• Title/Summary/Keyword: Thrombocytopenia

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A Case of Intestinal Hemangioma Complicated with Thrombocytopenia (Kasabach-Merritt syndrome) in Premature Infant (미숙아에서 혈소판 감소증에 의해 발견된 장 혈관종(Kasabach-Meritt 증후군) 1례)

  • Lee, Young-Jin;Bae, Sul-Hee;Song, Eun-Song;Choi, Soo-Jin-Na;Kim, Yoon-Ha;Choi, Young-Youn
    • Neonatal Medicine
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    • v.17 no.1
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    • pp.116-122
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    • 2010
  • Kasabach-Merritt syndrome is a rare thrombocytopenic consumptive coagulopathy associated with a giant hemangioma. We experienced a case of unexplained ascites with thrombocytopenia in a 32 week premature infant. An exploratory laparotomy was performed to determine the cause of the refractory ascites and thrombocytopenia. An intestinal hemangioma was found, but, surgical removal was not performed due to the extensive involvement. Hemangioma was confirmed by SPECT (single-photon emission computed tomography) and the thrombocytopenia was treated with steroid therapy. It is recommended that hemangioma of the visceral organs should be suspected when unexplained thrombocytopenia and disseminated intravascular coagulopathy persist.

Case Report of Thrombocytopenia Improved by Traditional Korean Medicine (한의치료로 호전을 보인 혈소판감소증 증례 1례)

  • Ye-seul Kim;Ji-yoon Park;Jung-hwa Hong;Eun-joo Seok;Young-ju Rhee;Lib Ahn;Dong-jun Choi
    • The Journal of Internal Korean Medicine
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    • v.44 no.2
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    • pp.216-221
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    • 2023
  • Objective: This study reports on the improvement of a patient with thrombocytopenia using Korean medicine. Methods: A 29-year-old woman was treated with acupuncture, moxibustion, and Korean herbal medicine. Platelet counts were checked periodically to identify improvements in thrombocytopenia. Results: The platelet count showed a marked improvement during treatment, with no side effects for the patient. Conclusion: This study suggests that Korean medicine could be used for the management of thrombocytopenia.

Advances in management of pediatric chronic immune thrombocytopenia: a narrative review

  • Jae Min Lee
    • Journal of Yeungnam Medical Science
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    • v.40 no.3
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    • pp.241-246
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    • 2023
  • Immune thrombocytopenia (ITP) is a disease in which thrombocytopenia occurs because of immune-mediated platelet destruction and decreased platelet production. Although many pediatric patients with ITP experience spontaneous remission or reach remission within 12 months of first-line therapy, approximately 20% progress to chronic ITP. Patients who do not respond to first-line treatment or experience frequent relapses are of great concern to physicians. This review summarizes recent treatments for second-line treatment of pediatric chronic ITP.

A Case of Carbamazepine-induced thrombocytopenia (Carbamazepine기인성으로 추정되는 혈소판감소증 치험 1례)

  • Kim Dong-Jo;Heo Geum-Jeong;Nam Chang-Gyu
    • The Journal of Internal Korean Medicine
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    • v.24 no.4_2
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    • pp.1080-1086
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    • 2003
  • As the use of anticonvulsant increases in neurologic field, more studies are needed to reveal various harmful effects of this medication. Especially as for carbamazepine, thrombocytopenia may appear during administration of the medication, regardless of dosage. We, the authors, report that we diagnosed the patient as Bigiheo and Eumheohyeolheo, who was suffering from insomnia, diarrhea, papura, and serious thrombocytopenia. We presumed that the symptoms could be induced by carbamazepine, and used Samulgwibitanggamibang to treat her and obtained positive results.

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A Case of Rifampin-induced Thrombocytopenia in Pulmonary Tuberculosis (Rifampin으로 폐결핵 치료 중 발생한 혈소판 감소증 1례)

  • Park, Seok Won;Cho, Hee Suk;Kim, Hwang Min;Lim, Baek Keun;Kim, Jong Soo
    • Pediatric Infection and Vaccine
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    • v.7 no.2
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    • pp.240-244
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    • 2000
  • Rifampin is a bactericidal antibiotic used primarily in the treatment of tuberculosis. The adverse effects of rifampin, though few, include dermatologic, gastrointestinal, and hepatic manifestations. Occasionally it produces a flu-like syndrome, interstitial nephritis, hemolytic anemia, and thrombocytopenia. These manifestations usually appear in patients who take the drug intermittently. We experienced a 13 year-old girl who developed thrombocytopenia during rifampin administration of daily dosage, therefore we report a brief review with the related literatures.

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A case of familial X-linked thrombocytopenia with a novel WAS gene mutation

  • Lee, Eu Kyoung;Eem, Yeun-Joo;Chung, Nack-Gyun;Kim, Myung Shin;Jeong, Dae Chul
    • Clinical and Experimental Pediatrics
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    • v.56 no.6
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    • pp.265-268
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    • 2013
  • Wiskott-Aldrich syndrome (WAS) is an inherited X-linked disorder. The WAS gene is located on the X chromosome and undergoes mutations, which affect various domains of the WAS protein, resulting in recurrent infection, eczema, and thrombocytopenia. However, the clinical features and severity of the disease vary according to the type of mutations in the WAS gene. Here, we describe the case of a 4-year-old boy with a history of marked thrombocytopenia since birth, who presented with recurrent herpes simplex infection and late onset of eczema. Examination of his family history revealed that older brother, who died from intracranial hemorrhage, had chronic idiopathic thrombocytopenia. Therefore, we proceeded with genetic analysis and found a new deletion mutation in the WAS gene: c.858delC (p.ser287Leufs$^*21$) as a hemizygous form.

Open Heart Surgery in Patient with Heparin- Induced Thrombocytopenia (헤파린 기인성 혈소판감소증 환자에서의 개심술)

  • 송석원;홍유선;곽영란;안신기
    • Journal of Chest Surgery
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    • v.35 no.6
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    • pp.475-478
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    • 2002
  • A 45 year old man was admitted for aggravated dyspnea, abdominal distension and poor oral intake. On Echocardiogram, mitral stenosis(severe), tricuspid regurgitaion(IV), and LA thrombus were diagnosed. We used heparin with continuous infusion for prevention of systemic thrombo embolism. On the 11th day of admission, the patient showed thrombocytopenia and we suspected Heparin-induced thrombocytopenia. Hirudin was used in this case as alternative anticoagulant during cardiopulmonary bypass to prevent serious complication of heparin. The patient was recovered without any complication as postoperative bleeding or systemic thromboembolism.

Confirmed cases of severe fever with thrombocytopenia syndrome in companion cats with a history of tick exposure in the Republic of Korea

  • Sun-Woo, Han;Ju-Hyun, An;Ji-Min, Rim;Eunseok, Jeong;Sungjun, Noh;Myoungdai, Kang;Jun-Gu, Kang;Joon-Seok, Chae
    • Journal of Veterinary Science
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    • v.23 no.6
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    • pp.83.1-83.7
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    • 2022
  • Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic disease, and its clinical information and prevalence are important. This study was conducted on 22 feline patients from the Republic of Korea (ROK), suspected to suffer from a tick-borne disease. Four cats were positive for SFTS, and genotypes B-1, B-3, D, and F were identified. Clinical symptoms, such as anorexia, jaundice, thrombocytopenia, leukopenia, and hyperbilirubinemia, were detected. This is the first report of SFTS virus genotypes B-1, D, and F from cats in the ROK. Moreover, our results suggest that jaundice may be an indicator of SFTS in cats.

Heparin-induced Thrombocytopenia Type II after Free Flap Operation

  • Baek, Jiwoong;Park, Jung Hyun;Cha, In-Ho;Kim, Hyung Jun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.35 no.6
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    • pp.408-411
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    • 2013
  • After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.

Immune thrombocytopenic purpura(ITP) (면역 혈소판감소 자색반병)

  • Shin, Hee Young
    • Clinical and Experimental Pediatrics
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    • v.49 no.8
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    • pp.830-832
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    • 2006
  • Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than $20,000/{\mu}L$. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection or insidiously with progressive petechiae, bruising, or purpura. In most cases the disease is self-limited; approximately 80% of children recover by 6 months after diagnosis, with or without treatment. Children with thrombocytopenia persisting for more than 6 months are defined as having chronic ITP. Clinical manifestations, diagnosis, laboratory findings, differential diagnosis and various treatment modalities are reviewed.