• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.1-7
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• 2008

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

• 대한물리치료과학회지
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• 제14권1_4호
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• pp.61-69
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• 2007

Physiotherapy may be defined as the use of physical techniques for the treatment of injuries and movement dysfunction. In the world of human medicine, physiotherapy has been proven as an indispensable aid in the recovery of many musculoskeletal conditions, as evidenced by the extensive physiotherapy departments within most hospitals. Nowadays, this important branch of medicine is also rapidly becoming a recognised tool in the prevention, cure, and rehabilitation of many equine, canine and feline injuries. In 1978, canine physical therapy techniques were described by Ann Downer, a physical therapist on faculty at Ohio State University. Animal physical therapy is a new and rapidly developing field of health care for animals. The benefits of physical therapy have long been recognized in humans. More recently, work in the veterinary field has shown the same benefits of physical therapy to be true for animal patients. Performing orthopaedic or neurological surgery, or fitting a human patient with a cast or splint, and then discharging the patient is an outdated approach. In such cases, physical therapy is clearly warranted. Similarly, recent research has shown that post-surgical rehabilitation and therapy after injuries significantly improves the functional outcomes for animals. The goals of physiotherapy are to relieve pain, restore range of motion/movement, improve function, prevent injuries and expand the physical potential of the patient. Once in the field, physical therapists actively continue their education to keep up to date on the latest treatments and technologies. Via continuing education courses, physiotherapists can learn how to apply their unique and specialized knowledge to other animal species.

• 농촌계획
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• 제28권3호
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• pp.83-94
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• 2022

This study was attempted to systematically analysis the characteristics and effects of studies that applied animal assisted therapy to elementary students. Literature searches were conducted in 4 domestic academic databases(RISS, KISS, ScienceON, KMBASE). The characteristics of selected 26 studies were individually analyzed and described by publication year, research method, subject characteristics, intervention characteristics, and outcome variables, and the characteristics of the study were systematically summarized. The effect of the assisted therapy was divided into psychological-emotional effect, interpersonal effect, and other effect. Most of the psychological-emotional indicators and interpersonal relationship indicators were found to be effective, and inconsistent results were found for some indicators. It is expected that it can be used as a useful data when conducting assisted therapy studies targeting elementary school students in the future.

• 디지털융복합연구
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• 제12권8호
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• pp.423-430
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• 2014

본 연구의 목적은 뇌졸중 동물 실험 모델에서 환경 강화는 기능 회복을 향상 시키고 이로 인하여 뇌에 형태학적, 생화학과 행동에서 특징적인 변화와 그 효과들을 소개하고, 뇌졸중 환자에 환경 강화의 적용은 재활치료 및 작업치료를 포함한 다양 치료와 전 임상 실험의 중요성을 설명하고자 한다. 이 종설 논문에서는 주로 뇌졸중 동물 실험 모델에서 환경 강화로 인한 기능적 회복에 대한 효과와 신경 친화성 물질, 특정 단백질의 발현 및 임상 적용 사례 등의 연구 결과들을 소개하였다. 마지막으로 임상에서 뇌졸중 환자에게 환경 강화의 적용 가능성과 작업치료 및 재활치료의 관점에서 설명하였다.

• 한국임상수의학회지
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• 제39권1호
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• pp.16-22
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• 2022

A 12-year-old spayed female beagle dog was presented with pollakiuria and stranguria. Abdominal ultrasonography identified irregular a marginated, hyperechoic mass in the urethra and trigon area of the bladder. Computed tomography (CT) revealed a heterogeneous mass in the trigone area leading to a urethra. There was no evidence of regional or distant metastasis. Cytologic analysis suspected transitional cell carcinoma (TCC). The patient was treated with piroxicam, mitoxantrone, and once weekly fractionated radiation therapy (RT) with volumetric modulated arc therapy (VMAT). A follow-up CT scan at 6 months after RT revealed a reduction in tumor size. At 17 months after the start of RT, the patient became severely anorectic and lethargic. Ultrasound examination revealed a hyperechoic mass in the apex area of bladder while the trigone area of the bladder and urethra appeared normal. Multiple hypoechoic nodules of various sizes were found in the liver and spleen. The patient was humanely euthanized at the request of the owner. A combination of piroxicam, mitoxantrone, and hypofractionated RT with VMAT protocol was well tolerated. This case described tumor response and survival time of a canine TCC treated with piroxicam, mitoxantrone, and once weekly palliative RT using computer-assisted planning and VMAT.

• 대한한방내과학회지
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• 제31권3호
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• pp.612-619
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• 2010

Background : Low level laser therapy may be an effective method to protect tissue damage in acute stroke. Recently, series of clinical studies on the basis of animal experiments report efficacy and safety of laser therapy at early stages of acute stroke. Laser promotes mitochondrial ATP synthesis to reduce cell death by ischemic infarction. Objectives : To report possibility of non-invasive laser therapy for acute stroke by reviewing literature about its effectiveness, safety and mechanism. Methods : We searched papers using PubMed and 'Web of Knowledge' of Thomson ISI, using the keywords "Laser Therapy, Low-Level" and "Stroke". Limitations were last 10 years of publications and only in English. Search range includes RCTs, clinical reports, reviews and animal experiments. Papers not matched with inclusion criteria were excluded. Results : A total 223 studies were found, 203 excluded during title and extract screening. After scanning 20 papers the final 2 serial RCTs were selected and analyzed. They reported that transcranial laser therapy led in neuroprotective effect for acute stroke patents. Clinical evaluation factors showed favorable trend and initial safety. Conclusions : Non-invasive laser secured safety of clinical application. It may be a favorable choice for the acute stage of stroke.

• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.327-335
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• 2021

본 연구는 치료도우미견을 활용한 동물매개치료가 아동의 자아존중감과 또래 관계에 어떠한 영향을 미치는지 살펴보고자 하였다. 연구대상은 I 시에 위치한 초등학교 저학년 아동 중 학교 사회복지사와 담임선생님의 추천을 받은 아동 20명이며, 실험집단 10명과 통제집단 10명을 선정하였다. 프로그램은 2019년 10월 1부터 12월 17일까지 동물매개치료 프로그램을 주 1회, 50분, 총 12회기를 실시하였다. 효과 검증을 위해 SPSS 20.0을 활용하여 실험집단과 통제집단에게 사전과 사후에 자아존중감, 또래관계 평정척도 측정을 실시하고 분석 하였다. 그 결과 첫째, 실험집단의 자아존중감 전체(Z=-2.75, p<.05), 가정에서의 자아존중감(Z=-2.02, p<.05), 학업적 자아존중감(Z=-2.06, p<.05)에서는 통계적으로 유의한 차이가 나타났다. 둘째, 실험집단의 또래관계 전체(Z=-3.83, p<.05), 하위 영역별로 주도성(Z=-2.68, p<.05), 협동공감(Z=-2.81, p<.05)에 유의미한 차이가 나타났다. 따라서 본 연구는 치료도우미견을 활용한 동물매개치료가 아동의 자아존중감과 또래관계에 긍정적인 영향을 준 것으로 확인이 되었다.

• 대한물리치료과학회지
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• 제10권1호
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• pp.180-189
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• 2003

The experiments were designated to evaluate the anti-nociceptive effect of low power laser stimulation on acupoint or non-acupoint using arthrogenic solution induced poly arthritis animal model. Evaluation of potential antinociceptive effect of low power laser on arthritis has employed measurements of the foot bending test, the development of either thermal or mechanical hyperalgesia following the arthritis induction. The analysis of thermal hyperalgesia includes Hargreaves's method. Randall-Sellitto test was utilized for evaluating mechanical hyperalgesia. In addition, the antinociceptive effect of low power laser stimulation on arthritis induced spinal Fos expression was analyzed using a computerized image analysis system. The results were summerized as follows: 1. In laser stimulation on acupoint treated animal, laser stimulation dramatically inhibited the development of pain in foot bending test as compared to those of non acupoint treated animal group and non treated animal group. 2. The threshold of thermal stimulation was significantly increased by low power laser stimulation on acupoint as compared to that of non treated control group. 3. Laser stimulation on acupoint dramatically attenuated the development of mechanical hyperalgesia as compared to that of non treated group. 4. Low power laser stimulation on acupoint significantly suppressed arthritis induced Fos expression in the lumbar spinal cord at 3 week post arthritis induction. In conclusion, the results of the present study demonstrated that low power laser stimulation on acupoint has potent anti-nociceptive effect on arthritis. Additional supporting data for an antinociceptive effect of laser stimulation was obtained using Fos immunohistochemical analysis on spinal cord section. Those data indicated that laser stimulation induced antinociception was mediated by suppression of spinal neuron activity in pain sensation.

• 대한수의학회지
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• 제41권3호
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• pp.447-451
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• 2001

2001년 2월 23일 연세대학교 의과대학 실험동물부에 6주령의 코커스파니엘이 운동실조를 주증으로 의뢰되었다. 늑골은 흉곽의 양측에서 흉골의 내측을 향하여 안쪽으로 휘어져 있었으며 양측 후지의 관절이 내번되어 있었다. 이를 기초로 누두흉으로 진단하였다. 환축은 호흡곤란, 배뇨곤란 등의 증상을 나타내지 않았으며, 심잡음과 기타 신경증상도 관찰되지 않았다. 재활치료로는 하루에 2-3회 양측 후지를 당겨주는 처지와 양손을 이용하여 늑연골을 위로 밀어주는 처치를 실시하였다. 치료실시 한달 후, 환축은 보행이 가능하였다. 이 후 치료를 지속하여 흉곽이 다소 둥근형태를 유지하는 것을 관찰할 수 있었다. 따라서 초기의 재활치료를 통하여 개의 누두흉이 발생 초기에 비하여 개선됨을 관찰할 수 있었다.

• Korean Journal of Acupuncture
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• 제38권3호
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• pp.122-132
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• 2021

Objectives : This systematic review aims to assess the effectiveness of thread embedding therapy on animal model for rheumatoid arthritis. Methods : Search was conducted in the Cochrane library, MEDLINE (PubMed), EMBASE, the Chinese National Knowledge Infrastructure, Wan-Fang Database, Technology Journal Database, the Korean Studies Information Service System, the Oriental Medicine Advanced Searching Integrated System, the Research Information Sharing Service, the National Digital Science Library, the Korean Traditional Knowledge Portal and the Korea Citation Index. Data were extracted concerning animal model, intervention and rheumatoid arthritis indicator by two independent reviewers. Reporting quality was also evaluated by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines 2.0. Results : One thousand thirty six studies were primarily selected. After screening, 10 studies met the inclusion criteria. 1 study was published 2005, 1 study was published 2010, 1 study was published 2012, 1 study was published 2015, 2 studies were published 2016, 3 studies were published 2017, 1 study was published 2018. The most frequently used acupoints were ST36 and BL23, and were used with an average frequency of 11.8 days. All of these thread embedding therapy studies were effective on behavioral, morphological, immunohistological and hematological indicators to treat of rheumatoid arthritis model. Conclusions : These results demonstrated the effectiveness of thread embedding therapy and suggested the putative mechanism. However, considering the small number of included studies, low reporting quality and differences in study design, further studies with rigorous designs and high reporting quality need to be conducted.