• 해양환경안전학회지
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• 제18권4호
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• pp.365-370
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• 2012

최근 소형선박 국제표준규격(ISO-12215)이 제정되면서 소형선박-선체구조 및 치수-제5장 부속서 B에 의하여 길이 2.5미터 이상 6미터 미만 소형선박의 낙하시험에 의한 강도시험 기준을 적용할 수 있게 되었으나, 육안검사로 실시되는 현재의 방법으로는 선체 강도 평가의 객관적인 평가가 어려운 문제점이 있다. 본 연구에서는 레저선박의 낙하시험의 정량적 평가가 가능한 평가시스템을 개발하기 위하여 레저선박의 낙하시험에 대한 국내 외 규정을 기반으로 한 낙하시험 평가시스템을 설계하였으며, 5미터급 알루미늄선박의 낙하시험을 통하여 시스템의 적용가능성을 검토하고 낙하 시 선박의 상태 및 낙하자세에 따라 발생되는 문제점을 확인하였다.

• 한국항공우주학회지
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• 제50권5호
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• pp.359-365
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• 2022

공대지유도탄은 항공기 외부에 탑재되어 운용 가능한 무기체계로 정밀 타격이 가능하고 높은 생존성을 보장한다. 공대지유도탄 운용 플랫폼 중 하나인 헬기는 평균적으로 수천~수만 비행시간 중 1회 낙뢰에 피격되는 것으로 보고되었다. 헬기 기체에 낙뢰가 피격되면 기체 스킨을 거쳐 헬기 내/외부 전자장비 케이블에 과도신호가 유기될 수 있다. 공대지유도탄 내 폭발물 관련 EID(Electrically Initiated Device)에 기준 이상의 과도신호가 유기되면 탄두 폭발 등으로 헬기 안전에 영향을 미칠 수 있다. 본 논문에서는 헬기에 대한 공대지유도탄 안전 영향성 입증을 위한 낙뢰 간접영향 시험방안을 제시하고, 이를 바탕으로 수행한 시험 결과를 제시한다.

• Korean Journal of Acupuncture
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• 제35권1호
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• pp.36-40
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• 2018

Objectives : Electronic moxibustion was developed to overcome the weakness of conventional moxibution. However, in spite of many benefits, it also can not be entirely free from the concern of burning. This study was performed to investigate the proper treatment time of electronic moxibustion. Methods : Male sprague-Dawley rats weighing about 350 g were used. Animals were anesthetized with sodium pentobarbital and shaved on the abdomen or back. The full charged-electronic moxibustion device was placed on the shaved site and it was observed if there happened any adverse event after treatment. Results : At the temperatures of 41, 43, and $45^{\circ}C$ there was no abnormal sign after moxibustion even in full time. However, at $47^{\circ}C$, the safe treatment time was 3 min. On the other hand, $49^{\circ}C$ produced diverse adverse events even in 1 min. Conclusions : Results of the present study suggest that the safe treatment time of electronic moxibustion is different according to the temperature. The most common adverse effect in this electronic moxibustion was the white spot and it is needed to observe whether there is any adverse event until 48 h after treatment.

• Archives of Plastic Surgery
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• 제46권2호
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• pp.108-113
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• 2019

Background The aim of this study was to assess the safety of one-per-mil tumescent injections into viable skin flaps that had survived an ischemic insult, in order to assess the potential suitability of one-per-mil tumescent injections in future secondary reconstructive procedures such as flap revision and refinements after replantation. Methods Forty groin flaps harvested from 20 healthy Wistar rats weighing 220 to 270 g were subjected to acute ischemia by clamping the pedicle for 15 minutes. All flaps showing total survival on the 7th postoperative day were randomly divided into group A (one-per-mil tumescent infiltration; n=14), group B (normal saline infiltration; n=13), and group C (control, with no infiltration; n=13) before being re-elevated. Transcutaneous oxygen tension ($TcPO_2$) was measured before and after infiltration, and changes in $TcPO_2$ were statistically analyzed using analysis of variance, the paired t-test, and the independent t-test. The viability of flaps was also assessed using the Analyzing Digital Images software at 7 days after the second elevation. Results Thirty-nine flaps survived to the final assessment, with the sole exception of a flap from group A that did not survive the first elevation. $TcPO_2$ readings showed significant decreases (P<0.05) following both one-per-mil tumescent ($99.9{\pm}5.7mmHg$ vs. $37.2{\pm}6.3mmHg$) and normal saline ($103{\pm}8.5mmHg$ vs. $48.7{\pm}5.9mmHg$) infiltration. Moreover, all groin flaps survived with no signs of tissue necrosis. Conclusions One-per-mil tumescent infiltration into groin flap tissue that had survived ischemia did not result in tissue necrosis, although the flaps experienced a significant decrease of cutaneous oxygenation.

• 해양환경안전학회지
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• 제20권2호
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• pp.234-240
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• 2014

본 연구에서는 허니컴 패널의 지배방정식을 이용하여 경계행렬식을 유도하였고, 이를 전달행렬법에 적용하여 허니컴 패널을 적용한 차음패널에 대한 해석 이론을 정립하였다. 또한, 허니컴 패널을 선박용 차음패널의 표면재로 적용하여 차음성능을 분석하였고, 철판을 표면재로 적용한 기존의 선박용 차음패널과 차음성능을 무게 당 감음량 기준으로 비교 분석하였다. 그 결과, 허니컴 패널의 차음성능이 0.35 mm 철판에 비해 STC 기준으로 2dB 높게 나와 허니컴 패널을 적용한 차음패널의 차음성능이 철판을 사용한 차음패널에 비해 무게 당 감음량을 고려할 시 우수하다는 것을 확인하였다. 또한, 허니컴 패널을 표면재로 사용한 차음패널의 면밀도가 철판을 사용한 차음패널에 비해 약 $5.2kg/m^2$ 가볍게 나타났고, 이는 약 31.7 % 무게 감소를 의미한다.

• 한국임상약학회지
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• 제31권1호
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• pp.21-26
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• 2021

Background: Pharmacogenomics is the study of how genetic mutations in patients affect their response to drugs. Pharmacogenomic studies aim to maximize drug effects and minimize adverse drug events. The Food and Drug Administration and the European Medicine Agency published guidelines for pharmacogenetics in 2005 and 2006, respectively; the Korean Ministry of Food and Drug Safety followed suit in 2015. Methods: This study analyzed pharmacogenomic information in the Korean Ministry of Food and Drug Safety's integrated drug information system to evaluate whether domestic pharmaceutical products reflect the current research on pharmacogenomic differences. Results: In June 2020, the Korean pharmacogenomic database contained genomic data on 90 compounds. Of these, 45 compounds were classified as "Antineoplastic and immunomodulating agents." The other 45 non-antineoplastic agents were in the following categories: Anti-infectives, Mental & behavior disorder, Hormone & metabolism related diseases, Cardiovascular system, Skin & subcutaneous tissue disease, Genito-urinary system and sex hormones, Blood and blood forming organs, Nervous system, Alimentary tract and metabolism, Musculo-skeletal system, and Other conditions including the respiratory system. In addition, 30 additives unrelated to the main ingredient were associated with genetic precautions. Conclusion: This study showed that antineoplastic and immunomodulating agents accounted for half the drugs associated with pharmacogenetic information. For antitumor and immunomodulatory drugs, genomic tests were recommended depending on the indication; this was in contrast to genomic testing recommendations for non-antineoplastic medications. Genomic tests were rarely requested or recommended for non-antineoplastic medications because the relationships between genotype and efficacy among those drugs were relatively weak.

• Fisheries and Aquatic Sciences
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• 제14권3호
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• pp.168-173
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• 2011

The purpose of this study was to obtain a fraction with high antioxidative activity from second rockfish gelatin hydrolysates (SRSGHs), which were hydrolyzed with Alcalase and Flavourzyme through ultrafiltration membranes with serial digestions for 1 and 2 h, respectively, and to investigate the feasibility of this fraction as a potential functional food ingredient. Among various fractions that were ultrafiltered from the SRSGH with four types of membrane (1, 5, 10, and 30 kDa), the SRSGH-III fraction, which permeated the 10 kDa membrane but not the 5 kDa membrane, showed the highest antioxidant activity (protection factor=5.13) and angiotensin-I-converting enzyme-inhibiting activity ($IC_{50}$=0.82 mg/mL). These results suggest that the SRSGH-III fraction from the SRSGH can be used as a functional food ingredient. However, further studies examining its antioxidant activity in vivo as well as the different antioxidant mechanisms are needed.

• 한국안전학회지
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• 제21권2호
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• pp.150-157
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• 2006

새건물증후군이란 새로 지은 건물에서 생활하는 사람들에게 눈이 따갑거나 목이나 코가 아프거나, 두통, 구토, 피부발진 등 증상이 나타나는 것을 일컫는 말이다. 새집증후군 원인물질의 주요 성분으로는 건축 자재나 벽지, 페인트, 가구 접착제 등에서 발생되는 포름알데이드(HCHO)와 톨루엔 등 휘발성 유기화합물(VOCs: Volatile Oragnic Compounds), 부유 박테리아, 곰팡이, 바이러스 등이다. 새집증후군을 저감하기 위한 방법으로는 환기에 의한 방법, 오염물질이 없는 친환경 재료의 사용 및 재료의 처리를 통해 오염물질을 저감하고자 제거하는 방법이 있다. 본 연구는 이들 방법 중 건축 재료 위에 표면코팅처리를 함으로써 실내 공기질을 향상시키기 위한 것으로, 건물 내 표면 코팅 전후의 공기질을 분석함으로써 실내 거주환경을 안전하게 조성하는 데 그 목적이 있다.

• Journal of Microbiology and Biotechnology
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• 제7권2호
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• pp.144-150
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• 1997

We developed a simple and efficient method to prepare a Pseudomonas vaccine of outer membrane (OM) proteins free from lipopolysaccharide (LPS). A three step purification process including extraction, ultrafiltration and ultracentrifugation effectively removed LPS from the OM protein fraction. Approximately 2 mg of the OM proteins was obtained from 1 g of wet cell. LPS contaminant in the vaccine preparation was less than 0.003% (w/w) of protein and protease activity was not detectable. To achieve a wide range of protection, OM proteins prepared from four attenuated P. aeruginosa strains were mixed in equal amounts and used as a vaccine, which elicited in rabbits a high titer of antibody reactive to all of the seven Fisher types. The antisera from the immunized rabbit had a strong reactivity to vaccine proteins larger than 25 kDa. In a burned mouse infection model, immunization with the vaccine significantly enhanced bacterial clearance in the Pseudomonas infected skin. The vaccination also provided mice an excellent protection against Pseudomonas infection (11, 16). Data on antigenicity, mutagenicity, acute, subacute toxicity and pharmacological tests confirmed the safety of the vaccine (1, 3, 10, 12, 17). These data demonstrate that this method can be applied to manufacture a bacterial vaccine of OM proteins with safety and prophylactic efficacy at a practical low cost.

• 한국식품위생안전성학회지
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• 제15권2호
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• pp.167-172
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• 2000

최근 동물성 식품 및 지방 섭취 증가로 인한 현대인의 식생활 변화로 혈소판 활성화가 직접적 원인인 뇌 .심혈관질환의 사망률이 증가되고, 성인병 예방과 치료의 대처방안으로 식품의 기능성에 대한 관심이 높아짐에 따라서 천연착색료이며 항균, 항암 작용이 있는 자근(Lithospermum erythrorhizon)으로부터 추출, 분리 . 정제한 분획물에서 혈소판 활성화 억제작용이 있는 생리활성물질을 분리 . 동정하였다 자근에서 methanol, n-hexane, ethyl acetate 등의 용매추출물과 methanol 추출물에 NaOH프 처리한 n-hexane 추출물에 대한 혈소판 응집 억제작용은 collagen의 응집작용에 대하여 n-hexane재추출물이, thrombin의 응집작용에 대하여 ethyl acetate추출물이 큰 억제작용을 보였고, 이러한 추출물에서 컬림 및 HPLC로 분리 .정제한 5개 물질의 화학구조를 IH과 13C-NMR 스펙트라 분석한 결과 shikonin, acethylshi onin, isobutylshikonin, $\alpha$-methyl-n-butylshikonin, $\beta$,$\beta$-dimethylacrylshikonin을 확인하였고, 혈소판 응집 억제작용은 $\beta$,$\beta$-dimethylacrylshi onin$\geq$$\alpha$-methyl-n-butylshikonin>isobutylshikonin>acetylshikonin>shikonin순으로 나타났다. 이상의 결과로부터 자근색소의 생리활성은 shikonin유도체이며 11번 탄소에 치환된 aliphatic 기의 탄소수가 많을수록 억제작용이 강하게 나타난다고 사료된다.