Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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Small Animal Small Animal $[^{18}F]$FDG PET Imaging for Tumor Model Study

종양 모델 연구를 위한 소동물 $[^{18}F]$FDG PET 영상화

  • Woo, Sang-Keun (Molecular Imaging Research Center, Radiological and Medical Sciences Research Institute, Korea Institute of Radiological and Medical Sciences) ;
  • Kim, Kyeong-Min (Molecular Imaging Research Center, Radiological and Medical Sciences Research Institute, Korea Institute of Radiological and Medical Sciences) ;
  • Cheon, Gi-Jeong (Molecular Imaging Research Center, Radiological and Medical Sciences Research Institute, Korea Institute of Radiological and Medical Sciences)
  • 우상근 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 김경민 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 천기정 (한국원자력의학원 방사선의학연구소 분자영상연구부)
  • Published : 2008.02.29
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Abstract

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

Keywords

References

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