroborated very well. By analysing the moment-curvature response of the pile, the structure can be represented by two bending stiffness parameters, namely the pre-yield (EI) and post-yield (EI_cr), where the cracks reduce the stiffness property by 89%. The pile deflection profile can be attained from optical fibre data through closed-form solutions, which generally matched with the displacements recorded by Linear Voltage Displacement Transducers (LVDTs).

• 문화기술의 융합
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• 제8권6호
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• pp.637-646
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• 2022

본 논문은 한국어의 겹받침 발음에 대하여 베트남인 한국어 학습자와 한국인을 비교 연구하였다. 언어학적인 연구를 통하여 조사하고 분석한 겹받침 발음에 관한 여러 오류와 제시한 교육 방법에 대하여 공학적 특히 음성 신호처리의 분석 방법을 활용하여서 이런 연구 결과를 확인하였고 이에 우리는 본 논문에서 새로운 교육 방법을 제시하였다. 인공지능의 기계 학습에 많이 활용되고 있는 서포팅 벡터 머신 (supporting vector machine, SVM)을 사용하여서 베트남인 학습자의 발음과 한국인의 발음을 비교하였다. SVM의 초결정 평면을 구할 수 있다는 것은 베트남인 학습자의 겹받침 발음이 한국인의 발음과 차이를 보인다는 것이고, 그 반대라면 발음을 잘하고 있다는 것이다. 본 논문에서 우리가 제시한 새로운 교육 방법은 쓰기와 듣기로만 구성하는 것이 아닌 음성 신호의 시간 영역에서 파형과 그것에 대응하는 신호의 에너지 등과 같은 피교육자에게 보일 수 있는 것들을 포함하는 효율적인 발음 교육 방법이다.

• 대한물리의학회지
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• 제17권2호
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• pp.41-51
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• 2022

PURPOSE: The functional limitations in stroke survivors promote sedentary lifestyles and quality of life inadequacies, but there is increasing evidence that this could be minimized by physical exercise. Therefore, this study examined the effects of physical exercise on the quality of life (QoL) and functional capacity (ability to stand up from a sitting position) among stroke survivors drafted from two tertiary hospitals in Osogbo, Nigeria. METHODS: A purposive sampling technique was used to select 21 registered right or left outpatient hemiplegic stroke survivors in a pre- and post-test experimental research design. The research questions were presented using descriptive statistics of frequency, percentage, mean and standard deviation, while an Analysis of Variance (ANOVA) was used to test the study hypothesis at the .05 alpha level for significance. RESULTS: Compared to the baseline (week 0), there were significant increases in the general quality of life, healthy well-being, physical exercise, pain perception, and environmental domains of QOL among the survivors in week four. Moreover, a significant increase was observed in these indices in week eight, compared to week four, except for the pain perception domain. Compared to the baseline, there was a significant decrease in the time it took the stroke survivors to stand up from a sitting position in week four. A significant decrease was observed in this index in week eight compared to week four. CONCLUSION: Marked corridor 20 meters brief walking exercise for eight weeks significantly improved the quality of life and ability to stand up from a sitting position in stroke survivors in Osogbo, Nigeria.