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Immune thrombocytopenic purpura(ITP)  

Shin, Hee Young (Department of Pediatrics, Seoul National University College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.49, no.8, 2006 , pp. 830-832 More about this Journal
Abstract
Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than $20,000/{\mu}L$. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection or insidiously with progressive petechiae, bruising, or purpura. In most cases the disease is self-limited; approximately 80% of children recover by 6 months after diagnosis, with or without treatment. Children with thrombocytopenia persisting for more than 6 months are defined as having chronic ITP. Clinical manifestations, diagnosis, laboratory findings, differential diagnosis and various treatment modalities are reviewed.
Keywords
Thrombocytopenia; Immune; Idiopathic; Acute; Chronic; Platelet; Antibody;
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1 Imbach P, Zimmerman S. Local and cultural aspects of childhood idiopathic thrombocytopenic purpura : a summary of statements from the 12 countries worldwide. J Pediatr Hematol Oncol 2003;25 Suppl 1:68-73   DOI   ScienceOn
2 Blanchette VS, Carcao M. Childhood acute immune thrombocytopenic purpura : 20 years later. Semin Thromb Hemost 2003;29:605-17   DOI   ScienceOn
3 Buchanan GR, Adix L. Outcome measures and treatment endpoints other than platelet count in childhood idiopathic thrombocytopenic purpura. Semin Thromb Hemost 2001;27: 277-85   DOI   ScienceOn
4 Choi HS, Park ES, Kang HJ, Shin HY, Ahn HS. Intravenous immune globulin in acute idiopathic thrombocytopenic purpura in childhood. Korean J Pediatr Hematol Oncol 2003;22-9
5 Shad AT, Gonzalez CE, Sandler SG. Treatment of immune thrombocytopenic purpura in children : current concepts. Pediatr Drugs 2005;7:325-36   DOI   ScienceOn
6 Imbach P, Barandun S, d'Apuzzo V. High dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1981;i:1228-31
7 Panepinto JA, Brousseau DC. Acute idiopathic thrombocytopenic purpura of childhood-diagnosis and therapy. Pediatr Emerg Care 2005;21:691-5   DOI   ScienceOn
8 Han HJ, Lee IS, Shin HY, Park ES, Choi HS, Ahn HS. $Cepharanthin^Ⓡ$. in chronic idiopathic thrombocytopenic purpura in children. Korean J Pecliatr Hematol Oncol 2004;11:26-31
9 Scaradavou A, Woo B, Woloski BMR. Intravenous anti-D treatement of immune thrombocytopenic purpura : experience in 272 patients. Blood 1997;89:2689-700
10 Iyori H, Bessho F, Ookawa H. for the Japanese Study Group on childhood ITP, Intracranial hemorrhage in children with immnue thrombocytopenic purpura. Ann Hematol 2000;79:691-95   DOI
11 Medeiros D, Buchanan GR. Major hemorrhage in children with idiopathic thrombocytopenic purpura : immediate response to therapy and long-term outcome. J Pediatr 1998; 133:334-9   DOI   ScienceOn