• Journal of Korean Neurosurgical Society
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• v.62 no.1
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• Korean Journal of Radiology
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• v.22 no.2
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• pp.291-292
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• 2021

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.1
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• pp.1-8
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• 2011

A coupled thermal/structural analysis of mechanical ablation is performed based on domain/boundary decomposition and finite element method. The ablative material non-linearity and boundary non-linearity can be easily localized within a few subdomains and/or on the boundary interfaces. An enthalpy method is applied to simplify the effect of heat of pyrolysis in the ablative subdomains. In addition, maximum in-plane shear stress is considered as a surface recession criterion for the mechanical ablation simulation. The basic characteristics of the proposed method are examined carefully through numerical experiments.

• Korean Journal of Metals and Materials
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• v.50 no.7
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• pp.539-544
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• 2012

Thermal shock behavior of TiN-coated SUS 304 substrate was investigated using a laser ablation method. By short surface ablation with a pulse Nd-YAG laser, considerable surface crack and spalling were observed, whereas there were few oxidation phenomena, such as grain growth of TiN crystallites, nucleation and growth of $TiO_2$ crystallites, which were observed from the coatings quenched from $700^{\circ}C$ in a chamber. The oxygen concentration of the ablated coating surface with the pulse laser also had a lower value than that of the quenched coating surface by Auger electron spectroscopy and electron probe micro analysis. These results were attributed to the fact that the properties of the pulse laser method have a very short heating time and so the diffusion time for oxidation was insufficient. Consequently, it was verified that the laser thermal shock test provides a way to evaluate the influence of the thermal shock load reduced oxidation effect.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.282-287
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• 2001

The CSCM Upwind method and Material Transport Analysis (MTA) have been used to predict the thermal response and ablation rate for non-charring material to be used as thermal protection material (TPM) in KSR-III test rocket nozzle. The thermal boundary conditions such as cold wall heat-transfer rate and recovery enthalpy for MTA code are obtained from the upwind Navier-Stokes solution procedure. The heat transfer rate and temperature variations at rocket nozzle wall were studied with shape change of the nozzle surface as time goes by. The surface recession was severely occurred at nozzle throat and this affected nozzle performance such as thrust coefficient substantially.

• The Korean Journal of Pain
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• v.27 no.1
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• pp.72-76
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• 2014

A 57-year-old male patient had myeloma. He had severe pain in the left clavicle that did not respond to radiotherapy; therefore, it was treated with radiofrequency thermal ablation (RFTA). Under fluoroscopic guidance, two RF needles at a distance of 1.5 cm from each other were inserted into the mass and conventional radiofrequency ($90^{\circ}C$ and 60 seconds) at two different depths (1 cm apart) was applied. Then, 2 ml of 0.5% ropivacaine along with triamcinolone 40 mg was injected in each needle. The visual analogue pain score (VAS from 0 to 10) was decreased from 8 to 0. In the next 3 months of follow-up, the patient was very satisfied with the procedure and the mass gradually became smaller. There were no complications. This study shows that RFTA could be a useful method for pain management in painful osteolytic myeloma lesions in the clavicle

• Journal of the Korean Society for Precision Engineering
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• v.24 no.2 s.191
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• pp.134-139
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• 2007

Usually nanosecond pulsed laser processing of metal is mainly affected by the thermal ablation. Many studies of the theoretical analysis and modeling to predict the laser ablation of metal are suggested on the basis of the photothermal mechanism at higher laser fluence. In this paper, we investigate the etching depth and laser fluence of laser ablation of copper foils and propose the simplified SSB Model(Srinivasan-Smrtic-Babu model) to study the photothermal effect of nanosecond pulsed laser ablation. The experimental results show that the photothermal ablation of the 355nm DPSS $NdYVO_{4}$ laser is useful to process the copper thin foils.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.667-668
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• 2006

Usually nanosecond pulsing laser ablation of metal is under thermal effect. Many studies of the theoretical analysis and modeling to predict a result of laser ablation of metal are suggested on the basis of the photothermal mechanism. In this paper, we investigate the etching depth and laser fluence of laser ablation of copper films. We proposed the simplified SSB Model(Srinivasan-Smrtic-Babudp model) to study the photothermal effect of nanosecond pulsing laser ablation of copper thin metal. The experimental results were obtained by using the 355nm DPSS $Nd:YVO_4$ laser.

• Journal of Photoscience
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• v.6 no.3
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• pp.103-108
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• 1999

We present recent results on ablation mechanism, single-pulse laser micropatterning , pulsed-laser deposition(PLD) and particulates formation accompanying laser ablation, with special emplasis on polymers, in particular polymide, (PI), and polytetrafluoroethylene, (PTFE). Ablation of polymers is described on the basis of photothermal bond breaking within the bulk material. Here, we assume a first order chemical reaction, which can be described by an Arrhenius law. Ablation starts when the density of broken bonds at the surface reaches a certain critical value. Single-pulse laser ablation of polyimide shows a clear-length dependence of the threshold fluence. This experimental result strongly supports a thermal ablation model. We discuss the various possibilities and drawbacks of PLD and describe the morphology, physical properties and applications of PTFE films.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.05a
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• pp.7.1-7.1
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• 2009

The use of Duplex stainless steel as a thermo-implant categorizes into two clinical applications: hyperthermia and thermal ablation or destruction. The goal of hyperthermia is to destroy the heat-sensitive abnormal cells and minimize normal cell death maintaining heat between $42^{\circ}C$ and $46^{\circ}C$. Thermal ablation takes place when the local tissue temperature increases greater than $46^{\circ}C$. This elevated temperature denatures protein irreversibly resulting cellular death. The author introduced several thermo-implants such as thermo-rod, thermo-stent, thermo-coil and thermoacupuncture-needle. Those thermo-implants are made of duplex stainless steel which can produce regulated heat by itself within an induction magnetic field. Thermal ablation characteristics of the thermo-rod on tumor hyperthermia depend on configurations of the thermo-rods and the magnitude of the induction magnetic strength. The exothermic properties of the thermo-implants can be characterized using the calorimetric test and the heat affected zone(HAZ) analyses in vitro. Thermal radiation studies using thermo-coils and thermo-stents show the capability of the occlusion of animal blood vessels and inhibiting the proliferation of the abnormal smooth muscle cell growth and inflammatory cell reactions maintaining the heat between $42^{\circ}C$ and $46^{\circ}C$ minimizing a normal cell death in the study on external iliac artery of the New Zealand White (NZW) rabbit. Thermal stimulation study using thermo-acupuncture needles suggests the potential applications of the automated acupunctural therapies.