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http://dx.doi.org/10.14402/jkamprs.2013.35.6.408

Heparin-induced Thrombocytopenia Type II after Free Flap Operation  

Baek, Jiwoong (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry)
Park, Jung Hyun (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry)
Cha, In-Ho (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry)
Kim, Hyung Jun (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.35, no.6, 2013 , pp. 408-411 More about this Journal
Abstract
After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.
Keywords
HIT type II; Heparin-induced thrombocytopenia; Free tissue flaps; Heparin;
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