Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Thread Embedding Therapy in Rheumatoid Arthritis: A Systematic Review of Animal Studies

매선요법의 류마티스 관절염 동물모델을 활용한 실험연구: 체계적 문헌고찰

  • Jun, Purumea (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Zhao, HuiYan (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Kang, Suk-Yun (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Han, Chang-Hyun (KM Science Research Division, Korea Institute of Oriental Medicine)
  • 전푸르메 (한국한의학연구원 한의과학연구부) ;
  • 조혜연 (한국한의학연구원 한의과학연구부) ;
  • 강석윤 (한국한의학연구원 한의과학연구부) ;
  • 한창현 (한국한의학연구원 한의과학연구부)
  • Received : 2021.08.18
  • Accepted : 2021.09.13
  • Published : 2021.09.27
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Abstract

Objectives : This systematic review aims to assess the effectiveness of thread embedding therapy on animal model for rheumatoid arthritis. Methods : Search was conducted in the Cochrane library, MEDLINE (PubMed), EMBASE, the Chinese National Knowledge Infrastructure, Wan-Fang Database, Technology Journal Database, the Korean Studies Information Service System, the Oriental Medicine Advanced Searching Integrated System, the Research Information Sharing Service, the National Digital Science Library, the Korean Traditional Knowledge Portal and the Korea Citation Index. Data were extracted concerning animal model, intervention and rheumatoid arthritis indicator by two independent reviewers. Reporting quality was also evaluated by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines 2.0. Results : One thousand thirty six studies were primarily selected. After screening, 10 studies met the inclusion criteria. 1 study was published 2005, 1 study was published 2010, 1 study was published 2012, 1 study was published 2015, 2 studies were published 2016, 3 studies were published 2017, 1 study was published 2018. The most frequently used acupoints were ST36 and BL23, and were used with an average frequency of 11.8 days. All of these thread embedding therapy studies were effective on behavioral, morphological, immunohistological and hematological indicators to treat of rheumatoid arthritis model. Conclusions : These results demonstrated the effectiveness of thread embedding therapy and suggested the putative mechanism. However, considering the small number of included studies, low reporting quality and differences in study design, further studies with rigorous designs and high reporting quality need to be conducted.

Keywords

Acknowledgement

This study is supported by grants from the project of the Korea Institute of Oriental Medicine (KIOM) (KSN2021210, KSN20214113).

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