• International Journal of Naval Architecture and Ocean Engineering
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• v.6 no.3
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• pp.749-761
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• 2014

Tubing adapter is a key connection device in Gas-Tight Deep-Sea Water Sampler (GTWS). The sealing performance of the tubing adapter directly affects the GTWS's overall gas tightness. Tubing adapters with good sealing performance can ensure the transmission of seawater samples without gas leakage and can be repeatedly used. However, the sealing performance of tubing adapters made of different materials was not studied sufficiently. With the research discussed in this paper, the materials match schemes of the tubing adapters were proposed. With non-linear finite element contact analysis and sea trials in the South China Sea, it is expected that the recommended materials match schemes not only meet the requirements of tubing adapters' sealing performance but also provide the feasible options for the following research on tubing adapters in GTWS.

• Tribology and Lubricants
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• v.34 no.6
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• pp.307-312
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• 2018

Unlike a typical static seals, spring-energized static seals exhibit improvement in leak-tightness by reinforcing the spring inside the aluminum lining. Thus, spring-energized static seals are widely used in various industrial fields, such as aerospace, semiconductors, and petrochemical industries. The primary objective of this study is to develop design guidelines for spring-energized static seals in a wide range of temperatures, including that of cryogenic environments, by analyzing the required performance and influence of design variables through simulations. There are various parameters that can be controlled to design a leak-tight seal. In this study, the finite element analysis (FEA) is performed by controlling the parameters related to the spring and the thickness of the aluminum lining, and the result of the leakage between the seal and the casing is confirmed. Considering the influence of each parameters, all of them are found to be important. However, it is observed that the spring-related variables are more important than the aluminum lining or other variables when complexity is considered. We can identify the threshold value of spring stiffness that changes leak-tight performance of the seal by performing FEA. Simulation results, under the conditions that are considered in this study, show that spring stiffness should be at least 3.6 N/m to maintain leak-tightness caused by the sufficient contact force between the aluminum lining and the upper and lower casings.

• Journal of Microbiology and Biotechnology
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• v.22 no.12
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• pp.1629-1635
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• 2012

Previously, we demonstrated that the erythropoietin receptor (EpoR) is present on fibroblasts, where it regulates focal contact. Here, we assessed whether this action of EpoR is involved in the reduced cell adhesion observed in colonocytes exposed to Clostridium difficile toxin A. EpoR was present and functionally active in cells of the human colonic epithelial cell line HT29 and epithelial cells of human colon tissues. Toxin A significantly decreased activating phosphorylations of EpoR and its downstream signaling molecules JAK-2 (Janus kinase 2) and STAT5 (signal transducer and activator of transcription 5). In vitro kinase assays confirmed that toxin A inhibited JAK 2 kinase activity. Pharmacological inhibition of JAK2 (with AG490) abrogated activating phosphorylations of EpoR and also decreased focal contacts in association with inactivation of paxillin, an essential focal adhesion molecule. In addition, AG490 treatment significantly decreased expression of occludin (a tight junction molecule) and tight junction levels. Taken together, these data suggest that inhibition of JAK2 by toxin A in colonocytes causes inactivation of EpoR, thereby enhancing the inhibition of focal contact formation and loss of tight junctions known to be associated with the enzymatic activity of toxin A.

• Journal of Food Hygiene and Safety
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• v.20 no.1
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• pp.13-17
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• 2005

The purpose of the present study was to investigate differences in the sensitizing potential of Rhus Veniciflua(Rhus-II), when tested by the guinea pig maximization test(GPMT) and Freund's complete adjuvant test(FCAT) with an identical, intradermal induction concentration. A new grading classification of the sensitization potential is proposed. The GPMT was conducted according to OECD guideline $\#406$, using a multiple-dose design and test results were analysed with logistic regression analysis. During the induction stage, we injected intradermally each three site 0.1 ml(l mg/animal) test material, 0.1 ml complete Freund's adjuvant and 0.lml the test agent emulsified in the adjuvant. 7 days later, we induced weak sensitization with $10\%$ sodium lauryl sulfate(SLS) and applide 1ml(l0mg/animal) test agent topically on the same site and made a tight occlusion. 14 days later we challenged with 1 ml(l 0mg/animal) of test material on the flank and observed ant 24 hours and 48 hours later. The results were also observed $0\%$ at 24 hours challenge. The results observed 48 hours after challenge were the identical. These data indicated that, although Rhus-II is a no contact allergen. It was reported that the skin sensitization by Rhus-II was not detected the skin sensitization in the guinea pig maximization test (GPMT). Consequently, it was confirmed that Rhus-II had no contact allergic sensitization in guinea pig maximization test.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.3
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• pp.35-43
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• 2008

Purpose: This review article was written to investigate how the various factors, such as lacrimal thickness, CL's thickness and Dk, affects the influx of $O_2$ diffusion into the cornea. Methods: A mathematical model was proposed to analyze the oxygen diffusion reaching the cornea through the tear layers and contact lens based on Fick's law and the principle of continuity of the diffusion flux through the each layers. Results: The model predicts how the parameters such as the thickness of tear layer on the cornea, both the Dk and thickness of contact lenses etc., affect the oxygen tension at cornea and oxygen flux entering the cornea. Conclusions: It is found that either too flat or too tightly fitted contact lenses can cause the oxygen deficiency at/inside the periphery of the cornea because of the reduction of oxygen flux resulted from too thickened tear layer.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.26 no.1
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• pp.19-23
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• 2020

Al-laminated packaging film incorporating ascorbic acid or tocopherol at inner food contact layer was tested in the potential to improve antioxidative preservation of powdered infant formula under CO₂-enriched atmosphere. Product of 200 g was packaged with the packaging film containing 0.3% antioxidant in sealant layer of low density polyethylene and stored at 30℃ for 286 days with periodic measurement of package atmosphere and product's quality attributes. The CO₂-flushed package resulted in shrinkage of tight contact between the product and the film not allowing gas sampling of package atmosphere after 140 days. Package of tocopherol-incorporated film allowed some ingress of oxygen after 112 days presumably due to its weakening of heat-seal area. The increased oxygen concentration in the tocopherol-added film package led to the concomitant increase of peroxide value, an index of lipid oxidation. On the other hand, packaging of ascorbic acid-added film pouch could suppress lipid oxidation marginally in consistent manner compared to control package without any antioxidant.

• Journal of Advanced Marine Engineering and Technology
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• v.27 no.1
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• pp.33-41
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• 2003

The optical properties of $ZnS_ySe_{1-\chi-y}:Te_{\chi}(\chi<0.08,y~0.11)$ alloys grown by molecular beam epitaxy (MBE) have been investigated by photoluminescence (PL) and PL-excitation (PLE) spectroscopy. Good optical properties and high crystal quality were established with lattice match condition to GaAs substrate. At room temperature, emission in the visible spectrum region from blue to green was obtained by varying the Te content of the ZnSSe:Te alloy. The efficient blue and green emission were assigned to $Te_1 and Te_n(n\geq2)$cluster bound excitons, respectively. Bright green (535 nm) and blue (462 nm) light emitting diodes (LEDs) have been developed using ZnSSe:Te system as an active layer. The turn-on voltage of 2.1 V in current-voltage characteristics is very small compared to that of commercial InGaN-based LEDs (>3.4 V), indicating the formation of a good ohmic contact due to the optimized p-ZnSe/p-ZnTe multi-quantum well (MQW) superlattice electrode layers.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07a
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• pp.18-21
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• 2002

As the mask design rules get smaller, the probability of the process failure becomes higher due to the narrow overlay margin between the contact and metal interconnect layers. To obtain the minimum process margin, a tabbing and cutting method is applied with the rule based optical proximity correction to the metal layer, so that the protection to bridge problems caused by the insufficient space margin between the metal layers can be accomplished. The side-lobe phenomenon from the attenuated phase shift mask with the tight design nile is analyzed through the aerial image simulation for test patterns with variation of the process parameters such as numerical aperture, transmission rate, and partial coherence. The corrected patterns are finally generated by the rules extracted from the side-lobe simulation.

• Journal of International Society for Simulation Surgery
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• v.3 no.2
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• pp.90-92
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• 2016

Horizontal bone defect in the anterior maxilla makes it difficult to place dental implant. The golden standard for bone augmentation is autogenous block bone graft. Tight contact with recipient site and rigid fixation are two key factors for successful block bone graft. Ramal bone graft has been the most reliable methods for dental implant field. However, the curvature of the alveolar ridge is different from ramal bone shape. Intraoperative trimming of ramal bone is cumbersome for surgeon. In this technical note, a simple way to design the ramal bone harvest using bone wax stent is reviewed.

• Proceedings of the IEEK Conference
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• 2002.06b
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• pp.209-212
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• 2002

As the mask design rules get smaller, the probability of the process failure becomes higher doc to the narrow overlay margin between the contact and metal interconnect layers. To obtain the minimum process margin, a tabbing and cutting method Is applied with the rule based optical\ulcorner proximity correction to the metal layer, so that the protection to bridge problems caused by the insufficient space margin between the metal layers can be accomplished. The side-lobe phenomenon from the attenuated phase shift mask with the tight design rule is analyzed through the aerial image simulation for test patterns with variation of the process parameters such as numerical aperture, transmission rate, and partial coherence. The corrected patterns are finally generated by the rules extracted from the side-lobe simulation.